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This is a review on the effects of aging on biliary tract cancer (BTC). We discuss the potential link between aging and BTC from the aspects of molecular mechanisms (including the DNA damage repair (DDR), cell senescence and the tumour microenvironment (TME)) and clinical challenges.

There is a dynamic, bi-directional relationship between aging and cancer.

RFS and CSS did not significantly differ between the three groups, but OS was significantly poorer in patients ≥80 years old. Radical nephroureterectomy exerts the same anticancer effects in older patients as in younger patients and may be an option for patients aged ≥80 years who can tolerate surgery.

Here, we report that platinum doublet combination therapy may be beneficial in older patients with NSCLC. The OS was significantly longer in patients treated with platinum doublet combination therapy than in those who received monotherapy. Moreover, we identified several laboratory values that reflect prolonged exhaustion owing to inflammation and might be predictors of outcomes in older patients with NSCLC.

In older patients with extensive-stage small-cell lung cancer with performance status ≥3, carboplatin plus etoposide shrinks tumors, but provides shorter survival than in those with performance status 2.

Acrometastases of the hand are extremely rare and may be the first manifestation of lung cancer, but they consider a poor prognosis marker. It is important for physicians who encounter patients with a persistent lesion at the site of a wound located in the hand to earlier diagnosis. This recognition will improve patient care and may lead to earlier diagnosis of malignancy.

A novel health system reliability method has been developed and applied to cardio and cancer death rate data. Accurate disease multiregional prediction is done.