Influenza A infection leads to a higher incidence of liver injury in HBV carriers than in patients infected with influenza A alone. Moreover, HBV carriers experience earlier onset and greater severity of liver injury than individuals with only influenza A.

Autoantibodies may appear characteristically in autoimmune liver disease, and some autoantibodies have become specific biomarkers. However, autoantibodies can also be detected in non-autoimmune liver diseases, such as viral liver disease and alcoholic liver disease with unclear distribution characteristics.

Copper is an essential trace metal indispensable for the function of numerous enzymatic molecules implicated in cellular metabolism. The authors review the process of copper metabolism, explore the underlying mechanisms of cuprotosis, and provide novel ideas for diagnosing and treating disorders of copper metabolism associated with copper toxicity.

We constructed an iASPP-derived short peptide A8, which can specifically combine with iASPP and reactivate the functional activity of p53, especially in apoptosis. Additionally, A8 restored the transcriptional function and DNA binding activities of p53 toward the Bax and PUMA gene promoters to finally inhibit tumor growth. Notably, our work presents a new candidate strategy to restore the tumor suppressive function of p53 in cancer cells.

This article investigated the clinical utility of the six serum tumor markers in differentiating between lung cancer and benign lung diseases through the comparative analysis of patient samples, and proved that combining the detection of ProGRP, NSE, CYFRA21-1, CEA, and SCCA significantly improves sensitivity when diagnosing lung cancer.