Recent multi-omics studies have demonstrated that belimumab specifically targets naïve B cells and a subset of memory B cells. This observation is consistent with belimumab's established efficacy and safety profile.

Advancements in artificial intelligence (AI) over the past 5 years have brought significant progress to the medical field, including rheumatoid arthritis (RA). AI integrates multimodal data, including clinical, imaging, omics, and longitudinal information, to enhance RA diagnosis and treatment. By leveraging techniques such as machine learning, deep learning, and natural language processing, AI facilitates precise diagnostics and personalized therapeutic strategies, driving innovations in RA management.

This review seeks to provide a thorough synthesis of the existing literature on the role of thrombopoietin receptor agonists in the treatment of primary and secondary immune thrombocytopenia, with particular emphasis on the compound Hetrombopag.

This meta-analysis evaluated the impact of statins on psoriasis severity, analyzing data from 10 studies and meta-analyzing only eight studies (638 observations). While statins, especially topical forms, showed some efficacy in reducing Psoriasis Area and Severity Index (PASI) scores (standardized mean difference [SMD]: −0.82, 95% confidence intervals [CI]: −1.47 to −0.16), the overall effect was not statistically significant (SMD: −0.36, 95% CI: −0.72 to 0.00). No significant improvements were observed in quality of life (Dermatology Life Quality Index: SMD: 0.24, 95% CI: −0.09 to 0.57) or inflammation (high-sensitivity C-reactive protein: SMD: −0.12, 95% CI: −0.42 to 0.18). These findings suggest limited benefits of systemic statins for psoriasis severity.

A pristane-induced systemic lupus erythematosus model was established in C57BL/6J mice. Mice were randomly assigned to a pristane group (0.5 mL pristane intraperitoneally) or a control group (0.5 mL saline intraperitoneally). Six months later, levels of antinuclear antibodies, serum inflammatory cytokines, urinary protein, renal injury, and immune cell changes were assessed.

Peripheral blood mononuclear cells were isolated from 12 systemic lupus erythematosus (SLE) patients and 12 healthy controls. The number and function of peripheral blood CD141⁺ dendritic cells (DCs) were compared between patients and controls. Moreover, the tolerogenic properties of CD141⁺ and CD1c⁺ DCs were compared in SLE patients.

Strategy to identify variants involved in gout pathogenesis in New Caledonia.