• Issue

    Chronic Diseases and Translational Medicine: Volume 9, Issue 3

    i, 183-272
    September 2023

TABLE OF CONTENTS

Open Access

Table of Contents

  • Page: i
  • First Published: 22 January 2024

ORIGINAL ARTICLES

Open Access

Trend analysis of noncommunicable diseases and their risk factors in Afghanistan

  • Pages: 210-221
  • First Published: 07 March 2023
Trend analysis of noncommunicable diseases and their risk factors in Afghanistan

Total noncommunicable disease deaths trend from 2008 to 2030—Afghanistan and the world.

Open Access

Cyclophilin D as a potential therapeutic target of liver ischemia/reperfusion injury by mediating crosstalk between apoptosis and autophagy

  • Pages: 238-249
  • First Published: 11 June 2023
Cyclophilin D as a potential therapeutic target of liver ischemia/reperfusion injury by mediating crosstalk between apoptosis and autophagy

In this study, we first reported the effect of cyclophilin D (CypD) in liver ischemia/reperfusion (I/R) by establishing liver-specific CypD knockout and AAV8-peptidyl prolyl isomerase F overexpression models in vivo. And found the hepatic CypD knockout can alleviate the liver injury caused by I/R by reducing hepatocyte necrosis and apoptosis, and inhibiting the overactivation of autophagy, and vice versa.

Open Access

Mechanism of RBBP8-mediated homologous recombination repair in gastric cancer synthetic lethal

  • Pages: 250-257
  • First Published: 22 June 2023
Mechanism of RBBP8-mediated homologous recombination repair in gastric cancer synthetic lethal

RBBP8 knockdown inhibited RAD51 activation induced by PARP inhibitors and exogenous RBBP8 overexpression ameliorated this (A). Si-RBBP8 knockdown inhibited the intranuclear staining of BrdU and its intranuclear colocalization with γ-H2AX (B). Scale bars = 8 mm.

CORRESPONDENCE

Open Access

A superficial siderosis-related transient focal neurological episode in a patient with Marfan syndrome

  • Pages: 269-272
  • First Published: 21 April 2023
A superficial siderosis-related transient focal neurological episode in a patient with Marfan syndrome

Sagittal computed tomography of lumbal spine showing dural ectasia and Tarlow Cyst (red arrows) (A). Magnetic resonance imaging (MRI) axial slice, susceptibility-weighted imaging (SWI) sequences showing siderosis in cerebellar sulci (red arrows) and in the inset uncharacteristic iron deposition in dental nuclei, more pronounced on the left side (red arrows) (B, inset). MRI, SWI, axial slice, showing numerous foci of superficial siderosis (C).