Postmortem studies on AMPA receptors in patients with addiction show that the hippocampus and amygdala may be pertinent to addictive disorders through their functions on learning and memory, whereas findings in other regions were inconsistent across the studies. Human postmortem studies are prone to degenerative changes after death, which emphasizes the need to investigate AMPA receptors in the living human brains.

Treatment of rat C6 astroglial cells (C6 cells) with amitriptyline increased Src family tyrosine kinase phosphorylation in a time- and concentration-dependent manner. The current findings suggest that the pharmacological effect of antidepressant such as amitriptyline is mediated through an intracellular signaling pathway via the LPAR1/Gαi/o/Src family tyrosine kinase, which leads to MMP-9 activation and glial cell line-derived neurotrophic factor production.

We developed the 23-item “School Teachers Job Stressor Scale (STJSS)” to measure specific stressors in Japanese teachers to improve their mental health care which could provide an accurate assessment tool with adequate reliability and validity.

Blonanserin is as effective as haloperidol for the treatment of schizophrenia. Blonanserin is more effective for negative symptoms with a lower risk of extrapyramidal symptoms compared with haloperidol. Blonanserin is considered an appropriate antipsychotic drug to combine with cognitive remediation therapy.

With facial myogenic potential topography, facial expressions can be evaluated objectively without being influenced by face shape or countenance. Cluster analysis of the expression of disgust showed four homogeneous subgroups. Color changes in topograms showed subtle changes in expressions that could not be supplemented with statistical processing alone, and these were useful in identifying individuality.

Effectiveness of rTMS in treatment-resistant depression: a randomized clinical trial of 37.5-minute vs 18.75-minute protocol

In-vivo microdialysis study showed that the intra-nucleus accumbens injection of mGluR group II antagonist was able to restore methamphetamine induced DA increase suppressed by the overexpression of Shati/Nat8l in the medial prefrontal cortex.

Our data obtained through a self-report questionnaire administered to 11,840 participants showed that individuals with photic sneeze syndrome were more likely to suffer from migraine and psychological distress than those without photic sneeze syndrome. Photic sneeze syndrome may be a potential target for the research of migraine and stress-related disorders.

In Syngap1^−/+ mice, a well-known model of SYNGAP-related ID, we could reproduce most of the previously reported cognitive and emotional deficits. The decreased sensitivity to painful stimuli and impaired motor function that we found in Syngap1^−/+ mice are consistent with the common characteristics of patients with SYNGAP-related ID. We further confirmed that the Syngap1 heterozygote mouse recapitulates the symptoms of ID and ASD patients.

Study, patient, and treatment characteristics of the included double-blinded, randomized placebo-controlled trials of patients with bipolar disorder

Oxidative stress plays a role in the neurotoxicity of MPTP in the striatum. Dietary intake of glucoraphanin could prevent the MPTP-induced neurotoxicity in mouse striatum. Dietary intake of glucoraphanin-rich vegetables may have beneficial effects on prevention of Parkinson's disease.

This is one-week, prospective, single-arm, clinical trial of fixed dose of suvorexant for insomnia included 57 patients with psychiatric disorders. Compared with the baseline scores, taking suvorexant was associated with significant improvements in total sleep time, time to sleep onset, wake time after sleep onset, and the patients' sleep satisfaction level at week 1.

We conducted a Bayesian analysis of data from phase 3 studies in Japan of quetiapine extended-release, 300 mg/d (QUEXR300), and olanzapine, 5-20 mg/day (OLA). Although the two drugs’ efficacy did not differ, OLA increased the risk of metabolic syndrome and QUEXR300 the risk of somnolence.