• Issue

    Immunity, Inflammation and Disease: Volume 13, Issue 6

    June 2025

ISSUE INFORMATION

Open Access

Issue Information

  • First Published: 03 June 2025

ORIGINAL ARTICLE

Open Access

Utility of Prognostic Nutritional Index and Systemic Immune-Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study

  • First Published: 17 June 2025
Utility of Prognostic Nutritional Index and Systemic Immune-Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study

In this study, we investigated the relationship with human inflammatory status and nutritional level with the occurrence and prognosis of SSNHL patients. Lower PNI values and higher SII values may promote the occurrence of SSNHL, while higher PNI values and lower SII values may suggest a better prognosis for SSNHL. Our findings will benefit clinicians in the disease management of SSNHL patients and in the development of individualized treatment plans.

ORIGINAL ARTICLE

Open Access

Visualization of Molluscum Contagiosum Virus in FFPE Skin Sections Using NanoSuit-CLEM: Ultrastructural Evidence of Viral Spread via Skin Barrier Disruption

  • First Published: 03 June 2025
Visualization of Molluscum Contagiosum Virus in FFPE Skin Sections Using NanoSuit-CLEM: Ultrastructural Evidence of Viral Spread via Skin Barrier Disruption

Molluscum contagiosum (MC) virus, a member of the Poxviridae family, primarily spreads through skin contact, with disrupted skin serving as a key entry point. Using NanoSuit-correlative light and electron microscopy (CLEM), we visualized MC virus particles densely packed in the stratum corneum but not penetrating intact epithelial layers. This study highlights the role of skin injury in MC transmission and provides a novel method for precise viral mapping, contributing to improved prevention strategies.