Multiple invasive foci has been shown to increase the risk of lymph node metastasis (LNM) in early breast cancer, but its prognostic implication remains unknown. In this study, we found that more than five invasive foci is an independent predictor for LNM and an unfavorable prognostic parameter. Furthermore, the invasive lesion index, established by the number of invasive foci and the invasive component size, could potentially be used to predict survival prognosis in patients with DCIS-MI.

Using the National Cancer Database, male gender, facility location, and lack of insurance were associated with metastatic disease at presentation. Furthermore, a significant benefit was associated with the use of pelvic radiotherapy in these patients.

Bone marrow involvement by biopsy complemented performance status in predicting those patients with a higher risk for relapse or progression. In this cohort, bone marrow involvement by PET/CT could not independently predict a shorter PFS and/or OS.

Weight variation during adjuvant chemotherapy for early stage breast cancer may occur as both weight gain and weight loss in a balanced manner. Furthermore, this variation seems to be transient in nature and does not appear to significantly influence recurrence rates and overall survival.

The present study confirmed that the tumor location was a risk factor for the OS in patients who underwent curative treatment for colon cancer. Tumor location may, therefore, need to be considered a stratification factor in future phase III trials of colon cancer.

Keratin 19 (K19) is known to be a cancer stem cells (CSCs) marker in hepatocellular carcinoma (HCC). However, easily-measurable surrogate marker of K19 +  HCC-CSCs has not been identified. This study showed that serum CYFRA 21-1 is the significant predictor of K19 expression in human HCC, and that CYFRA 21-1 levels reflect K19 function and TGFβ receptor 1 inhibitor treatment efficacy in HCC cells.

The study is the first analysis of lncRNAs profile in external auditory canal squamous cell carcinoma and provides new insights into molecular pathogenesis. We also demonstrated that lnc-MMP3-1 is a novel prognostic predictor for this rare disease.

PD-L1-expressing NSCLC had a high glucose metabolism. The SUVmax in preoperative 18F-FDG PET/CT was a predictor of PD-L1 protein expression in patients with NSCLC.

Fatigue might be perceived differently among breast cancer patients over time as a consequence of patients’ adaptation and psychological adjustment to their cancer experience which can be related to response shift. Several response shift effects were evidenced in different groups and women seemed to adapt differently to their treatment and breast cancer experience possibly indicating differing needs for medical/psychological support.

The frequency of brain metastases developing in advanced regional melanoma (Stage IIIB and C) remains poorly defined. We performed a retrospective analysis of a large patient sample that were staged and managed using contemporary techniques from the intergroup trial SWOG 0008 to provide an estimate of the risk of CNS relapse. Difference between treatment arms was not expected. This data provides a basis for design of future studies for surveillance and treatment of early brain metastases.

Nomogram to predict the overall survival stage IV breast cancer patients. This would be helpful to clinical decision-making.

Crowdsourcing has the potential to improve the quality and speed of cancer research while reducing costs. Thus, it is critical to increase the visibility and accessibility of crowdsourcing methods, perhaps by providing online educational offerings to cancer researchers.

This systematic review in early-phase trials in patients with medulloblastoma summarizes the recent experience in therapeutic strategies in patients with relapsed and refractory medulloblastoma and highlights the strengths and pitfalls of current trials.

Tissue and stem cells microarrays from nine glioblastomas samples were used to evaluate expression and chromosomal abnormalities of ALK, ROS1, and MET. No molecular rearrangement of these three important genes was observed but rather an overexpression of ALK and MET in some of the glioblastoma stem cell samples, supporting the role of these two genes in tumorigenicity.

Establishment, culture, and analysis of tumor-bearing brain explants as a drug evaluation system for malignant brain tumors.

Novel ATP-competitive Akt inhibitor afuresertib exerts tumor-specific antiproliferative effect on MPM cells. Afuresertib significantly enhanced cisplatin-induced cytotoxicity, suggesting that afuresertib is a useful anticancer drug for treating patients with MPM.

Nucleotide-binding oligomerization domain (NOD)-like receptor (NLR)C and NLRX family proteins play a key role in the innate immune response. The relationship between these proteins and hepatocellular carcinoma (HCC) remains unclear. This study investigated the prognostic significance of NLRC and NLRX family protein levels in HCC patients.

Utilization of dietary bioactive molecules as chemo-sensitizers is an emerging approach in developing combination strategies that can potentially provide more efficacy and less toxicity for anticancer treatments. Our study offers preclinical proof for combinatorial strategy using natural product, pterostilbene, with histone deacetylase inhibitor, SAHA, as a MTA1-targeted interventional therapy to abrogate prostate cancer. Changes in MTA1-associated proangiogenic factors in serum may be used as molecular response biomarkers for such therapy.

GRHL2 has a significantly positive correlation with E-cadherin and CD133 in 155 resected human primary PDAC tissues. GRHL2 is highly expressed in liver metastatic cells than in primary invasive cells of both human and mouse PDAC, accompanied by a positive correlation with E-cadherin expression. Knockdown studies followed by flow cytometry analysis for a subpopulation of CD133+ showed that GRHL2 facilitates CFPAC-1 cells to maintain stem-like characters including self-renewal capacity and anoikis resistance.

Long-term exposure to Rhodospirillum rubrum L-asparaginase (RrA) induced telomere shortening and eventual growth arrest and apoptosis in vitro. Telomerase inhibition using RrA may be considered as a promising approach for cancer treatment.

Urine is a noninvasive and attractive biofluid for biomarker research, and has the potential to reflect early and small pathological changes in the body. Urine proteins changed significantly with cancer development in a tumor-bearing rat model. Our results indicate that urine proteins could enable early detection of cancer at an early onset of tumor growth and monitoring of cancer progression.

The HPV-16/18 AS04-adjuvanted vaccine produced a sustained immune response in women aged 15–55 years at vaccination for up to 10 years, with an acceptable safety profile. Study results suggest that women in age groups not targeted by adolescent immunization and catch-up programs may still individually benefit from HPV vaccination.

Data regarding central venous catheter-related thrombosis (CRT) in breast cancer (BC) patients are limited, although CVC placement for chemotherapy is common in this population and BC is the first cause of cancer in women worldwide. We conducted a large prospective multicentre study (9 cancer hospitals, 524 patients). The 6-months cumulative probability of symptomatic and asymptomatic CRT was 11.5%. BMI >30 kg/m² and lobular carcinoma histology were the main risk factors for CRT.

Our work demonstrates that Blacks with pancreatic neuroendocrine tumors have poor survival than non-Black patients. The possible contributors to this survival disparity may be later diagnosis, less access to surgery and genetic differences.