• Issue

    Journal of Heterocyclic Chemistry: Volume 53, Issue 5

    i, 1333-1669
    September 2016
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Renshuai Zhang,  Shaopeng Chen,  Guanzhao Wu,  Shengbiao Wan,  Tao Jiang, 
  • Page: i
  • First Published: 19 September 2016
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The cover image, by Tao Jiang et al., is based on the Article Design and Synthesis of Novel EGFR Inhibitors with L-Rhamnose–Benzoxazinone Hybrids, DOI: 10.1002/jhet.2463.

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  • Pages: 1333-1345
  • First Published: 19 September 2016

Articles

Synthesis and Antimicrobial Activities of Novel 2-[substituted-1H-pyrazol-4-yl] Benzothiazoles, Benzoxazoles, and Benzimidazoles

Vikas S. Padalkar,  Bhushan N. Borse,  Vinod D. Gupta,  Kiran R. Phatangare,  Vikas S. Patil,  Nagaian Sekar, 
  • Pages: 1347-1355
  • First Published: 01 June 2016
Synthesis and Antimicrobial Activities of Novel 2-[substituted-1H-pyrazol-4-yl] Benzothiazoles, Benzoxazoles, and Benzimidazoles

A Simple Efficient Procedure for the Synthesis of Benzopyrano[2,3-c]pyrazoles

H. Turki,  M. Kamoun,  S. Lahiani,  R. El Gharbi, 
  • Pages: 1356-1362
  • First Published: 19 July 2016
A Simple Efficient Procedure for the Synthesis of Benzopyrano[2,3-c]pyrazoles

Revelation from the Reaction of 1,4-Diazabutadiene with Perchloric Acid: An Approach to the Synthesis of Imidazolium Perchlorates

Hongxing Xin,  Xiaohe Zhu,  Hong Yan,  Xiuqing Song, 
  • Pages: 1363-1366
  • First Published: 13 June 2016
Revelation from the Reaction of 1,4-Diazabutadiene with Perchloric Acid: An Approach to the Synthesis of Imidazolium Perchlorates

Highly Efficient Cycloaddition Reaction of 1,3-Diynes with Sodium Azide: A New Way to 5-Substituted-4-acetylene-1H-1,2,3-triazoles

Jia-Liang Tang,  Ling Ming,  Xiao-Ming Zhao, 
  • Pages: 1367-1370
  • First Published: 16 June 2016
Highly Efficient Cycloaddition Reaction of 1,3-Diynes with Sodium Azide: A New Way to 5-Substituted-4-acetylene-1H-1,2,3-triazoles

Synthesis and Pharmacological Evaluation of 3-propyl-2-substitutedamino-3H-quinazolin-4-ones as Analgesic and Anti-Inflammatory Agents

R. V. Sheorey,  A. Thangathiruppathy,  V. Alagarsamy, 
  • Pages: 1371-1377
  • First Published: 28 June 2016
Synthesis and Pharmacological Evaluation of 3-propyl-2-substitutedamino-3H-quinazolin-4-ones as Analgesic and Anti-Inflammatory Agents

2,6,8-Triaryl-3-iodoquinolin-4(1H)-ones as Substrates for the Synthesis of 2,3,6,8-Tetraarylquinolin-4(1H)-ones and the 2-Substituted 4,6,8-Triaryl-1H-furo[3,2-c]quinolines

Malose J. Mphahlele, 
  • Pages: 1378-1385
  • First Published: 31 May 2016
2,6,8-Triaryl-3-iodoquinolin-4(1H)-ones as Substrates for the Synthesis of 2,3,6,8-Tetraarylquinolin-4(1H)-ones and the 2-Substituted 4,6,8-Triaryl-1H-furo[3,2-c]quinolines

Green Oxidation Process in the Synthesis of LLM-105 with H2O2/Peroxotungstate System and its Theoretical Study

Jie Zhu,  Xue-Jing Zhao,  Peng-Cheng Wang,  Ming Lu, 
  • Pages: 1386-1394
  • First Published: 01 June 2016
Green Oxidation Process in the Synthesis of LLM-105 with H2O2/Peroxotungstate System and its Theoretical Study

Novel Flurbiprofen-iminothiazoline Hybrid Compounds: Synthesis and Characterization

Aamer Saeed,  Saira Shabbir,  Ulrich Flörke, 
  • Pages: 1395-1401
  • First Published: 26 May 2016
Novel Flurbiprofen-iminothiazoline Hybrid Compounds: Synthesis and Characterization

Highly Efficient Ultrasonic-Assisted CuCl-Catalyzed 1,3-Dipolar Cycloaddition Reactions in Water: Synthesis of Coumarin Derivatives Linked with 1,2,3-Triazole Moiety

Xu Li,  Xiaolan Chen,  Yuqin Jiang,  Senshen Chen,  Lingbo Qu,  Zhibo Qu,  Jinwei Yuan,  Hanyu Shi, 
  • Pages: 1402-1411
  • First Published: 20 July 2016
Highly Efficient Ultrasonic-Assisted CuCl-Catalyzed 1,3-Dipolar Cycloaddition Reactions in Water: Synthesis of Coumarin Derivatives Linked with 1,2,3-Triazole Moiety

Synthesis of β-Keto Lactone with Basic Skeleton of Przewalskin B

Jing-Ping Liu,  Li-Qin Wang,  Yong Zhao,  Yan Zhao,  Ying-Hui He,  Zi-Rong Wang,  Hong-Bin Zhang, 
  • Pages: 1412-1415
  • First Published: 15 August 2016
Synthesis of β-Keto Lactone with Basic Skeleton of Przewalskin B

Novel 7-Nitro-1-(Piperidin-4-yl)-4,5-Dihydro-[1,2,4] Triazolo[4,3-a]Quinoline-Sulphonamide Derivatives as Antimicrobial Agents: Design, Synthesis, and Bio-Activity

Bijivemula N. Reddy,  Peddiahgari Vasu Govardhana Reddy,  Bhoomireddy Rajendra Prasad Reddy,  Sirigi Reddy Sudharsan Reddy,  S. M. Reddy,  Madhvesh Pathak, 
  • Pages: 1416-1423
  • First Published: 18 May 2015
Novel 7-Nitro-1-(Piperidin-4-yl)-4,5-Dihydro-[1,2,4] Triazolo[4,3-a]Quinoline-Sulphonamide Derivatives as Antimicrobial Agents: Design, Synthesis, and Bio-Activity

Experimental and Theoretical DFT Study on Synthesis of Sterically Crowded 2,3,3,(4)5-Tetrasubstituted-4-nitroisoxazolidines via 1,3-Dipolar Cycloaddition Reactions Between Ketonitrones and Conjugated Nitroalkenes

Radomir Jasiński,  Kamila Mróz,  Agnieszka Kącka, 
  • Pages: 1424-1429
  • First Published: 07 August 2015
Experimental and Theoretical DFT Study on Synthesis of Sterically Crowded 2,3,3,(4)5-Tetrasubstituted-4-nitroisoxazolidines via 1,3-Dipolar Cycloaddition Reactions Between Ketonitrones and Conjugated Nitroalkenes

A Practical and Scalable Synthesis of GTx-134, an IGF-1R Inhibitor

Yahu A. Liu,  Vlad E. Gregor, 
  • Pages: 1430-1438
  • First Published: 04 June 2015
A Practical and Scalable Synthesis of GTx-134, an IGF-1R Inhibitor

Two-step Synthesis of New γ-Lactones via Cyclization of 7-Chloro-2-(methoxycarbonyl)-4-6-dimethylocta-(2E,4E,6E)-trienoic acid

Jean-Marc Dillenschneider,  Laurent Dufossé,  Mireille Fouillaud,  Nuthathai Sutthiwong,  Roger Labia,  Alain Valla, 
  • Pages: 1439-1442
  • First Published: 27 May 2015
Two-step Synthesis of New γ-Lactones via Cyclization of 7-Chloro-2-(methoxycarbonyl)-4-6-dimethylocta-(2E,4E,6E)-trienoic acid

Synthesis and Insecticidal Efficacy of Novel Bis Quinazolinone Derivatives

Manal M. Elshahawi,  Ahmed K. EL-Ziaty,  Jehan M. Morsy,  Aly F. Aly, 
  • Pages: 1443-1448
  • First Published: 27 May 2015
Synthesis and Insecticidal Efficacy of Novel Bis Quinazolinone Derivatives

Exploration and Optimization of an Efficient One-pot Sequential Synthesis of Di/tri-substituted Thiazoles from α-Bromoketones, Thioacids Salt, and Ammonium Acetate

Eeda Venkateswararao,  Hitesh B. Jalani,  Manickam Manoj,,  Sang-Hun Jung, 
  • Pages: 1449-1456
  • First Published: 07 August 2015
Exploration and Optimization of an Efficient One-pot Sequential Synthesis of Di/tri-substituted Thiazoles from α-Bromoketones, Thioacids Salt, and Ammonium Acetate

An Efficient Route to Pyridazino[4, 3-e][1, 3, 4]thiadiazines

Mohsen Nikpour,  Mahmoud Gholami,  Ebrahim Molashahi, 
  • Pages: 1457-1460
  • First Published: 27 May 2015
An Efficient Route to Pyridazino[4, 3-e][1, 3, 4]thiadiazines

Synthesis and Characterization of Thienothiophene Conjugated Benzo[c]Thiophene Analogs

Ramakrishnan Sivasakthikumaran,  J Arul Clement,  Meganathan Nandakumar,  Arasambattu K. Mohanakrishnan, 
  • Pages: 1461-1468
  • First Published: 27 May 2015
Synthesis and Characterization of Thienothiophene Conjugated Benzo[c]Thiophene Analogs

A New Method for the Synthesis of Oxadiazine Insecticide Indoxacarb

Defeng Xu,  Jing Guan,  Xing Xu,  Shunze Gong,  Hui Xu, 
  • Pages: 1469-1473
  • First Published: 19 June 2015
A New Method for the Synthesis of Oxadiazine Insecticide Indoxacarb

SiO2 Nanoparticle-catalyzed Facile and Efficient One-pot Synthesis of N-alkyl-2,5-bis[(E)-2-phenylvinyl]-1,3-dioxol-4-amine Under Solvent-free Conditions

Mohammad Bayat,  Hamideh Nasehfard, 
  • Pages: 1474-1478
  • First Published: 06 August 2015
SiO2 Nanoparticle-catalyzed Facile and Efficient One-pot Synthesis of N-alkyl-2,5-bis[(E)-2-phenylvinyl]-1,3-dioxol-4-amine Under Solvent-free Conditions

Synthesis and Characterization of New Heterocyclic Compounds Containing Thienylbenzo[h]Quinoline Moiety

Elham A. Al-Taifi,  Mohamed S. Abbady,  Etify A. Bakhite, 
  • Pages: 1479-1487
  • First Published: 06 August 2015
Synthesis and Characterization of New Heterocyclic Compounds Containing Thienylbenzo[h]Quinoline Moiety

Heck Reaction as Key Step in the Synthesis of Hydrogenated 2-benzazepin-1-ones

Matthias P. Quick,  Bernhard Wünsch, 
  • Pages: 1488-1493
  • First Published: 07 August 2015
Heck Reaction as Key Step in the Synthesis of Hydrogenated 2-benzazepin-1-ones

Synthesis and Herbicidal Evaluation of Novel Uracil Derivatives Containing Benzothiazol-2-yl Moiety

Jian-Yi Che,  Xiang-Suo Meng,  Xiao-Yun Xu,  Shan Jiang,  Yu-Cheng Gu,  De-Qing Shi, 
  • Pages: 1494-1498
  • First Published: 19 June 2015
Synthesis and Herbicidal Evaluation of Novel Uracil Derivatives Containing Benzothiazol-2-yl Moiety

5-Hydroxyl Hydantoins via One-Pot Microwave-Assisted Air Oxidation of Ugi Products

Adrian Huang,  Kellie Wo,  Allene Pierson,  So Yeun Christine Lee,  Erin Yang,  Catherine Johnson, 
  • Pages: 1499-1504
  • First Published: 22 June 2015
5-Hydroxyl Hydantoins via One-Pot Microwave-Assisted Air Oxidation of Ugi Products

Synthesis of Pyrazolyl-Pyrazoles and Pyrazolyl-[1,2,4]-Triazolo[3,4-d][1,5]Benzothiazepines as p53 Activators Using Hydrazonoyl Chlorides

Sobhi M. Gomha,  Thoraya A. Farghaly,  Abdelwahed R. Sayed,  Mohamed M. Abdalla, 
  • Pages: 1505-1511
  • First Published: 27 July 2015
Synthesis of Pyrazolyl-Pyrazoles and Pyrazolyl-[1,2,4]-Triazolo[3,4-d][1,5]Benzothiazepines as p53 Activators Using Hydrazonoyl Chlorides

Utilization of 2(3H)-Furanone Bearing a Pyrazolyl Side Chain for the Construction of a Variety of Thiazolidinone Derivatives

Wael S. I. Abou-Elmagd,  Ahmed I. Hashem, 
  • Pages: 1512-1518
  • First Published: 13 August 2015
Utilization of 2(3H)-Furanone Bearing a Pyrazolyl Side Chain for the Construction of a Variety of Thiazolidinone Derivatives

Synthesis, Cytotoxic Evaluation, and In Silico Studies of 4-Substituted Coumarins

Prabhjot Kaur,  Rupinder Kaur Gill,  Gagandip Singh,  Jitender Bariwal, 
  • Pages: 1519-1527
  • First Published: 28 August 2015
Synthesis, Cytotoxic Evaluation, and In Silico Studies of 4-Substituted Coumarins

Synthesis, Spectral Characterization, and Antimicrobial Activity of Novel 2,4,6-Trisubstituted Quinazoline Derivatives by Buchwald and Suzuki Coupling Reactions

Kotla Veena Vani,  Garlapati Ramesh,  Chunduri Venkata Rao, 
  • Pages: 1528-1533
  • First Published: 22 June 2015
Synthesis, Spectral Characterization, and Antimicrobial Activity of Novel 2,4,6-Trisubstituted Quinazoline Derivatives by Buchwald and Suzuki Coupling Reactions

Synthesis, Anti-Microbial, and Cytotoxic Activities Evaluation of Some New Pyrido[2,3-d]Pyrimidines

Samir Kamel Elsaedany,  Mohamed AbdEllatif Zein,  Elsayed Mohmoud AbedelRehim,  Reda Mohammed Keshk, 
  • Pages: 1534-1543
  • First Published: 28 August 2015
Synthesis, Anti-Microbial, and Cytotoxic Activities Evaluation of Some New Pyrido[2,3-d]Pyrimidines

4-Toluenesulfonamide as a Building Block for Synthesis of Novel Triazepines, Pyrimidines, and Azoles

A. Khodairy,  Ali M. Ali,  M. T. El-Wassimy, 
  • Pages: 1544-1553
  • First Published: 04 September 2015
4-Toluenesulfonamide as a Building Block for Synthesis of Novel Triazepines, Pyrimidines, and Azoles

Microwave-assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)

Abdullah S. Al-Bogami,  Ahmed E. M. Mekky, 
  • Pages: 1554-1562
  • First Published: 04 September 2015
Microwave-assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)

Design and Synthesis of Novel EGFR Inhibitors with L-Rhamnose–Benzoxazinone Hybrids

Renshuai Zhang,  Shaopeng Chen,  Guanzhao Wu,  Shengbiao Wan,  Tao Jiang, 
  • Pages: 1563-1569
  • First Published: 09 October 2015
Design and Synthesis of Novel EGFR Inhibitors with L-Rhamnose–Benzoxazinone Hybrids

An Improved Protocol for Synthesis of 3-Substituted 5-Arylidene-2-thiohydantoins: Two-step Procedure Alternative to Classical Methods

Olga Yu Kuznetsova,  Roman L. Antipin,  Anna V. Udina,  Olga O. Krasnovskaya,  Elena K. Beloglazkina,  Vladimir I. Terenin,  Victor E. Koteliansky,  Nikolay V. Zyk,  Alexander G. Majouga, 
  • Pages: 1570-1577
  • First Published: 28 August 2015
An Improved Protocol for Synthesis of 3-Substituted 5-Arylidene-2-thiohydantoins: Two-step Procedure Alternative to Classical Methods

Green Synthesis of Spiro[indoline-3,4′-pyrazolo[3,4-b][1,6]naphthyridine]-2,5′(1′H)-diones Catalyzed by TsOH in Ionic Liquids

Bin-Bin Feng,  Rong-Zhang Jin,  Mei-Mei Zhang,  Xiang-Shan Wang, 
  • Pages: 1578-1583
  • First Published: 04 September 2015
Green Synthesis of Spiro[indoline-3,4′-pyrazolo[3,4-b][1,6]naphthyridine]-2,5′(1′H)-diones Catalyzed by TsOH in Ionic Liquids

Construction of Hexahydropyrido[3,2-c]carbazole and Hexahydropyrrolo[3,2-c]carbazole Skeletons for the Synthesis of Related Indole Alkaloids

Cevher Gündoğdu Hızlıateş,  Sibel Gülle, 
  • Pages: 1584-1588
  • First Published: 04 September 2015
Construction of Hexahydropyrido[3,2-c]carbazole and Hexahydropyrrolo[3,2-c]carbazole Skeletons for the Synthesis of Related Indole Alkaloids

Synthesis and in vitro Antimicrobial Activity of Nalidixic Acid Hydrazones

Łukasz Popiołek,  Anna Biernasiuk,  Anna Malm, 
  • Pages: 1589-1594
  • First Published: 21 July 2015
Synthesis and in vitro Antimicrobial Activity of Nalidixic Acid Hydrazones

Synthesis of Novel 6-Mercapto-12-phenethyl-quinazolino[3,4-a]quinazolinones

Negar Mohammadhosseini,  Shahram Moradi,  Mehdi Khoobi,  Abbas Shafiee, 
  • Pages: 1595-1602
  • First Published: 28 August 2015
Synthesis of Novel 6-Mercapto-12-phenethyl-quinazolino[3,4-a]quinazolinones

Synthesis and Anti-inflammatory Screening of Some Mono and Bis-Alkoxyphthalimide Linked Benzimidazole and their Quinazoline and Pyrimidine Derivatives

Prakash Prajapat,  Ganpat L. Talesara, 
  • Pages: 1603-1610
  • First Published: 13 August 2015
Synthesis and Anti-inflammatory Screening of Some Mono and Bis-Alkoxyphthalimide Linked Benzimidazole and their Quinazoline and Pyrimidine Derivatives

AgNO3 Catalyzed Regio-Selective Synthesis of 3-Alkyl/Aryl-idene-3,4-dihydro-4-tosyl-2H-1,4-Benzoxazine: Novel Anti-Tubercular Scaffolds

Sivanandhan Karunanidhi,  Rajshekhar Karpoormath,  Milan Bera,  Rajesh A. Rane,  Mahesh B. Palkar, 
  • Pages: 1611-1616
  • First Published: 28 August 2015
AgNO3 Catalyzed Regio-Selective Synthesis of 3-Alkyl/Aryl-idene-3,4-dihydro-4-tosyl-2H-1,4-Benzoxazine: Novel Anti-Tubercular Scaffolds

Selective Synthesis of New Tetracyclic Coumarin-fused Pyrazolo[3,4-b]pyridines and Pyrazolo[3,4-b]pyridin-6(7H)-ones

Meilin Liu,  Guodong Yin,  Can Zhu,  Chaochao Yao, 
  • Pages: 1617-1625
  • First Published: 07 September 2015
Selective Synthesis of New Tetracyclic Coumarin-fused Pyrazolo[3,4-b]pyridines and Pyrazolo[3,4-b]pyridin-6(7H)-ones

Notes

One-Pot Three-Component Synthesis of 2-Amino Pyrimidines in Aqueous PEG-400 at Ambient Temperature

Dhanaji V. Jawale,  Umesh R. Pratap,  Manisha R. Bhosale,  Ramrao A. Mane, 
  • Pages: 1626-1630
  • First Published: 15 August 2016
One-Pot Three-Component Synthesis of 2-Amino Pyrimidines in Aqueous PEG-400 at Ambient Temperature

Synthesis of Pyrazole-linked Norcantharidin Analogues of Substituted Chromones

Wei Wang,  Liping Deng,  Shenlong Tang,  Qing Qian, 
  • Pages: 1631-1634
  • First Published: 31 May 2016
Synthesis of Pyrazole-linked Norcantharidin Analogues of Substituted Chromones

Design and Synthesis of 3-Substituted-thiazolyl-2-iminothiazolidin-4-ones as a New Class of Anticonvulsants

V. Alagarsamy,  M. Senthilraja,  V. Raja Solomon, 
  • Pages: 1635-1639
  • First Published: 02 June 2016
Design and Synthesis of 3-Substituted-thiazolyl-2-iminothiazolidin-4-ones as a New Class of Anticonvulsants

Synthesis and Characterization of Novel 1,2,4-oxadiazoline Derivatives Containing Pyrazole Moiety by 1,3-Dipolar Cycloaddition

Ting-Hong Fei,  Ying-Lei Zhou,  Le Huang,  Fang-Ming Liu, 
  • Pages: 1640-1645
  • First Published: 17 June 2016
Synthesis and Characterization of Novel 1,2,4-oxadiazoline Derivatives Containing Pyrazole Moiety by 1,3-Dipolar Cycloaddition

One-pot Synthesis of Novel 2,8-dithioxopyrano[2,3-d:6,5-d′]dipyrimidine-4,6(1H)-dione Catalyzed by p-Toluenesulfonic Acid

N. O. Mahmoodi,  B. Sharifzadeh,  M. Mamaghani,  K. Tabatabaeian,  S. Shoja, 
  • Pages: 1646-1650
  • First Published: 20 May 2016
One-pot Synthesis of Novel 2,8-dithioxopyrano[2,3-d:6,5-d′]dipyrimidine-4,6(1H)-dione Catalyzed by p-Toluenesulfonic Acid

Synthesis of Symmetrical Bis(5-substituted oxadiazolyl/thiadiazolyl/triazolylmethyl)sulfones

Padmaja Adivireddy,  Pedamalakondaiah Devanaboina,  Lavanya Gopala,  Rajasekhar Chittoor, 
  • Pages: 1651-1654
  • First Published: 13 July 2016
Synthesis of Symmetrical Bis(5-substituted oxadiazolyl/thiadiazolyl/triazolylmethyl)sulfones

The Effect of Oxidizing Agents in the Preparation of 2,3,5-triaryl-2H-tetrazolium Salts from 1,3,5-triarylformazans

Kalin I. Penev,  Kibret Mequanint, 
  • Pages: 1655-1660
  • First Published: 30 July 2015
The Effect of Oxidizing Agents in the Preparation of 2,3,5-triaryl-2H-tetrazolium Salts from 1,3,5-triarylformazans

An Efficient One-Pot Synthesis of Bis Butenolides

Mohammad Bayat,  Joseph M. Fox, 
  • Pages: 1661-1664
  • First Published: 20 September 2015
An Efficient One-Pot Synthesis of Bis Butenolides

Communication to the Editor

[2 + 2] Cycloaddition Reactions of Butadienyl Ketene with 1,4-Diazabuta-1,3-dienes: Synthesis of Functionalized Butadienyl-4-iminomethyl-azetidin-2-ones and Butenylidene-butadienyl-[2,2′-biazetidine]-4,4′-diones

Deepak Bains,  Yogesh Kumar,  Prabhpreet Singh,  Gaurav Bhargava, 
  • Pages: 1665-1669
  • First Published: 28 August 2015
[2 + 2] Cycloaddition Reactions of Butadienyl Ketene with 1,4-Diazabuta-1,3-dienes: Synthesis of Functionalized Butadienyl-4-iminomethyl-azetidin-2-ones and Butenylidene-butadienyl-[2,2′-biazetidine]-4,4′-diones