Synthesis of Pyrazolyl-Pyrazoles and Pyrazolyl-[1,2,4]-Triazolo[3,4-d][1,5]Benzothiazepines as p53 Activators Using Hydrazonoyl Chlorides
Sobhi M. Gomha
Department of Chemistry, Faculty of Science, University of Cairo, Giza, 12613 Egypt
Search for more papers by this authorCorresponding Author
Thoraya A. Farghaly
Department of Chemistry, Faculty of Science, University of Cairo, Giza, 12613 Egypt
Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, Saudi Arabia
E-mail: [email protected]Search for more papers by this authorAbdelwahed R. Sayed
Department of Chemistry, Faculty of Science, KFU, Saudi Arabia
Department of Chemistry, Faculty of Science, University of Beni Suef, Egypt
Search for more papers by this authorMohamed M. Abdalla
Research Unit, Saco Pharm. Co., 6th October City, Egypt
Search for more papers by this authorSobhi M. Gomha
Department of Chemistry, Faculty of Science, University of Cairo, Giza, 12613 Egypt
Search for more papers by this authorCorresponding Author
Thoraya A. Farghaly
Department of Chemistry, Faculty of Science, University of Cairo, Giza, 12613 Egypt
Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, Saudi Arabia
E-mail: [email protected]Search for more papers by this authorAbdelwahed R. Sayed
Department of Chemistry, Faculty of Science, KFU, Saudi Arabia
Department of Chemistry, Faculty of Science, University of Beni Suef, Egypt
Search for more papers by this authorMohamed M. Abdalla
Research Unit, Saco Pharm. Co., 6th October City, Egypt
Search for more papers by this authorAbstract
Di-pyrazoles, tripyrazoles, and pyrazolyltriazolobenzothiazepines were prepared from α,β-unsaturated ketones and hydrazonoyl chlorides. The structure of all the newly synthesized compounds was established on the bases of their spectral data and elemental analyses. The activity of all products was examined as p53 ubiquitination which showed promising activities.
References and Notes
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