Volume 53, Issue 5 pp. 1367-1370
Article

Highly Efficient Cycloaddition Reaction of 1,3-Diynes with Sodium Azide: A New Way to 5-Substituted-4-acetylene-1H-1,2,3-triazoles

Jia-Liang Tang

Jia-Liang Tang

Department of Chemistry, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai, 200092 People's Republic of China

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Ling Ming

Ling Ming

Department of Chemistry, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai, 200092 People's Republic of China

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Xiao-Ming Zhao

Corresponding Author

Xiao-Ming Zhao

Department of Chemistry, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai, 200092 People's Republic of China

E-mail: [email protected]Search for more papers by this author
First published: 16 June 2016
Citations: 14

Abstract

A cycloaddition reaction of a range of 1,3-diynes with sodium azide has been realized, which provided 5-substituted-4-acetylene-1H-1,2,3-triazoles in 75–99% yields. The chemical structures of the new compounds 3 are established by IR, NMR, Mass, and HRMS.

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