A particular type of zirconium metal–organic framework (MOF) called chiral UiO-66 was created to serve as a stationary phase in gas chromatography. It successfully achieved high-resolution separation of enantiomers, such as linalool and α-pinene, as well as positional isomers. This MOFs is effective for chiral analysis in the chemical and pharmaceutical industries.

This study revealed that hydrogen bonding, π–π stacking, and hydrophobic interactions are the key interacting forces driving the enantioseparation.

The specific rotation of L-arginine depends on the solution that the amino acid is dissolved in. The variations in the optical activity arise from changes in the zwitterionic structure upon protonation and/or complex formation with a metal cation.