AgNO3 Catalyzed Regio-Selective Synthesis of 3-Alkyl/Aryl-idene-3,4-dihydro-4-tosyl-2H-1,4-Benzoxazine: Novel Anti-Tubercular Scaffolds
Sivanandhan Karunanidhi
Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
Search for more papers by this authorCorresponding Author
Rajshekhar Karpoormath
Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Milan Bera
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076 India
E-mail: [email protected]; [email protected]Search for more papers by this authorRajesh A. Rane
Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
Search for more papers by this authorMahesh B. Palkar
Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
Search for more papers by this authorSivanandhan Karunanidhi
Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
Search for more papers by this authorCorresponding Author
Rajshekhar Karpoormath
Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Milan Bera
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076 India
E-mail: [email protected]; [email protected]Search for more papers by this authorRajesh A. Rane
Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
Search for more papers by this authorMahesh B. Palkar
Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
Search for more papers by this authorAbstract
A facile and efficient method for the construction of 3-alkyl/aryl substituted 1,4-benzoxazine and benzoxazepine via AgNO3 catalyzed cyclization of propargyloxy sulfonamides and their anti-tubercular activity against Mycobacterium tuberculosis H37RV is described. This cyclization proceeds through 6-exo-dig manner to generate the products in moderate to good yields.
Supporting Information
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