• Issue

    Obesity: Volume 32, Issue 3

    437-633
    March 2024

ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 437-442
  • First Published: 27 February 2024

BRIEF CUTTING EDGE REPORTS

ORIGINAL ARTICLES

Clinical Trials and Investigations

Open Access

A ketogenic diet lowers myocardial fatty acid oxidation but does not affect oxygen consumption: a study in overweight humans

  • Pages: 506-516
  • First Published: 23 January 2024

A ketogenic diet lowers myocardial fatty acid oxidation but does not affect oxygen consumption: a study in overweight humans

11 individuals with overweight were studied twice in a randomized cross-over design after either a standard or 3-week ketogenic (KD) diet. As expected, the KD resulted in markedly increased levels of ketone bodies, but also reduced glucose and insulin concentrations. Free fatty acid concentrations were discretely increased. Using PET to study cardiac substrate metabolism, we observed a significant reduction in myocardial fatty acid uptake and oxidation presumably due to increased ketone body oxidation. However, this metabolic shift did not affect myocardial oxygen consumption.

Obesity Biology and Integrated Physiology

FAP deficiency enhances thermogenesis and attenuates metabolic inflammation in diet-induced obesity

  • Pages: 528-539
  • First Published: 15 December 2023
FAP deficiency enhances thermogenesis and attenuates metabolic inflammation in diet-induced obesity

FAP promotes obesity and associated metabolic dysfunction by inhibiting thermogenesis and promoting inflammation.