In extensive disease small cell lung cancer, immune-related adverse events were less associated with prolonged overall survival.

The dual oral metronomic vinorelbine and capecitabine regimen showed very good safety features and improved compliance without loss of efficacy in both first- and second-line treatments.

A composite genetic signature of POLE/POLD1 mutated or TMB > 18 can be a prognostic factor for overall survival and progression-free survival in advanced stage NSCLC patients treated with immunotherapy.

The expression of SERPINB5 was upregulated and demethylated in LUAD. High expression of SERPINB5 was significantly correlated with poor overall survival (OS), and it might be a potential prognostic biomarker for LUAD. The overexpression of SERPINB5 in LUAD cell lines can promote cell proliferation, migration, invasion, and epithelial-mesenchymal transition.

Determination of the TS value. Created with BioRender.com.

The incidence of postoperative pulmonary complications (PPCs) and 30-day mortality rates after emergency surgery in patients infected with severe acute respiratory syndrome coronavirus 2 are higher compared to prepandemic baseline rates. This will help clinicians in their efforts to reduce the incidence of PPCs and the mortality of patients with severe acute respiratory infections.

Restin is a member of the melanoma-associated-antigen (MAGE) superfamily. Its expression has been reported to be dysregulated in cancer. Preclinical data suggest its role as a tumor suppressor. We aimed to evaluate the expression of restin and its prognostic value in non-small cell lung cancer (NSCLC). We found that restin is moderately to strongly expressed in the majority (85.9%) of NSCLC tumors but its expression evaluated by immunohistochemistry has no prognostic value in patients with NSCLC.

ICI-induced CRS is a rare adverse event, however, ICI combination therapy induced CRS in this case. CRS with severe dermatological disorders improved by steroid therapy.

Intrathoracic LGFMS is an extremely rare thoracic malignancy. An 84-year-old woman initially suspected of having right lower lobe lung cancer (A) underwent surgical resection (B). Further analysis through FISH showed FUS gene (D) translocations (E, F), leading to a diagnosis of LGFMS. Unfortunately, postoperative recurrence occurred as peritoneal disseminations, highlighting the aggressive nature of the disease.

This case report highlights the dynamic changes in cancer cells after pembrolizumab treatment and salvage surgeries. It is the first case report to compare pathological changes following immunotherapy and subsequent surgeries in metastatic lung adenocarcinoma.