This review highlights the role of p16 and GLUT-1 and GLUTs proteins in malignancies especially in lung cancer, focusing on the pathways activated leading to cell cycle dysregulation, cancer growth and migration. Since they have a clinical prognostic value, they may become targets for novel therapies.

The model created by five selected textural feature parameters can differentiate solid SCC from AC without contrast media. The selected five texture feature parameters are correlated to the immunohistochemical markers P63 and P40.

In our study we compared the similarities and differences between male and female breast cancer. The biological characteristics and prognostic factors of male breast cancer were analyzed.

Our research revealed that stemness is a latent inhibitor of the resistance of lung cancer cisplatin-resistant cells and might be effectively inhibited by aspirin

We report that increasing lines of evidence indicate the role of miRNAs in gene regulation in relation to tumor development. The aim of this study was to elucidate the undefined function and mechanism of miR-429 in the proliferation, metastasis, and invasion in breast cancer. Overexpression of miR-429 contributed to a notable impairment of proliferation, invasion, and epithelial-to-mesenchymal transition (EMT) in vitro. miR-429 suppressed proliferation and invasion of breast cancer via inhibiting the Wnt/β-catenin signaling pathway.

Radiation therapy is an essential local treatment for locally advanced lung cancer; however, the large fields of irradiation may have collateral effects. We revealed that lymphocyte counts decrease for a long time after irradiation, worsening OS and PFS. The other important issue is that low lymphocyte counts may affect the potential of immunotherapy. Immunotherapy at different time points and use of smaller radiation fields with high doses may be key issues for the future of lung cancer treatment.

Mucinous lung adenocarcinoma shows an incidence of STAS of 72%. STAS is an independent poor prognostic predictor even in mucinous adenocarcinoma. STAS is associated with older age, and lobulated and spiculated margins on CT.

HAX1 enhances the survival, invasion and epithelial–mesenchymal transition of NSCLC cells through the AKT/mTOR signaling pathway. HAX1 play an important role in NSCLC and should be taken into consideration.

The results of this study indicate that MMP-14 upregulation commonly occurs in human ESCC and is correlated with to tumor T classification, N classification, degree of differentiation, and clinical stage of ESCC patients. MMP-14 knockdown can additionally compromise the proliferative and invasive activity of these tumor cells, suggesting that MMP-14 may be a viable therapeutic target for the treatment of ESCC, although further research will be needed to validate these findings. Furthermore, downregulation of the MMP-14 expression level decreased cell proliferation and invasion ability.

We demonstrated for the first time that E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7 and the antitumor activity of LKB1 was determined by two factors, one was phosphorylation of LKB1, the other was that p-LKB1 must be located in the cytoplasm, both were indispensable.

The research exhibited the critical role of circ_0000518 in BC. Circ_0000518 accelerated BC progression via elevating FGFR1 expression by sponging miR-326. The findings highlighted the prospect of circ_0000518 as a new target for BC treatment.

In our longitudinal analyses, we found significantly decreasing ALC, and significantly increasing ANC levels in advanced-stage lung cancer patients during disease progression. Interestingly, patients with brain metastases have descending-ascending PLT trendlines, while patients with bone metastases exhibit ascending-descending trendlines during disease progression. The current study might help to improve patient selection and treatment strategies for brain and bone metastatic lung cancer patients.

NUT carcinoma showed poorly differentiated to undifferentiated features with strong nuclear expression of NUT. NUT carcinoma can show various morphologies that can be misdiagnosed. It is important to consider NUT carcinoma in patients of relatively young age.

Non-small cell lung cancer patients with ipsilateral pleural dissemination can benefit from primary tumor resection, especially patients who are not candidates for targeted therapy.

This study demonstrates immune-modulator changes in serum during the first cycle of anti-PD-1 antibody therapy in non-small cell lung cancer. Serum baseline perforin levels were found to be closely associated with clinical outcome with anti-PD-1 antibody therapies.

Workflow of circulating genetically abnormal cells enumeration.

Circulating genetically abnormal cell detection in early stage non-small-cell lung cancer was feasible.

Circulating genetically abnormal cell test has good stability and adaptability for different patient populations.

Circulating genetically abnormal cells could be used as a promising noninvasive biomarker for the early diagnosis of NSCLC.

A total of 35 skin biopsies were obtained, of which 60% were female and 40% male, and the mean age of the participants was 60.6 ± 11.7 years. They were divided into three groups: pretreatment (12 patients: 34.3%); adequate response to treatment (12 patients: (34.3%); and no response to treatment (11 patients: 31.4%). We found that EGFR expression, STAT3, and the thickness of the stratum corneum (both in millimeters and in number of skin layers) had a statistically significant correlation with an adequate response to treatment with EGFR inhibitors in patients with stage IV lung adenocarcinoma. EGFR, p27 and the number of stratum corneum layers were related to better progression-free survival. The relationship between EGFR inhibition in skin and in the tumor explains the parallel biological effect.

We conducted a meta-analysis of 27 studies involving 12047 patients to investigate the prognostic value of pretreatment smoking status for small cell lung cancer (SCLC), which demonstrated that smoking history was closely related to poorer survival outcome. Smoking history should be considered as an independent poor prognostic factor for patients with SCLC.

The current meta-analysis showed a moderate sensitivity and specificity of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for the prediction of PD-L1 expression in NSCLC patients. The DOR was low and the likelihood ratio scattergram indicated that 18F-FDG PET/CT might not be useful for the prediction of PD-L1 expression in NSCLC patients or its exclusion. This study supports that the role of 18F-FDG PET/CT for predicting tumor expression of PD-L1 should be further elucidated.

We revealed that the expression of YTHDC2 was decreased in NSCLC tissues and cell lines. Gain and loss of function assays demonstrated that YTHDC2 could suppress proliferation and migration ability of NSCLC cells. Moreover, YTHDC2 might be a remarkable prognostic marker for NSCLC.

Among 535 patients who developed recurrence, 24 (4.5%) patients achieved post-recurrence cure. The post-recurrence cure patients who sustained cancer-free status for five years after treatment for recurrent lesions did not develop second recurrence. All post-recurrence cure patients received only local treatment, and the solitary recurrent lesions and local treatment at the initial recurrent sites were significantly associated with post-recurrence cure.

Proliferation and migration abilities are more malignant in HCC827/GR cells. CCL2 expression is higher and regulated by ß-catenin in HCC827/GR.Gefitinib-resistant cell lines attract many more macrophages by releasing more CCL2 to reduce the sensitivity of cells to gefitinib.

GPX8 is considered to play a crucial functional role in the GPX family, but few studies have shown the implications of GPX8 in cancer research, especially in lung cancer. In this study, we focus on exploring the function and clinical value of GPX8 in non-small cell lung cancer (NSCLC). The results indicate that GPX8 could serve as a prognostic predictor and therapeutic target for NSCLC.

Significant findings of the study: Oncological advantage of the non-intubated thoracic surgery: better compliance with therapy protocol. What this study adds: NITS lobectomies contribute to better administration of adjuvant chemotherapy with the planned cycle number and dosage.

The safety and effectiveness of pirfenidone combined with cytotoxic agents or immune checkpoint inhibitors (ICIs) in patients with idiopathic pulmonary fibrosis (IPF) and non-small cell lung cancer (NSCLC) have not been investigated. This study showed that pirfenidone combined with carboplatin-based chemotherapy or ICIs was safe for patients with IPF and NSCLC and did not induce acute exacerbations of IPF.

In this work, we elaborated the enhancement effect of a novel carcinogenetic molecule, ie, p130cas (breast cancer antiestrogen resistance 1, BCAR1) on proliferation and cell growth of lung cancer cells,and to explore the possible networks of interacting proteins of BCAR1. We found BCAR1 can promote proliferation and cell growth, probably via upregulation of POLR2A and subsequent enhancement of catalytic activity and transferase activity.

In this prospective observational study, patients with advanced NSCLC who were scheduled for immunotherapy from October 2018 to December 2019 were enrolled. The baseline NK cell activity was significantly higher in the non-PD group than in the PD group. NK cell activity from peripheral blood before immunotherapy is a non-invasive, simple, and novel way to predicting the treatment response in patients with NSCLC.

Comparison between our TULUNG data and pooled survival data from clinical trials showed higher real-life effectiveness for most of the studied first-line regimens. We found that lower ECOG PS, younger age, female sex and adverse events were associated with longer survival. We demonstrated that real-life effectiveness of certain treatments may strongly differ in various populations and health care systems.

In this study we identified male sex, age = 65 years, lack of family support and liver and brain metastases as poor prognostic factors for overall survival (OS) in patients with stage IV lung ADC. The presence of liver metastases emerged as the worst prognostic factor. Consequently, it should be considered as a stratification factor for future studies evaluating new cancer treatments including immunotherapy.

Andrographolide can be used as a tool to study the interaction between the lung and intestine, providing an experimental basis for the theory of traditional Chinese medicine.

We report a successful case of a customized prosthesis using a 3D-printed titanium alloy to repair and reconstruct bone defects in a patient with sternal osteosarcoma who underwent radical resection of the whole sternum.

We report a case of acute intestinal obstruction as the initial presentation of primary lung cancer in a male patient. The patient underwent emergency surgery for multiple luminal malignancy with mesenteric masses, and immunohistochemical staining of the specimen revealed metastatic large cell carcinoma originating from the lung.

We present the case of a patient with an advanced TC harboring EGFR exon 20 insertion who successively benefited from two antiangiogenic agents after multiline therapy. After the failure of one tyrosine kinase inhibitor, the other was still active and effectively controlled the growth of the lesion.

Cystic lymphangioma is a rare disease occurring infrequently in the chest wall of adult patients. MRI is useful for diagnosis and surgical resection is recommended as the main treatment.

Anti-PD-1 therapy might worsen chronic infection by reactivating the immune response to infectious diseases. Here, we describe the first successful case of a patient safely treated with nivolumab for advanced stage NSCLC complicated by pulmonary aspergilloma.

If calcification develops within the tumor and tumor shrinkage is maintained after treatment with anti-PD-1 drugs, the calcification may be dystrophic owing to tumor necrosis caused by drug effects, and salvage surgery might be beneficial in removing the tumor.

Systemic air embolism developed after CT-guided TTNB, leading to ST-elevation, myocardial infarction and acute ischemic stroke. The patient recovered completely without sequelae and was diagnosed with adenocarcinoma harboring activating EGFR mutation. Treatment with gefitinib showed a response.

This case of invasive mucinous adenocarcinoma (IMA) showed subpleural micronodular opacities and chylothorax as unusual chest computed tomography (CT) patterns for IMA. IMA should be considered in the differential diagnosis of subpleural micronodular opacities accompanied by pleural effusion on chest CT.

Our method uses one-step PCR to amplify the entire circular plasmid. The PCR products were transformed into E. coli and cyclized by homologous recombination in vivo. Free from the limitation of restriction enzyme sites and omitting the ligation process, our method offers a flexible and economical option of plasmid construction.