We explored the genes responsible for mediastinal lymph node metastasis in lung adenocarcinoma with EGFR 19Del or L858R mutation by using transcriptome sequencing and bioinformatics analysis from 10 patients with lung adenocarcinoma resection specimens of primary tumors. EEF1A2 and ERN2 were for the first time observed exhibiting distinct expressional patterns in process of MLNM in lung adenocarcinomas harboring EGFR 19Del and EGFR L858R mutation by inter-individual DEGs analysis.

A total of 105 patients (35 cases with benign GGOs and 70 matched controls with malignant GGOs) were enrolled to identify characteristics that would help the differential diagnosis. It is shown that a higher smoking index, cough, larger size, similar or increased size during follow-up, location in the upper and middle lobes, air bronchogram sign on CT, lesion margin to pleura distance over 1 cm, and malignant tendency on PET/CT reports are associated with malignancy. Pathological patterns of benign GGOs are also provided.

We systematically investigated the effect of avitinib, one newly developed third-generation EGFR-TKI, on the pharmacokinetics of osimertinib both in vitro and in vivo using rat model.

We performed a retrospective study to compare the clinicopathological characteristics and explore treatment strategies of pure and combined SCLC and found the prognosis of C-SCLCs were more susceptible to extent of resection than P-SCLCs. Patients with C-SCLC who underwent limited resection had a significantly increased risk of shorter overall survival. Based on these results, we recommend a lobectomy should be performed, especially in resectable C-SCLC patients.

HPD is strongly associated with poor prognosis. In this study, age, primary lesion size, and number of metastases were risk factors of HPD. The area under the curve of the prediction model for HPD was 0.9556.

Bone metastasis is common in patients with advanced non-small cell lung and considered as one of the negative prognostic factors, but the impact of bone metastases on clinical outcomes of immune checkpoint inhibitors remains unclear. Our study demonstrated that bone metastases attenuated the efficacy of ICIs monotherapy in patients with advanced NSCLC. Of patients with bone metastases who received ICIs monotherapy, neither palliative radiotherapy nor bisphosphonate drugs improved OS.

In this population-based study, we indicated that the addition of neoadjuvant RT for pT3-4N0 diseases followed by esophagectomy was associated with improved cancer-specific survival in patients with tumor lengths 5 cm and squamous cell carcinoma. The identification of higher-risk patients for neoadjuvant therapy would be expected to yield better results than taking a uniform approach to this population, to avoid unnecessary and possibly harmful treatment in node-negative diseases.

We found that high MOB1 expression in surgical specimens of lung adenocarcinoma was associated with poor disease-free survival and with intratumoral vascular invasion. MOB1 expression also promoted the invasiveness of NSCLC cells in vitro. Our results suggest that MOB1 might contribute to early recurrence in NSCLC.

Our study described that SPLC patients demonstrated a great survival, with a five-year survival rate of 68.6% and a five-year RMST of 49.4 months. In addition to sex and tumor size of SPLC, we also identified several IPLC-related prognostic factors such as histology, clinical stage and T stage. We found patients that underwent lobectomy, segmentectomy and wedge resection for both IPLC and SPLC revealed a similar survival outcome.

CASC8 rs1562430 A>G may cause susceptibility to ESCC and CASC8 SNPs may play a vital role in ESCC risk, thereby serving as a potential biomarker for diagnosing ESCC.

In our article, a previously synthesized conjugate (G11) of cyanine dye and nonselective MAOA inhibitor was applied for evaluating the function of MAOA in paclitaxel (PTX)-resistant NSCLC cells (H460/PTX). The results showed the antitumor efficacy of G11 against paclitaxel-resistant NSCLC was closely correlated with MAOA inhibition.

Kaplan–Meier analysis of (a) progression-free survival (PFS) and (b) overall survival for the 96 patients in the study.

Downregulation of lncRNA HCG11 is related to adverse clinical outcomes in NSCLC patients. HCG11 has been shown to inhibit cell viability and motility in NSCLC, and HCG11 functions as a ceRNA of miR-522-3p to upregulate SOCS5.

Significant findings of the study: EG-P-LMB can effectively capture CTCs in the peripheral blood of patients with lung cancer. CTC detection can accurately identify mutations in the EGFR gene and improve the ability to obtain tumor tissue in clinical practice. What this study adds: This study added EGFR peptide lipid magnetic spheres to capture CTC in the blood. Genetic testing was performed and compared with tissues. It solves the problem of clinically difficult tumor tissue sampling.

We identified differences in the ceRNA regulatory networks and constructed a four-gene expression-based survival predictor model, which could be referential for future clinical research.

We conducted this study to compare the incidence of postoperative anastomotic stricture formation and dysphagia three years after an esophagectomy with modified Collard anastomosis or end-to-side (ETS) hand-sewn anastomosis.

These data indicate that ICI consolidation therapy can achieve favorable short-term efficacy, while exhibiting good safety and acceptable toxicity profiles in Chinese patients with inoperable stage III NSCLC.

ChemoRT was associated with a greater radiologic response than chemotherapy alone in patients with upfront unresectable TET

Extended resections for lung cancer include tumors spreading outside the lung. In this population-based study, the rate of extended resection was 14.9% with major complications occurring in 7.5% and five-year survival was 75.6%. Guideline-based evaluation results with excellent outcome in real-world practice.

PD1⁺CD8⁺, rather than TIM3⁺CD8⁺, T cells are the main component that could predict the response of neoadjuvant therapies in breast cancer. Incremental levels of PD1⁺CD8⁺ T cells in non-pCR post-neoadjuvant-treatment tumors suggest PD1 inhibition might be beneficial to patients.

Expression levels of CXCR4, CXCR5 and CCR7 were significantly higher in tumor tissues, and expression of CXCR5 and CCR7 were independent prognostic factors for survival. Moreover, all three chemokines were correlated to the survival outcomes of patients with clinical T1N0M0 NSCLC, providing potential prognosticators and therapy targets for lung cancer treatment.

In M1-type macrophages, the levels of Grx1 were elevated. Glutathionylation of STAT1 was negatively regulated by Grx1. Furthermore, depletion of Grx1 increased the activity of STAT1, and promoted the mRNA levels of CXCL9 in the process of macrophages polarized to M1 phenotype.

Relative to patients with a PD-L1 tumor proportion score of <50%, patients with a PD-L1 tumor proportion score of =50% had significantly lower miR200b expression in the bronchoscopy specimens and serum-derived exosomes.

We found that the lung cancer treatments of 9.1% of patients included in the study were delayed during the COVID-19 pandemic. However, the treatments of most of these patients were delayed at their request. Oncologists should bear in mind that cancer patients tend to have more anxiety than expected under special circumstances such as the COVID-19 pandemic.

• EGF+61 SNP was assessed in TKI-treated NSCLC patients harboring EGFR-sensitizing mutations.

• EGF+61 SNP (AG + GG) was independently associated stable in EGFR-mutated TKI-treated NSCLC patients.

• EGF+61 SNP (AG + GG) cannot predict progression-free and overall survival or overall response rate to first generation TKIs.

We characterized the binding capability of a seven-amino-acid peptide derived from tau to microtubules and sought to develop it as a fluorescent peptide for monitoring microtubules.

cystic cavity-characteristic CT signs of translymphatic pulmonary metastasis in cholangiocarcinom.

We provide a case analysis of two patients with advanced NSCLC with negative driver genes who received immune checkpoint inhibitor (ICI) treatment for less than two years but continued to benefit after drug withdrawal. These two case reports suggested that early withdrawal of immunotherapy was also beneficial to advanced lung adenocarcinoma patients with negative driver genes who achieve an early response to immunotherapy.

Tracheal fistula is a rare but severe complication of esophageal surgery. Here, we report the case of a tracheal fistula in a patient after esophageal surgery suggested by pneumothorax and confirmed by fiberoptic bronchoscopy, and introduce a new bedside tool - lung ultrasound - to sensitively detect pneumothorax.

High-grade myofibroblastic sarcoma (HGMS) is a rare disease. This is the first case diagnosed with HGMS originating from the pleura that was nonsurgically treated.

Primary signet-ring cell carcinoma of the lung is an extremely rare subtype of lung adenocarcinoma and relatively highly invasive. Early diagnosis and positive treatment could bring a good prognosis to this kind of patients

This is the first case of metachronous lung adenocarcinoma harboring EGFR L858R/T790M mutations in a treatment-naïve non-small lung cancer patient. Comprehensive clinical and molecular analysis could be helpful in differentiating multiple primary lung cancer from intrapulmonary metastasis.

Respiratory support with extracorporeal membrane oxygenation (ECMO) in managing patients with advanced lung cancer remains unclear given the poor prognosis. Targeted agents for patients with driver mutations offer rapid responses and may be administered even while under critical care. In some patients with critical lung cancer, ECMO may become a bridge through the critical period with respect to effective anti-cancer therapies.

Here, we report a rare case of incidental early diagnosis of biphasic pulmonary blastoma while a patient was undergoing imaging surveillance for primary lung adenocarcinoma. Next-generation sequencing revealed distinct second primary cancer with a high mutation burden which might have therapeutic implications in further studies.

We report a case of pericardial immunoglobulin G4-related inflammatory pseudotumor that appeared after right upper lobectomy for lung cancer, and which naturally disappeared without any treatment.

Lung adenocarcinoma with extensive calcification, apparently related to the formation of parathyroid hormone- producing psammoma bodies.

This is the first report of IL-5-producing malignant pleural mesothelioma with eosinophilic pleural effusion.