This becomes very challenging when oncologists must make decisions among many therapies with similar efficacy and / or specific toxicity characteristics. The advantage of meta-analysis in this study is that it can reduce publication bias and identify obvious results with higher efficiency. Due to the combination of smaller and larger studies, the effective sample size will be greatly increased. The results of this meta-analysis can help oncologists choose the type of immune checkpoint inhibitor when deciding on an ICI plan and when planning to use ICI for future research.

Cardiopulmonary exercise test can stratify surgical risk. Prediction of the peak oxygen uptake () value from the 3CRT yields an unacceptable level of error. Reach 49 chair rises or more during the 3CRT predict a  ≥ 15 ml/kg/min.

In Inner Mongolia, incidence and mortality rates of esophageal cancer were higher in urban areas than in rural areas and in men than in women between 2010 and 2015, and in middle-aged and elderly than in younger people. Prevention and control programs, in addition to early diagnosis and treatment of esophageal cancer, should be tailored to specifically target rural men and middle-aged and old individuals in order to reduce the incidence and mortality rates of this pathology.

Surgical resection by VATS may be recommended for PMC management as a primary therapeutic strategy. The cysts with maximal diameter greater than 5 cm or the cysts that are adjacent to vital mediastinal structures can increase the surgical difficulties.

The neuroendocrine tumors of the thymus is a rare invasive tumor with a poor prognosis, and visualization models are needed to provide patients with appropriate individualized treatment strategies.In this study, we established and validated a new Nomogram model to predict the survival of patients with neuroendocrine tumors of the thymus.

The present study showed that anti-PD-1/PD-L1antibody monotherapy was not effective for non-small cell lung cancer patients with active brain metastases. Intracranial and extracranial response rates were 13.3% and 26.7% respectively. Further studies on immunotherapy are needed for patients with active BMs.

• CEACAM6 expression is upregulated in the DDP-resistant LUAD cells and tissues.

• CEACAM6 promotes DDP-resistance via regulating EMT, stemness and RhoA activation.

• miR-146a and miR-26a could counteract biological effects of CEACAM6.

D-dimer increases discontinuously after lung cancer surgery and applying risk-stratified cutoff values of it makes for better venous thromboembolism (VTE) exclusion.

Cytoplasmic HDAC3 is an independent prognostic factor for the overall survival and brain metastasis-free survival of breast cancer patients.Cytoplasmic expression of HDAC3 was further upregulated in the brain metastases compared with the matched primary tumours, while nuclear expression was downregulated.

LINC02323 acts as a competing endogenous RNA (ceRNA), which sponged miR-1343-3p to upregulate the TGFBR1 expression and promote the EMT and metastasis in LUAD.

The PCI group had higher short- and long-term risks of revascularization. Careful long-term management of cardiovascular risk is required for the PCI group.

The lower nucleolin expression and higher nucleophosmin expression were related to the pleural (locoregional) invasion of pulmonary adenocarcinoma. Pleural malignant mesothelioma showed lower nucleolin expression than pleura invading pulmonary adenocarcinoma

CDDP plus PEM adjuvant therapy with a short hydration method is well tolerated in the outpatient setting with limited toxicity.

We tried to compare the results of disease-free survival (DFS) in patients with non-small-cell lung carcinoma (NSCLC) through radiomics with those of traditional staging systems or genetic analysis to determine if incremental values can be obtained when combining them. The addition of selected radiomics and genomic features using the LASSO method improved the stratification of lung cancer patients upon survival. Our results show that integration of radiomics and genomic features with the current clinicopathologic model may lead to improved prognostic accuracy compared to conventional clinicopathological data alone.

Antibiotic treatment has been shown to deter outcomes in patients treated with immune checkpoint inhibitors. The effect of antibiotics is studied for the first time in Latin American patients undergoing ICI therapy. Patients treated with antibiotics prior or during ICI therapy had a significantly shorter overall survival.

DLL3 was a predictive marker of sensitivity to platinum-based adjuvant chemotherapy for LCNEC. Among patients with DLL3 expression-negative LCNEC, platinum-based adjuvant chemotherapy significantly improved the OS and RFS, although it did not do so among patients with DLL3 expression-positive LCNEC.

Taken all into account, upregulation of LINC00511 in LAC tissues and cell lines was validated. Upregulation of LINC00511 was closely correlated with shorter overall survival in LAC patients. We explored the biological function of LINC00511 in promoting LAC cell proliferation, migration and invasion. Moreover, LINC00511 knockdown could partially by sponging miR-625-5p, and then up-regulate PKM2 to exert its tumor-suppressive effect. Our studies confirmed the roles of a novel LINC00511/miR-625-5p/PKM2 axis in LAC progression, which might provide a promising application in LAC treatment.

In this research, we investigated the frequency of common driving genes in 884 patients with non-small cell lung cancer and analyzed their association with clinicopathologic parameters in in eastern China. Most patients had at least one genetic alteration, and individual patients harbored synchronous mutation. Each gene alteration has unique clinicopathologic characteristics.

Endobronchial ultrasound elastography accurately predicted malignancy with a high diagnostic accuracy rate and negative predictive value in radiologically normal-sized lymph nodes. The additional use of B-mode sonographic features resulted in a higher negative predictive value.

We found a relationship between margin-related radiomic features and tumor doubling time. Margin-related radiomic features can potentially be used as noninvasive biomarkers to predict tumor doubling time in lung adenocarcinoma and inform treatment strategies.

From a large number of patients' analysis, we achieved a neat model to be able to predict the OS, PFS, LRFS and DMFS of postoperative III-N2 NSCLC.

This study focuses on the use of neoadjuvant chemoradiotherapy to esophageal carcinoma patients with clinically staged node-negative (cN0) status. Finally, compared with surgery alone, cN0 esophageal cancer with falsely node-negative (pN+) or localized truly node-negative (pT3-4N0) gain a significant survival benefit from neoadjuvant chemoradiation. However, neoadjuvant chemoradiation plus surgery was associated with decreased survival for early-staged true node-negative (pT1-2N0) patients. Despite the inherent limitations, this population-based study allows for a robust analysis of patients with cN0 esophageal carcinoma and the benefits of neoadjuvant chemoradiation when stratified by nodal and tumor status, and this finding may have significant implications on the use of neoadjuvant chemoradiation in patients with cN0 disease.

The present study showed that mAb NJ001 inhibits lung AD cell migration and invasion in vitro, which were mediated by the FOXP1 binding sites in the TIMP-3 promoter region. It may have clinical applications in preventing and treating metastatic lung AD.

In this updated nonrandomized study, we found that overall survival of locally advanced lung cancer patients treated with definitive concurrent chemoradiotherapy was not statistically different between those treated with IGRT versus non-IGRT. The results should be interpreted with caution given the nonrandomized design. Randomized controlled trials are needed to clarify this finding.

Our study demonstrates that chest CT-based radiomics combined with lightGBM classifier has the ability in identifying sarcopenia in NSCLC patients, and skeletal muscle radiomics would be a potential biomarker for sarcopenia identity in NSCLC patients.

CirCHIPK3 regulated miR-193a/HMGB1/PI3K/AKT signaling to facilitate BC development and progression, providing a novel therapeutic target for BC.

This was a retrospective study which assessed the etiologies of delayed diagnosis and characteristics of patients with newly diagnosed advanced lung cancer who initially presented with respiratory failure.

miR-138 and miR-193 both specially targeted and regulated lncRNA-UCA1. Overexpression of UCA1 reversed the proliferation, migration and invasion suppression effect of miR-138 or miR-193. UCA1 regulated the expression of CDK6 as a miR-138 and miR-193 common target.

Localization of small pulmonary nodules is an inevitable challenge for the thoracic surgeon. This study demonstrated that the 3D printing localization technique is a feasible and accessible strategy to localize non-palpable pulmonary nodules.

DTX1 rs1732786A>G was associated with better prognosis in patients with early-stage non-small cell lung cancer, in the previous study. DTX1 rs1732786A>G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer.

3DP PEEK implant was anchored to the clavicle and remaining ribs using steel wires.

Osimertinib can be associated with pneumonitis. This case highlights extremely early onset with severe pneumonitis. In such case, discontinuation of osimertinib as well as administration of corticosteroid, and retreatment with osimertinib carefully may be a fine treatment option especially when patients have brain metastasis.

Our case reports an advanced EGFR-mutant lung adenocarcinoma patient achieved PR and a PFS of 6 months to a combination of immunotherapy and anti-angiogenic agent, sintilimab and bevacizumab, as subsequent-line therapy. Sintilimab and bevacizumab combination therapy was well-tolerated and effective, resulting in dramatic tumor reduction and improvement in clinical symptoms.

We here report an extremely rare case of a 31-year-old non-smoking pregnant female who was diagnosed as lung adenocarcinoma with multiple metastasis including choroid metastasis. Whole exon sequencing was performed but no appropriate therapeutic target has been identified.

Though checkpoint inhibitor associated pneumonitis was the leading cause of ICIs-related death, clinicians should be alerted that hemoptysis attributed to ICIs in advanced lung cancer deserves more concern.

An 88-year-old woman with squamous cell lung cancer was administered pembrolizumab. After 5 cycles of pembrolizumab, she developed severe pancytopenia. Pancytopenia improved under observation without steroid administration after cessation of pembrolizumab. During recovery from this irAE, the patient also maintained long-term anti-tumor efficacy.

This case suggested that YES1 amplification might be associated with primary resistance to EGFR-TKIs. YES1 amplification might be a negative predictor of EGFR-TKIs treatment in NSCLC patients harboring EGFR sensitive mutation.

Small-cell lung cancer treatment options are scarce and limited, which sometimes leads to readministration of previously used drugs in heavily treated patients. Carboplatin and etoposide (CE) readministration with atezolizumab was effective in the current case, which may be based on two tentative mechanisms: additive and synergistic effects of atezolizumab on CE.

Patients with lung adenocarcinoma harboring the EGFR S768I and G724S mutations appear less sensitive to first-generation tyrosine kinase inhibitors than patients with sensitive EGFR.However, the patient benefited from treatment with afatinib.

Black pigmentation of the airways (black bronchoscopy) can be caused by many etiologies. We herein reported a case of black bronchoscopy for pulmonary malignant melanoma.