Highlights

• The management of T1D in pregnancy has been enhanced in large part due to development of more effective glucose monitoring and insulin delivery systems.
• CGM has been demonstrated to improve glycemic control and minimize excursions in pregnant mothers and leads to better neonatal outcomes.
• CSII has often led to better maternal glycemic control; however, outcome data for its use in pregnancy remain mixed.
• Further research evaluating newer and upcoming technologies in this understudied population is needed.

Highlights

• Allogeneic islet transplantation has been developed for unstable type 1 diabetic patients to stabilize the blood glucose levels and prevent hypoglycemia, and donor shortage is the most serious issue.
• To alleviate the donor shortage issue, non-heart-beating donor and living donors were used and to solve the donor shortage issue porcine islets have been used for islet transplantation.
• Recent new technologies including CRISPR and blastocyst complementation should improve the efficacy of islet xenotransplantation.

Highlights

• Glucagon-like peptide 1 receptor agonists and sodium glucose cotransporter inhibitors have been tried globally with some benefit in type 1 diabetes.
• Dapagliflozin and sotagliflozin have been licensed for use in type 1 diabetes, as the first two oral agents, in Europe and Japan.

Highlights

• This is the first study to explore the current status and efficacy of additional metformin therapy in patients with type 1 diabetes mellitus (T1DM) under real-life conditions in China.
• Metformin is initiated more in T1DM patients with dyslipidemia or higher body mass index in current practice in China.
• Additional metformin has no effect on glycemic control, but it helps maintain body weight and reduce insulin dosage in adult patients with T1DM.

Highlights

• About two-thirds of all age patients with T1D underwent PR phase, and juvenile-onset patients are more likely to have PR during the disease course.
• Age of onset and the male sex were correlated with the frequency of PR in children; while the related factors in adults were initial HbA1c and C-peptide levels.
• Baseline onset age was positively correlated with the duration of PR in children with T1D.