Highlights

• Charcot neuroarthropathy (CN) is associated with demineralization of foot bone, but there is no established medical treatment for chronic CN.
• This study explored the role of teriparatide in chronic CN and demonstrated a significant increase in foot bone remodeling with teriparatide.

Highlights

• Hypoglycemia is frequent in patients with type 1 and type 2 diabetes who are treated with insulin and/or insulin secretagogues.
• Hypoglycemia can be fatal and appears to increase the risk of cardiovascular disease and subsequent mortality.
• Clinicians must make efforts to reduce hypoglycemia while maintaining optimal control. These efforts include patient education, use of continuous glucose monitoring, and the use of medications with a lower risk of hypoglycemia.

Highlights

• Type 1 diabetes (T1D) in north India is strongly associated with HLA-DRB1*03 haplotypes.
• The association between HLA-DRB1*04 and T1D in north India differs from that in south India and in Caucasians.

Highlights

• This meta-analysis found that metformin use was associated with a significantly increased risk of vitamin B₁₂ deficiency and significantly lower serum vitamin B₁₂ concentrations in a dose- and duration-dependent manner in patients with diabetes.
• The meta-analysis did not find significant associations between metformin use and the risk of anemia or neuropathy in patients with diabetes.
• Annual vitamin B₁₂ assessment in diabetic patients taking metformin is recommended, and appropriate preventative and therapeutic measures should be taken when necessary.

Highlights

• Higher folate and lower vitamin B₁₂ levels were associated with higher glucose and a higher risk of gestational diabetes mellitus (GDM).
• The association between folate and vitamin B₁₂ imbalance and GDM risk can be further modified by maternal risk factors.

Highlights Serum apolipoprotein (apo) B is associated with existing metabolic syndrome (MetS) and is a possible predictor of the risk of MetS among middle-aged and elderly Chinese. The association between serum apoB and the risk of MetS was more prominent among normal weight individuals than in overweight or obese individuals.