Highlights

• The Bayesian network analysis in this first study is the first to use appropriate statistical methods to provide an indirect comparison for the currently available dressings for healing patients with diabetic foot ulcer (DFU), based on all available information from randomized trials.
• The nine dressings evaluated in this study had different advantages in promoting the healing of DFU, but most of the differences between the dressings were not significant.

Highlights

• To investigate the relationship between serum uric acid (SUA) and blood glucose, a national cross-sectional study of SUA was conducted in those with and without diabetes.
• Stratified analysis showed an L-shaped curve between SUA and blood glucose only in diabetic females, regardless of whether fasting plasma glucose or HbA1c were used to measure blood glucose.

Highlights

• Type 1 diabetes (T1D) patients had a higher percentage of memory regulatory T cells (Tregs), but T1D patients had a lower frequency of Foxp3^high Tregs and lower serum interleukin-10 concentrations with impaired suppression.
• Expression of CD39 was detected on memory Tregs, but rarely on resting and effector Tregs.
• After stimulation of CD3/CD28 beads on Peripheral blood mononuclear cells(PBMCs) from T1D patients, the percentage of resting Tregs was decreased and that of effector/memory Tregs was increased in both healthy controls and T1D patients; however, CD39 expression on effector and memory Tregs remained lower in T1D patients.

Highlights

• A large prospective cohort study was conducted to test whether there were racial and sex differences in the incidence of major diabetic complications between African Americans and Whites with diabetes.
• African Americans with diabetes had lower rates of coronary heart disease (CHD) and higher rates of heart failure, stroke, and end-stage renal disease than Whites with diabetes.
• The risk of CHD was lower in African American men than in White men, and the risk of stroke was higher in African American women than in White women.

Highlights

• The present study is the first to investigate associations between physical activity levels and sociodemographic and health-related factors in gestational diabetes mellitus (GDM) in Brazil.
• Surprisingly, some factors, namely age, self-declared skin color, smoking, pharmacological treatment for GDM, self-reported hypertension, and body mass index did not affect physical activity levels.
• Some factors related to not being active were not living with a partner, greater income, being employed, and having four or more children.

Highlights

• Mortality during a 9-year follow-up of patients with peripheral arterial disease was 40%.
• HbA1c is a useful marker in preoperative risk assessment of patients with unknown glycemic status at admission for vascular surgery.

Highlights

• This study investigated the relationship between energy intake and sarcopenia in elderly patients with type 2 diabetes (T2D).
• Habitual food and nutrient intake of 391 physically active T2D patients aged ≥65 years and the presence of sarcopenia, defined using grip strength and the skeletal muscle mass index, were assessed.
• The energy intake of T2D patients was significantly negatively associated with the presence of sarcopenia.

Highlights

• This meta-analysis is the first of its kind to study both type 1 diabetes (T1D) and type 2 diabetes (T2D) susceptible gene polymorphisms with latent autoimmune diabetes in adults (LADA).
• Polymorphisms of T1D genes (protein tyrosine phosphatase non-receptor 22 [PTPN22] rs2476601, insulin [INS] rs689) and a T2D gene (transcription factor 7-like 2 [TCF7L2] rs7903146) are associated with the risk of LADA, indicating that it could be a genetic admixture of both T1D and T2D.
• Understanding the effects of genetic factors underlying the pathogenic mechanism of LADA would shed light on the classification and optimal treatment strategy despite its low prevalence rate.