• Issue

    Asia-Pacific Journal of Clinical Oncology: Volume 21, Issue 3

    241-341
    June 2025

ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 241-242
  • First Published: 26 April 2025

ORIGINAL ARTICLE

Open Access

Post-Prostatectomy Magnetic Resonance-Guided Radiotherapy on a 1.5 Tesla Magnetic Resonance Integrated Linear Accelerator: Feasibility, Toxicity, and Preliminary Clinical Outcomes

  • Pages: 247-255
  • First Published: 04 December 2024
Post-Prostatectomy Magnetic Resonance-Guided Radiotherapy on a 1.5 Tesla Magnetic Resonance Integrated Linear Accelerator: Feasibility, Toxicity, and Preliminary Clinical Outcomes

This study prospectively investigated magnetic resonance (MR)-guided radiotherapy (MRgRT) for post-prostatectomy prostate cancer and reported the preliminary clinical outcomes in 30 patients. The preliminary results suggest the feasibility, excellent patient tolerance, and encouraging efficacy of post-prostatectomy MRgRT, serving as a benchmark for future investigation.

Impact of Antibiotics and Chronic Medications on Efficacy of Immune Checkpoint Inhibitors in Patients With Hepatocellular Carcinoma

  • Pages: 256-265
  • First Published: 27 November 2024
Impact of Antibiotics and Chronic Medications on Efficacy of Immune Checkpoint Inhibitors in Patients With Hepatocellular Carcinoma

The use of antibiotics may diminish ICI efficacy in HCC patients of viral hepatitis etiology, while the use of metformin, statins, beta-blockers, NSAIDs, and aspirin is not associated with significant clinical outcomes.

Free to Read

Comparison of Epidemiology, Demography, Treatment (Surgery and Radiotherapy), and Survival Between Aboriginal and Torres Strait Islander and Non-Indigenous Women With Cervical Cancer in NSW, Australia in 2009–2018

  • Pages: 266-274
  • First Published: 17 November 2024
Comparison of Epidemiology, Demography, Treatment (Surgery and Radiotherapy), and Survival Between Aboriginal and Torres Strait Islander and Non-Indigenous Women With Cervical Cancer in NSW, Australia in 2009–2018

•This population-based study shows a higher incidence and earlier age at diagnosis of cervical cancer among Aboriginal compared to non-Aboriginal women in NSW, Australia.

•Stage at diagnosis and treatment rates for radiotherapy and surgery showed no significant differences, and 5-year overall survival was also similar.

•Although overall access to cancer treatment appears equitable, there were significant disparities in access to treatment associated with socioeconomic disadvantage and residing in remote areas among Aboriginal women.

Completion Rate of Paper-Based and Electronic Patient Reported Outcome Measures in a Multidisciplinary Cancer Survivorship Clinical Setting

  • Pages: 275-280
  • First Published: 15 December 2024
Completion Rate of Paper-Based and Electronic Patient Reported Outcome Measures in a Multidisciplinary Cancer Survivorship Clinical Setting

Survivorship Clinic managed 622 initial survivor visits from 2013 to 2019 (pre-coronavirus disease 2019); paper patient-reported outcome measurements (PROMs) completion rates varied from 55% to 92%. Electronic PROMS were introduced in 2020; completion rates for PROMs were 99% for the initial visit (n = 198/200); and 92% for electronic PROMs (n = 169/184). The completion rate was high regardless of the mode of delivery.

The Effectiveness of Afatinib as First-Line Treatment in Vietnamese Patients With EGFR-Mutant Non–Small Cell Lung Cancer and Brain Metastases

  • Pages: 281-289
  • First Published: 18 December 2024
The Effectiveness of Afatinib as First-Line Treatment in Vietnamese Patients With EGFR-Mutant Non–Small Cell Lung Cancer and Brain Metastases

The median CNS-PFS and OS were 17.9 and 29.9 months, respectively. The CNS-ORR and ORR were 77.4% and 71.3%, respectively. Patients with uncommon mutations experienced significantly shorter survival. CNS-PFS and OS in the group receiving a starting dose of 40 mg or less were not significantly different.

Open Access

Smoking Cessation Practices in Australian Oncology Settings: A Cross-Sectional Study of Who, How, and When

  • Pages: 290-299
  • First Published: 05 February 2025
Smoking Cessation Practices in Australian Oncology Settings: A Cross-Sectional Study of Who, How, and When

The data on the smoking cessation practices of oncology HCPs found that differences existed between specialties and provision was more likely for those who had received training. A greater understanding of referral to behavioural support and pharmacotherapy is required through training for all staff involved in oncology patient care.

Adjuvant Radiotherapy After Surgical Resection Improves Local Control in Adrenocortical Carcinoma

  • Pages: 300-304
  • First Published: 01 December 2024
Adjuvant Radiotherapy After Surgical Resection Improves Local Control in Adrenocortical Carcinoma

This study demonstrates that adrenocortical carcinoma patients who receive postoperative adjuvant radiotherapy have a significantly higher estimated 3-year local recurrence-free survival compared to those treated with surgery alone.

Real-World Outcomes of Patients Treated With Gemcitabine Using Standardized Dose and Rate and Docetaxel for Advanced Soft Tissue Sarcoma in an Australian Sarcoma Center

  • Pages: 305-310
  • First Published: 17 November 2024
Real-World Outcomes of Patients Treated With Gemcitabine Using Standardized Dose and Rate and Docetaxel for Advanced Soft Tissue Sarcoma in an Australian Sarcoma Center

This retrospective analysis examined the efficacy and toxicity of gemcitabine, using a standardized dose and rate, in combination with docetaxel for advanced soft tissue sarcoma. These data demonstrate favorable activity and toxicity in a real-life patient population despite altered gemcitabine dosing and a heavily pretreated patient population. Practical benefits of this regimen include shorter chemotherapy chair time and consistency with other gemcitabine-containing protocols.

Deficient Mismatch Repair and BRAF Mutations in Metastatic Colorectal Cancer in the South Island of New Zealand

  • Pages: 311-318
  • First Published: 14 January 2025
Deficient Mismatch Repair and BRAF Mutations in Metastatic Colorectal Cancer in the South Island of New Zealand

In a population-based cohort study, of 845 colorectal cancer (CRC) patients, 20 patients had deficient mismatch repair (dMMR) metastatic CRC (7.8%) and potentially could have benefitted from ICI treatment. BRAF mutation was frequent in dMMR CRC, demonstrating sporadic cancer as the main cause of dMMR CRC in the South Island of NZ.

Open Access

Pneumocystis jirovecii Pneumonia in Cancer Patients, a Lethal Yet Fully Preventable Disease: Insights From a Tertiary Cancer Center in East India

  • Pages: 319-327
  • First Published: 14 February 2025
Pneumocystis jirovecii Pneumonia in Cancer Patients, a Lethal Yet Fully Preventable Disease: Insights From a Tertiary Cancer Center in East India

Age and history of lung radiotherapy are overlooked risk factors for Pneumocystis jirovecii pneumonia (PCP) in cancer patients. Prophylaxis appeared to be fully effective. 21-day mortality rate in the PCP group was 35.4%. Hematologic malignancy and lung cancer patients are at highest risk for mortality.

Open Access

Thoracic Cancer Exercise Services in Australia: A Point-Prevalence Survey

  • Pages: 328-337
  • First Published: 17 February 2025
Thoracic Cancer Exercise Services in Australia: A Point-Prevalence Survey

Our Australian prospective, observational, multicenter, and point-prevalence study found that only 67% of surveyed exercise services accepted lung cancer referrals, with just 38% of these programs providing exercise services to lung cancer patients during the study period, highlighting a gap in the integration of exercise pre- and rehabilitation into lung cancer care.