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    2022
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Research Article
Open Access

The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia

Dandan Zhang,  Yue Jia,  Xingzong Sun,  Haoran Li,  Min Yin,  Hongliang Li,  Lili Dai,  Li Han,  Lei Wang,  Menghan Qian,  Jing Du,  Keming Zhu,  Hongkun Bao, 
  • First Published: 28 December 2022
Research Article
Open Access

Identification of Immune-Related Genes and Small-Molecule Drugs in Interstitial Cystitis/Bladder Pain Syndrome Based on the Integrative Machine Learning Algorithms and Molecular Docking

Yiheng Jiang,  Xinqing Zhu,  Abdullah Y. Al-danakh,  Qiwei Chen,  Deyong Yang, 
  • First Published: 28 December 2022
Research Article
Open Access

Ag85A, As an S2 Vaccine Carrier, Reduces the Toxicity of the S2 Vaccine and Enhances the Protective Ability of Mice against Brucella

Shuai Zhang,  Lumen Chao,  Lemuge She,  Humujile Sui,  Huaxin Niu,  Zeliang Chen,  Xiangyang Li,  Jingbo Zhai, 
  • First Published: 26 December 2022
Review Article
Open Access

In Vitro Assays for Diagnosis of Drug-Induced Nonsevere Exanthemas: A Systematic Review and Meta-Analysis

Szymon Drygala,  Elzbieta Rdzanek,  Grzegorz Porebski,  Pawel Dubiela, 
  • First Published: 21 December 2022
Research Article
Open Access

The NLRP3 Genetic Variant (rs10754555) Reduces the Risk of Adverse Outcome in Middle-Aged Patients with Chronic Coronary Syndrome

Trine B. Opstad,  Jostein Nordeng,  Alf-Aage R. Pettersen,  Sissel Åkra,  Vibeke Bratseth,  Hani Zaidi,  Ragnhild Helseth,  Svein Solheim,  Ingebjørg Seljeflot, 
  • First Published: 20 December 2022
Research Article
Open Access

Anti-SARS-Cov-2 S-RBD IgG Formed after BNT162b2 Vaccination Can Bind C1q and Activate Complement

Anas H. A. Abu-Humaidan,  Fatima M. Ahmad,  Dima Awajan,  Raba’a F. Jarrar,  Nader Alaridah, 
  • First Published: 17 December 2022
Research Article
Open Access

IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells

Li Cheng,  Yang Jiao,  Wei Jiang,  Xin Zhang,  Liping Zhang,  Gongwei Jia, 
  • First Published: 16 December 2022
Research Article
Open Access

HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population

Wei Bai,  Xiaosheng Huang,  Xiaoli Shen,  Ye Ye,  Shiming Peng,  Tianhui Zhu,  Shaoyi Mei,  Jiajie Kuang,  Sejie Yu,  Xiaochen Ma,  Jun Zhao, 
  • First Published: 09 December 2022
Research Article
Open Access

Pentraxin 3 Facilitates Shrimp-Allergic Responses in IgE-Activated Mast Cells

Jyun-Yi Du,  Hong-Yue Lai,  Yu-Wei Hsiao,  Jhih-Ying Chi,  Ju-Ming Wang, 
  • First Published: 07 December 2022
Research Article
Open Access

Hypoxia Inhibits Osteogenesis and Promotes Adipogenesis of Fibroblast-like Synoviocytes via Upregulation of Leptin in Patients with Rheumatoid Arthritis

Menglei Ding,  Yu Cheng,  Zhen Xu,  Ying Lu,  Jing Li,  Liu Lu,  Ming Zong,  Lieying Fan, 
  • First Published: 07 December 2022
Research Article
Open Access

Histopathological and Immunohistochemical Features of Small to Big Satellite Nevus Uncover the Nevogenesis of Large/Giant Congenital Melanocytic Nevus

Jieyu Gu,  Boxuan Wei,  Bowen Gao,  Ran Duan,  Lingling Sheng,  Danning Zheng,  Yongyang Bao,  Feng Xie, 
  • First Published: 05 December 2022
Research Article
Open Access

Pretreatment Pan-Immune-Inflammation Value Efficiently Predicts Survival Outcomes in Glioblastoma Multiforme Patients Receiving Radiotherapy and Temozolomide

Erkan Topkan,  Ahmet Kucuk,  Ugur Selek, 
  • First Published: 28 November 2022
Research Article
Open Access

Intranasal Vaccination with rePcrV Protects against Pseudomonas aeruginosa and Generates Lung Tissue-Resident Memory T Cells

Yangxue Ou,  Ying Wang,  Ting Yu,  Zhiyuan Cui,  Xin Chen,  Weijun Zhang,  Quanming Zou,  Jiang Gu,  Qianfei Zuo, 
  • First Published: 26 November 2022
Research Article
Open Access

Serum sPD1 and sPDL1 as Biomarkers for Evaluating the Immune State of Lung Adenocarcinoma Patients

Yumin Wu,  Hui Guo,  Jiawei Yue,  Peng Xu, 
  • First Published: 25 November 2022
Research Article
Open Access

Role of Serum Amyloid A as a Biomarker for Predicting the Severity and Prognosis of COVID-19

Amal A. Abbas,  Asma Alghamdi,  Sonia Mezghani,  Mourad Ben Ayed,  Ahmed M. Alamori,  Ghazi A. Alghamdi,  Wail Bajhmom,  Hanan Wajeeh,  Salma S. Almutairi,  Wafaa M. Radwan, 
  • First Published: 24 November 2022
Research Article
Open Access

An In Vitro Comparison of Costimulatory Domains in Chimeric Antigen Receptor T Cell for Breast Cancer Treatment

Nattarika Khuisangeam,  Sirirut Jewmoung,  Rattapoom Thaiwong,  Suparat Tudsamran,  Nattiya Hirankarn,  Koramit Suppipat,  Supannikar Tawinwung, 
  • First Published: 22 November 2022
Review Article
Open Access

Prognostic and Clinical Value of the Systemic Immune-Inflammation Index in Biliary Tract Cancer: A Meta-Analysis

Xiulan Peng,  Xia Wang,  Li Hua,  Rui Yang, 
  • First Published: 17 November 2022
Research Article
Open Access

Suppression of T-Cell Proliferation by Normal Density Granulocytes Led to CD183 Downregulation and Cytokine Inhibition in T-Cells

Julia Westerlund,  Sandra Askman,  Åsa Pettersson,  Thomas Hellmark,  Åsa C. M. Johansson,  Markus Hansson, 
  • First Published: 16 November 2022
Research Article
Open Access

The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma

Si-Qi Jia,  Ran Zhuo,  Zi-Mu Zhang,  Yang Yang,  Yan-Fang Tao,  Jian-Wei Wang,  Xiao-Lu Li,  Yi Xie,  Gen Li,  Di Wu,  Yan-Ling Chen,  Juan-Juan Yu,  Chen-xi Feng,  Zhi-Heng Li,  Rong-Fang Zhou,  Ran-Dong Yang,  Peng-Cheng Yang,  Bi Zhou,  Xiao-Mei Wan,  Yu-Meng Wu,  Wan-Yan Jiao,  Ni-Na Zhou,  Fang Fang,  Jian Pan, 
  • First Published: 16 November 2022
Research Article
Open Access

Integrated Analysis of mRNA and lncRNA Expression Profiles Reveals Regulatory Networks Associated with Decompensated Cirrhosis

Li Zhang,  Xiaoyu Fang,  Suhua Wang,  Shasha Ma,  Jinyan Zhang,  Xiang Dong,  Jing Dai,  Chuanmiao Liu,  Yu Gao, 
  • First Published: 16 November 2022
Research Article
Open Access

Cuproptosis-Related Signature Predicts the Prognosis, Tumor Microenvironment, and Drug Sensitivity of Hepatocellular Carcinoma

Xiangjun Qi,  Jiayun Guo,  Guoming Chen,  Caishan Fang,  Leihao Hu,  Jing Li,  Chi Zhang, 
  • First Published: 16 November 2022
Research Article
Open Access

Cytomegalovirus-Specific T Cells from Third-Party Donors Successfully Treated Refractory Cytomegalovirus Retinitis after Unrelated Umbilical Cord Blood Transplantation

Na Li,  Guangyu Sun,  Lihua Zhu,  Kang Ding,  Huilan Liu,  Xiaoyu Zhu,  Baolin Tang,  Wen Yao,  Xiang Wan,  Liangquan Geng,  Ping Qiang,  Kaidi Song,  Changcheng Zheng,  Zimin Sun,  Juan Tong, 
  • First Published: 15 November 2022
Review Article
Open Access

Cytokines in Thyroid-Associated Ophthalmopathy

Pengbo Zhang,  Huang Zhu, 
  • First Published: 14 November 2022
Research Article
Open Access

Low Level of Advanced Glycation End Products in Serum of Patients with Allergic Rhinitis and Chronic Epstein-Barr Virus Infection at Different Stages of Virus Persistence

Svitlana Zubchenko,  Iryna Kril,  Halyna Potemkina,  Anna Havrylyuk,  Aleksandra Kuzan,  Andrzej Gamian,  Valentyna V. Chopyak, 
  • First Published: 11 November 2022
Research Article
Open Access

Oxidative Phosphorylation-Related Signature Participates in Cancer Development, and PTPRG Overexpression Suppresses the Cancer Progression in Clear Cell Renal Cell Carcinoma

Liang Huang,  Yu Xie,  Weiqing Han,  Shusuan Jiang,  Lingfeng Zeng, 
  • First Published: 10 November 2022
Research Article
Open Access

A Lamin Family-Based Signature Predicts Prognosis and Immunotherapy Response in Hepatocellular Carcinoma

Yongyu Yang,  Wang Xiao,  Ruoqi Liu,  Lei Gao,  Junzhang Chen,  Heping Kan, 
  • First Published: 10 November 2022
Research Article
Open Access

Identification of Malassezia globosa as a Gastric Fungus Associated with PD-L1 Expression and Overall Survival of Patients with Gastric Cancer

Zhenzhan Zhang,  Yaopeng Qiu,  Hao Feng,  Donghua Huang,  Binshu Weng,  Zhou Xu,  Qingfeng Xie,  Zhe Wang,  Wenfu Ding,  Guoxin Li,  Hao Liu, 
  • First Published: 09 November 2022
Research Article
Open Access

Comprehensive Analysis Reveals PTK6 as a Prognostic Biomarker Involved in the Immunosuppressive Microenvironment in Breast Cancer

Lili Wang,  Shuimei Luo,  Ziming Wang,  Yiqiang Huang,  Yang Luo,  Xianhe Xie, 
  • First Published: 09 November 2022
Research Article
Open Access

Saikosaponin-d Attenuates Hashimoto’s Thyroiditis by Regulating Macrophage Polarization

Peng Du,  Jianbin Xu,  Yanfei Jiang,  Jing Zhao,  Chaoqun Gao,  Yudie Fang,  Xiaorong Yang,  Yan-ping Yang,  Jin-an Zhang, 
  • First Published: 08 November 2022
Review Article
Open Access

The Mechanisms of Systemic Inflammatory and Immunosuppressive Acute-on-Chronic Liver Failure and Application Prospect of Single-Cell Sequencing

Kai Kou,  Xiaodong Sun,  Guangyao Tian,  Yao Zhi,  Zhongqi Fan,  Guoyue Lv, 
  • First Published: 02 November 2022
Research Article
Open Access

Differential Expression and Bioinformatics Analysis of Plasma-Derived Exosomal circRNA in Type 1 Diabetes Mellitus

Haipeng Pang,  Wenqi Fan,  Xiajie Shi,  Shuoming Luo,  Yimeng Wang,  Jian Lin,  Yang Xiao,  Xia Li,  Gan Huang,  Zhiguo Xie,  Zhiguang Zhou, 
  • First Published: 27 October 2022
Research Article
Open Access

Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavior

Man Zhang,  Xiao-Long Wang,  Hui Shi,  Lan-Qing Meng,  Hong-Feng Quan,  Lin Yan,  Hui-Fang Yang,  Xiao-Dong Peng, 
  • First Published: 26 October 2022
Research Article
Open Access

The Regulation between CD4+CXCR5+ Follicular Helper T (Tfh) Cells and CD19+CD24hiCD38hi Regulatory B (Breg) Cells in Gastric Cancer

Ying Zhang,  Jun Wu,  Haibo Zhang,  Chen Wu, 
  • First Published: 26 October 2022
Research Article
Open Access

Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study

Cong Peng,  Zongwei Guo,  Yue Zhao,  Rui Li,  Liang Wang,  Wenping Gong, 
  • First Published: 26 October 2022
Research Article
Open Access

Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling

Chalystha Yie Qin Lee,  Yee Teng Chan,  Yi Ying Cheok,  Grace Min Yi Tan,  Ting Fang Tang,  Heng Choon Cheong,  Jamuna Vadivelu,  Suhailah Abdullah,  Chung Yeng Looi,  Won Fen Wong, 
  • First Published: 22 October 2022
Research Article
Open Access

Effects of Lycium Barbarum Polysaccharides on the Metabolism of Dendritic Cells: An In Vitro Study

Baochen Zhang,  Kengyu Chen,  Li Liu,  Xiuyun Li,  Enhui Wu,  Liang Han,  Zhongfeng Shi,  Xiangliang Deng, 
  • First Published: 19 October 2022
Research Article
Open Access

Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma

Zedan Zhang,  Yanlin Tang,  Lei Li,  Wuping Yang,  Yawei Xu,  Jingcheng Zhou,  Kaifang Ma,  Kenan Zhang,  Hongkai Zhuang,  Yanqing Gong,  Kan Gong, 
  • First Published: 19 October 2022
Research Article
Open Access

Identifying Hub Genes and Immune Cell Infiltration for the Progression of Carotid Atherosclerotic Plaques in the Context of Predictive and Preventive Using Integrative Bioinformatics Approaches and Machine-Learning Strategies

Han Zhang,  Yinde Huang,  Xin Li,  Wenbin Chen,  Yu Lun,  Jian Zhang, 
  • First Published: 18 October 2022
Research Article
Open Access

Adiponectin Protects Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Suppressing Autophagy

Jia Guo,  Kaiyi Zhu,  Zhidong Li,  Chuanshi Xiao, 
  • First Published: 17 October 2022
Research Article
Open Access

The Impact of Radiation Dose on Preoperative Neoadjuvant Chemoradiotherapy Effects for Patients with Locally Advanced Squamous Cell Esophageal Carcinoma: A Propensity Score-Matched Retrospective Study

Yanru Mu,  Hui Wang,  Tao He,  Li Xu, 
  • First Published: 15 October 2022
Research Article
Open Access

Comparative Safety, Immunogenicity, and Efficacy of CEF Cell-Based and DF-1 Cell Line Adapted Infectious Bursal Disease Vaccines in Specific-Pathogen-Free Chickens

Daniel Workineh,  Molalegne Bitew,  Daniel Oluwayelu,  Belayneh Getachew,  Takele Abayneh,  Esayas Gelaye,  Hawa Mohammed,  Tedros Fikru,  Mastewal Birhan,  Bereket Dessalegn,  Getaw Deresse,  Kassaye Adamu,  Saddam Mohammed Ibrahim, 
  • First Published: 15 October 2022
Research Article
Open Access

Definition of a Novel Cuproptosis-Relevant lncRNA Signature for Uncovering Distinct Survival, Genomic Alterations, and Treatment Implications in Lung Adenocarcinoma

Zhuning Wang,  Junqiao Yao,  Tengyu Dong,  Xing Niu, 
  • First Published: 14 October 2022
Research Article
Open Access

Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2

Lihua Wang,  Lei Yang,  Tingting Zhuang,  Xiuqing Shi, 
  • First Published: 14 October 2022
Research Article
Open Access

HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop

Qiaohui Gao,  Zhenghua Ren,  Shengyuan Jiao,  Juan Guo,  Xia Miao,  Jin Wang,  Junye Liu, 
  • First Published: 13 October 2022
Research Article
Open Access

A Network Pharmacology Study on the Cervix Prescription for Treatment of Cervical Cancer

Yingping Zhu,  Liangping Wang,  Leilai Xu,  Pian Ying, 
  • First Published: 12 October 2022
Research Article
Open Access

Effects of Hyperthyroidism on Venous Thromboembolism: A Mendelian Randomization Study

Fushi Han,  Chunyang Zhang,  Miao Xuan,  Zhuangli Xie,  Kunming Zhang,  Ying Li, 
  • First Published: 12 October 2022
Research Article
Open Access

Correlation between Ferroptosis-Related Gene Signature and Immune Landscape, Prognosis in Breast Cancer

Jiahao Zhu,  Qingqing Chen,  Ke Gu,  You Meng,  Shengjun Ji,  Yutian Zhao,  Bo Yang, 
  • First Published: 11 October 2022
Research Article
Open Access

Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma

Shunhan Yao,  Meiling Deng,  Xiaojing Du,  Qingfeng Chen,  Rongzhi Huang, 
  • First Published: 08 October 2022
Research Article
Open Access

Jujuboside B Reverse CUMS-Promoted Tumor Progression via Blocking PI3K/Akt and MAPK/ERK and Dephosphorylating CREB Signaling

Zhen Yang,  Weijia Cai,  Yitian Chen,  Zhijun Guo,  Zhijun Xiao,  Ting Zhou,  Yuanchi Cheng,  Feng Xu, 
  • First Published: 08 October 2022
Review Article
Open Access

Recent Advances in the Allergic Cross-Reactivity between Fungi and Foods

Haiyan Xing,  Jianyong Wang,  Yuemei Sun,  Hongtian Wang, 
  • First Published: 07 October 2022
Research Article
Open Access

The Contribution of Hepatic Macrophage Heterogeneity during Liver Regeneration after Partial Hepatectomy in Mice

Pengfei Ma,  Wenchao Zhao,  Chunchen Gao,  Zhiwei Liang,  Longshuan Zhao,  Hongyan Qin,  Xiaolin Sun, 
  • First Published: 07 October 2022
Research Article
Open Access

Membrane Bound CRT Fragment Accelerates Tumor Growth of Melanoma B16 Cell In Vivo through Promoting M2 Polarization via TLR4

Hong-Min Wang,  Zhe Zhou,  Jie Miao,  Bo Zhu,  Xiao-Qiu Dai,  Qiao Zhong,  Fang-Yuan Gong,  Xiao-Ming Gao, 
  • First Published: 06 October 2022
Research Article
Open Access

Analysis of the Renal Protection and Antioxidative Stress Effects of Panax notoginseng Saponins in Diabetic Nephropathy Mice

Wei Mi,  Min Yu,  Shuying Yin,  Yuhan Ji,  Tala Shi,  Ning Li, 
  • First Published: 05 October 2022
Research Article
Open Access

Upper Airways Spray for Viral Infections Prevention

Beniamino Palmieri,  Maria Vadalà, 
  • First Published: 04 October 2022
Research Article
Open Access

Integrated Single-Cell and RNA Sequencing Analysis Identifies Key Immune Cell and Dendritic Cells Associated Genes Participated in Myocarditis

Qiang Gong,  Jianfeng Huang,  Qicai Wu, 
  • First Published: 03 October 2022
Research Article
Open Access

NLRP3 Inflammasome Simultaneously Involved in Autophagy and Phagocytosis of THP-1 Cells to Clear Aged Erythrocytes

Qin Li,  Fengyong Zhao,  Jiamin Zhang,  Ying Yang,  Zhonghui Guo,  Chen Wang,  Qixiu Yang,  Ying Sun,  Ziyan Zhu, 
  • First Published: 30 September 2022
Research Article
Open Access

Downregulated PRNP Facilitates Cell Proliferation and Invasion and Has Effect on the Immune Regulation in Ovarian Cancer

Kuan Hu,  Xiaofang Zhang,  Lei Zhou,  Juanni Li, 
  • First Published: 29 September 2022
Research Article
Open Access

Conciliatory Anti-Allergic Decoction Attenuates Pyroptosis in RSV-Infected Asthmatic Mice and Lipopolysaccharide (LPS)-Induced 16HBE Cells by Inhibiting TLR3/NLRP3/NF-κB/IRF3 Signaling Pathway

Ya-qin Chen,  Yan Zhou,  Qi-li Wang,  Jian Chen,  Hua Chen,  Hui-hui Xie,  Lan Li, 
  • First Published: 29 September 2022
Research Article
Open Access

N-Glycosylation on Asn50 of SND1 Is Required for Glioma U87 Cell Proliferation and Metastasis

Ying Zhou,  Qingyu Li,  Jianfeng Zheng,  Nengming Lin, 
  • First Published: 29 September 2022
Research Article
Open Access

Factors Contributing to Diagnosis and Prognosis in Sinonasal Malignancies

Wenjing Li,  Jianqiang You,  Haixiang Xue,  Changjiang Chao, 
  • First Published: 29 September 2022
Research Article
Open Access

ATXN2-Mediated PI3K/AKT Activation Confers Gastric Cancer Chemoresistance and Attenuates CD8+ T Cell Cytotoxicity

Qi Wang,  Tianyu Cao,  Xiaohui Zhang,  Juan Hui,  Chen Wang,  Wenyao Zhang,  Pei Wang,  Yun Zhou,  Shuang Han, 
  • First Published: 28 September 2022
Research Article
Open Access

Expression of PD-L1 and YWHAZ in Patients with Diffuse Large B Cell Lymphoma: A Possible Association with the Prognosis of Lymphoma

Shufang Yan,  Qinyu Shang,  Zhaopu Fan,  Yuping Yang,  Yanping Liu,  Hongliang Gao,  Ken Chen,  Fei Liang,  Xinxia Li,  Qian Zhang,  Huifang Yan, 
  • First Published: 28 September 2022
Research Article
Open Access

Decreased Jumonji Domain-Containing 3 at the Promoter Downregulates Hematopoietic Progenitor Kinase 1 Expression and Cytoactivity of T Follicular Helper Cells from Systemic Lupus Erythematosus Patients

Shuaihantian Luo,  Yuming Xie,  Junke Huang,  Juan Liu,  Qing Zhang, 
  • First Published: 28 September 2022
Review Article
Open Access

Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases

Njinju Asaba Clinton,  Sodiq Ayobami Hameed,  Eugene Kusi Agyei,  Joy Chinwendu Jacob,  Victor Oyewale Oyebanji,  Cyril Ekabe Jabea, 
  • First Published: 27 September 2022
Research Article
Open Access

Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis

Lei Liu,  Jundi Wang,  Peiyu Zhang,  Wenjia Sun,  Xiuliang Zhu,  Xiujuan Sun,  Jing Xue,  Huaxiang Wu, 
  • First Published: 26 September 2022
Research Article
Open Access

Construction of a Cuprotosis-Related Gene-Based Model to Improve the Prognostic Evaluation of Patients with Gastric Cancer

Chunyan Han,  Kai Zhang,  XinKai Mo, 
  • First Published: 22 September 2022
Research Article
Open Access

Expression Analysis of Ligand-Receptor Pairs Identifies Cell-to-Cell Crosstalk between Macrophages and Tumor Cells in Lung Adenocarcinoma

Xiaodong Yang,  Zhao An,  Zhengyang Hu,  Junjie Xi,  Chenyang Dai,  Yuming Zhu, 
  • First Published: 22 September 2022
Research Article
Open Access

Network Pharmacology and Molecular Docking Approach to Reveal the Immunotherapeutic Mechanism of Cuscutae Semen in Treating Thin Endometrium

Wenyan Zhang,  Yuan Yuan,  Guangrong Huang, 
  • First Published: 22 September 2022
Research Article
Open Access

Integrated Bioinformatics and Validation of lncRNA-Mediated ceRNA Network in Myocardial Ischemia/Reperfusion Injury

Ying Han,  Gong Jin,  Min Pan,  Zhoufei Fang,  Dan Lu,  Wenqin Cai,  Changsheng Xu, 
  • First Published: 21 September 2022
Research Article
Open Access

Is Vitamin D Deficiency the Cause or the Effect of Systemic Lupus Erythematosus: Evidence from Bidirectional Mendelian Randomization Analysis

Yang Ding,  Shengyi Yang,  Shasha Fan,  Yi Tang,  Yan Teng,  Xiaohua Tao,  Wei Lu, 
  • First Published: 21 September 2022
Research Article
Open Access

Antibodies Recognizing Yersinia enterocolitica Lipopolysaccharides of Various Chemotypes in Synovial Fluids From Patients With Juvenile Idiopathic Arthritis

Katarzyna Kasperkiewicz,  Anna S. Świerzko,  Mateusz Michalski,  Łukasz Eppa,  Mikael Skurnik,  Zbigniew Żuber,  Maciej Cedzyński, 
  • First Published: 21 September 2022
Research Article
Open Access

Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population

Xiaogang Cui,  Tianqi Yuan,  Pengyuan Ning,  Jie Han,  Yue Liu,  Jiao Feng,  Fan Lian,  Mingyuan Hao,  Li Dong,  Jinqi Hao,  Li Xing,  Changxin Wu, 
  • First Published: 20 September 2022
Research Article
Open Access

Host Immune Response to Clinical Hypervirulent Klebsiella pneumoniae Pulmonary Infections via Transcriptome Analysis

Langhuan Lei,  Xiaoli Zhang,  Rui Yang,  Haiming Jing,  Yue Yuan,  Zhifu Chen,  Qiang Gou,  Zhuo Zhao,  Jinyong Zhang,  Xingyong Wang, 
  • First Published: 20 September 2022
Research Article
Open Access

Correlation Analysis of Pathological Features and Axillary Lymph Node Metastasis in Patients with Invasive Breast Cancer

Hongye Chen,  Xiangchao Meng,  Xiaopeng Hao,  Qiao Li,  Lin Tian,  Yue Qiu,  Yuhui Chen, 
  • First Published: 19 September 2022
Review Article
Open Access

Meta-Analysis of Alterations in Regulatory T Cells’ Frequency and Suppressive Capacity in Patients with Vitiligo

Prashant S. Giri,  Jahanvi Mistry,  Mitesh Dwivedi, 
  • First Published: 16 September 2022
Research Article
Open Access

Salmonella Exhibit Altered Cellular Localization in the Presence of HLA-B27 and Codistribute with Endo-Reticular Membrane

Janos Kriston-Vizi,  Izabela Lenart,  Takao Iwawaki,  Keith Gould,  Darren Nesbeth,  Simon J. Powis,  Antony N. Antoniou, 
  • First Published: 16 September 2022
Research Article
Open Access

ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages

Yan Jiang,  Qiming Gong,  Jinmei Huang,  Yuanxun Gong,  Qiang Tang,  Dalong Wei,  Qianli Tang,  Jingjie Zhao,  Jian Song,  Lingzhang Meng, 
  • First Published: 16 September 2022
Research Article
Open Access

Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma

Simin Li,  Yang Wang,  Rui Sun,  Debora Franceschi,  Hongying Pan,  Chenxuan Wei,  Anthony Chukwunonso Ogbuehi,  Bernd Lethaus,  Vuk Savkovic,  Sebastian Gaus,  Rüdiger Zimmerer,  Dirk Ziebolz,  Gerhard Schmalz,  Xiao Jiang, 
  • First Published: 16 September 2022
Research Article
Open Access

Exosomal miR-452-5p Induce M2 Macrophage Polarization to Accelerate Hepatocellular Carcinoma Progression by Targeting TIMP3

Hu Zongqiang,  Chen Jiapeng,  Zhao Yingpeng,  Yan Chuntao,  Wang Yiting,  Zhu Jiashun,  Li Li, 
  • First Published: 16 September 2022
Research Article
Open Access

The MicroRNA-106a/20b Strongly Enhances the Antitumour Immune Responses of Dendritic Cells Pulsed with Glioma Stem Cells by Targeting STAT3

Hui Zhou,  Chengmei Sun,  Cong Li,  Shiting Hua,  Feng Li,  Ruichun Li,  Dongpeng Cai,  Yuxi Zou,  Yingqian Cai,  Xiaodan Jiang, 
  • First Published: 15 September 2022
Research Article
Open Access

Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients

Prashant S. Giri,  Ankit H. Bharti,  Mitesh Dwivedi, 
  • First Published: 15 September 2022
Research Article
Open Access

Therapeutic Effect of Gypenosides on Antioxidant Stress Injury in Orbital Fibroblasts of Graves’ Orbitopathy

Chao Ma,  Haoyu Li,  Wei Liu,  Shuwen Lu,  Xian Li,  Jinyuan Chen,  Kaijun Li,  Wenzhan Wang, 
  • First Published: 15 September 2022
Research Article
Open Access

Identification of RNA Modification-Associated Alternative Splicing Signature as an Independent Factor in Head and Neck Squamous Cell Carcinoma

Jie Liu,  Wenmin Deng,  Zhiwen Xiao,  Xiaofeng Huang,  Minmin Lin,  Zhen Long, 
  • First Published: 13 September 2022
Research Article
Open Access

Cortistatin-14 Exerts Neuroprotective Effect Against Microglial Activation, Blood-brain Barrier Disruption, and Cognitive Impairment in Sepsis-associated Encephalopathy

Qiang Wen,  Qian Ding,  Jinchao Wang,  Yanhua Yin,  Shangchen Xu,  Yuanrong Ju,  Hongsheng Ji,  Bin Liu, 
  • First Published: 13 September 2022
Research Article
Open Access

EMAP II Expression Is Increased on Peripheral Blood Cells from Non-Hodgkin Lymphoma

Manal Mohamed Saber, 
  • First Published: 12 September 2022
Research Article
Open Access

Partial Reconstruction of Uterus Cervix in Rat by Decellularized Human Uterine Cervical Scaffold Combined with Adipose-Derived Stem Cells (ADSCs)

Yuqi Li,  Chunbo Li,  Luopei Guo,  Xiaotong Liu,  Keqin Hua,  Xuyin Zhang, 
  • First Published: 12 September 2022
Research Article
Open Access

C/EBPα-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection

Heng Lu,  Yi Chen,  Yinhai Chen,  Lingchen Huang,  Liangwan Chen, 
  • First Published: 12 September 2022
Research Article
Open Access

Electroacupuncture-Regulated miR-34a-3p/PDCD6 Axis Promotes Post-Spinal Cord Injury Recovery in Both In Vitro and In Vivo Settings

Lili Ma,  Lizhong Ma,  Yu Yang,  Ting Chen,  Limin Wang,  Qilong Deng, 
  • First Published: 12 September 2022
Research Article
Open Access

LINC01094/SPI1/CCL7 Axis Promotes Macrophage Accumulation in Lung Adenocarcinoma and Tumor Cell Dissemination

Zhuo Wu,  Xue Bai,  Zhengbo Lu,  Shijun Liu,  Hongfang Jiang, 
  • First Published: 09 September 2022
Research Article
Open Access

Tacrolimus Concentration Is Effectively Predicted Using Combined Clinical and Genetic Factors in the Perioperative Period of Kidney Transplantation and Associated with Acute Rejection

Fang Cheng,  Qiang Li,  Zheng Cui,  Zhendi Wang,  Fang Zeng,  Yu Zhang, 
  • First Published: 09 September 2022
Research Article
Open Access

Profiling Serum Cytokines and Anticytokine Antibodies in Psoriasis Patients

Dan Hong,  Xiuting Liu,  Xiaonan Qiu,  Siyao Lu,  Yanyun Jiang,  Guozhen Tan,  Zhenrui Shi,  Liangchun Wang, 
  • First Published: 08 September 2022
Research Article
Open Access

FBXL16 Promotes Endometrial Progesterone Resistance via PP2AB55α/Cyclin D1 Axis in Ishikawa

Haoen Liu,  Li Han,  Liyan Zhong,  Xiaodan Zhuang,  Yan Peng, 
  • First Published: 05 September 2022
Research Article
Open Access

Comparison of Transcriptomic Signatures between Monkeypox-Infected Monkey and Human Cell Lines

Do Thi Minh Xuan,  I-Jeng Yeh,  Chung-Che Wu,  Che-Yu Su,  Hsin-Liang Liu,  Chung-Chieh Chiao,  Su-Chi Ku,  Jia-Zhen Jiang,  Zhengda Sun,  Hoang Dang Khoa Ta,  Gangga Anuraga,  Chih-Yang Wang,  Meng-Chi Yen, 
  • First Published: 01 September 2022
Research Article
Open Access

Exosomal lncRNA PCAT1 Promotes Tumor Circulating Cell-Mediated Colorectal Cancer Liver Metastasis by Regulating the Activity of the miR-329-3p/Netrin-1-CD146 Complex

Xingbao Fang,  Yongping Xu,  Kezhi Li,  Peiwan Liu,  Hong Zhang,  Yang Jiang,  Jianwei Tang,  Yuehong Li, 
  • First Published: 31 August 2022
Research Article
Open Access

Antibody Avidity and Neutralizing Response against SARS-CoV-2 Omicron Variant after Infection or Vaccination

Francesca Dapporto,  Serena Marchi,  Margherita Leonardi,  Pietro Piu,  Piero Lovreglio,  Nicola Decaro,  Nicola Buonvino,  Angela Stufano,  Eleonora Lorusso,  Emilio Bombardieri,  Antonella Ruello,  Simonetta Viviani,  Eleonora Molesti,  Claudia Maria Trombetta,  Alessandro Manenti,  Emanuele Montomoli, 
  • First Published: 31 August 2022
Research Article
Open Access

Trametenolic Acid Ameliorates the Progression of Diabetic Nephropathy in db/db Mice via Nrf2/HO-1 and NF-κB-Mediated Pathways

Qi Duan,  Lingling Tian,  Jiabing Feng,  Xinbo Ping,  Lihong Li,  Hasnaa Yaigoub,  Rongshan Li,  Yafeng Li, 
  • First Published: 30 August 2022
Research Article
Open Access

Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration

Bo Wu,  Xinzhou Huang,  Mu Zhang,  Wei Chu, 
  • First Published: 30 August 2022
Research Article
Open Access

Characterization of the Tumor Microenvironment in Osteosarcoma Identifies Prognostic- and Immunotherapy-Relevant Gene Signatures

Jianye Tan,  Xuhui Feng,  Hangxing Wu,  Bingsheng Yang,  Meiling Shi,  Chao Xie,  Zexin Su,  Lin Li,  Mengliang Luo,  Zhijie Zuo,  Shuang Zhu,  Jiancheng Yang,  Lijun Lin, 
  • First Published: 27 August 2022
Research Article
Open Access

CIRBP Regulates Pancreatic Cancer Cell Ferroptosis and Growth by Directly Binding to p53

Hongqiang Gao,  Ran Xie,  Rong Huang,  Chonglin Wang,  Yue Wang,  Dongdong Wang,  Kaimin Liu,  Conghui Yang,  Qingxiong Yang,  Long Chen, 
  • First Published: 25 August 2022
Review Article
Open Access

Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis

Qianlei Wang,  James Asenso,  Ning Xiao,  Jinzhang Gao,  Feng Xiao,  Jiajie Kuai,  Wei Wei,  Chun Wang, 
  • First Published: 24 August 2022
Research Article
Open Access

Comprehensive Analysis of N6-Methyladenosine RNA Methylation Regulators in the Diagnosis and Subtype Classification of Acute Myocardial Infarction

Xianpei Wang,  Ying Wu,  Ruoyao Guo,  Linwei Zhao,  Juanjuan Yan,  Chuanyu Gao, 
  • First Published: 24 August 2022
Research Article
Open Access

Use of Nomogram to Predict the Risk of Lymph Node Metastasis among Patients with Cervical Adenocarcinoma

Yongju Tian,  Yiping Hao,  Qingqing Liu,  Ruowen Li,  Zhonghao Mao,  Nan Jiang,  Bingyu Wang,  Wenjing Zhang,  Xiaofang Zhang,  Baoxia Cui, 
  • First Published: 23 August 2022
Research Article
Open Access

GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma

Zhao-shou Yang,  Qin Yang,  Xiao-xiao Sun,  Kui Xiong,  Xiao-ting Zhu,  Yi-chen Wang,  Qian-yao Ren,  Guo-hui Wu,  Shi-min Wang,  Xu-qin Cao,  Xiao-rong Yang,  Wen-gong Jiang, 
  • First Published: 23 August 2022
Research Article
Open Access

Comprehensive Analysis of Gene Signatures of m6ARNA Methylation Regulators in Lung Adenocarcinoma and Development of a Risk Scoring System

Chundi Gao,  Huayao Li,  Wenzhe Ma,  Qiming Zhang,  Cun Liu,  Lijuan Liu,  Jing Zhuang,  Changgang Sun, 
  • First Published: 23 August 2022
Research Article
Open Access

HBV Infection-Related PDZK1 Plays an Oncogenic Role by Regulating the PI3K-Akt Pathway and Fatty Acid Metabolism and Enhances Immunosuppression

Xin Chen,  Xiaodong Wang,  Feng Zhu,  Chao Qian,  Fanggui Xu,  Xin Huang,  Wenjie Zhang,  Beicheng Sun, 
  • First Published: 23 August 2022
Research Article
Open Access

Identification of a Hypoxia-Angiogenesis lncRNA Signature Participating in Immunosuppression in Gastric Cancer

Zicheng Wang,  Xisong Liang,  Hao Zhang,  Zeyu Wang,  Xun Zhang,  Ziyu Dai,  Zaoqu Liu,  Jian Zhang,  Peng Luo,  Jiarong Li,  Quan Cheng, 
  • First Published: 23 August 2022
Research Article
Open Access

Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis

Zhengfang Liang,  Fengwei Nong,  Jingjie Zhao,  Dalong Wei,  Qianli Tang,  Jian Song,  Lingzhang Meng, 
  • First Published: 22 August 2022
Research Article
Open Access

miR-214-3p Deficiency Enhances Caspase-1-Dependent Pyroptosis of Microglia in White Matter Injury

Liufang He,  Tingyan Wei,  Yong Huang,  Xueli Zhang,  Dongbo Zhu,  Huazhen Liu,  Zhangxing Wang, 
  • First Published: 22 August 2022
Research Article
Open Access

Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B

Yunyan Li,  Jianfu Chen,  Yuan Yang,  Yuxue Wang,  Yong Zhang,  Yan Zhou,  Yan Bao,  Zongmei Zhang,  Yongping Lu, 
  • First Published: 19 August 2022
Research Article
Open Access

The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment

Ze-Tao Zhan,  Lu Liu,  Ming-Zhen Cheng,  Yi Gao,  Wei-Jie Zhou, 
  • First Published: 18 August 2022
Research Article
Open Access

A Systematic Review with Meta-Analysis of Comparative Efficacy and Safety of Risankizumab and Ustekinumab for Psoriasis Treatment

Qianying Yu,  Xiaopei Ge,  Mingyi Jing,  Xiongfei Mi,  Jing Guo,  Min Xiao,  Qing Lei,  Mingling Chen, 
  • First Published: 18 August 2022
Research Article
Open Access

The Long Noncoding RNA MEG3 Retains Epithelial-Mesenchymal Transition by Sponging miR-146b-5p to Regulate SLFN5 Expression in Breast Cancer Cells

Xuefeng Gu,  Jingyi Li,  Xiaojia Zuo,  Kaijie Chen,  Guoqing Wan,  Li-li Deng,  Weiming Zhao,  Changlian Lu, 
  • First Published: 18 August 2022
Research Article
Open Access

Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis

Qiaohui Hong,  Yue Zhang,  Weixian Lin,  Wei Wang,  Yafei Yuan,  Jiajia Lin,  Zhanzhan Xie,  Xu Li,  Ying Meng, 
  • First Published: 18 August 2022
Research Article
Open Access

Machine Learning-Devised Immune-Related lncRNA Signature Panel Predicts the Prognosis and Immune Landscape in Breast Cancer Novel IRLP Signature in BRCA

Jun-Yu Zhu,  An-Qi Lyu,  Zhang-Ting Wang,  Wai-Yee Chan,  Tao Qin,  Kai-Kei Miu,  He-Rui Yao, 
  • First Published: 18 August 2022
Research Article
Open Access

Establishing Reference Values for Peripheral Blood Lymphocyte Subsets of Healthy Children in China Using a Single Platform

Liangjun Zhang,  Huixiu Zhong,  Bin Wei,  Jiwen Fan,  Jingyuan Huang,  Yi Li,  Weiping Liu, 
  • First Published: 17 August 2022
Research Article
Open Access

FABP6 Expression Correlates with Immune Infiltration and Immunogenicity in Colorectal Cancer Cells

Wenping Lian,  Zhongquan Wang,  Yajie Ma,  Yalin Tong,  Xinyu Zhang,  Huifang Jin,  Shuai Zhao,  Ruijing Yu,  Shaotan Ju,  Xinyun Zhang,  Xiaona Guo,  Tao Huang,  Xianfei Ding,  Mengle Peng, 
  • First Published: 17 August 2022
Research Article
Open Access

Blood Biomarkers Predict Survival Outcomes in Patients with Hepatitis B Virus-Induced Hepatocellular Carcinoma Treated with PD-1 Inhibitors

Rui Huang,  Yanfen Zheng,  Wenxue Zou,  Chao Liu,  Jibing Liu,  Jinbo Yue, 
  • First Published: 17 August 2022
Review Article
Open Access

Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease

Nuria Cortes-Serra,  Melisa Gualdron-Lopez,  Maria-Jesus Pinazo,  Ana Claudia Torrecilhas,  Carmen Fernandez-Becerra, 
  • First Published: 17 August 2022
Review Article
Open Access

The Role of Decorin in Autoimmune and Inflammatory Diseases

Yuanji Dong,  Jixin Zhong,  Lingli Dong, 
  • First Published: 17 August 2022
Research Article
Open Access

Endoplasmic Reticulum Stress-Related Signature for Predicting Prognosis and Immune Features in Hepatocellular Carcinoma

Genhao Zhang,  Jianping Sun, 
  • First Published: 14 August 2022
Research Article
Open Access

Extracellular Volume Fraction Based on Cardiac Magnetic Resonance T1 Mapping: An Effective Way to Evaluate Cardiac Injury Caused by Cardiac Amyloidosis in Patients with Multiple Myeloma

Minghui Liu,  Liang Shao,  Zhaoxia Yang,  Qian Wang,  Balu Wu,  Xiaoyan Liu,  Yalan Yu,  Tingting Huang,  Meixing Wang,  Yong He,  Guohong Liu,  Fuling Zhou, 
  • First Published: 13 August 2022
Research Article
Open Access

Levels of Pathogenic Th17 and Th22 Cells in Patients with Rheumatoid Arthritis

Marlen Vitales-Noyola,  Berenice Hernández-Castro,  Diana Alvarado-Hernández,  Lourdes Baranda,  Sofía Bernal-Silva,  Carlos Abud-Mendoza,  Perla Niño-Moreno,  Roberto González-Amaro, 
  • First Published: 13 August 2022
Research Article
Open Access

Identification of Hub Genes Involved in Tubulointerstitial Injury in Diabetic Nephropathy by Bioinformatics Analysis and Experiment Verification

Jiayi Yang,  Li Peng,  Yuqiu Tian,  Wenbin Tang,  Linlin Peng,  Jianping Ning,  Dongjie Li,  Yun Peng, 
  • First Published: 12 August 2022
Research Article
Open Access

The Role of the Key Differentially Mutated Gene FGFR3 in the Immune Microenvironment of Bladder Cancer

Jun Jiang,  Yan Zhan,  Jun Li, 
  • First Published: 12 August 2022
Research Article
Open Access

miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute Kidney Injury through Downregulation of NEK7

Meng Zhang,  Deyuan Zhi,  Jin Lin,  Pei Liu,  Yajun Wang,  Meili Duan, 
  • First Published: 10 August 2022
Research Article
Open Access

m6A-Related lncRNA Signature Is Involved in Immunosuppression and Predicts the Patient Prognosis of the Age-Associated Ovarian Cancer

Ming Li,  Liang Zhang,  Miaoxiao Feng,  Xiao Huang, 
  • First Published: 10 August 2022
Research Article
Open Access

Protein Regulator of Cytokinesis 1 (PRC1) Upregulation Promotes Immune Suppression in Liver Hepatocellular Carcinoma

Canjing Zhang,  Huiwen Xu,  Xianxian Sui,  Ting Wu,  Bobin Chen,  Songmei Wang,  Xuanyi Wang, 
  • First Published: 09 August 2022
Research Article
Open Access

Augmenter of Liver Regeneration (ALR) Protects Kidney from Ischemia/Reperfusion (I/R) Injury via Regulation of TLR4/MAPK Signaling Pathway

Ying Li,  Yanying Xiong,  Huihui Li,  Yan Luo,  Ling Zhang,  Qin Zhang,  Weijian Xiong,  Haitao Tu, 
  • First Published: 09 August 2022
Research Article
Open Access

Identification of Cytosolic DNA Sensor cGAS-STING as Immune-Related Risk Factor in Renal Carcinoma following Pan-Cancer Analysis

Zheng Wu,  Ying Lin,  Li-Min Liu,  Yan-Li Hou,  Wei-Ting Qin,  Lei Zhang,  Shu-Heng Jiang,  Qin Yang,  Yong-Rui Bai, 
  • First Published: 09 August 2022
Research Article
Open Access

Calreticulin as an Adjuvant In Vivo to Promote Dendritic Cell Maturation and Enhance Antigen-Specific T Lymphocyte Responses against Melanoma

Zheng Gong,  Ming Chen,  Jie Miao,  Chao-Jie Han,  Qiao Zhong,  Fang-Yuan Gong,  Xiao-Ming Gao, 
  • First Published: 09 August 2022
Research Article
Open Access

Immunogenomic-Based Analysis of Hierarchical Clustering of Diffuse Large Cell Lymphoma

Longhao Wang,  Wei Yuan,  Lifeng Li,  Zhibo Shen,  Qishun Geng,  Yuanyuan Zheng,  Jie Zhao, 
  • First Published: 09 August 2022
Research Article
Open Access

Vaginal Microbial Environment Skews Macrophage Polarization and Contributes to Cervical Cancer Development

Guannan Zhou,  Fangyue Zhou,  Yuanyuan Gu,  Menglei Zhang,  Ganrong Zhang,  Fang Shen,  Keqin Hua,  Jingxin Ding, 
  • First Published: 09 August 2022
Research Article
Open Access

The Effect and Mechanism of Curcumin Combined with Carboplatin Chemotherapy Promoting on Apoptosis of Lung Cancer HCC827 Cells

Lingping Huang,  Xiangyuan He,  Xuan Zuo, 
  • First Published: 08 August 2022
Research Article
Open Access

Dysregulation of NK and CD8+T Cells by the Microbiota Promotes the Progression of Lung Cancer

Shouxin Hu,  Yanfang Zha,  Wenwen Yang,  Kele Cui,  Min Cheng, 
  • First Published: 05 August 2022
Research Article
Open Access

BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens

Amanda Contreras,  Darin L. Wiesner,  Brock Kingstad-Bakke,  Woojong Lee,  John P. Svaren,  Bruce S. Klein,  M. Suresh, 
  • First Published: 05 August 2022
Research Article
Open Access

PEGylated Cisplatin Nanoparticles for Treating Colorectal Cancer in a pH-Responsive Manner

Wei Li,  Yongjun Sun,  Jian Chen,  Zhibin Jiang,  Jinbao Yang, 
  • First Published: 05 August 2022
Research Article
Open Access

Aerosol Inhalation of Heat-Killed Clostridium butyricum CGMCC0313-1 Alleviates Allergic Airway Inflammation in Mice

Laodong Li,  Qixiang Sun,  Huan Xiao,  Qiannan Zhang,  Siyue Xu,  Lejin Lai,  Zhengning Li,  Chaoqian Li, 
  • First Published: 05 August 2022
Research Article
Open Access

Establishment of a Monoclonal Antibody-Based Enzyme-Linked Immunosorbent Assay to Measure Soluble B7-H5 in Patients with Cancer

Tongguo Shi,  Shuru Zhou,  Ting Zhang,  Shiyang Han,  Li Zhang,  Fengqing Fu,  Ruhong Yan,  Xueguang Zhang, 
  • First Published: 04 August 2022
Research Article
Open Access

Efficiency of Disease and Disease Activity Diagnosis Models of Systemic Lupus Erythematosus Based on Protein Array Analysis

Yafei Zhao,  Yuanyuan Qi,  Xinran Liu,  Yan Cui,  Zhanzheng Zhao, 
  • First Published: 04 August 2022
Research Article
Open Access

BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia

Xu Sang,  Yongping Zhang,  Fang Fang,  Li Gao,  Yanfang Tao,  Xiaolu Li,  Zimu Zhang,  Jianwei Wang,  Yuanyuan Tian,  Zhiheng Li,  Di Yao,  Yumeng Wu,  Xinran Chu,  Kunlong Zhang,  Li Ma,  Lihui Lu,  Yanling Chen,  Juanjuan Yu,  Ran Zhuo,  Shuiyan Wu,  Zhen Zhang,  Jian Pan,  Shaoyan Hu, 
  • First Published: 01 August 2022
Research Article
Open Access

Expanded CD1c+CD163+ DC3 Population in Synovial Tissues Is Associated with Disease Progression of Osteoarthritis

Guowei Qiu,  Sheng Zhong,  Jun Xie,  Hui Feng,  Songtao Sun,  Chenxin Gao,  Xirui Xu,  Bingxin Kang,  Hui Xu,  Chi Zhao,  Lei Ran,  A. Xinyu,  Bo Xu,  Xiaohui Meng,  Lu Meng,  Xiaoming Zhang,  Lianbo Xiao, 
  • First Published: 01 August 2022
Research Article
Open Access

Upregulation of PD-1 Expression and High sPD-L1 Levels Associated with COVID-19 Severity

Danielle Rosa Beserra,  Ricardo Wesley Alberca,  Anna Claudia Calvielli Castelo Branco,  Luana de Mendonça Oliveira,  Milena Mary de Souza Andrade,  Sarah Cristina Gozzi-Silva,  Franciane Mouradian Emidio Teixeira,  Tatiana Mina Yendo,  Alberto José da Silva Duarte,  Maria Notomi Sato, 
  • First Published: 01 August 2022
Research Article
Open Access

Identifying RBBP7 as a Promising Diagnostic Biomarker for BK Virus-Associated Nephropathy

Yicun Wang,  Yuxuan Wang,  Di Zhang,  Hao Zhang,  Wei Wang,  Xiaopeng Hu, 
  • First Published: 31 July 2022
Research Article
Open Access

Application of Mesoporous Silica Nanoparticle-Chitosan-Loaded BMP-2 in the Repair of Bone Defect in Chronic Osteomyelitis

Min Yi,  Yu Nie,  Chengyun Zhang,  Bin Shen, 
  • First Published: 31 July 2022
Research Article
Open Access

The Mechanism of Inflammatory Factors and Soluble Vascular Cell Adhesion Molecule-1 Regulated by Nuclear Transcription Factor NF-κB in Unstable Angina Pectoris

Qingfeng Su,  Linhu Zhang,  Zhenhui Qi,  Bo Huang, 
  • First Published: 30 July 2022
Research Article
Open Access

Transmembrane Protein ANTXR1 Regulates γ-Globin Expression by Targeting the Wnt/β-Catenin Signaling Pathway

Tingting Jin,  Zhaojun Zhang,  Yuanyuan Han,  Di Li,  Juan Liu,  Minmin Jiang,  Junwei Zhu,  Ryo Kurita,  Yukio Nakamura,  Fangfang Hu,  Yongjie Xu,  Xiangdong Fang,  Shengwen Huang,  Zhaolin Sun, 
  • First Published: 30 July 2022
Research Article
Open Access

Role of Autophagy Inducers and Inhibitors in Intestinal Barrier Injury Induced by Intestinal Ischemia–Reperfusion (I/R)

Yuejin Li,  Peng Zhang,  Jian Zhang,  Weimin Bao,  Jinyuan Li,  Yan Wei,  Jinchao Ni,  Kunmei Gong, 
  • First Published: 30 July 2022
Research Article
Open Access

Identification of Pathologic Grading-Related Genes Associated with Kidney Renal Clear Cell Carcinoma

Weijian Xiong,  Jin Zhong,  Ying Li,  Xunjia Li,  Lili Wu,  Ling Zhang, 
  • First Published: 30 July 2022
Research Article
Open Access

SARS-CoV-2 Spike Protein Vaccine-Induced Immune Imprinting Reduces Nucleocapsid Protein Antibody Response in SARS-CoV-2 Infection

Juan F. Delgado,  Mónica Vidal-Pla,  M. Carmen Moya,  Mateu Espasa,  Antonio Casabella,  Manel Seda,  Joan Calvet,  Jordi Gratacós,  Rosa M. Serrano,  Pilar Peña, 
  • First Published: 29 July 2022
Research Article
Open Access

The Activation of the Tumor Suppressor Protein p53 by Acriflavine Leads to Mitochondrial Dysfunction and Improves the Radiosensitivity of Colon Cancer Cells

Caizhao Lin,  Xiaohua Chen,  Huayun Qiu,  Benfeng Li,  Min Guo, 
  • First Published: 29 July 2022
Research Article
Open Access

Guanxinning Tablet Attenuates Coronary Atherosclerosis via Regulating the Gut Microbiota and Their Metabolites in Tibetan Minipigs Induced by a High-Fat Diet

Qinqin Yang,  Yanyun Xu,  Liye Shen,  Yongming Pan,  Junjie Huang,  Quanxin Ma,  Chen Yu,  Jiaojiao Chen,  Yu Chen,  Minli Chen, 
  • First Published: 28 July 2022
Research Article
Open Access

Methotrexate Treatment Suppresses Monocytes in Nonresponders to Pneumococcal Conjugate Vaccine in Rheumatoid Arthritis Patients

Evelina Elmér,  Per Nived,  Åsa Pettersson,  Lillemor Skattum,  Thomas Hellmark,  Meliha C. Kapetanovic,  Åsa C. M. Johansson, 
  • First Published: 28 July 2022
Review Article
Open Access

Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy

Jinhua Chen,  Zhenhua Yin,  Wenping Song,  Baoxia He,  Wenzhou Zhang, 
  • First Published: 28 July 2022
Research Article
Open Access

SARS-CoV-2-Specific T Cell Immunity in HIV-Associated Kaposi Sarcoma Patients in Zambia

Owen Ngalamika,  Marie Claire Mukasine,  Patrick Kamanzi,  Musonda Kawimbe,  Aaron Mujajati,  For Yue Tso,  Salum J. Lidenge,  Chibamba Mumba, 
  • First Published: 28 July 2022
Research Article
Open Access

Systematic Construction and Validation of a Novel Ferroptosis-Related Gene Model for Predicting Prognosis in Cervical Cancer

Wentao Qin,  Can He,  Daqiong Jiang,  Yang Gao,  Yu Chen,  Min Su,  Yuanjun Yang,  Zhao Yang,  Hongbing Cai,  Hua Wang, 
  • First Published: 28 July 2022
Research Article
Open Access

Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker

Hang Yi,  Yiwen Lin,  Yutong Li,  Yeqi Guo,  Ligong Yuan,  Yousheng Mao, 
  • First Published: 28 July 2022
Research Article
Open Access

Intratumoral IL-28B Gene Delivery Elicits Antitumor Effects by Remodeling of the Tumor Microenvironment in H22-Bearing Mice

Zhi Li,  Jianghua Wang,  Chong Chen,  Qi He,  Xiaoying Xu,  Zejiao Da,  Bo Wang,  Meng Wang,  Xiaotong Gao,  Guochao Zhang,  Qi Gao,  Xiaoli Si,  Yanping Luo,  Xingming Ma, 
  • First Published: 28 July 2022
Research Article
Open Access

Anticancer Effect of Puerarin on Ovarian Cancer Progression Contributes to the Tumor Suppressor Gene Expression and Gut Microbiota Modulation

Yongju Ye,  Yang Gao,  Yuan Fang,  Lixia Xu,  Fule He, 
  • First Published: 28 July 2022
Research Article
Open Access

Prognosis Analysis and Validation of Fatty Acid Metabolism-Related lncRNAs and Tumor Immune Microenvironment in Cervical Cancer

Xiaolin Lang,  Changchang Huang,  Hongyin Cui, 
  • First Published: 28 July 2022
Research Article
Open Access

miR-199a-5p Relieves Obstructive Sleep Apnea Syndrome-Related Hypertension by Targeting HIF-1α

Chunyan Guo,  Minghui Zhang,  Wei Su,  Min Xu,  Shumei Zhao, 
  • First Published: 27 July 2022
Research Article
Open Access

Identification of Genes Predicting Poor Response of Trastuzumab in Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer

Xinrui Dong,  Huijuan Dai,  Aijun Sun,  Zhenfeng Yu,  Yueyao Du, 
  • First Published: 27 July 2022
Research Article
Open Access

A Novel Identified Long Intergenic Noncoding RNA, LINC01574, Contributes to Breast Cancer Deterioration via the Regulation of miR-6745/TTYH3 Axis

Liang Zhang,  Lingyuan Wu,  Mengjiao Wei,  Peikai Ding,  Xingsong Tian,  Kunbing Zhu, 
  • First Published: 27 July 2022
Research Article
Open Access

Age-Stratified Analysis of Vaginal Microbiota Dysbiosis and the Relationship with HPV Viral Load in HPV-Positive Women

Mingzhu Li,  Chao Zhao,  Yun Zhao,  Jingran Li,  Lihui Wei, 
  • First Published: 27 July 2022
Research Article
Open Access

A New Prognostic Indicator of Immune Microenvironment and Therapeutic Response in Lung Adenocarcinoma Based on Peroxisome-Related Genes

Zhen Xiong,  Liwen Zhang,  Wei Fan, 
  • First Published: 26 July 2022
Research Article
Open Access

Identification of Metabolite Markers Associated with Kidney Function

Hongquan Peng,  Xun Liu,  Chiwa Aoieong,  Tou Tou,  Tsungyang Tsai,  Kamleong Ngai,  Hao I Cheang,  Zhi Liu,  Peijia Liu,  Haibin Zhu, 
  • First Published: 26 July 2022
Research Article
Open Access

Intravenous Thrombolysis Combined with Arterial Thrombolysis (Bridging Therapy) Effectively Improves Vascular Recanalization Rate in Patients with Cerebral Infarction

Junting Huo,  Wei Li,  Yu Liu, 
  • First Published: 26 July 2022
Research Article
Open Access

The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways

Seth A. Domfeh,  Patrick W. Narkwa,  Osbourne Quaye,  Kwadwo A. Kusi,  Bright S. Addy,  Sian Lant,  Rebecca P. Sumner,  Carlos Maluquer de Motes,  Gordon A. Awandare,  Charles Ansah,  Mohamed Mutocheluh, 
  • First Published: 26 July 2022
Research Article
Open Access

Development and Verification of Prognostic Prediction Models for Patients with Brain Trauma Based on Coagulation Function Indexes

Lanjuan Xu,  Tingting An,  Chengjian Li,  Xin Shi,  Bo Yang, 
  • First Published: 26 July 2022
Research Article
Open Access

Myeloid-Derived Suppressor Cells and CD68+CD163+M2-Like Macrophages as Therapeutic Response Biomarkers Are Associated with Plasma Inflammatory Cytokines: A Preliminary Study for Non-Small Cell Lung Cancer Patients in Radiotherapy

Minghe Lv,  Xibing Zhuang,  Shali Shao,  Xuan Li,  Yunfeng Cheng,  Duojiao Wu,  Xiangdong Wang,  Tiankui Qiao, 
  • First Published: 26 July 2022
Research Article
Open Access

Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human Polyomavirus

Ilaria Bononi,  Elisa Mazzoni,  Silvia Pietrobon,  Maria Rosa Iaquinta,  Andrea Caselli,  Elena Torreggiani,  Maura Pugliatti,  Ilaria Casetta,  Massimiliano Castellazzi,  Enrico Granieri,  Fernanda Martini,  Mauro Tognon, 
  • First Published: 26 July 2022
Research Article
Open Access

Atypical Mucin Expression Predicts Worse Overall Survival in Resectable Pancreatic Ductal Adenocarcinoma

Yunzhen Qian,  Yitao Gong,  Yu Liu,  Yusheng Chen,  Ruijie Wang,  Zhengjie Dai,  Xuan Zou,  Yesiboli Tasiheng,  Guopei Luo,  Xuan Lin,  Xu Wang,  He Cheng,  Xianjun Yu,  Chen Liu, 
  • First Published: 21 July 2022
Research Article
Open Access

BCHE as a Prognostic Biomarker in Endometrial Cancer and Its Correlation with Immunity

Junxiu Liu,  Tian Tian,  Xiangyu Liu,  Zhumei Cui, 
  • First Published: 21 July 2022
Research Article
Open Access

lncRNA MALAT1 Promotes Diabetic Nephropathy Progression via miR-15b-5p/TLR4 Signaling Axis

Zijun Yang,  Dongxu Song,  Yulin Wang,  Lin Tang, 
  • First Published: 21 July 2022
Research Article
Open Access

[Retracted] Comparison of Outcomes between Two Surgical Techniques for Patients with Intestinal Neuronal Dysplasia

Yu Lin,  Dianming Wu,  Yong Shen,  Yuanbin He,  Jianxin Ye, 
  • First Published: 21 July 2022

Research Article
Open Access

Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint Blockade

Hao Luo,  Gao-Lei Liu,  Dan Jian,  Dan-Dan Liang,  Xue-Mei Li,  Li Zhong,  Bo Yang,  Jun Jiang,  Dong Wang,  Meng-Xia Li,  Wei-Hua Lan,  Nan Dai, 
  • First Published: 21 July 2022
Research Article
Open Access

Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib

Lifeng Gong,  Yu Tang,  Li Jiang,  Wei Tang,  Shengjun Luo, 
  • First Published: 21 July 2022
Research Article
Open Access

Identification of Ferroptosis-Associated Long Noncoding RNA Prognostic Model and Tumor Immune Microenvironment in Thyroid Cancer

Yongjian Lin,  Fu Gan,  Xiaoyu He,  Huachu Deng,  Yong Li, 
  • First Published: 20 July 2022
Review Article
Open Access

Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus

Yue Fei,  Qi Liu,  Na Peng,  Guocan Yang,  Ziwei Shen,  Pan Hong,  Shengjun Wang,  Ke Rui,  Dawei Cui, 
  • First Published: 20 July 2022
Research Article
Open Access

Sex-Biased Immune Responses to Antibiotics during Anti-PD-L1 Treatment in Mice with Colon Cancer

Nan Jing,  Luoyang Wang,  Huiren Zhuang,  Chao Ai,  Guoqiang Jiang,  Zheng Liu, 
  • First Published: 19 July 2022
Research Article
Open Access

Progression of Type 1 Diabetes: Circulating MicroRNA Expression Profiles Changes from Preclinical to Overt Disease

Aritania Sousa Santos,  Ludmila Rodrigues Pinto Ferreira,  Amanda Cabral da Silva,  Laís Isidoro Alves,  Jullian Gabriel Damasceno,  Leslie Kulikowski,  Edecio Cunha-Neto,  Maria Elizabeth Rossi da Silva, 
  • First Published: 19 July 2022
Research Article
Open Access

CXCR2 Is Essential for Radiation-Induced Intestinal Injury by Initiating Neutrophil Infiltration

Jing Hu,  Qian Ji,  Fei Chen,  Xiaoqin Gong,  Chuansheng Chen,  Kaijun Zhang,  Ye Hua,  Jinlei Wang,  Rongkun Li,  Xu Wang,  Chunhua Dai,  Ye Tian, 
  • First Published: 16 July 2022
Corrigendum
Open Access

Corrigendum to “Dual Effects of Cellular Immunotherapy in Inhibition of Virus Replication and Prolongation of Survival in HCV-Positive Hepatocellular Carcinoma Patients”

Lei Qian,  Nanya Wang,  Huimin Tian,  Haofan Jin,  Hengjun Zhao,  Chao Niu,  Hua He,  Tingwen Ge,  Wei Han,  Jifan Hu,  Dan Li,  Fujun Han,  Jianting Xu,  Xiao Ding,  Jingtao Chen,  Wei Li,  Jiuwei Cui, 
  • First Published: 16 July 2022

Research Article
Open Access

Flavokawain B Weakens Gastric Cancer Progression via the TGF-β1/SMAD4 Pathway and Attenuates M2 Macrophage Polarization

Yongzhao Zhu,  Weining Fan,  Yuanzhen Wang,  Huan Ding,  Shaoqi Yang,  Fang He, 
  • First Published: 16 July 2022
Research Article
Open Access

Methylated RNA Immunoprecipitation Sequencing Reveals the m6A Landscape in Oral Squamous Cell Carcinoma

Xi Wang,  Jie Wu,  Leyu Zhang,  Wei Zhao,  Jiayin Deng, 
  • First Published: 15 July 2022
Research Article
Open Access

Influencing Mechanism of Nod-Like Receptor Protein 3 Inflammasome Activation in A375 Cell Activity in Human Cutaneous Malignant Melanoma

Akebaier Sulaiman,  Jin Lv,  Junwei Fan,  Reyila Abuliezi,  Qian Zhang,  Xuefeng Wan, 
  • First Published: 15 July 2022
Review Article
Open Access

Asthma and Vitamin D Deficiency: Occurrence, Immune Mechanisms, and New Perspectives

Fardis Salmanpour,  Naghmeh Kian,  Noosha Samieefar,  Mohammad Amin Khazeei Tabari,  Nima Rezaei, 
  • First Published: 15 July 2022
Research Article
Open Access

hsa_circ_0000518 Facilitates Non-Small-Cell Lung Cancer Progression via Moderating miR-330-3p and Positively Regulating SLC1A5

Huilai Lv,  Zhihua Shi,  Aixia Sui,  Yan Zhang,  Liangbiao Peng,  Mingbo Wang,  Fan Zhang, 
  • First Published: 15 July 2022
Research Article
Open Access

Relationship between Serum miR-106 and MYL4 Levels and the Prevalence, Risk Stratification, and Prognosis of Atrial Fibrillation

Yanfeng Liu,  Haiwen Zhou,  Yu Tao,  Zhicheng Xu,  Hengli Lai, 
  • First Published: 14 July 2022
Research Article
Open Access

Construction of a Novel Clinical Stage-Related Gene Signature for Predicting Outcome and Immune Response in Hepatocellular Carcinoma

Liu Yang,  Long-fei Zeng,  Guo-qing Hong,  Qing Luo,  Xing Lai, 
  • First Published: 12 July 2022
Review Article
Open Access

Mechanism of Lower Airway Hyperresponsiveness Induced by Allergic Rhinitis

Yiting Liu,  Jichao Sha,  Cuida Meng,  Dongdong Zhu, 
  • First Published: 12 July 2022
Research Article
Open Access

Study on the Prognostic Values of TTC36 Correlated with Immune Infiltrates and Its Methylation in Hepatocellular Carcinoma

Wei Jing,  Ruoyu Peng,  Xiaogai Li,  Shaogang Lv,  Yu Duan,  Shitao Jiang, 
  • First Published: 08 July 2022
Research Article
Open Access

Effect of Perioperative Interleukin-6 and Tumor Necrosis Factor-α on Long-Term Outcomes in Locally Advanced Gastric Cancer: Results from the CLASS-01 Trial

Zhenzhan Zhang,  Binshu Weng,  Yaopeng Qiu,  Hao Feng,  Renyi Zhang,  Jiachen Zhang,  Yanfeng Hu,  Jiang Yu,  Guoxin Li,  Hao Liu, 
  • First Published: 08 July 2022
Research Article
Open Access

A Hypoxia-Related lncRNA Signature Correlates with Survival and Tumor Microenvironment in Colorectal Cancer

Xinyang Zhong,  Xuefeng He,  Yaxian Wang,  Zijuan Hu,  Deshui Yu,  Huixia Huang,  Senlin Zhao,  Ping Wei,  Dawei Li, 
  • First Published: 08 July 2022
Research Article
Open Access

Effect and Mechanism of Yisui Fuyongtang (YSFYT) Decoction on Cognitive Function and Synaptic Plasticity in Rats with Vascular Cognitive Impairment

Tingliang Gong,  Zhaoliang Luo,  Li Huang,  Caixian Xiao,  Junlu Yi,  Junfeng Yan,  Qian Chen,  Weihong Li,  Wenqiang Tao, 
  • First Published: 08 July 2022
Research Article
Open Access

lncRNA ZFAS1 Promotes HMGCR mRNA Stabilization via Binding U2AF2 to Modulate Pancreatic Carcinoma Lipometabolism

Luoluo Wang,  Yi Ruan,  Xiang Wu,  Xinhua Zhou, 
  • First Published: 08 July 2022
Research Article
Open Access

Trimethylamine N-Oxide Promotes Cell Proliferation and Angiogenesis in Colorectal Cancer

Shuyan Yang,  Hui Dai,  Yimei Lu,  Rui Li,  Chengjin Gao,  Shuming Pan, 
  • First Published: 04 July 2022
Research Article
Open Access

LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer

Min Meng,  Yi-chen Wu, 
  • First Published: 04 July 2022
Research Article
Open Access

Identification of Survival Risk and Immune-Related Characteristics of Kidney Renal Clear Cell Carcinoma

Xiaobin Wu,  Yonghui Liang,  Xian Chen,  Xiangyang Long,  Wujun Xu,  Li Liu,  Binhui Wang,  Xiong Zou, 
  • First Published: 04 July 2022
Research Article
Open Access

PCSK9 Modulates Macrophage Polarization-Mediated Ventricular Remodeling after Myocardial Infarction

Feifei Wang,  Min Li,  Aidong Zhang,  Hairui Li,  Can Jiang,  Jun Guo, 
  • First Published: 04 July 2022
Research Article
Open Access

Landscape of Alternative Splicing Events Related to Prognosis and Immune Infiltration in Glioma: A Data Analysis and Basic Verification

Hong-xin Su,  Gang Yang,  Fei Su,  Chen-xiao Hu,  Tao Zhang,  Jun-tao Ran,  Quan-lin Guan, 
  • First Published: 04 July 2022
Research Article
Open Access

Prediction of Postoperative Survival in Young Colorectal Cancer Patients: A Cohort Study Based on the SEER Database

Sheng Pan,  Wenchao Mei,  Linfei Huang,  Yan’e Tao,  Jing Xu,  Yuelu Ruan, 
  • First Published: 04 July 2022
Research Article
Open Access

Chinese Herbal Formula Huayu-Qiangshen-Tongbi Decoction Attenuates Rheumatoid Arthritis through Upregulating miR-125b to Suppress NF-κB-Induced Inflammation by Targeting CK2

Xiu-min Chen,  Kai-xin Gao,  Xiao-Dong Wu,  Huang-sheng Liang,  Ze-hao Liu,  Mao-jie Wang,  Li-yan Mei,  Qing-chun Huang,  Run-yue Huang, 
  • First Published: 04 July 2022
Research Article
Open Access

Thyroid Dysfunction as a Predictive Indicator in Camrelizumab of Advanced Esophageal Squamous Cell Carcinoma

Ying Chen,  Lei Zhuang,  Danhong Zhang,  Xianghui Du,  Liming Sheng, 
  • First Published: 04 July 2022
Research Article
Open Access

Immunomodulatory Effects of Lepidium meyenii Walp. Polysaccharides on an Immunosuppression Model Induced by Cyclophosphamide

Wen-ting Fei,  Na Yue,  Ai-min Li,  Shu-hui Yu,  Dan-ping Zhao,  Ying-li Zhu,  Chun Wang,  Jian-jun Zhang,  Lin-yuan Wang, 
  • First Published: 04 July 2022
Research Article
Open Access

Epithelial to Mesenchymal Transition Relevant Subtypes with Distinct Prognosis and Responses to Chemo- or Immunotherapies in Osteosarcoma

Yang Zhou,  Gai Li,  Hu Li,  Fuchong Lai,  Pingguo Duan,  Ming Cheng, 
  • First Published: 04 July 2022
Research Article
Open Access

A Novel Prognostic Signature Revealed the Interaction of Immune Cells in Tumor Microenvironment Based on Single-Cell RNA Sequencing for Lung Adenocarcinoma

Xing Jin,  Zhengyang Hu,  Qihai Sui,  Mengnan Zhao,  Jiaqi Liang,  Zhenyu Liao,  Yuansheng Zheng,  Hao Wang,  Yu Shi, 
  • First Published: 01 July 2022
Research Article
Open Access

Genome-Wide Association and Transcriptome-Wide Association Studies Identify Novel Susceptibility Genes Contributing to Colorectal Cancer

Ruimin Yin,  Binbin Song,  Jingjing Wang,  Chaodan Shao,  Yufen Xu,  HongGang Jiang, 
  • First Published: 01 July 2022
Research Article
Open Access

Methane Alleviates Lung Injury through the IL-10 Pathway by Increasing T Regulatory Cells in a Mouse Asthma Model

Ying Yao,  Xiaoyong Miao,  Liping Wang,  Zhengyu Jiang,  Lingxia Li,  Ping Jiang,  Yifei Wang,  Aixia Jin,  Na Li,  Changli Wang,  Kezhe Tan,  Yan Meng,  Jinjun Bian,  Yan Zhang,  Xiaoming Deng,  Jianping Cao, 
  • First Published: 30 June 2022
Research Article
Open Access

NAV3 Is a Novel Prognostic Biomarker Affecting the Immune Status of the Tumor Microenvironment in Colorectal Cancer

Menglong Li,  Zhiqiang Wang,  Shuai Dong,  Yang Xu, 
  • First Published: 30 June 2022
Research Article
Open Access

Downregulated Copper Homeostasis-Related Gene FOXO1 as a Novel Indicator for the Prognosis and Immune Response of Breast Cancer

Rong Zeng,  Bi Peng,  Emin Peng, 
  • First Published: 28 June 2022
Research Article
Open Access

Refractory Mycoplasma Pneumonia in Children: A Systematic Review and Meta-analysis of Laboratory Features and Predictors

Wanjie Huang,  Xianhong Xu,  Wenqi Zhao,  Qi Cheng, 
  • First Published: 26 June 2022
Research Article
Open Access

An Integrative Analysis Revealing ZFHX4-AS1 as a Novel Prognostic Biomarker Correlated with Immune Infiltrates in Ovarian Cancer

Changchang Huang,  Hongyin Cui,  Xiaolin Lang,  Fen Zhao, 
  • First Published: 26 June 2022
Research Article
Open Access

Knocking Out of CEACAM1 Can Reduce Oxidative Stress and Promote Cell Proliferation in the HPMVECs under Hypoxia

Zhixuan Li,  Xiaokang He,  Xueting Zhang,  Junhua Zou,  Hao Li,  Jing Wang, 
  • First Published: 26 June 2022
Research Article
Open Access

Immune Infiltration of Ulcerative Colitis and Detection of the m6A Subtype

Chenzheng Gu,  Junlu Wu,  Wei Zhang,  Yiwen Yao,  Wenhui Yan,  Yi Yuan,  Weiwei Wang,  Anquan Shang, 
  • First Published: 25 June 2022
Research Article
Open Access

Construction of Metabolic Molecular Classification and Immune Characteristics for the Prognosis Prediction of Ovarian Cancer

Kexin Wang,  Hui He,  Xue Feng, 
  • First Published: 25 June 2022
Research Article
Open Access

A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets

Xinghao Fu,  Feihong Ji,  Qi He,  Xinguang Qiu, 
  • First Published: 24 June 2022
Review Article
Open Access

Understanding the Immune System in Fetal Protection and Maternal Infections during Pregnancy

Tarique Hussain,  Ghulam Murtaza,  Dildar Hussain Kalhoro,  Muhammad Saleem Kalhoro,  Yulong Yin,  Muhammad Ismail Chughtai,  Bie Tan,  Anjaleena Yaseen,  Zia Ur Rehman, 
  • First Published: 24 June 2022
Review Article
Open Access

Mast Cell Activation Syndrome in COVID-19 and Female Reproductive Function: Theoretical Background vs. Accumulating Clinical Evidence

Dariusz Szukiewicz,  Piotr Wojdasiewicz,  Mateusz Watroba,  Grzegorz Szewczyk, 
  • First Published: 22 June 2022
Research Article
Open Access

Study on the Correlation between Interleukin-27 and CXCL10 in Pulmonary Tuberculosis

Jiahui Fan,  Yefeng Yang,  Liang Wang,  Xiaoqian Shang,  Li Zhang,  Hu Sun,  Yujie Ma,  Ying Li,  Jing Wang,  Xiumin Ma, 
  • First Published: 22 June 2022
Research Article
Open Access

Prediction of Necroptosis-Related Markers in Head and Neck Carcinoma by Bioinformatics

Lin Zheng,  Minhui Li,  Ruiyuan Gu,  Haoxiang Zhang,  Xiaotong Qi,  Honglin Dong, 
  • First Published: 22 June 2022
Research Article
Open Access

Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors

Mengqi Zhang,  Lulu Wang,  Wan Liu,  Tian Wang,  Francesco De Sanctis,  Lifang Zhu,  Guizhong Zhang,  Jian Cheng,  Qin Cao,  Jingying Zhou,  Aldo Tagliabue,  Vincenzo Bronte,  Dehong Yan,  Xianchun Wan,  Guang Yu, 
  • First Published: 22 June 2022
Research Article
Open Access

Role of CD4+ T and CD8+ T Lymphocytes-Mediated Cellular Immunity in Pathogenesis of Chronic Obstructive Pulmonary Disease

Weilin Xue,  Jianying Ma,  Yue Li,  Chunxia Xie, 
  • First Published: 22 June 2022
Research Article
Open Access

Treatment with Distinct Antibiotic Classes Causes Different Pulmonary Outcomes on Allergic Airway Inflammation Associated with Modulation of Symbiotic Microbiota

Gregório Grama Cavalcante,  Anna Gabriella Guimarães,  Camila Pereira Queiroz-Glauss,  Marcela Helena Gonçalves Pereira,  Angélica Samer Lallo Dias,  Laila Sampaio Horta,  Jamil Silvano de Oliveira,  Silvia Dantas Cangussú,  Paula Prazeres Magalhães,  Remo Castro Russo,  H. C. Santiago, 
  • First Published: 22 June 2022
Research Article
Open Access

Improvement of Myocardial Cell Injury by miR-199a-3p/mTOR Axis through Regulating Cell Apoptosis and Autophagy

Weixiong Wu,  Xingfeng Chen,  Qingyang Hu,  Xuefei Wang,  Jingyu Zhu,  Qianzhen Li, 
  • First Published: 22 June 2022
Research Article
Open Access

Sonic Hedgehog Promotes Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Rho/ROCK Signaling

Zaiying Hu,  Yingdi Chen,  Shangling Zhu,  Xiaoxue Feng,  Baiyu Zhang,  Jianlin Huang, 
  • First Published: 22 June 2022
Research Article
Open Access

Peptidoglycan-Like Components in Z-100, Extracted from Mycobacterium tuberculosis Strain Aoyama B, Increase IL-12p40 via NOD2

Takayuki Horii,  Yuki Orikawa,  Yuta Ohira,  Runa Eta,  Uiko Tominaga,  Takanori Sato,  Takao Tanaka, 
  • First Published: 22 June 2022
Research Article
Open Access

Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis

Zhenzhen Su,  Jie Chen,  Junlong Zhang,  Yunfei An,  Yun Liao,  Xiaojuan Wu,  Chuanmin Tao,  Lanlan Wang,  Bei Cai, 
  • First Published: 22 June 2022
Research Article
Open Access

HMGA1 Promotes Macrophage Recruitment via Activation of NF-κB-CCL2 Signaling in Hepatocellular Carcinoma

Junming Chen,  Kang Ji,  Lingyan Gu,  Yu Fang,  Ming Pan,  Shuxia Tian, 
  • First Published: 22 June 2022
Research Article
Open Access

circACTG1 Promotes Hepatocellular Carcinoma Progression by Regulating miR-940/RIF1 Axis and Activating AKT/mTOR Pathway

Chunchen Wu,  She Tian,  Yuting Guo,  Chao Yu,  Linhan Lei,  Dijie Zheng,  Huahua Xie,  Jian Zheng,  Chengyi Sun, 
  • First Published: 19 June 2022
Research Article
Open Access

Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation

Lei Zhu,  Kai X. Zhou,  Ming Z. Ma,  Lin L. Yao,  Yan L. Zhang,  Hui Li,  Chang Du,  Xiao M. Yang, 
  • First Published: 19 June 2022
Research Article
Open Access

Semaphorin-3 Promotes Specific Immunotherapy Effects on Experimental Food Allergy

Huang Huang,  Yu Liu,  Yanan Wang,  Huazhen Liu,  Bailing Xie,  Michael B. W. Zheng,  Liteng Yang,  Qinmiao Huang,  Yongjin Wu,  Gaohui Wu,  Pengyuan Zheng,  Pingchang Yang, 
  • First Published: 19 June 2022
Research Article
Open Access

The Potential Diagnostic Value of Immune-Related Genes in Interstitial Fibrosis and Tubular Atrophy after Kidney Transplantation

Bin Yang,  Dike Shi,  Yahong Chen,  Yi Zhu, 
  • First Published: 17 June 2022
Research Article
Open Access

Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis

Dongxu Lin,  Mengyang Zhang,  Changcheng Luo,  Pengyu Wei,  Kai Cui,  Zhong Chen, 
  • First Published: 17 June 2022
Research Article
Open Access

Prediction of Immune Infiltration Diagnostic Gene Biomarkers in Kawasaki Disease

Hongjun Ba,  Yao Wang,  Lili Zhang,  Huishen Wang,  Zhan-Peng Huang,  Youzhen Qin, 
  • First Published: 17 June 2022
Research Article
Open Access

Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma

Kawuli Jumai,  Tangjuan Zhang,  Bingzhang Qiao,  Julaiti Ainiwaer,  Haiping Zhang,  Zhichao Hou,  Idris Awut,  Madinyat Niyaz,  Liwei Zhang,  Ilyar Sheyhidin, 
  • First Published: 17 June 2022
Research Article
Open Access

MAIP1-Related Tumor Immune Infiltration: As a Potential Prognostic Biomarker for Esophageal Cancer

Xiaoyu He,  Fu Gan,  Yongjian Lin,  Guoqing Liu,  Yunhua Lin,  Dongxu Chen, 
  • First Published: 14 June 2022
Research Article
Open Access

Deletion of Mettl3 at the Pro-B Stage Marginally Affects B Cell Development and Profibrogenic Activity of B Cells in Liver Fibrosis

Xinmei Kang,  Shuhan Chen,  Lijie Pan,  Xiaoqi Liang,  Di Lu,  Huaxin Chen,  Yanli Li,  Chang Liu,  Mian Ge,  Qi Zhang,  Qiuli Liu,  Yan Xu, 
  • First Published: 14 June 2022
Research Article
Open Access

lncRNA FR215775 Regulates Th2 Differentiation in Murine Allergic Rhinitis

Yue Ma,  Le Shi,  Keqing Zhao,  Chunquan Zheng, 
  • First Published: 14 June 2022
Research Article
Open Access

Impact of Amarogentin on Gastric Carcinoma Cell Multiplication, Apoptosis and Migration via circKIF4A/miR-152-3p

Zhi Tan,  Weining Wang,  Jin Peng,  Zhen Zhou,  Jia Pan,  Aiming Peng,  Hui Cao,  Wenling Fan, 
  • First Published: 14 June 2022
Research Article
Open Access

The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps

Chen Wang,  Min-Li Zhou,  Yong-Cai Liu,  Ke-Jia Cheng, 
  • First Published: 14 June 2022
Research Article
Open Access

Identification of Biomarkers Associated with Diagnosis of Osteoarthritis Patients Based on Bioinformatics and Machine Learning

Yihao Liang,  Fangzheng Lin,  Yunfei Huang, 
  • First Published: 13 June 2022
Review Article
Open Access

Tumor-Associated Inflammation: The Tumor-Promoting Immunity in the Early Stages of Tumorigenesis

Qing Bi,  Ji-Yue Wu,  Xue-Meng Qiu,  Jian-Dong Zhang,  Ze-Jia Sun,  Wei Wang, 
  • First Published: 13 June 2022
Research Article
Open Access

Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network Pharmacology and Experiments

Beihui He,  Zheng Chen,  Yunmeng Nie,  Minmin Luo,  Sumei Xu,  Junbin Yan,  Zhiyun Chen, 
  • First Published: 12 June 2022
Research Article
Open Access

HIF-1α Regulated WTAP Overexpression Promoting the Warburg Effect of Ovarian Cancer by m6A-Dependent Manner

Yuanyuan Lyu,  Yilin Zhang,  Yuhan Wang,  Yonghong Luo,  Huafeng Ding,  Peiling Li,  Guantai Ni, 
  • First Published: 12 June 2022
Research Article
Open Access

FCGBP Is a Promising Prognostic Biomarker and Correlates with Immunotherapy Efficacy in Oral Squamous Cell Carcinoma

Ting Shen,  Jianying Zhang,  Yali Wang,  Binjie Liu, 
  • First Published: 12 June 2022
Research Article
Open Access

lncRNA SNHG15 as a ceRNA modulates Osteoclast Differentiation, Proliferation, and Metastasis by Sponging miR-381-3p/NEK2 Axis

YiFan Wang,  GuanYin Zhu,  Fang Pei,  ZhiHe Zhao, 
  • First Published: 12 June 2022
Review Article
Open Access

Tumor Microenvironment: Lactic Acid Promotes Tumor Development

Yuting Gao,  Hao Zhou,  Gege Liu,  Junlu Wu,  Yi Yuan,  Anquan Shang, 
  • First Published: 12 June 2022
Research Article
Open Access

The Ratio of CD226 and TIGIT Expression in Tfh and PD-1+ICOS+Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation

Ji-wen Fan,  Yu Fan,  Zheng-li Wan,  Lin Yan,  Ya-mei Li,  Yang-juan Bai,  Lan-lan Wang,  Jie Chen,  Yi Li, 
  • First Published: 12 June 2022
Review Article
Open Access

The Bioactivities of Phycocyanobilin from Spirulina

Yi Li, 
  • First Published: 11 June 2022
Research Article
Open Access

Blood Stasis Syndrome Accelerates the Growth and Metastasis of Breast Cancer by Promoting Hypoxia and Immunosuppressive Microenvironment in Mice

Lu Jin,  Biqiang Tang,  Xia Liu,  Weiye Mao,  Linying Xia,  Yueguang Du,  Bing Ji,  Qiyang Shou,  Huiying Fu, 
  • First Published: 07 June 2022
Research Article
Open Access

Comprehensive Analysis Identifies PI3K/Akt Pathway Alternations as an Immune-Related Prognostic Biomarker in Colon Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitor Treatment

Anqi Lin,  Tianqi Gu,  Xigang Hu,  Jian Zhang,  Peng Luo, 
  • First Published: 06 June 2022
Research Article
Open Access

Comprehensive Analysis of the Expression and Prognostic Value of LMAN2 in HER2+ Breast Cancer

Di Zhang,  Liping Ye,  Shuang Hu,  Qingqing Zhu,  Chenxi Li,  Chengming Zhu, 
  • First Published: 06 June 2022
Research Article
Open Access

High Expression of PDLIM2 Predicts a Poor Prognosis in Prostate Cancer and Is Correlated with Epithelial-Mesenchymal Transition and Immune Cell Infiltration

Songzhe Piao,  Lan Zheng,  Haihong Zheng,  Mengya Zhou,  Qin Feng,  Suna Zhou,  Mang Ke,  Haihua Yang,  Xuequan Wang, 
  • First Published: 06 June 2022
Research Article
Open Access

Efficacy of Acupuncture Treatment for Postprandial Distress Syndrome: A Systematic Review and Meta-Analysis

Jihang Du,  Yinhao Feng,  Qiang Yuan,  Haiping Gong,  Jie An,  Liu Wu,  Qian Dai,  Bojun Xu,  Haozhong Wang,  Jian Luo, 
  • First Published: 02 June 2022
Research Article
Open Access

Immunotherapy and Antivascular Targeted Therapy in Patients’ Treatment with Concurrent Malignant Tumors after Organ Transplantation: Opportunity or Challenge

Bairu Shen,  Zi Guo,  Peng Huang,  Minghua Tan,  Xiaoshen Zhang,  Siyao Lin,  Changshan Song,  Jiaqing Wang,  Minqian Huang, 
  • First Published: 02 June 2022
Research Article
Open Access

Development and Validation of a Novel PPAR Signaling Pathway-Related Predictive Model to Predict Prognosis in Breast Cancer

Yingkun Xu,  Dan Shu,  Meiying Shen,  Qiulin Wu,  Yang Peng,  Li Liu,  Zhenrong Tang,  Shun Gao,  Yuan Wang,  Shengchun Liu, 
  • First Published: 02 June 2022
Research Article
Open Access

Asiaticoside Suppresses Gastric Cancer Progression and Induces Endoplasmic Reticulum Stress through the miR-635/HMGA1 Axis

Chao Zhang,  Xiaolin Ji,  Zhenguang Chen,  Zhichao Yao, 
  • First Published: 02 June 2022
Research Article
Open Access

IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING

Xue Zeng,  Xiaosong Li,  Yundong Zhang,  Chaoxia Cao,  Qin Zhou, 
  • First Published: 02 June 2022
Research Article
Open Access

Detection of Cannabinoid Receptor Expression by Endometriotic Lesions in Women with Endometriosis as an Alternative to Opioid-Based Pain Medication

Sarah Allam,  Elizabeth Paris,  Itzel Lazcano,  Pincas Bitterman,  Sanjib Basu,  James O’Donnell,  Animesh Barua, 
  • First Published: 02 June 2022
Research Article
Open Access

miR-214 Modulates the Growth and Migration of Oral Cancer before and after Chemotherapy through Mediating ULK1

Yongtao Yang,  Xiaolan Sun,  Minghua Li,  Limei Li,  Shanshan Wang,  Yaomin Zhu, 
  • First Published: 02 June 2022
Review Article
Open Access

Cellular Immunity of Patients with Tuberculosis Combined with Diabetes

Peng Cheng,  Liang Wang,  Wenping Gong, 
  • First Published: 01 June 2022
Research Article
Open Access

The Invasion and Metastasis of Colon Adenocarcinoma (COAD) Induced by SALL4

Wenjuan Zhang,  Yan Hu,  Wenbing Zhang,  Ke Yi,  Xiaohui Xu,  Zhihua Chen, 
  • First Published: 01 June 2022
Research Article
Open Access

Characterization of m6A Methylation Modification Patterns in Colorectal Cancer Determines Prognosis and Tumor Microenvironment Infiltration

Qingfang Yue,  Yuan Zhang,  Fei Wang,  Fei Cao,  Jun Bai,  Xianglong Duan, 
  • First Published: 01 June 2022
Research Article
Open Access

ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1

Peng Liu,  Yan Zhou,  Xin Dong,  Biao Zheng,  Bo Liang,  Rui Liang,  Zhong Liu,  Li Li,  Peng Gong, 
  • First Published: 01 June 2022
Research Article
Open Access

Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients

Amal Abouda,  Z. Hajjej,  A. Mansart,  W. Kaabechi,  D. Elhaj Mahmoud,  O. Lamine,  E. Ghazouani,  M. Ferjani,  I. Labbene, 
  • First Published: 31 May 2022
Research Article
Open Access

Classification of Muscle Invasive Bladder Cancer to Predict Prognosis of Patients Treated with Immunotherapy

Zhifeng Wang,  Xiqing Li,  Xiaoqing Wang,  Jie Liu,  Lingdian Wang,  Wei Wei,  Xiaoyu Duan,  Degang Ding, 
  • First Published: 30 May 2022
Research Article
Open Access

Novel Circulating Tumour Cell-Related Risk Model Indicates Prognosis and Immune Infiltration in Lung Adenocarcinoma

Lu Liang,  Yueying Liu,  Shiyao Jiang,  Jingjing Huang,  Hua He,  Li Shen,  Li Cong,  Yiqun Jiang, 
  • First Published: 29 May 2022
Research Article
Open Access

Identification of an Autophagy-Related Signature Based on Whole Bone Marrow Sequencing for the Prognosis and Immune Microenvironment Characterization of Multiple Myeloma

Licheng Li,  Ting Chen,  Jishi Wang,  Mengxing Li,  Qinshan Li, 
  • First Published: 29 May 2022
Research Article
Open Access

miR-138-5p Inhibits Vascular Mimicry by Targeting the HIF-1α/VEGFA Pathway in Hepatocellular Carcinoma

Hongwei Liu,  Tao Tang,  Xiujin Hu,  Weihe Tan,  Peng Zhou,  Huixian Zhang,  Yanmei Liu,  Chen Chen,  Meng Yang,  Meifang Zhou,  Shuxia Xuan,  Bin Cheng,  Weiguo Yin,  Jinduan Lin, 
  • First Published: 28 May 2022
Review Article
Open Access

The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection

Karolina Rogulska,  Iwona Wojciechowska-Koszko,  Barbara Dołęgowska,  Ewa Kwiatkowska,  Paulina Roszkowska,  Patrycja Kapczuk,  Danuta Kosik-Bogacka, 
  • First Published: 28 May 2022
Research Article
Open Access

MZF1 Transcriptionally Activated MicroRNA-328-3p Suppresses the Malignancy of Stomach Adenocarcinoma via Inhibiting CD44

Zining Qi,  Jing Wang,  Yaoping Li,  Yanzhao Xu, 
  • First Published: 28 May 2022
Research Article
Open Access

Th22 Cells/IL-22 Serves as a Protumor Regulator to Drive Poor Prognosis through the JAK-STAT3/MAPK/AKT Signaling Pathway in Non-Small-Cell Lung Cancer

Yinan Yao,  Guangdie Yang,  Guohua Lu,  Jiani Ye,  Luyun Cui,  Zhu Zeng,  Junjun Chen,  Jianying Zhou, 
  • First Published: 28 May 2022
Review Article
Open Access

Human Leukocyte Antigen (HLA) System: Genetics and Association with Bacterial and Viral Infections

Sadeep Medhasi,  Narisara Chantratita, 
  • First Published: 26 May 2022
Research Article
Open Access

Plasma CXCL3 Levels Are Associated with Tumor Progression and an Unfavorable Colorectal Cancer Prognosis

Can Cui,  Rui Zhang,  Feng Gu,  Yunfeng Pei,  Li Sun,  Yueyang Huang,  Guoping Niu,  Jian Li, 
  • First Published: 26 May 2022
Research Article
Open Access

Blockade of NLRP3/Caspase-1/IL-1β Regulated Th17/Treg Immune Imbalance and Attenuated the Neutrophilic Airway Inflammation in an Ovalbumin-Induced Murine Model of Asthma

Ling Chen,  Weiwei Hou,  Fen Liu,  Ruochen Zhu,  Anping Lv,  Wenqiang Quan,  Song Mao, 
  • First Published: 25 May 2022
Research Article
Open Access

Deoxyschizandrin Inhibits the Proliferation, Migration, and Invasion of Bladder Cancer Cells through ALOX5 Regulating PI3K-AKT Signaling Pathway

Baojin Chi,  Yao Sun,  Jintao Zhao,  Yugang Guo, 
  • First Published: 25 May 2022
Research Article
Open Access

Long-Term GAD-alum Treatment Effect on Different T-Cell Subpopulations in Healthy Children Positive for Multiple Beta Cell Autoantibodies

Falastin Salami,  Lampros Spiliopoulos,  Marlena Maziarz,  Markus Lundgren,  Charlotte Brundin,  Rasmus Bennet,  Magnus Hillman,  Carina Törn,  Helena Elding Larsson, 
  • First Published: 25 May 2022
Research Article
Open Access

A Novel Mitochondrial-Related Gene Signature for the Tumor Immune Microenvironment Evaluation and Prognosis Prediction in Lung Adenocarcinoma

Yin-ping Li,  Gui-xia Liu,  Zhan-ling Wu,  Ping-hua Tu,  Guang Wei,  Man Yuan,  Min-hua Zhong,  Ke-lan Deng, 
  • First Published: 25 May 2022
Research Article
Open Access

Potential Value of Circular RNA circTBC1D4 in Gastrointestinal Stromal Tumors

Chunyan-Zou,  Yanpeng-He,  Changshun-Xie,  Fulai-Gao,  Xiaoli-Xie,  Xiukun-Chai,  Chenxi-He,  Dongqiang-Zhao, 
  • First Published: 24 May 2022
Research Article
Open Access

miR-196a-5p-Rich Extracellular Vesicles from Trophoblasts Induce M1 Polarization of Macrophages in Recurrent Miscarriage

Jing Zhang,  Yu Tao,  Renfei Cai,  Yao Wang, 
  • First Published: 23 May 2022
Research Article
Open Access

Low-Dose Gallic Acid Administration Does Not Improve Diet-Induced Metabolic Disorders and Atherosclerosis in Apoe Knockout Mice

Jie Bai,  Qiu-Yue Lin,  Xiangbo An,  Shuang Liu,  Yao Wang,  Yunpeng Xie,  Jiawei Liao, 
  • First Published: 23 May 2022
Research Article
Open Access

Differential Regulation of NK Cell Receptors in Acute Lymphoblastic Leukemia

Le Jie Lee,  Norfarazieda Hassan,  Siti Zuleha Idris,  Suresh Kumar Subbiah,  Heng Fong Seow,  Norhafizah Mohtaruddin,  Kian Meng Chang,  Raudhawati Osman,  Hishamshah Mohd Ibrahim,  Sheila Nathan,  Maha Abdullah, 
  • First Published: 23 May 2022
Research Article
Open Access

Identification of Significant Secreted or Membrane-Located Proteins in Laryngeal Squamous Cell Carcinoma

Li Yan,  Chunyan Hu,  Yangyang Ji,  Lifen Zou,  Yang Zhao,  Yi Zhu,  Xiaoshen Wang, 
  • First Published: 23 May 2022
Research Article
Open Access

Incidence and Patterns of Interstitial Lung Disease and Their Clinical Impact on Mortality in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Korean Single-Centre Observational Study

Jang Woo Ha,  Jung Yoon Pyo,  Sung Soo Ahn,  Jason Jungsik Song,  Yong-Beom Park,  Sang-Won Lee, 
  • First Published: 23 May 2022
Research Article
Open Access

M2-Macrophage-Derived Exosomes Promote Meningioma Progression through TGF-β Signaling Pathway

Xiao-Hong Fu,  Jian-Ping Li,  Xue-Ying Li,  Yan Tan,  Min Zhao,  Shao-Fu Zhang,  Xue-Dong Wu,  Jian-Guo Xu, 
  • First Published: 20 May 2022
Research Article
Open Access

Identification of Three Prognosis-Related Differentially Expressed lncRNAs Driven by Copy Number Variation in Thyroid Cancer

Jinyi Tian,  Bin Luo, 
  • First Published: 20 May 2022
Research Article
Open Access

Respiratory Syncytial Virus Nonstructural Protein 1 Promotes 5-Lipoxygenase via miR-19a-3p

Mei Zheng,  Panpan Fan,  Pu Yang,  Junwen Zheng,  Dongchi Zhao, 
  • First Published: 20 May 2022
Review Article
Open Access

Efficacy of PD-1/PD-L1 Inhibitors versus Chemotherapy in Lung Cancer with Brain Metastases: A Systematic Review and Meta-Analysis

Xiaojun Yang,  Yihong Zeng,  Qinquan Tan,  Zhihua Huang,  Jun Jia,  Guanming Jiang, 
  • First Published: 20 May 2022
Research Article
Open Access

The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer

Changkun Huang,  Xiaolin Ai,  Liping Hu,  Da Ren, 
  • First Published: 19 May 2022
Review Article
Open Access

Crosstalk between Body Microbiota and the Regulation of Immunity

Carolina Rojas,  Felipe Gálvez-Jirón,  Javiera De Solminihac,  Cristina Padilla,  Ignacio Cárcamo,  Natalia Villalón,  Mónica Kurte,  Karina Pino-Lagos, 
  • First Published: 19 May 2022
Research Article
Open Access

[Retracted] Mutational Screening of Skeletal Genes in 14 Chinese Children with Osteogenesis Imperfecta Using Targeted Sequencing

Wei Tan,  Yuelun Ji,  Yuepeng Qian,  Yongchang Lin,  Ruolian Ye,  Weiping Wu,  Yibin Li,  Yongjian Sun,  Jianyin Pan, 
  • First Published: 19 May 2022

Research Article
Open Access

Identification of an Inflammatory Response-Related Gene Signature to Predict Survival and Immune Status in Glioma Patients

Zhaoyue Yan,  Yushuai Gao,  Jinliang Yu,  Zhiyuan Shen,  Xingyao Bu, 
  • First Published: 18 May 2022
Research Article
Open Access

lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p

Xiangkun Wu,  Shuai Yin,  Lihua Yan,  Yongxi Liu,  Lilin Shang,  Jun Liu, 
  • First Published: 18 May 2022
Research Article
Open Access

Endothelial Cell-Derived Extracellular Vesicles Target TLR4 via miRNA-326-3p to Regulate Skin Fibroblasts Senescence

Xinni Yang,  Jiyong Tan,  Jiqing Shen,  Xin Zhang,  Gaoxiang Huang,  Xiaoxue Su,  Jing Li, 
  • First Published: 18 May 2022
Research Article
Open Access

Identification of an Immune Gene-Based Cisplatin Response Model and CD27 as a Therapeutic Target against Cisplatin Resistance for Ovarian Cancer

Ying Guo,  Na Yang,  Gang Li,  Xiurong Yin,  Lixia Dong, 
  • First Published: 18 May 2022
Research Article
Open Access

Associations between Autoimmunity and Depression: Serum IL-6 and IL-17 Have Directly Impact on the HAMD Scores in Patients with First-Episode Depressive Disorder

Lijuan Mao,  Xiajin Ren,  Xin Wang,  Feng Tian, 
  • First Published: 16 May 2022
Research Article
Open Access

ncRNA-Mediated High Expression of LPCAT1 Correlates with Poor Prognosis and Tumor Immune Infiltration of Liver Hepatocellular Carcinoma

Qiu Sun,  Xudong Liu,  Qunlong Peng,  Lei Hu,  Xiaochun Jiang, 
  • First Published: 16 May 2022
Research Article
Open Access

Hypoxia Promotes Glioma Stem Cell Proliferation by Enhancing the 14-3-3β Expression via the PI3K Pathway

Weidong Cao,  Qiang Zhou,  Hongwei Wang,  Wei Rao,  Gang Cheng,  Peng Wang,  Shengli Guo,  Bin Ren,  Jianning Zhang, 
  • First Published: 14 May 2022
Review Article
Open Access

Biological and Immune Responses to Current Anti-SARS-CoV-2 mRNA Vaccines beyond Anti-Spike Antibody Production

Maurizio Federico, 
  • First Published: 14 May 2022
Research Article
Open Access

Overexpression of TP53INP2 Promotes Apoptosis in Clear Cell Renal Cell Cancer via Caspase-8/TRAF6 Signaling Pathway

Xunjia Li,  Daixing Hu,  Ying Li,  Yan Luo,  Bing Liang,  Kexiao Yu,  Weijian Xiong,  Deyu Zuo, 
  • First Published: 14 May 2022
Research Article
Open Access

A Substance P (SP)/Neurokinin-1 Receptor Axis Promotes Perineural Invasion of Pancreatic Cancer and Is Affected by lncRNA LOC389641

Tengfei Ji,  Keqiang Ma,  Hongsheng Wu,  Tiansheng Cao, 
  • First Published: 12 May 2022
Research Article
Open Access

L-Borneol 7-O-[β-D-Apiofuranosyl-(1→6)]-β-D-Glucopyranoside Alleviates Myocardial Ischemia-Reperfusion Injury in Rats and Hypoxic/Reoxygenated Injured Myocardial Cells via Regulating the PI3K/AKT/mTOR Signaling Pathway

Ziyi Tong,  Gaowen Li,  Chengxiao Su,  Liyan Zhou,  Ling Zhang,  Qun Chen,  Qing Xia, 
  • First Published: 12 May 2022
Research Article
Open Access

hsa-miR-9-5p-Mediated TSPAN9 Downregulation Is Positively Related to Both Poor Hepatocellular Carcinoma Prognosis and the Tumor Immune Infiltration

Shengkui Tan,  Xin Song,  Chenchen Zhang,  Yishu Sun,  Jiaxi Zhang,  Zhongqi Zhang,  Rongcheng Zhang,  Tianmiao Zhang,  Xiaonian Zhu,  Hongzhuan Tan, 
  • First Published: 12 May 2022
Research Article
Open Access

Comprehensive Analysis of PDLIM3 Expression Profile, Prognostic Value, and Correlations with Immune Infiltrates in Gastric Cancer

Xinpeng Hu,  Minfeng Chen,  Qiang Ruan,  Changzheng Shi,  Jinghua Pan,  Liangping Luo, 
  • First Published: 12 May 2022
Research Article
Open Access

The PD-1 with PD-L1 Axis Is Pertinent with the Immune Modulation of Atrial Fibrillation by Regulating T Cell Excitation and Promoting the Secretion of Inflammatory Factors

Guodong Chang,  Yingwei Chen,  Zichang Liu,  Yong Wang,  Wenkun Ge,  Yongan Kang,  Shuling Guo, 
  • First Published: 12 May 2022
Research Article
Open Access

NUF2 Is a Potential Immunological and Prognostic Marker for Non-Small-Cell Lung Cancer

Xia Li,  Lianlian Zhang,  Zhongquan Yi,  Jing Zhou,  Wenchun Song,  Panwen Zhao,  Jixiang Wu,  Jianxiang Song,  Qinggan Ni, 
  • First Published: 12 May 2022
Research Article
Open Access

Survival Prediction in Patients with Hypertensive Chronic Kidney Disease in Intensive Care Unit: A Retrospective Analysis Based on the MIMIC-III Database

Zuoxun Xia,  Peng Xu,  Ye Xiong,  Yunbo Lai,  Zhaohui Huang, 
  • First Published: 12 May 2022
Research Article
Open Access

Effect of HLA-G5 Immune Checkpoint Molecule on the Expression of ILT-2, CD27, and CD38 in Splenic B cells

Hana Rohn,  Cordula Lang,  Sabine Schramm,  Falko M. Heinemann,  Mirko Trilling,  Anja Gäckler,  Oliver Witzke,  Peter A. Horn,  Vera Rebmann, 
  • First Published: 12 May 2022
Research Article
Open Access

Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis

Fabiola Gonzalez-Ponce,  Jorge Ivan Gamez-Nava,  Eli Efrain Gomez-Ramirez,  Melissa Ramirez-Villafaña,  Heriberto Jacobo-Cuevas,  Norma Alejandra Rodriguez-Jimenez,  Eva Maria Olivas-Flores,  Yussef Esparza-Guerrero,  Alejandro Martelli-García,  Aline Priscilla Santiago-Garcia,  Cesar Arturo Nava-Valdivia,  Alejandra Martinez-Hernandez,  Sergio Antonio Gonzalez-Vazquez,  Alfredo Celis,  Carlos Enrique Cabrera-Pivaral,  Sylvia Totsuka-Sutto,  Ernesto German Cardona-Muñoz,  Laura Gonzalez-Lopez, 
  • First Published: 10 May 2022
Research Article
Open Access

A Two-eRNA-Based Signature Can Impact the Immune Status and Predict the Prognosis and Drug Sensitivity of Lung Adenocarcinoma

Li Wang,  Shao-quan Zhou,  Yu Zhou,  Jia-xi Lu, 
  • First Published: 10 May 2022
Review Article
Open Access

Crosstalk between ILC2s and Th2 CD4+ T Cells in Lung Disease

Lan-lan Mi,  Wei-wei Guo, 
  • First Published: 10 May 2022
Research Article
Open Access

Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus

Shuaihantian Luo,  Ruifang Wu,  Qianwen Li,  Guiying Zhang, 
  • First Published: 10 May 2022
Corrigendum
Open Access

Corrigendum to “Hydroxychloroquine Use in Lupus Patients during Pregnancy Is Associated with Longer Pregnancy Duration in Preterm Births”

S. J. Kroese,  M. J. H. de Hair,  M. Limper,  A. T. Lely,  J. M. van Laar,  R. H. W. M. Derksen,  R. D. E. Fritsch-Stork, 
  • First Published: 09 May 2022

Review Article
Open Access

Role of Exosomes in Chronic Liver Disease Development and Their Potential Clinical Applications

Chen Wang,  Jinwen Liu,  Yongmin Yan,  Youwen Tan, 
  • First Published: 06 May 2022
Research Article
Open Access

Echinacoside Induces Mitochondria-Mediated Pyroptosis through Raf/MEK/ERK Signaling in Non-Small Cell Lung Cancer Cells

Ye Shi,  Hui Cao,  Zhengcheng Liu,  Lei Xi,  Changqing Dong, 
  • First Published: 06 May 2022
Research Article
Open Access

A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer

Xin Zhang,  Xingda Zhang,  Guozheng Li,  Yi Hao,  Lei Liu,  Lei Zhang,  Yihai Chen,  Jiale Wu,  Xinheng Wang,  Shuai Yang,  Shouping Xu, 
  • First Published: 05 May 2022
Research Article
Open Access

Identification of Common Oncogenic Genes and Pathways Both in Osteosarcoma and Ewing’s Sarcoma Using Bioinformatics Analysis

Jingwei Zhang,  Junchao Huang,  Wenjun Liu,  Liang Ding,  Dongdong Cheng,  Haijun Xiao, 
  • First Published: 05 May 2022
Research Article
Open Access

Development of a Transcription Factor-Based Prognostic Model for Predicting the Immune Status and Outcome in Pancreatic Adenocarcinoma

Xianbin Zhang,  Li Li,  Peng Liu,  Yu Tian,  Peng Gong, 
  • First Published: 05 May 2022
Research Article
Open Access

Prognostic Risk Signature and Comprehensive Analyses of Endoplasmic Reticulum Stress-Related Genes in Lung Adenocarcinoma

CaiZhen Yang,  YuHui Wei,  WenTao Li,  JinMei Wei,  GuoXing Chen,  MingPeng Xu,  GuangNan Liu, 
  • First Published: 04 May 2022
Review Article
Open Access

Breast Implant-Associated Immunological Disorders

Lily J. Suh,  Imran Khan,  Christine Kelley-Patteson,  Ganesh Mohan,  Aladdin H. Hassanein,  Mithun Sinha, 
  • First Published: 04 May 2022
Research Article
Open Access

Metformin Improves the Prognosis of Adult Mice with Sepsis-Associated Encephalopathy Better than That of Aged Mice

Gaofei Song,  Huoyan Liang,  Heng Song,  Xianfei Ding,  Dong Wang,  Xiaojuan Zhang,  Tongwen Sun, 
  • First Published: 04 May 2022
Research Article
Open Access

Identification of Five m6A-Related lncRNA Genes as Prognostic Markers for Endometrial Cancer Based on TCGA Database

Li Shan,  Ye Lu,  Cheng-Cheng Xiang,  Xiaoli Zhu,  Er-Dong Zuo,  Xu Cheng, 
  • First Published: 04 May 2022
Review Article
Open Access

Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer

Loredana Maria Himiniuc,  Bogdan Florin Toma,  Razvan Popovici,  Ana Maria Grigore,  Alexandru Hamod,  Constantin Volovat,  Simona Volovat,  Irina Nica,  Decebal Vasincu,  Maricel Agop,  Mihaela Tirnovanu,  Lacramioara Ochiuz,  Anca Negura,  Mihaela Grigore, 
  • First Published: 04 May 2022
Research Article
Open Access

Cecal Patches Generate Abundant IgG2b-Bearing B Cells That Are Reactive to Commensal Microbiota

Masato Tsuda,  Hiraku Okada,  Natsuki Kojima,  Fumiya Ishihama,  Yuhei Muraki,  Toshiki Oguma,  Nanako Hattori,  Takumi Mizoguchi,  Kiyoaki Mori,  Satoshi Hachimura,  Yoshimasa Takahashi,  Kyoko Takahashi,  Shuichi Kaminogawa,  Akira Hosono, 
  • First Published: 04 May 2022
Research Article
Open Access

Identification of Important Modules and Hub Gene in Chronic Kidney Disease Based on WGCNA

Jia Wang,  Yuan Yin,  Qun Lu,  Yan-rong Zhao,  Yu-jie Hu,  Yun-Zhao Hu,  Zheng-Yin Wang, 
  • First Published: 04 May 2022
Research Article
Open Access

Bone Marrow-Derived Cells Contribute to the Maintenance of Thymic Stroma including TECs

Shami Chakrabarti,  Mohammed Hoque,  Nawshin Zara Jamil,  Varan J. Singh,  Daniel Pollacksmith,  Neelab Meer,  Mark T. Pezzano, 
  • First Published: 29 April 2022
Research Article
Open Access

Potential Key Markers for Predicting the Prognosis of Gastric Adenocarcinoma Based on the Expression of Ferroptosis-Related lncRNA

Yanqun Cai,  Susu Wu,  Yifan Jia,  Xiao Pan,  Caiqin Li, 
  • First Published: 29 April 2022
Research Article
Open Access

Innate Immunity Stimulation during the COVID-19 Pandemic: Challenge by Parvulan

Beniamino Palmieri,  Antonio Manenti,  Francesca Galotti,  Maria Vadalà, 
  • First Published: 29 April 2022
Research Article
Open Access

Combined Effects of 2-Methoxyestradiol (Hypoxia-Inducible Factor 1α Inhibitor) and Dasatinib (A Second-Generation Tyrosine Kinase Inhibitor) on Chronic Myelocytic Leukemia Cells

Yuexian Zhang,  Heng Chen,  Yunfeng Shen,  Xin Zhou, 
  • First Published: 28 April 2022
Research Article
Open Access

lncRNA STAT4-AS1 Inhibited TH17 Cell Differentiation by Targeting RORγt Protein

Hanlin He,  Xiangjie Qiu,  Mingming Qi,  Ousman Bajinka,  Ling Qin,  Yurong Tan, 
  • First Published: 28 April 2022
Research Article
Open Access

Different In Situ Immune Patterns between Primary Tumor and Lymph Node in Non-Small-Cell Lung Cancer: Potential Impact on Neoadjuvant Immunotherapy

Zheng-Hao Ye,  Hao Long,  Ze-Rui Zhao, 
  • First Published: 28 April 2022
Research Article
Open Access

The Diagnostic and Predictive Significance of Immune-Related Genes and Immune Characteristics in the Occurrence and Progression of IgA Nephropathy

Jian-Bo Qing,  Wen-Zhu Song,  Chang-Qun Li,  Ya-Feng Li, 
  • First Published: 28 April 2022
Research Article
Open Access

Integrated Analysis Identifies Four Genes as Novel Diagnostic Biomarkers Which Correlate with Immune Infiltration in Preeclampsia

Mu-yi Yang,  Ming-hui Ji,  Tian Shen,  Lei Lei, 
  • First Published: 28 April 2022
Research Article
Open Access

Hydroxyacid Oxidase 2 (HAO2) Inhibits the Tumorigenicity of Hepatocellular Carcinoma and Is Negatively Regulated by miR-615-5p

Yuxuan Li,  Mingchao Zhang,  Xiuling Li,  Yanyan Wang,  Yu Wang,  Yuan Li,  Huihui Zhu,  Hui Ding,  Xiaofang Li,  Suofeng Sun, 
  • First Published: 28 April 2022
Corrigendum
Open Access

Corrigendum to “Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study”

Sylvia J. Kroese,  Carolien N. H. Abheiden,  Birgit S. Blomjous,  Jacob M. van Laar,  Ronald W. H. M. Derksen,  Irene E. M. Bultink,  Alexandre E. Voskuyl,  A. Titia Lely,  Marjon A. de Boer,  Johanna I. P. de Vries,  Ruth D. E. Fritsch-Stork, 
  • First Published: 26 April 2022

Research Article
Open Access

Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology

Jessica Ramirez,  Pincas Bitterman,  Sanjib Basu,  Animesh Barua, 
  • First Published: 26 April 2022
Research Article
Open Access

Associations between Circulating VEGFR2hi-Neutrophils and Carotid Plaque Burden in Patients Aged 40-64 without Established Atherosclerotic Cardiovascular Disease

Vadim Genkel,  Ilya Dolgushin,  Irina Baturina,  Albina Savochkina,  Karina Nikushkina,  Anna Minasova,  Alla Kuznetsova,  Igor Shaposhnik, 
  • First Published: 26 April 2022
Research Article
Open Access

Polymorphisms of ATG5 Gene Are Associated with Autoimmune Thyroid Diseases, Especially Thyroid Eye Disease

Wen Wang,  Zheng-yao Yu,  Rong-hua Song,  Shuang-tao He,  Liang-feng Shi,  Jin-an Zhang, 
  • First Published: 26 April 2022
Research Article
Open Access

Comprehensive Analysis of lncRNA Expression Profile and the Potential Role of ENST00000604491 in Graves’ Disease

Yingzhao Liu,  Junli Zou,  Juan Xu,  Xuehua Wang,  Jie Xing,  Li Wang,  Huiyong Peng, 
  • First Published: 25 April 2022
Research Article
Open Access

A Comprehensive Prognostic and Immune Analysis of Ferroptosis-Related Genes Identifies SLC7A11 as a Novel Prognostic Biomarker in Lung Adenocarcinoma

Li Qian,  Fu Wang,  Shu-min Lu,  Hua-jie Miao,  Xin He,  Jia Feng,  Hua Huang,  Rong-feng Shi,  Jian-guo Zhang, 
  • First Published: 25 April 2022
Research Article
Open Access

PLAC8 Overexpression Promotes Lung Cancer Cell Growth via Wnt/β-Catenin Signaling

Wei Chen,  Junlu Wu,  Weiwei Wang,  Li Yu,  Xianghuai Xu, 
  • First Published: 22 April 2022
Review Article
Open Access

Tumor-Associated Regulatory T Cells in Non-Small-Cell Lung Cancer: Current Advances and Future Perspectives

Jiaqi Liang,  Guoshu Bi,  Guangyao Shan,  Xing Jin,  Yunyi Bian,  Qun Wang, 
  • First Published: 22 April 2022
Research Article
Open Access

Prediction of the Short-Term Risk of New-Onset Renal Dysfunction in Patients with Type 2 Diabetes: A Longitudinal Observational Study

Jianbo Xu,  Xiaoyun Shan,  Yina Xu,  Yongjun Ma,  Huabin Wang, 
  • First Published: 20 April 2022
Research Article
Open Access

Revealing Potential Diagnostic Gene Biomarkers Associated with Immune Infiltration in Patients with Renal Fibrosis Based on Machine Learning Analysis

Yu-Chao Sun,  Zhen-Zhen Qiu,  Fu-Li Wen,  Jin-Quan Yin,  Hao Zhou, 
  • First Published: 20 April 2022
Research Article
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Norcantharidin Nanostructured Lipid Carrier (NCTD-NLC) Suppresses the Viability of Human Hepatocellular Carcinoma HepG2 Cells and Accelerates the Apoptosis

Zijun Yan,  Kun Yang,  Xiang Tang,  Yunfeng Bi,  Yuzhen Ding,  Mengyue Deng,  Die Xia,  Yunqi Zhao,  Tong Chen, 
  • First Published: 20 April 2022
Research Article
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Histone Methyltransferase SETDB1 Promotes Immune Evasion in Colorectal Cancer via FOSB-Mediated Downregulation of MicroRNA-22 through BATF3/PD-L1 Pathway

Jiale Tian,  Weiwei Wang,  Jichao Zhu,  Yun Zhuang,  Chunrun Qi,  Zhengxin Cai,  Wenhui Yan,  Wenying Lu,  Anquan Shang, 
  • First Published: 20 April 2022
Research Article
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PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer

Jing Li,  Wei-min Kong, 
  • First Published: 20 April 2022
Research Article
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Identification of Serum miRNAs as Effective Diagnostic Biomarkers for Distinguishing Primary Central Nervous System Lymphoma from Glioma

Pei-pei Si,  Xiao-hui Zhou,  Zhen-zhen Qu, 
  • First Published: 20 April 2022
Review Article
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Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19

Alhasan Alsalman,  Mohammad A. Al-Mterin,  Eyad Elkord, 
  • First Published: 19 April 2022
Research Article
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Comprehensive Landscape of Prognostic Significance and Immune Characteristics of Myosins in Squamous Cell Carcinoma of the Head and Neck

Yuying Zhu,  Shikang Zheng,  Xingyou Zhai,  Cheng Wang,  Aijun Liu,  Jun Ju,  Xin Peng,  Liwei Chen,  Yongxia Zhang,  Nan Ren,  Yingli Xie,  Junda Fan,  Kai Zhao,  Mingbo Liu, 
  • First Published: 18 April 2022
Research Article
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Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis

Yue Sun,  Xiao-Xin Zhang,  Shan Huang,  Hong Pan,  Yan-Zhi Gai,  Yao-Qi Zhou,  Lei Zhu,  Hui-Zhen Nie,  Dong-Xue Li, 
  • First Published: 18 April 2022
Research Article
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Prognostic Biomarker NUMB Is Inhibited by Breast Cancer Cell Exosomes to Promote Breast Cancer Progression

Xue Qin,  Youde Cao, 
  • First Published: 18 April 2022
Research Article
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Association of HLA-DR1, HLA-DR13, and HLA-DR16 Polymorphisms with Systemic Lupus Erythematosus: A Meta-Analysis

Tingrui Wang,  Hong Wang,  Lijuan Qiu,  Lingling Wu,  Huayun Ling,  Yu Xue,  Ying Zhou,  Huijuan Chen,  Dong-Qing Ye,  Bin Wang, 
  • First Published: 16 April 2022
Research Article
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Efficacy and Safety of Antivascular Endothelial Growth Factor (Anti-VEGF) in Treating Neovascular Age-Related Macular Degeneration (AMD): A Systematic Review and Meta-analysis

Xiaobei Yin,  Ting He,  Shanshan Yang,  Hui Cui,  Wenlan Jiang, 
  • First Published: 15 April 2022
Research Article
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Synthesis, Characterization, and In Vivo Cytokinome Profile of IL-12-Loaded PLGA Nanospheres

Ryan A. Lacinski,  Justin E. Markel,  Jabeen Noore,  Hillary G. Pratt,  Brock A. Lindsey, 
  • First Published: 14 April 2022
Research Article
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Proteomic Profiling and Functional Analysis of B Cell-Derived Exosomes upon Pneumocystis Infection

Dan Ma,  Qian-Yu Zhang,  Heng-Mo Rong,  Kan Zhai,  Zhao-Hui Tong, 
  • First Published: 14 April 2022
Research Article
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Oral S2-Ag85 DNA Vaccine Activated Intestinal Cell dsDNA and RNA Sensors to Promote the Presentation of Intestinal Antigen

Dang Sheng,  Sui Xin,  Wu Dongxing,  Wen Shubo,  Song Yang,  Chen Zeliang,  Zhai Jingbo, 
  • First Published: 13 April 2022
Research Article
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[Retracted] Ameliorative Impact of Liraglutide on Chronic Intermittent Hypoxia-Induced Atrial Remodeling

Jun Wang,  Yongzheng Liu,  Changhui Ma,  Yue Zhang,  Meng Yuan,  Guangping Li, 
  • First Published: 13 April 2022

Review Article
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Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials

Poliana Guiomar de Almeida Brasiel,  Fernanda Verdini Guimarães,  Patrícia Machado Rodrigues e Silva,  Dumith Chequer Bou-Habib,  Vinicius de Frias Carvalho, 
  • First Published: 13 April 2022
Review Article
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Research Progress on the Mechanism of Persistent Low-Level HBsAg Expression in the Serum of Patients with Chronic HBV Infection

Jie Wu,  Yu Yu,  Yuzhu Dai,  Yingjie Zhang,  Jun Cheng, 
  • First Published: 13 April 2022
Research Article
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Prediction of Prognosis and Recurrence of Bladder Cancer by ECM-Related Genes

Hongfan Zhao,  Zihao Chen,  Yunze Fang,  Mingqiang Su,  Yipeng Xu,  Zhifeng Wang,  Michael Adu Gyamfi,  Junfeng Zhao, 
  • First Published: 12 April 2022
Research Article
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Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells

S. González-Ochoa,  M. C. Tellez-Bañuelos,  A. S. Méndez-Clemente,  A. Bravo-Cuellar,  G. Hernández Flores,  L. A. Palafox-Mariscal,  J. Haramati,  E. J. Pedraza-Brindis,  K. Sánchez-Reyes,  P. C. Ortiz-Lazareno, 
  • First Published: 12 April 2022
Research Article
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The Impact of Curcumin on the Inflammatory Profile of SW982 Cells in a Rheumatoid Arthritis Model

Kamil Więcek,  Piotr Kupczyk,  Grzegorz Chodaczek,  Marta Woźniak, 
  • First Published: 12 April 2022
Research Article
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Allogeneic Expanded Human Peripheral NK Cells Control Prostate Cancer Growth in a Preclinical Mouse Model of Castration-Resistant Prostate Cancer

Fangming Wang,  Xuejiao Dong,  Jing Wang,  Feiya Yang,  Donghua Liu,  Jianlin Ma,  Shuai Liu,  Dehua Chang,  Nianzeng Xing, 
  • First Published: 11 April 2022
Research Article
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The Association between Regulatory T Cell Subpopulations and Severe Pneumonia Post Renal Transplantation

Quan Zhuang,  Haozheng Cai,  Min Yang,  Bo Peng,  Yulin Luo,  Ying Zhang,  Yingzi Ming, 
  • First Published: 09 April 2022
Research Article
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Optimized Protocol for the Isolation of Extracellular Vesicles from the Parasitic Worm Schistosoma mansoni with Improved Purity, Concentration, and Yield

Marije E. Kuipers,  Roman I. Koning,  Erik Bos,  Cornelis H. Hokke,  Hermelijn H. Smits,  Esther N. M. Nolte-‘t Hoen, 
  • First Published: 08 April 2022
Research Article
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New Paradigm in Cell Therapy Using Sperm Head to Restore Brain Function and Structure in Animal Model of Alzheimer’s Disease: Support for Boosting Constructive Inflammation vs. Anti-Inflammatory Approach

Nafiseh Pakravan,  Ardeshir Abbasi,  Zuhair Mohammad Hassan, 
  • First Published: 07 April 2022
Review Article
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miR-155: An Important Role in Inflammation Response

Jingyan Hu,  Songli Huang,  Xiaoli Liu,  Yuan Zhang,  Shengli Wei,  Xiuhua Hu, 
  • First Published: 06 April 2022
Research Article
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Effects of Sodium Chlorophyllin Copper on APO-1 Expression in Bone Marrow Mesenchymal Stem Cells of Rats with Aplastic Anaemia

Xin Jin,  Guanhai Dai,  Liyang Xuan,  Meng Zhang,  Huifang Jiang,  Yang Sui, 
  • First Published: 06 April 2022
Research Article
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Concurrent Chemoradiotherapy Increases the Levels of Soluble Immune Checkpoint Proteins in Patients with Locally Advanced Cervical Cancer

Chao Liu,  Xiaohui Li,  Aijie Li,  Wenxue Zou,  Rui Huang,  Xiaoyu Hu,  Jinming Yu,  Xiaoling Zhang,  Jinbo Yue, 
  • First Published: 04 April 2022
Research Article
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Long Noncoding RNA Hotair Promotes the Progression and Immune Escape in Laryngeal Squamous Cell Carcinoma through MicroRNA-30a/GRP78/PD-L1 Axis

Xiaowei Yuan,  Qinhua Shen,  Wenxue Ma, 
  • First Published: 04 April 2022
Research Article
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Isthmin 1 is Expressed by Progenitor-Like Cells in the Lung: Phenotypical Analysis of Isthmin 1+ Hematopoietic Stem-Like Cells in Homeostasis and during Infection

Guadalupe Rivera-Torruco,  Carolina A. Martínez-Mendiola,  Tania Angeles-Floriano,  Gustavo Alberto Jaimes-Ortega,  José Luis Maravillas-Montero,  Rodolfo García-Contreras,  Yolanda González,  Esmeralda Juárez,  Porfirio Nava,  Vianney Ortiz-Navarrete,  Oscar Medina-Contreras,  Paula Licona-Limón,  Ricardo Valle-Rios, 
  • First Published: 01 April 2022
Research Article
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A Novel Gene Signature Based on CDC20 and FCN3 for Prediction of Prognosis and Immune Features in Patients with Hepatocellular Carcinoma

Xing Lai,  Ya-kun Wu,  Guo-qing Hong,  Jun-ke Li,  Qing Luo,  Jin Yuan,  Guo-hua Dai,  Shuang-quan Liu,  Hua-guo Feng, 
  • First Published: 30 March 2022
Research Article
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Comprehensive Landscape of ARID Family Members and Their Association with Prognosis and Tumor Microenvironment in Hepatocellular Carcinoma

Ji Sun,  Nan-sheng Cheng, 
  • First Published: 30 March 2022
Research Article
Open Access

Exosomal miR-543 Inhibits the Proliferation of Ovarian Cancer by Targeting IGF2

Shupei Zhang,  Diling Pan,  Shaoyu Zhang,  Qiumei Wu,  Lan Zhen,  Shihuang Liu,  Jingjing Chen,  Rong Lin,  Qiuhua Hong,  Xiangqin Zheng,  Huan Yi, 
  • First Published: 29 March 2022
Review Article
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The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)

Payam Behzadi,  Aga Syed Sameer,  Saniya Nissar,  Mujeeb Zafar Banday,  Márió Gajdács,  Herney Andrés García-Perdomo,  Kulsum Akhtar,  Marina Pinheiro,  Peter Magnusson,  Meysam Sarshar,  Cecilia Ambrosi, 
  • First Published: 26 March 2022
Review Article
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Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis

Chenyang Lei,  Juan Jiang,  Yanyan Zhang,  Gaoyun Xiong, 
  • First Published: 26 March 2022
Research Article
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The Beneficial Effect of IL-12 and IL-18 Transduced Dendritic Cells Stimulated with Tumor Antigens on Generation of an Antitumor Response in a Mouse Colon Carcinoma Model

Jagoda Mierzejewska,  Katarzyna Węgierek-Ciura,  Joanna Rossowska,  Agnieszka Szczygieł,  Natalia Anger-Góra,  Bożena Szermer-Olearnik,  Magdalena Geneja,  Elżbieta Pajtasz-Piasecka, 
  • First Published: 25 March 2022
Research Article
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Low Activation of CD8+ T Cells in response to Viral Peptides in Mexican Patients with Severe Dengue

Tania Estrada-Jiménez,  Lilian Flores-Mendoza,  Laura Ávila-Jiménez,  Carlos Francisco Vázquez-Rodríguez,  Gilma Guadalupe Sánchez-Burgos,  Verónica Vallejo-Ruiz,  Julio Reyes-Leyva, 
  • First Published: 25 March 2022
Research Article
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Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer

Yan-ping Song,  Peng Xian,  Hong Luo,  Jun-yong Dai,  Yu Bai,  Yuan Li,  Xian-li Tang, 
  • First Published: 24 March 2022
Review Article
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Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases

Yanling Li,  Tingting Zhao,  Jiaxin Li,  Mengyao Xia,  Yuling Li,  Xiaoyu Wang,  Chuanguo Liu,  Tingting Zheng,  Renjie Chen,  Dongfang Kan,  Yicheng Xie,  Jingjie Song,  Yu Feng,  Tiangui Yu,  Peng Sun, 
  • First Published: 23 March 2022
Research Article
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Panax quinquefolius Polysaccharides Ameliorate Antibiotic-Associated Diarrhoea Induced by Lincomycin Hydrochloride in Rats via the MAPK Signaling Pathways

Duo-duo Ren,  Shan-shan Li,  Hong-mei Lin,  Yun-shi Xia,  Zhi-man Li,  Pan-pan Bo,  Rui Mu,  Li-juan Zhao,  Yin-shi Sun, 
  • First Published: 19 March 2022
Review Article
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Recent Advances and Next Breakthrough in Immunotherapy for Cancer Treatment

Ling Yang,  Qian Ning,  Sheng-song Tang, 
  • First Published: 18 March 2022
Research Article
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Ebosin Attenuates the Inflammatory Responses Induced by TNF-α through Inhibiting NF-κB and MAPK Pathways in Rat Fibroblast-Like Synoviocytes

Yang Zhang,  Lifei Wang,  Liping Bai,  Rong Jiang,  Jianbo Wu,  Yuan Li, 
  • First Published: 17 March 2022
Research Article
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Autologous Cytokine-Induced Killer Cell Immunotherapy Enhances Chemotherapy Efficacy against Multidrug-Resistant Tuberculosis

Peijun Tang,  Xingnian Chen,  Junchi Xu,  Yunlong Hu,  Zhijian Ye,  Xiafang Wang,  Yumei Xiao,  Xinghua Shen,  Jianping Zhang,  Yanjun Feng,  Cuilin Shi,  Xin Yu,  Lixian Yi,  Xinchun Chen,  Binfeng Lu,  Ping Xu,  Zhongwen Sun,  Meiying Wu, 
  • First Published: 17 March 2022
Research Article
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Dysbiosis of Gastric Mucosal Fungal Microbiota in the Gastric Cancer Microenvironment

Zhenzhan Zhang,  Hao Feng,  Yaopeng Qiu,  Zhou Xu,  Qingfeng Xie,  Wenfu Ding,  Hao Liu,  Guoxin Li, 
  • First Published: 16 March 2022
Review Article
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The Effects of Vitamins and Micronutrients on Helicobacter pylori Pathogenicity, Survival, and Eradication: A Crosstalk between Micronutrients and Immune System

Ali Nabavi-Rad,  Mahsa Azizi,  Shaghayegh Jamshidizadeh,  Amir Sadeghi,  Hamid Asadzadeh Aghdaei,  Abbas Yadegar,  Mohammad Reza Zali, 
  • First Published: 16 March 2022
Review Article
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Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response

Guo Liu,  Feng Liu, 
  • First Published: 12 March 2022
Research Article
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Different Airway Inflammatory Phenotypes Correlate with Specific Fungal and Bacterial Microbiota in Asthma and Chronic Obstructive Pulmonary Disease

Rui Yang,  Qiao Zhang,  Zhidong Ren,  Hong Li,  Qianli Ma, 
  • First Published: 11 March 2022
Research Article
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Multidimension Analysis of the Prognostic Value, Immune Regulatory Function, and ceRNA Network of LY6E in Individuals with Colorectal Cancer

Ting Li,  Weidong Liu,  Chun Wang,  Man Wang,  Wenjia Hui,  Jiajie Lu,  Feng Gao, 
  • First Published: 11 March 2022
Research Article
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RIPK4 Is an Immune Regulating-Associated Biomarker for Ovarian Cancer and Possesses Generalization Value in Pan-Cancer

Cui Liao,  Yi-xia Zhao,  Wei-di Han,  Nian-yu Lai, 
  • First Published: 09 March 2022
Research Article
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Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis

Gu Man,  Haiwen Yang,  Kai Shen,  Donghong Zhang,  Julin Zhang,  Hao Wu,  Hongyu Zhang,  Jinhuan Wang, 
  • First Published: 08 March 2022
Research Article
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The Proinflammatory Cytokines IL-18, IL-21, and IFN-γ Differentially Regulate Liver Inflammation and Anti-Mitochondrial Antibody Level in a Murine Model of Primary Biliary Cholangitis

Ya-Fei Xu,  Yuan Yao,  Min Ma,  Shu-Han Yang,  Peng Jiang,  Jinjun Wang,  Koichi Tsuneyama,  Chan Wang,  Xiangdong Liu,  Liang Li,  Zhe-Xiong Lian, 
  • First Published: 07 March 2022
Review Article
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The Nervous System Contributes to the Tumorigenesis and Progression of Human Digestive Tract Cancer

Dayou Dai,  Hao Liu, 
  • First Published: 07 March 2022
Research Article
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Determination of T Cell Responses in Thai Systemic Sclerosis Patients

Oranit Likhit,  Worawit Louthrenoo,  Sa-nga Pattanakitsakul,  Aroonroong Suttitheptumrong,  Supot Hannongbua,  Thanyada Rungrotmongkol,  Hiroshi Noguchi,  Fujio Takeuchi,  Kobporn Boonnak, 
  • First Published: 07 March 2022
Research Article
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Altered Phenotype of Circulating Dendritic Cells and Regulatory T Cells from Patients with Acute Myocarditis

Paola del Carmen Guerra-de-Blas,  Daniela Cruz-González,  Elena B. Martínez-Shio,  Roberto González-Amaro,  Héctor González-Pacheco,  Esther Layseca-Espinosa,  Carlos D. Escobedo-Uribe,  Adriana E. Monsiváis-Urenda, 
  • First Published: 28 February 2022
Research Article
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Clinical Significance of OX40 and OX40 Ligand in the Peripheral Blood of Patients with Myasthenia Gravis

Xiaoling Zhou,  Xiaoyuan Wang,  Yanzheng Gu,  Lan Chen,  Yueping Shen,  Jingluan Tian,  Chen Shujun,  Mingyuan Wang,  Xiaoyu Duan,  Hanqing Gao,  Xiaopei Ji,  Qi Fang,  Xueguang Zhang,  Qun Xue, 
  • First Published: 28 February 2022
Research Article
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Comprehensive Analysis of Immune Infiltrates of Ferroptosis-Related Long Noncoding RNA and Prediction of Colon Cancer Patient Prognoses

Wenzheng Chen,  Yafei Chen,  Li Liu,  Yukang Wu,  Pengcheng Fu,  Yi Cao,  Jianbo Xiong,  Yi Tu,  Zhengrong Li,  Yi Liu,  Zhigang Jie, 
  • First Published: 27 February 2022
Research Article
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Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer

Yanfei Ma,  Yanghong Li,  Pengwei Guo,  Jingjie Zhao,  Qiang Qin,  Jiajia Wang,  Zhengfang Liang,  Dalong Wei,  Zechen Wang,  Jiajia Shen,  Siyuan He,  Qianli Tang,  Guanming Lu,  Guiling Shi,  Lingzhang Meng, 
  • First Published: 27 February 2022
Research Article
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Development and Evaluation of an In-House ELISA to Detect Anti-FcεR1α IgG Autoantibodies in Chronic Spontaneous Urticaria Patients

Chattip Sripatumtong,  Tunsuda Tansit,  Papapit Tuchinda,  Duangjit Kanistanon,  Kanokvalai Kulthanan,  Yuttana Srinoulprasert, 
  • First Published: 25 February 2022
Research Article
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Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages’ Function but Does Not Trigger the Adaptive T Cell Immune Response

Milena J. Tosiek,  Kerstin Groesser,  Anton Pekcec,  Monika Zwirek,  Gavuthami Murugesan,  Eric Borges, 
  • First Published: 25 February 2022
Research Article
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Predictors of Response to Oral Medications and Low-Histamine Diet in Patients with Chronic Urticaria

Hui-Ling Chiang,  Chen-Hung Chen,  Malcolm Koo,  Tzung-Yi Tsai,  Cheng-Han Wu, 
  • First Published: 22 February 2022
Research Article
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Long Noncoding RNA TUG1 Inhibits Tumor Progression through Regulating Siglec-15-Related Anti-Immune Activity in Hepatocellular Carcinoma

Yanyi Ren,  Jiayi Lyu,  Yaoguang Guo,  Yuan Yao,  Lin Hu, 
  • First Published: 21 February 2022
Research Article
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High Dimensionality Reduction and Immune Phenotyping of Natural Killer and Invariant Natural Killer Cells in Latent Tuberculosis-Diabetes Comorbidity

Gokul Raj Kathamuthu,  Nathella Pavan Kumar,  Kadar Moideen,  Pradeep A. Menon,  Subash Babu, 
  • First Published: 21 February 2022
Research Article
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Oral and Intestinal Bacterial Substances Associated with Disease Activities in Patients with Rheumatoid Arthritis: A Cross-Sectional Clinical Study

Kaori Kitamura,  Hiroshi Shionoya,  Suguru Suzuki,  Richio Fukai,  Shinichi Uda,  Chiyuki Abe,  Hiromitsu Takemori,  Keita Nishimura,  Hisashi Baba,  Kou Katayama,  Kuniaki Terato,  Takaki Waritani, 
  • First Published: 18 February 2022
Research Article
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The Expression and Clinical Significance of PCNAP1 in Hepatocellular Carcinoma Patients

Yanhong Chen,  Jiao Zhang,  Jia Liu,  Jianguo Wang,  Chao Shi,  Lu Lu,  Xing Cheng,  Guoping Niu,  Shuangshuang Zhang, 
  • First Published: 18 February 2022
Review Article
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Commensal and Pathogenic Bacterial-Derived Extracellular Vesicles in Host-Bacterial and Interbacterial Dialogues: Two Sides of the Same Coin

Samira Tarashi,  Mohammad Saber Zamani,  Mir Davood Omrani,  Abolfazl Fateh,  Arfa Moshiri,  Ahmad Saedisomeolia,  Seyed Davar Siadat,  Stan Kubow, 
  • First Published: 17 February 2022
Research Article
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The Role of Dendritic Cell Subsets in Recurrent Spontaneous Abortion and the Regulatory Effect of Baicalin on It

Nannan Lai,  Xiaoxiao Fu,  Guozhen Hei,  Weiwei Song,  Ran Wei,  Xiaoxiao Zhu,  Qiang Guo,  Zhen Zhang,  Chu Chu,  Ke Xu,  Xia Li, 
  • First Published: 17 February 2022
Research Article
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Impact of Notch3 Activation on Aortic Aneurysm Development in Marfan Syndrome

Kathryn Jespersen,  Chenxin Li,  Rishi Batra,  Christopher A. Stephenson,  Paul Harding,  Kylie Sestak,  Ryan T. Foley,  Harrison Greene,  Trevor Meisinger,  Jason R. Cook,  B. Timothy Baxter,  Wanfen Xiong, 
  • First Published: 15 February 2022
Research Article
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Pharmacological Inhibition of Glutaminase 1 Normalized the Metabolic State and CD4+ T Cell Response in Sjogren’s Syndrome

Jiayao Fu,  Yiping Pu,  Baoli Wang,  Hui Li,  Xiujuan Yang,  Lisong Xie,  Huan Shi,  Zhijun Wang,  Junhao Yin,  Tianle Zhan,  Yanxiong Shao,  Changyu Chen,  Qi Luo,  Jiabao Xu,  Zirui Zong,  Xindi Wei,  Wanwen Xiao,  Chuangqi Yu,  Lingyan Zheng, 
  • First Published: 15 February 2022
Research Article
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Analysis of Related Risk Factors and Prognostic Factors of Gastric Cancer with Bone Metastasis: A SEER-Based Study

Chen Xiaobin,  Xu Zhaojun,  Liu Tao,  Dai Tianzeng,  Huang Xuemei,  Zheng Fan,  Huang Chunyin,  Huang Jianqiang,  Lin Chen, 
  • First Published: 15 February 2022
Research Article
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29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses

Ming Liu,  Keman Xu,  Fatma Saaoud,  Ying Shao,  Ruijing Zhang,  Yifan Lu,  Yu Sun,  Charles Drummer IV,  Li Li,  Sheng Wu,  Satya P. Kunapuli,  Gerard J. Criner,  Jianxin Sun,  Huimin Shan,  Xiaohua Jiang,  Hong Wang,  Xiaofeng Yang, 
  • First Published: 15 February 2022
Research Article
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The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages

Duaa Abuarqoub,  Nouf N. Mahmoud,  Rand Zaza,  Rana Abu-Dahab,  Enam A. Khalil,  Dima A. Sabbah, 
  • First Published: 10 February 2022
Research Article
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Vitamin D Receptor Genetic Variations May Associate with the Risk of Developing Late Fracture-Related Infection in the Chinese Han Population

Xing-qi Zhao,  Kun Chen,  Hao-yang Wan,  Si-ying He,  Han-jun Qin,  Bin Yu,  Nan Jiang, 
  • First Published: 10 February 2022
Research Article
Open Access

COVID-19 Vaccination Acceptance among Healthcare Staff in Sudan, 2021

Eman Omer Mohamed Yassin,  Haybat Awad Allah Faroug,  Zainab Bushra Yousif Ishaq,  Mustafa Mohammed Alfaki Mustafa,  Mohammed Meshal Abdulkareem Idris,  Samah Elnour Khalifa Widatallah,  Ghada Omer Hamad Abd El-Raheem,  Maha Y. Suliman, 
  • First Published: 09 February 2022
Research Article
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Arsenic Trioxide Cooperate Cryptotanshinone Exerts Antitumor Effect by Medicating Macrophage Polarization through Glycolysis

Tao Jiang,  Jian-Bo Huang,  Chu-Yu Xu,  Yuan-Lin Lv,  Jun Lu,  Zheng-Qi Zhao,  Dan-Qian Yang,  Zhao-Huan Lou,  Guang-Ji Zhang, 
  • First Published: 08 February 2022
Research Article
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Crucial Genes in Aortic Dissection Identified by Weighted Gene Coexpression Network Analysis

Hongliang Zhang,  Tingting Chen,  Yunyan Zhang,  Jiangbo Lin,  Wenjun Zhao,  Yangyang Shi,  Huichong Lau,  Yang Zhang,  Minjun Yang,  Cheng Xu,  Lijiang Tang,  Baohui Xu,  Jianjun Jiang,  Xiaofeng Chen, 
  • First Published: 07 February 2022
Review Article
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New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells

Lixian Lin,  Zengqi Tang,  Zhenrui Shi,  Qing Guo,  Hui Xiong, 
  • First Published: 07 February 2022
Research Article
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Human Neutrophil Antigen Genotype and Allele Frequencies in Iranian Blood Donors

Behnaz Esmaeili,  Behnaz Bayat,  Atefe Alirezaee,  Mona Delkhah,  Mohammad Reza Mehdizadeh,  Zahra Pourpak, 
  • First Published: 07 February 2022
Research Article
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Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

Yanqiao Li,  Guangxing Wang,  Qian Wang,  Yun Zhang,  Lei Cui,  Xin Huang, 
  • First Published: 03 February 2022
Research Article
Open Access

Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control Individuals

Xu Wang,  Zejun Zhou,  David Turner,  Michael Lilly,  Tongwen Ou,  Wei Jiang, 
  • First Published: 03 February 2022
Research Article
Open Access

The Frequency of Intrathyroidal Follicular Helper T Cells Varies with the Progression of Graves’ Disease and Hashimoto’s Thyroiditis

Yun Cai,  Zhixiao Wang,  Xiaoyun Liu,  Ling Wei,  Shushu Li,  Xuqin Zheng,  Tao Yang,  Xinyu Xu, 
  • First Published: 02 February 2022
Research Article
Open Access

A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity

Lanlin Zhang,  Jiangyuan Du,  Qian Song,  Chufan Zhang,  Xianghua Wu, 
  • First Published: 01 February 2022
Review Article
Open Access

Low-Density Granulocytes in Immune-Mediated Inflammatory Diseases

Xin Ning,  Wen-Ming Wang,  Hong-Zhong Jin, 
  • First Published: 31 January 2022
Research Article
Open Access

Diagnostic Value of Systemic Inflammatory Response Index for Catheter-Related Bloodstream Infection in Patients Undergoing Haemodialysis

Jiajia Yang,  Hongmei Wang,  Qing Hua,  Jian Wu,  Ying Wang, 
  • First Published: 29 January 2022
Corrigendum
Open Access

Corrigendum to “Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients”

Long-Shan Ji,  Qiu-Tian Gao,  Ruo-Wen Guo,  Xin Zhang,  Zhen-Hua Zhou,  Zhuo Yu,  XiaoJun Zhu,  Ya-Ting Gao,  Xue-Hua Sun,  Yue-Qiu Gao,  Man Li, 
  • First Published: 25 January 2022

Research Article
Open Access

Urinary Exosomal Long Noncoding RNA TERC as a Noninvasive Diagnostic and Prognostic Biomarker for Bladder Urothelial Carcinoma

Chen Chen,  Anquan Shang,  Zujun Sun,  Yuting Gao,  Jingjuan Huang,  Yili Ping,  Wenjing Chang,  Chenzheng Gu,  Junjun Sun,  Ping Ji,  Yi Yuan,  Renquan Lu,  Dong Li, 
  • First Published: 25 January 2022
Research Article
Open Access

Insights from Dysregulated mRNA Expression Profile of β-Cells in Response to Proinflammatory Cytokines

Zhen Wang,  Kunlin Huang,  Jing Xu,  Jia Liu,  Ying Zheng, 
  • First Published: 22 January 2022
Research Article
Open Access

Interleukin-32γ in the Control of Acute Experimental Chagas Disease

Yarlla L. L. Braga,  José R. C. Neto,  Arthur W. F. Costa,  Muriel V. T. Silva,  Marcos V. Silva,  Mara R. N. Celes,  Milton A. P. Oliveira,  Leo A. B. Joosten,  Fátima Ribeiro-Dias,  Rodrigo S. Gomes,  Juliana R. Machado, 
  • First Published: 20 January 2022
Research Article
Open Access

Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis

Alexander Jacob,  Michael Phelps,  Shane Fraher,  Marcos Lopez,  Anthony Chang,  Richard J. Quigg,  Jessy J. Alexander, 
  • First Published: 20 January 2022
Research Article
Open Access

Clinical Features and Prevalence of Spondyloarthritis in a Cohort of Italian Patients Presenting with Acute Nongranulomatous Anterior Uveitis

Elena Bolletta,  Pierluigi Macchioni,  Giorgia Citriniti,  Valentina Mastrofilippo,  Raffaella Aldigeri,  Luca De Simone,  Fabrizio Gozzi,  Chantal Adani,  Anna Sangiovanni,  Chiara Posarelli,  Michele Figus,  Francesco Muratore,  Nicolò Pipitone,  Carlo Salvarani,  Luca Cimino, 
  • First Published: 18 January 2022
Research Article
Open Access

Ferric Ammonium Citrate Upregulates PD-L1 Expression through Generation of Reactive Oxygen Species

Eun Jung Choi,  Chang Hyun Jeon,  In-Kyu Lee, 
  • First Published: 17 January 2022
Research Article
Open Access

Copy Number Variation and Frequency of rs179008 in TLR7 Gene Associated with Systemic Lupus Erythematosus in Two Mexican Populations

Guillermo Valencia Pacheco,  Yumi E. Nakazawa Ueji,  Julián Ramírez Bello,  Rosa E. Barbosa Cobos,  Eduardo D. Jiménez Becerra,  Lizbeth J. González Herrera,  Gerardo J. Pérez Mendoza,  Nubia A. Rivero Cárdenas,  Angélica V. Angulo Ramírez,  Ricardo F. López Villanueva, 
  • First Published: 17 January 2022
Research Article
Open Access

Differences of Circulating CD25hi Bregs and Their Correlations with CD4 Effector and Regulatory T Cells in Autoantibody-Positive T1D Compared with Age-Matched Healthy Individuals

Jie Zhang,  Qi Fu,  Yunqiang He,  Hui Lv,  Yu Qian,  YuYue Zhang,  Heng Chen,  Xinyu Xu,  Tao Yang,  Kuanfeng Xu, 
  • First Published: 17 January 2022
Research Article
Open Access

The Probiotics in Pediatric Asthma Management (PROPAM) Study in the Primary Care Setting: A Randomized, Controlled, Double-Blind Trial with Ligilactobacillus salivarius LS01 (DSM 22775) and Bifidobacterium breve B632 (DSM 24706)

Lorenzo Drago,  Luigi Cioffi,  Maria Giuliano,  Marco Pane,  Angela Amoruso,  Irene Schiavetti,  Gregor Reid,  Giorgio Ciprandi,  PROPAM Study Group, 
  • First Published: 17 January 2022
Research Article
Open Access

Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses

Aisha M. Mergaert,  Michael F. Denny,  Brock Kingstad-Bakke,  Mandar Bawadekar,  S. Janna Bashar,  Thomas F. Warner,  Marulasiddappa Suresh,  Miriam A. Shelef, 
  • First Published: 17 January 2022
Research Article
Open Access

Risk of Multidrug Resistant Bacteria Acquisition in Patients with Declared β-Lactam Allergy during Hospitalization in Intensive Care Unit: A Retrospective Cohort Study (2007-2018)

Alessio Strazzulla,  Maria Concetta Postorino,  Nabil Belfeki,  Laura Iordache,  Astrid de Pontfarcy,  Aurelia Pitsch,  Pierre Leroy,  Sebastien Jochmans,  Mehran Monchi,  Sylvain Diamantis, 
  • First Published: 12 January 2022
Review Article
Open Access

Mechanism of Neonatal Intestinal Injury Induced by Hyperoxia Therapy

Tian-Ming Li,  Dong-Yan Liu, 
  • First Published: 12 January 2022
Research Article
Open Access

Expression of Killer Immunoglobulin Receptor Genes among HIV-Infected Individuals with Non-AIDS Comorbidities

Farouk F. Abou Hassan,  Mirna Bou Hamdan,  Khalil El Asmar,  Nada M. Melhem, 
  • First Published: 12 January 2022
Research Article
Open Access

C-Reactive Protein Knockout Attenuates Temporomandibular Joint Inflammation in Rats

Yao He,  Mengjiao Zhou,  Zixiang Jian,  Lingli Fang,  Lan Huang,  Jinlin Song, 
  • First Published: 10 January 2022
Research Article
Open Access

Circular RNA circFGFR1 Functions as an Oncogene in Glioblastoma Cells through Sponging to hsa-miR-224-5p

Qian Zhang,  Shan Chen,  Yingwei Zhen,  Peng Gao,  Zhenyu Zhang,  Hao Guo,  Yong Wang, 
  • First Published: 10 January 2022
Review Article
Open Access

Macrophage Extracellular Traps: Current Opinions and the State of Research regarding Various Diseases

Weizhen Weng,  Zuoyu Hu,  Yunfeng Pan, 
  • First Published: 07 January 2022
Research Article
Open Access

The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis

Jiao Gong,  Yaqiong Chen,  Jing Cao,  Yang Wang,  Jiahao Chen,  Danyang Li,  Liuping Sha,  Xinhua Li,  Yutian Chong,  Bo Hu, 
  • First Published: 06 January 2022
Research Article
Open Access

Control of Tumors by Antigen-Specific CD8+ T Cells through PDL1-Targeted Delivery of Antigenic Peptide

Po-Hao Feng,  Xiaoxu Wang,  Louise Ferrall,  T.-C. Wu,  Chien-Fu Hung, 
  • First Published: 04 January 2022
Research Article
Open Access

Systematic Pan-Cancer Analysis of KLRB1 with Prognostic Value and Immunological Activity across Human Tumors

Xin Cheng,  Yucheng Cao,  Xiaowei Wang,  Lin Cheng,  Yaqiong Liu,  Jun Lei,  Weijun Peng,  Dazun Shi, 
  • First Published: 03 January 2022