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    Hepatology: Volume 70, Issue 6

    1881-2250, 1477A-1501A
    December 2019
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Cover Image

  • First Published: 29 November 2019

Issue Information

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Masthead

  • First Published: 29 November 2019
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Table of contents

  • First Published: 29 November 2019

Hepatology Highlights

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Hepatology Highlights

Joseph F. Pisa,  Robert S. Brown Jr.,  Lauren M. Yang,  Daryl T.Y. Lau,  Brett E. Fortune,  Sayed Obaidullah Aseem,  Robert E. Schwartz,  Nicholas Russo,  Vikas Gupta,  Muhammad Amir,  Giorgio Roccaro,  Nidhi Jalan-Sakrikar,  Enis Kostallari,  Amaia Navarro-Corcuera, 
  • Pages: 1881-1884
  • First Published: 29 November 2019

Editorials

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The 20% Rule of NASH Progression: The Natural History of Advanced Fibrosis and Cirrhosis Caused by NASH

Rohit Loomba M.D., M.H.Sc.,  Leon A. Adams M.B.B.S., Ph.D., F.R.A.C.P., 
  • Pages: 1885-1888
  • First Published: 13 September 2019
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Predicting Heart Failure After TIPS: Still More Questions Than Answers

Anna Baiges M.D.,  Juan Carlos Garcia-Pagán M.D., Ph.D., 
  • Pages: 1889-1891
  • First Published: 13 September 2019

Original Articles

VIRAL HEPATITIS

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Hepatitis E Virus Infections Among Human Immunodeficiency Virus–Positive Individuals During an Outbreak of Acute Hepatitis A in Taiwan

Kuan-Yin Lin,  Pi-Han Lin,  Hsin-Yun Sun,  Yi-Ting Chen,  Li-Hsin Su,  Yi-Ching Su,  Shu-Yuan Ho,  Wen-Chun Liu,  Sui-Yuan Chang,  Chien-Ching Hung,  Shan-Chwen Chang, 
  • Pages: 1892-1902
  • First Published: 17 May 2019
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Baseline Level of Hepatitis B Core Antibody Predicts Spontaneous Hepatitis B e Antigen (HBeAg) Seroconversion in HBeAg-Positive Children With a Normal Alanine Aminotransferase Level

Ho-Sheng Chen,  Jia-Feng Wu,  Tung-Hung Su,  Huey-Ling Chen,  Hong-Yuan Hsu,  Ning-Shao Xia,  Pei-Jer Chen,  Mei-Hwei Chang, 
  • Pages: 1903-1912
  • First Published: 23 May 2019

STEATOHEPATITIS/METABOLIC LIVER DISEASE

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The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials

Arun J. Sanyal,  Stephen A. Harrison,  Vlad Ratziu,  Manal F. Abdelmalek,  Anna Mae Diehl,  Stephen Caldwell,  Mitchell L. Shiffman,  Raul Aguilar Schall,  Catherine Jia,  Bryan McColgan,  C. Stephen Djedjos,  John G. McHutchison,  G. Mani Subramanian,  Robert P. Myers,  Zobair Younossi,  Andrew J. Muir,  Nezam H. Afdhal,  Jaime Bosch,  Zachary Goodman, 
  • Pages: 1913-1927
  • First Published: 16 April 2019
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A Prospective Study Identifying Predictive Factors of Cardiac Decompensation After Transjugular Intrahepatic Portosystemic Shunt: The Toulouse Algorithm

Chloé Billey,  Sophie Billet,  Marie Angèle Robic,  Thomas Cognet,  Maeva Guillaume,  Jean Pierre Vinel,  Jean Marie Péron,  Olivier Lairez,  Christophe Bureau, 
  • Pages: 1928-1941
  • First Published: 12 September 2019
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F-box/WD Repeat-Containing Protein 5 Mediates the Ubiquitination of Apoptosis Signal-Regulating Kinase 1 and Exacerbates Nonalcoholic Steatohepatitis in Mice

Lan Bai,  Ming-Ming Chen,  Ze-Dong Chen,  Peng Zhang,  Song Tian,  Yan Zhang,  Xue-Yong Zhu,  Ye Liu,  Zhi-Gang She,  Yan-Xiao Ji,  Hongliang Li, 
  • Pages: 1942-1957
  • First Published: 31 January 2019
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Phosphodiesterase 4 Inhibition as a Therapeutic Target for Alcoholic Liver Disease: From Bedside to Bench

Walter E. Rodriguez,  Banrida Wahlang,  Yali Wang,  Jingwen Zhang,  Manicka V. Vadhanam,  Swati Joshi-Barve,  Philip Bauer,  Robert Cannon,  Ali Reza Ahmadi,  Zhaoli Sun,  Andrew Cameron,  Shirish Barve,  Claudio Maldonado,  Craig McClain,  Leila Gobejishvili, 
  • Pages: 1958-1971
  • First Published: 13 May 2019
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Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice

Nina L. Gluchowski,  Katlyn R. Gabriel,  Chandramohan Chitraju,  Roderick T. Bronson,  Niklas Mejhert,  Sebastian Boland,  Kun Wang,  Zon Weng Lai,  Robert V. Farese Jr.,  Tobias C. Walther, 
  • Pages: 1972-1985
  • First Published: 13 May 2019
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Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice

Chia-Yu Wang,  Xia Xiao,  Abraham Bayer,  Yang Xu,  Som Dev,  Susanna Canali,  Anil V. Nair,  Ricard Masia,  Jodie L. Babitt, 
  • Pages: 1986-2002
  • First Published: 24 May 2019

HEPATOBILIARY MALIGNANCIES

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Axis inhibition protein 1 (Axin1) Deletion–Induced Hepatocarcinogenesis Requires Intact β-Catenin but Not Notch Cascade in Mice

Yu Qiao,  Jingxiao Wang,  Eylul Karagoz,  Binyong Liang,  Xinhua Song,  Runze Shang,  Katja Evert,  Meng Xu,  Li Che,  Matthias Evert,  Diego F. Calvisi,  Junyan Tao,  Bruce Wang,  Satdarshan P. Monga,  Xin Chen, 
  • Pages: 2003-2017
  • First Published: 08 February 2019
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Methionine Adenosyltransferase α1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression

Ben Murray,  Hui Peng,  Lucia Barbier-Torres,  Aaron E. Robinson,  Tony W. H. Li,  Wei Fan,  Maria Lauda Tomasi,  Roberta A. Gottlieb,  Jenny Van Eyk,  Zhimin Lu,  Maria L. Martínez-Chantar,  Suthat Liangpunsakul,  Nicholas J. Skill,  José M. Mato,  Shelly C. Lu, 
  • Pages: 2018-2034
  • First Published: 11 May 2019

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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Bezafibrate Improves GLOBE and UK-PBC Scores and Long-Term Outcomes in Patients With Primary Biliary Cholangitis

Akira Honda,  Atsushi Tanaka,  Tetsuji Kaneko,  Atsumasa Komori,  Masanori Abe,  Mie Inao,  Tadashi Namisaki,  Naoaki Hashimoto,  Kazuhito Kawata,  Atsushi Takahashi,  Masashi Ninomiya,  Jong-Hon Kang,  Mie Arakawa,  Satoshi Yamagiwa,  Satoru Joshita,  Takeji Umemura,  Ken Sato,  Akira Kaneko,  Kentaro Kikuchi,  Jun Itakura,  Takako Nomura,  Keisuke Kakisaka,  Hideki Fujii,  Norifumi Kawada,  Yasuhiro Takikawa,  Tsutomu Masaki,  Hiromasa Ohira,  Satoshi Mochida,  Hitoshi Yoshiji,  Satoshi Iimuro,  Yasushi Matsuzaki,  Hajime Takikawa,  Japan PBC Study Group , 
  • Pages: 2035-2046
  • First Published: 08 February 2019
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Prevention of Cholestatic Liver Disease and Reduced Tumorigenicity in a Murine Model of PFIC Type 3 Using Hybrid AAV-piggyBac Gene Therapy

Susan M. Siew,  Sharon C. Cunningham,  Erhua Zhu,  Szun S. Tay,  Elena Venuti,  Christine Bolitho,  Ian E. Alexander, 
  • Pages: 2047-2061
  • First Published: 17 May 2019

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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Quality Measures, All-Cause Mortality, and Health Care Use in a National Cohort of Veterans With Cirrhosis

Marina Serper,  David E. Kaplan,  Justine Shults,  Peter P. Reese,  Lauren A. Beste,  Tamar H. Taddei,  Rachel M. Werner, 
  • Pages: 2062-2074
  • First Published: 20 May 2019

LIVER INJURY/REGENERATION

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IL-6 Trans-signaling Controls Liver Regeneration After Partial Hepatectomy

Nastaran Fazel Modares,  Robin Polz,  Fereshteh Haghighi,  Larissa Lamertz,  Kristina Behnke,  Yuan Zhuang,  Claus Kordes,  Dieter Häussinger,  Ursula R. Sorg,  Klaus Pfeffer,  Doreen M. Floss,  Jens M. Moll,  Roland P. Piekorz,  M. Reza Ahmadian,  Philipp A. Lang,  Jürgen Scheller, 
  • Pages: 2075-2091
  • First Published: 17 May 2019
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Mammalian Target of Rapamycin Complex 1 Signaling Is Required for the Dedifferentiation From Biliary Cell to Bipotential Progenitor Cell in Zebrafish Liver Regeneration

Jianbo He,  Jingying Chen,  Xiangyong Wei,  Hui Leng,  Hongliang Mu,  Pengcheng Cai,  Lingfei Luo, 
  • Pages: 2092-2106
  • First Published: 28 May 2019

LIVER BIOLOGY/PATHOBIOLOGY

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Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans

Charles DeRossi,  Kathryn Bambino,  Joshua Morrison,  Isabel Sakarin,  Carlos Villacorta-Martin,  Changwen Zhang,  Jillian L. Ellis,  M. Isabel Fiel,  Maria Ybanez,  Youngmin A. Lee,  Kuan-lin Huang,  Chunyue Yin,  Takuya F. Sakaguchi,  Scott L. Friedman,  Augusto Villanueva,  Jaime Chu, 
  • Pages: 2107-2122
  • First Published: 23 April 2019
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Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease

Mrigya Babuta,  Istvan Furi,  Shashi Bala,  Terence N. Bukong,  Patrick Lowe,  Donna Catalano,  Charles Calenda,  Karen Kodys,  Gyongyi Szabo, 
  • Pages: 2123-2141
  • First Published: 15 May 2019
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Dual Roles of Mammalian Target of Rapamycin in Regulating Liver Injury and Tumorigenesis in Autophagy-Defective Mouse Liver

Hong-Min Ni,  Xiaojuan Chao,  Hua Yang,  Fengyan Deng,  Shaogui Wang,  Qingyun Bai,  Hui Qian,  Yue Cui,  Wei Cui,  Yinghong Shi,  Wei-Xing Zong,  Zhengtao Wang,  Li Yang,  Wen-Xing Ding, 
  • Pages: 2142-2155
  • First Published: 16 May 2019
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Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation and Trafficking to the Hepatocyte Plasma Membrane

Pijun Wang,  Wen-Jun Wang,  Jo Choi-Nurvitadhi,  Yaniuska Lescaille,  John W. Murray,  Allan W. Wolkoff, 
  • Pages: 2156-2170
  • First Published: 18 May 2019
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Glucose-6-Phosphate Regulates Hepatic Bile Acid Synthesis in Mice

Joanne A. Hoogerland,  Yu Lei,  Justina C. Wolters,  Jan Freark de Boer,  Trijnie Bos,  Aycha Bleeker,  Niels L. Mulder,  Theo H. van Dijk,  Jan A. Kuivenhoven,  Fabienne Rajas,  Gilles Mithieux,  Rebecca A. Haeusler,  Henkjan J. Verkade,  Vincent W. Bloks,  Folkert Kuipers,  Maaike H. Oosterveer, 
  • Pages: 2171-2184
  • First Published: 18 May 2019

Concise Review

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Exome Sequencing in Clinical Hepatology

Sílvia Vilarinho,  Pramod K. Mistry, 
  • Pages: 2185-2192
  • First Published: 20 June 2019

Reviews

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Sarcopenia in Cirrhosis: Looking Beyond the Skeletal Muscle Loss to See the Systemic Disease

Rahima A. Bhanji,  Aldo J. Montano-Loza,  Kymberly D. Watt, 
  • Pages: 2193-2203
  • First Published: 29 April 2019
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Liver Injury and Failure in Critical Illness

Thomas Horvatits,  Andreas Drolz,  Michael Trauner,  Valentin Fuhrmann, 
  • Pages: 2204-2215
  • First Published: 19 June 2019

Hepatology Elsewhere

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Dose and Duration of Aspirin Use to Reduce Incident Hepatocellular Carcinoma

Naoto Fujiwara M.D., Ph.D.,  Amit G. Singal M.D.,  Yujin Hoshida M.D., Ph.D., 
  • Pages: 2216-2217
  • First Published: 17 June 2019
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Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ε

Varman T. Samuel M.D., Ph.D.,  Max C. Petersen M.D.,  Brandon M. Gassaway Ph.D.,  Daniel F. Vatner M.D., Ph.D.,  Jesse Rinehart Ph.D.,  Gerald I. Shulman M.D., Ph.D., F.A.C.P., M.A.C.E., 
  • Pages: 2217-2220
  • First Published: 20 June 2019

Clinical Observations in Hepatology

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Plectin Mutations in Progressive Familial Intrahepatic Cholestasis

Shang-Hsin Wu,  Jacob Shujui Hsu,  Hui-Ling Chen,  Mu-Ming Chien,  Jia-Feng Wu,  Yen-Hsuan Ni,  Bang-Yu Liou,  Ming-Chih Ho,  Yung-Ming Jeng,  Mei-Hwei Chang,  Pei-Lung Chen,  Huey-Ling Chen, 
  • Pages: 2221-2224
  • First Published: 03 July 2019
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A Pilot Experience of Endoscopic Submucosal Dissection of Barrett’s Dysplasia Despite Esophageal Varices and Decompensated Cirrhosis

Andrew Y. Wang,  Elliot Z. Smith,  Bryan G. Sauer,  Zachary H. Henry,  Neeral L. Shah,  Stephen H. Caldwell, 
  • Pages: 2225-2227
  • First Published: 11 July 2019
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Portal Pressure in Noncirrhotic Portal Hypertension: To Measure or Not to Measure

Ben L. Da,  Pallavi Surana,  Devika Kapuria,  Anusha Vittal,  Elliot Levy,  David E. Kleiner,  Christopher Koh,  Theo Heller, 
  • Pages: 2228-2230
  • First Published: 18 July 2019

Correspondence

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Letter to Editor: Repair or Prevent: What Is the Real Impact of Normothermic Machine Perfusion in Liver Transplantation?

Andrea Schlegel M.D.,  Philipp Dutkowski M.D., 
  • Pages: 2231-2232
  • First Published: 17 February 2019
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Depression: An Overlooked Villain in Autoimmune Hepatitis?

Maciej K. Janik M.D.,  Ewa Wunsch M.D., Ph.D.,  Joanna Raszeja-Wyszomirska M.D., Ph.D.,  Marcin Krawczyk M.D., Ph.D.,  Piotr Milkiewicz M.D., M.R.C.P. (UK), 
  • Pages: 2232-2233
  • First Published: 17 February 2019
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Letter to the Editor: Tale of Two ACLF Definitions: Choices Are Getting Clearer

Ashok Choudhury,  Shiv Kumar Sarin M.D., D.M., 
  • Pages: 2233-2235
  • First Published: 27 June 2019
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Letter to the Editor: Incidence and Mortality of Acute on Chronic Liver Failure Using Two Definitions in Patients With Compensated Cirrhosis

Narendra S. Choudhary M.D., D.M.,  Neeraj Saraf M.D., D.N.B.,  Sanjiv Saigal M.D., D.M.,  Arvinder S. Soin M.S., F.R.C.S., 
  • Pages: 2235-2236
  • First Published: 27 June 2019
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Reply:

Nadim Mahmud M.D., M.S., M.P.H.,  David E. Kaplan M.D. M.Sc.,  Tamar H. Taddei M.D.,  David S. Goldberg M.D., M.S.C.E., 
  • Pages: 2236-2238
  • First Published: 27 June 2019
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Letter to the Editor: Prevalence of NAFLD in China: What Did We Learn From the Recent Meta-Analysis?

Yuankai Wu M.D.,  Yee Hui Yeo M.D., M.Sc.,  Mindie H. Nguyen M.D., M.A.S.,  Ramsey C. Cheung M.D., 
  • Pages: 2238-2239
  • First Published: 07 August 2019
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Reply:

Feng Zhou M.D., Ph.D.,  Jianghua Zhou M.D.,  Wenxin Wang M.S.,  Xiao-Jing Zhang Ph.D.,  Yan-Xiao Ji Ph.D.,  Peng Zhang Ph.D.,  Zhi-Gang She M.D., Ph.D,  Lihua Zhu M.D.,  Jingjing Cai M.D.,  Hongliang Li M.D., Ph.D., 
  • Pages: 2239-2240
  • First Published: 07 August 2019
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Letter to the Editor: Noninvasive Markers of Advanced Liver Fibrosis in HBV/HIV Coinfected Patients

Rui Huang M.D., Ph.D.,  Jian Wang M.D.,  Xiaomin Yan M.D.,  Zhaoping Zhang M.D.,  Chao Wu M.D., Ph.D., 
  • Pages: 2240-2241
  • First Published: 20 August 2019
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Reply:

Richard K. Sterling M.D., M.Sc.,  Wendy C. King Ph.D.,  David E. Kleiner M.D., Ph.D., 
  • Pages: 2241-2242
  • First Published: 21 August 2019

Corrections

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Correction

  • Page: 2243
  • First Published: 28 October 2019

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Corrections

  • Page: 2243
  • First Published: 15 November 2019

Retraction

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Retraction statement: Redox-dependent regulation of hepatocyte absent in melanoma 2 inflammasome activation in sterile liver injury in mice

  • Page: 2244
  • First Published: 04 September 2019

Referees

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2019 Hepatology Referees (Volumes 69 and 70)

  • Pages: 2245-2250
  • First Published: 29 November 2019

Issue Information

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Notices

  • First Published: 29 November 2019

Abstracts

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Late-Breaking Abstracts - Presented at the 70th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting™ 2019

  • Pages: 1477A-1501A
  • First Published: 29 November 2019

Issue Information

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Instructions to Authors

  • First Published: 29 November 2019