• Issue

    Liver International: Volume 43, Issue 8

    1615-1843
    August 2023
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ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 1615-1619
  • First Published: 14 July 2023

EDITORS' PERSPECTIVE

Free Access

Immunotherapy in biliary tract cancer: The race has begun!

Ezequiel Mauro,  Alejandro Forner, 
  • Pages: 1620-1622
  • First Published: 14 July 2023

EDITORIALS

Free Access

Sweating it out: How physical activity can combat high genetic risk for nonalcoholic fatty liver disease

Jonathan G. Stine,  Stefano Romeo, 
  • Pages: 1623-1625
  • First Published: 14 July 2023
Free Access

Improving prediction of hepatocellular carcinoma in chronic hepatitis B by machine learning: Productive relationship of medicine with computer science

Terry C. F. Yip,  Cihan Yurdaydin, 
  • Pages: 1626-1628
  • First Published: 14 July 2023

REVIEWS & META-ANALYSES

Free Access

Accumulating awareness on the clinical significance and relevance of frailty in cirrhosis: Time to dig deeper into mechanistic basis!

You Deng,  Yangyang Hui,  Binxin Cui,  Wen Xie,  Chao Sun, 
  • Pages: 1629-1643
  • First Published: 08 June 2023
Accumulating awareness on the clinical significance and relevance of frailty in cirrhosis: Time to dig deeper into mechanistic basis!

The efficient and effective management of frailty is still challenging, but many attempts have been made to overcome barriers of affordability and availability. Clinical trials revealed that home-based exercise and individualized nutrition therapy show benefits in patients with cirrhosis, and high adherence to the treatment regimen may direct better efficacy and performance.

Open Access

Predictors and management of post-banding ulcer bleeding in cirrhosis: A systematic review and meta-analysis

Maria de Brito Nunes,  Matthias Knecht,  Reiner Wiest,  Jaume Bosch,  Annalisa Berzigotti, 
  • Pages: 1644-1653
  • First Published: 24 May 2023

LIVER DISEASE AND PUBLIC HEALTH

Open Access

Patient-reported quality of care in primary sclerosing cholangitis

Martine Walmsley,  Dávid Tornai,  Nora Cazzagon,  Angela Leburgue,  Anna Mrzljak,  Henrike Lenzen,  Marco Carbone,  João Madaleno,  Ana Lleo,  Norman Junge,  Christoph Schramm,  Annika Bergquist, 
  • Pages: 1654-1662
  • First Published: 13 June 2023

VIRAL HEPATITIS

Open Access

Quality-of-life scores improve after 96 weeks of PEG-IFNa-2a treatment of hepatitis D: An analysis of the HIDIT-II trial

Katja Dinkelborg,  Julia Kahlhöfer,  Petra Dörge,  Cihan Yurdaydin,  Svenja Hardtke,  Florin Alexandru Caruntu,  Manuela G. Curescu,  Kendal Yalcin,  Ulus S. Akarca,  Selim Gürel,  Stefan Zeuzem,  Andreas Erhardt,  Stefan Lüth,  George V. Papatheodoridis,  Onur Keskin,  Kerstin Port,  Monica Radu,  Mustafa K. Celen,  Ramazan Idilman,  Kristina Weber,  Judith Stift,  Ulrike Wittkop,  Benjamin Heidrich,  Ingmar Mederacke,  Heiko von der Leyen,  Hans Peter Dienes,  Markus Cornberg,  Armin Koch,  Michael P. Manns,  Heiner Wedemeyer,  Katja Deterding,  The HIDIT-2 Study Team , 
  • Pages: 1663-1676
  • First Published: 15 May 2023

Hepatocellular organellar abnormalities following elimination of hepatitis C virus

Haruyo Aoyagi,  Hiroko Iijima,  Eman S. Gaber,  Takuma Zaitsu,  Mami Matsuda,  Kosho Wakae,  Koichi Watashi,  Ryosuke Suzuki,  Takahiro Masaki,  Jeffrey Kahn,  Takeshi Saito,  Mohamed El-Kassas,  Noritomo Shimada,  Keizo Kato,  Masaru Enomoto,  Kazuhiko Hayashi,  Akihito Tsubota,  Ayako Mimata,  Yuriko Sakamaki,  Shizuko Ichinose,  Masamichi Muramatsu,  Kenjiro Wake,  Takaji Wakita,  Hideki Aizaki, 
  • Pages: 1677-1690
  • First Published: 13 June 2023

METABOLIC & TOXIC LIVER DISEASES

Metabolic-associated fatty liver disease in relation to site-specific and multiple-site subclinical atherosclerosis

Xinyu Wang,  Ruosu Zhang,  Sailimai Man,  Jun Lv,  Canqing Yu,  Jianchun Yin,  Xiaona Wang,  Yuhan Deng,  Bo Wang,  Liming Li,  Yuanjie Pang, 
  • Pages: 1691-1698
  • First Published: 20 June 2023
Open Access

Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals

Huan Su,  Madhuri Haque,  Svea Becker,  Karolina Edlund,  Julia Duda,  Qingbi Wang,  Johanna Reißing,  Hanns-Ulrich Marschall,  Lena S. Candels,  Mohamed Mohamed,  Wilhelm Sjöland,  Lijun Liao,  Stephan A. Drexler,  Till Strowig,  Jörg Rahnenführer,  Jan G. Hengstler,  Maximilian Hatting,  Christian Trautwein, 
  • Pages: 1699-1713
  • First Published: 18 April 2023
Open Access

Increased let-7d-5p in non-alcoholic fatty liver promotes insulin resistance and is a potential blood biomarker for diagnosis

Jorge Infante-Menéndez,  Andrea R. López-Pastor,  Tamara González-Illanes,  Paula González-López,  Raquel Huertas-Lárez,  Esther Rey,  Águeda González-Rodríguez,  Carmelo García-Monzón,  Nikita P. Patil,  Melina Vega de Céniga,  Aaron B. Baker,  Almudena Gómez-Hernández,  Oscar Escribano, 
  • Pages: 1714-1728
  • First Published: 14 April 2023

Inhibition of ACSS2 attenuates alcoholic liver steatosis via epigenetically regulating de novo lipogenesis

Yawen Lu,  Yimeng Chen,  Wenxin Hu,  Meng Wang,  Xiaodong Wen,  Jie Yang, 
  • Pages: 1729-1740
  • First Published: 15 May 2023

GUT-LIVER AXIS, IMMUNOLOGY, IMMUNE MEDIATED AND CHOLESTATIC DISEASES

The causal effects of inflammatory bowel disease on primary biliary cholangitis: A bidirectional two-sample Mendelian randomization study

Hongchen Zhang,  Lanlan Chen,  Zhongqi Fan,  Guoyue Lv, 
  • Pages: 1741-1748
  • First Published: 07 June 2023
Open Access

Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries

Miren García-Cortés,  Aida Ortega-Alonso,  Gonzalo Matilla-Cabello,  Inmaculada Medina-Cáliz,  Agustín Castiella,  Isabel Conde,  Elvira Bonilla-Toyos,  José Pinazo-Bandera,  Nelia Hernández,  Martin Tagle,  Vinicius Nunes,  Raymundo Parana,  Fernando Bessone,  Neil Kaplowitz,  M. Isabel Lucena,  Ismael Alvarez-Alvarez,  Mercedes Robles-Díaz,  Raúl J. Andrade, 
  • Pages: 1749-1760
  • First Published: 03 June 2023

GENETICS AND RARE LIVER DISEASES

Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease

Rosaria M. Pipitone,  Francesco Malvestiti,  Grazia Pennisi,  Oveis Jamialahmadi,  Paola Dongiovanni,  Giorgio Bertolazzi,  Jussi Pihlajamäki,  Hannele Yki-Järvinen,  Umberto Vespasiani-Gentilucci,  Federica Tavaglione,  Samantha Maurotti,  Cristiana Bianco,  Gabriele Di Maria,  Marco Enea,  Anna L. Fracanzani,  Vesa Kärjä,  Giulia Lupo,  Ville Männistö,  Marica Meroni,  Roberto Piciotti,  Sami Qadri,  Rossella Zito,  Antonio Craxì,  Vito Di Marco,  Calogero Cammà,  Claudio Tripodo,  Luca Valenti,  Stefano Romeo,  Salvatore Petta,  Stefania Grimaudo, 
  • Pages: 1761-1771
  • First Published: 23 April 2023
Open Access

An adult-based genetic risk score for liver fat associates with liver and plasma lipid traits in children and adolescents

Yun Huang,  Sara E. Stinson,  Helene Bæk Juel,  Morten A. V. Lund,  Louise Aas Holm,  Cilius E. Fonvig,  Trine Nielsen,  Niels Grarup,  Oluf Pedersen,  Michael Christiansen,  Elizaveta Chabanova,  Henrik S. Thomsen,  Aleksander Krag,  Stefan Stender,  Jens-Christian Holm,  Torben Hansen, 
  • Pages: 1772-1782
  • First Published: 20 May 2023

CIRRHOSIS, LIVER FAILURE AND TRANSPLANTATION

EUS-guided coil and glue injection versus endoscopic glue injection for gastric varices: International multicentre propensity-matched analysis

Jayanta Samanta,  Zaheer Nabi,  Antonio Facciorusso,  Jahnvi Dhar,  Wahid Akbar,  Aritra Das,  Chhagan Lal Birda,  Benedetto Mangiavillano,  Francesco Auriemma,  Stefano Francesco Crino,  Rakesh Kochhar,  Sundeep Lakhtakia,  Duvvur Nageshwar Reddy, 
  • Pages: 1783-1792
  • First Published: 03 June 2023
Open Access

Influence of NOD2 risk variants on hepatic encephalopathy and association with inflammation, bacterial translocation and immune activation

Cristina Ripoll,  Robin Greinert,  Philipp Reuken,  Matthias Christian Reichert,  Susanne N. Weber,  Yvonne Hupfer,  Raphaela Staltner,  Magdalena Meier Clinien,  Frank Lammert,  Tony Bruns,  Alexander Zipprich, 
  • Pages: 1793-1802
  • First Published: 30 May 2023

LIVER CANCER

Open Access

Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer: An early exploratory analysis of real-world data

Margherita Rimini,  Lorenzo Fornaro,  Sara Lonardi,  Monica Niger,  Daniele Lavacchi,  Tiziana Pressiani,  Jessica Lucchetti,  Guido Giordano,  Andrea Pretta,  Emiliano Tamburini,  Chiara Pirrone,  Ilario Giovanni Rapposelli,  Anna Diana,  Erika Martinelli,  Ingrid Garajová,  Francesca Simionato,  Marta Schirripa,  Vincenzo Formica,  Caterina Vivaldi,  Enrico Caliman,  Mario Domenico Rizzato,  Valentina Zanuso,  Federico Nichetti,  Lorenzo Angotti,  Matteo Landriscina,  Mario Scartozzi,  Matteo Ramundo,  Alessandro Pastorino,  Bruno Daniele,  Noemi Cornara,  Mara Persano,  Eleonora Gusmaroli,  Riccardo Cerantola,  Francesca Salani,  Francesca Ratti,  Luca Aldrighetti,  Stefano Cascinu,  Lorenza Rimassa,  Lorenzo Antonuzzo,  Andrea Casadei-Gardini, 
  • Pages: 1803-1812
  • First Published: 14 July 2023

A machine learning model for predicting hepatocellular carcinoma risk in patients with chronic hepatitis B

Hye Won Lee,  Hwiyoung Kim,  Taeyun Park,  Soo Young Park,  Young Eun Chon,  Yeon Seok Seo,  Jae Seung Lee,  Jun Yong park,  Do Young Kim,  Sang Hoon Ahn,  Beom Kyung Kim,  Seung Up Kim, 
  • Pages: 1813-1821
  • First Published: 14 July 2023

BASIC HEPATOLOGY

Open Access

Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans

Bernat Córdoba-Jover,  Jordi Ribera,  Irene Portolés,  Elena Lecue,  Juan Rodriguez-Vita,  Leticia Pérez-Sisqués,  Francesco Mannara,  Estel Solsona-Vilarrasa,  Carmen García-Ruiz,  José C. Fernández-Checa,  Gregori Casals,  Laia Rodríguez-Revenga,  María Isabel Álvarez-Mora,  Ana Arteche-López,  Aranzazu Díaz de Bustamante,  Rosa Calvo,  Anna Pujol,  Mikel Azkargorta,  Felix Elortza,  Cristina Malagelada,  Roser Pinyol,  Júlia Huguet-Pradell,  Pedro Melgar-Lesmes,  Wladimiro Jiménez,  Manuel Morales-Ruiz, 
  • Pages: 1822-1836
  • First Published: 14 June 2023

LETTERS TO THE EDITOR

Enhanced muscle function in cause-specific mortality among patients with NAFLD-related sarcopenia

Hsien-Hui Chung, 
  • Pages: 1837-1838
  • First Published: 12 June 2023

Zebrafish: An emerging and expedient model for liver studies?

Gerald J. Shami,  Delfine Cheng,  Marco Morsch,  Filip Braet, 
  • Pages: 1839-1840
  • First Published: 29 June 2023

Response Letter to: Zebrafish: An emerging and expedient model for liver studies?

Cheng Chang,  Huicong Li,  Ruilin Zhang, 
  • Page: 1841
  • First Published: 22 June 2023

Response to overcoming the challenges in eliminating viral hepatitis in low- and middle-income countries

Homie Razavi, 
  • Pages: 1842-1843
  • First Published: 22 June 2023