We generated BMP2/4 knock-out osteoblast cell lines. The cells will be used for study of osteoblast cell lineages and osteogenesis.

In this study we propose a model of EF-dependent re-localisation of Kv1.2 channels at the cathode-facing membrane of electrotaxing cells, where cortactin coordinates protein binding of Kv1.2 channel with actin in cytoskeleton and establishes a directional migration. Over expression of Kv1.2 channels or pharmacological inhibition respectively resulted in increased and reduced electrotactic response, respectively, indicating pivotal role of Kv1.2 channels in EF-sensing.

Anabolic androgenic steroids (AAS) are among the drugs most used by athletes for improving physical performance, as well as for aesthetic purposes. This study investigates the effects of nandrolone on testosterone biosynthesis in Leydig cells using various methods. The results obtained show that testosterone levels increase at a 3.9 µM concentration of nandrolone and return to the basal level a 15.6 µM dose of nandrolone. Nandrolone-induced testosterone increment was associated with upregulation of StAR and downregulation of CYP17A1.