Highlights

• Coronavirus disease 2019 (COVID-19) takes an unfavorable course in patients with type 2 diabetes mellitus (T2DM), and the risk increases in individuals with certain conditions, some of which are not modifiable.
• This study showed significantly higher mortality due to COVID-19 in hospitalized patients with T2DM than without (13.6% vs 8.7%; hazard ratio 1.75; 95% CI, 1.58-1.93).
• Older age, male gender, obesity, preexisting insulin treatment, low lymphocyte count, and pulmonary involvement on admission were the significant associates of COVID-19 mortality.

Highlights

• We revealed a high disease burden in the low-middle sociodemographic index (SDI) quintile, Southeast Asia, and Iran, the United Kingdom, Indonesia, Georgia, and the Czech Republic, and determined that the increased burden of type 2 diabetes mellitus (T2DM) disability-adjusted life years (DALYs) is mainly attributable to lifestyle factors (eg, high body mass index, low physical activity, high fasting plasma glucose, and high sugar-sweetened beverage and red meat intakes).
• Our study adds important information about the spatial distribution of T2DM burden and the contributions of risk factors to T2DM DALYs globally.

Highlights

• Metabolic syndrome (MetS) is a vital prognostic indicator of outcomes in coronavirus disease 2019.
• Patients with MetS had worse clinical outcomes compared with the ones without MetS.
• Patients with MetS had a higher need for intensive care unit irrespective of their age, sex, or race.
• Need for mechanical ventilation was higher for all patients with MetS except Caucasians.
• Females, younger patients (<65), and African Americans with MetS had higher mortality.

Highlights

• Depression and anxiety symptoms were highly prevalent during the coronavirus disease 2019 (COVID-19) pandemic regardless of diabetes status.
• Women, unmarried individuals, employees (particularly health care providers), students, younger adults, and those with lower income were more vulnerable to psychological distress during the COVID-19 outbreak than others.
• People with diabetes who had their diabetes visit canceled during the pandemic, had no method of telecommunication with HCPs, or A1C≥10%; women; HCPs; students; unmarried individuals; and those with lower income were more likely to report depression and/or anxiety symptoms

Highlights Outcomes for children with type 1 diabetes who experience COVID-19 are currently unknown. We report 266 cases from US diabetes clinics of children with type 1 diabetes who had COVID-19. Diabetic ketoacidosis was the major adverse outcome, and it was associated with higher A1c.

Highlights

• There is a positive relationship between in silico docking and in vitro assays.
• Several of the herbal compounds studied regulate postprandial hyperglycemia.
• Apigenin is a monotherapeutic agent, inhibiting both α-amylase and α-glucosidase.
• Most herbal compounds are not more toxic than acarbose.

Highlights

• Admission serum or point-of-care glucose is a greater predictor of mortality than glycosylated hemoglobin in persons with type 2 diabetes and coronavirus disease 2019 (COVID-19).
• Those with diabetes and COVID-19 who were intubated had a higher morality than those who were not intubated.
• Older age, male gender, and history of chronic kidney disease, hypertension, or coronary artery disease increased the risk of mortality. Race and insurance type had no impact on mortality.

Highlights

• Diabetes may predispose COVID-19 hospitalized patients to worse clinical outcomes.
• Our findings indicate that diabetes is significantly associated with increased odds of severe COVID-19, acute respiratory distress syndrome, mortality, and need for mechanical ventilation in hospitalized patients.
• COVID-19 patients with diabetes are at high risk of morbidity and mortality.

Highlights

• The impact of stress-induced hyperglycemia on outcome is poorly reflected by absolute glucose levels.
• The stress hyperglycemia ratio (SHR) biomarker discriminates between interpatient variation in normal premorbid background glycemia related to glycosylated hemoglobin and the acute relative increase in glucose related to physiological stress that truly represents stress-induced hyperglycemia.
• SHR at admission was superior to glucose in predicting ischemic stroke outcome.
• There is a need for interventional studies based on SHR rather than glucose to best assess management of stress-induced hyperglycemia.

Highlights

1. Increased METS-IR and 6-year METS-IR change were positively associated with risk of incident T2DM in a rural Chinese population.
2. We observed an association of METS-IR and 6-year METS-IR change with incident T2DM by sex, age, and baseline FPG level.
3. Dose-response analysis revealed significantly increased probability of incident T2DM with increasing METS-IR and 6-year METS-IR change.