Highlights

• Long-term exposure to relatively high SUA, despite within normal range, was associated with nearly 2-fold increased risk of renal function decline.
• In addition, long-term exposure to relatively low SUA level was also associated with increased risk of albuminuria.
• This study suggested that time-averaged SUA, rather than baseline SUA, is an independent predictor of incident DKD.

Highlights

• Low-dose intake of alcohol is associated with a lower risk of end-stage kidney disease (ESKD) in nondiabetic participants.
• Joint exposure to heavy drinking and diabetes is associated with a substantially higher risk of ESKD.
• Recommendations on alcohol intake among patients at risk of ESKD should consider the presence of diabetes as a comorbidity.

Highlights

• High luteinizing hormone (LH) levels are positively associated with established type 2 diabetic kidney disease (DKD) among Chinese men and postmenopausal women.
• The positive associations between LH and macroalbuminuria risk were independent of age, diabetes duration, or other metabolic factors.
• The increase of circulating LH may be a promising clinical factor for identifying established DKD.

Highlights

1. Low-dose colchicine effectively and safely lowered NRCI in T2D patients with microalbuminuria.
2. Low-dose colchicine did not prevent the incidence of overt nephropathy.

Highlights

• Based on nationwide insurance data in Korea, the use of dipeptidyl peptidase IV inhibitors (DPP-IVi) not requiring renal dose adjustment (NRDA DPP-IVi) is widespread in the type 2 diabetes chronic kidney disease (T2D CKD) population.
• Instead of prescribing NRDA DPP-IVi, the use of DPP-IVi requiring renal dose adjustment with appropriate renal dose adjustments in T2D CKD patients can achieve a considerable annual cost saving of up to 7.8%.

Highlights

• In a cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) participants with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), we observed an increased use of metformin (59%-68%) and a decreased use of sulfonylureas (55%-37%) and thiazolidinediones (25%-5%) in 2013-2016 compared to 2006-2008.
• Guideline-discordant use of metformin (8% of CKD stage 4/5) and glyburide (3% of CKD stages 3-5) observed in 2013-2016 warrants stronger policy implementations regarding inappropriate drug use.

Highlights

• Approximately 63.6% of diabetes patients with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² have normal albuminuria.
• The factors related to normoalbuminuria and eGFR < 60 mL/min/1.73 m² were male sex, older age, higher triglyceride levels, lower extremity arterial disease, and a longer duration of diabetes.
• Compared with patients with both albuminuria and eGFR decline, those with normoalbuminuria have better control of metabolic indicators.

Highlights

• Urinary C-peptide/creatinine ratio (UCPCR) is a biomarker of insulin resistance.
• High UCPCR is associated with the vascular complications of diabetes.
• The addition of UCPCR could be used to improve the categorization of patients with diabetes, and we present an updated classification comprising subgroups with specific clinical characteristics.