Volume 35, Issue 10 pp. 5527-5563

REVIEW

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Khadijeh Khezri,

Corresponding Author

Khadijeh Khezri

[email protected]

orcid.org/0000-0002-4671-985X

Deputy of Food and Drug Administration, Urmia University of Medical Sciences, Urmia, Iran

Correspondence

Khadijeh Khezri, Deputy of Food and Drug Administration, Urmia University of Medical Sciences, Urmia, Iran.

Email: [email protected]

Majid Saeedi, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Email: [email protected]

Search for more papers by this author

Majid Saeedi,

Corresponding Author

Majid Saeedi

[email protected]

Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran

Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Correspondence

Khadijeh Khezri, Deputy of Food and Drug Administration, Urmia University of Medical Sciences, Urmia, Iran.

Email: [email protected]

Majid Saeedi, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Email: [email protected]

Search for more papers by this author

Hassan Mohammadamini,

Hassan Mohammadamini

Khoy University of Medical Sciences, Khoy, Iran

Search for more papers by this author

Abbas Seyed Zakaryaei,

Abbas Seyed Zakaryaei

Urmia University of Medical Sciences, Urmia, Iran

Search for more papers by this author

Khadijeh Khezri,

Corresponding Author

Khadijeh Khezri

[email protected]

orcid.org/0000-0002-4671-985X

Deputy of Food and Drug Administration, Urmia University of Medical Sciences, Urmia, Iran

Correspondence

Khadijeh Khezri, Deputy of Food and Drug Administration, Urmia University of Medical Sciences, Urmia, Iran.

Email: [email protected]

Majid Saeedi, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Email: [email protected]

Search for more papers by this author

Majid Saeedi,

Corresponding Author

Majid Saeedi

[email protected]

Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran

Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Correspondence

Khadijeh Khezri, Deputy of Food and Drug Administration, Urmia University of Medical Sciences, Urmia, Iran.

Email: [email protected]

Majid Saeedi, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Email: [email protected]

Search for more papers by this author

Hassan Mohammadamini,

Hassan Mohammadamini

Khoy University of Medical Sciences, Khoy, Iran

Search for more papers by this author

Abbas Seyed Zakaryaei,

Abbas Seyed Zakaryaei

Urmia University of Medical Sciences, Urmia, Iran

Search for more papers by this author

First published: 15 June 2021

https://doi.org/10.1002/ptr.7190

Citations: 16

Share a link

Email
Wechat
Bluesky

Abstract

Today, due to the prevalence of various diseases such as the novel coronavirus (SARS-CoV-2), diabetes, central nervous system diseases, cancer, cardiovascular disorders, and so on, extensive studies have been conducted on therapeutic properties of natural and synthetic agents. A literature review on herbal medicine and commercial products in the global market showed that curcumin (Cur) has many therapeutic benefits compared to other natural ingredients. Despite the unique properties of Cur, its use in clinical trials is very limited. The poor biopharmaceutical properties of Cur such as short half-life in plasma, low bioavailability, poor absorption, rapid metabolism, very low solubility (at acidic and physiological pH), and the chemical instability in body fluids are major concerns associated with the clinical applications of Cur. Recently, nanoformulations are emerging as approaches to develop and improve the therapeutic efficacy of various drugs. Many studies have shown that Cur nanoformulations have tremendous therapeutic potential against various diseases such as SARS-CoV-2, cancer, inflammatory, osteoporosis, and so on. These nanoformulations can inhibit many diseases through several cellular and molecular mechanisms. However, successful long-term clinical results are required to confirm their safety and clinical efficacy. The present review aims to update and explain the therapeutic potential of Cur nanoformulations.

CONFLICT OF INTEREST

Authors declare that there is no conflict of interest in this study.

Open Research

DATA AVAILABILITY STATEMENT

The data for this study can be requested from the corresponding author via email.

REFERENCES

Abdolahi, M., Jafarieh, A., Sarraf, P., Sedighiyan, M., Yousefi, A., Tafakhori, A., … Djalali, M. (2019). The neuromodulatory effects of ω-3 fatty acids and nano-curcumin on the COX-2/iNOS network in migraines: A clinical trial study from gene expression to clinical symptoms. Endocrine, Metabolic & Immune Disorders-Drug Targets, 19(6), 874–884.
10.2174/1871530319666190212170140
CAS PubMed Web of Science® Google Scholar
Abdolahi, M., Tafakhori, A., Togha, M., Okhovat, A. A., Siassi, F., Eshraghian, M. R., … Djalali, M. (2017). The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients. Immunogenetics, 69(6), 371–378.
10.1007/s00251-017-0992-8
CAS PubMed Web of Science® Google Scholar
Aboali, F. A., Habib, D. A., Elbedaiwy, H. M., & Farid, R. M. (2020). Curcumin-loaded Proniosomal gel as a Biofreindly alternative for treatment of ocular inflammation: In-vitro and in-vivo assessment. International Journal of Pharmaceutics, 589, 119835.
10.1016/j.ijpharm.2020.119835
CAS PubMed Web of Science® Google Scholar
Abu-Taweel, G. M., Attia, M. F., Hussein, J., Mekawi, E. M., Galal, H. M., Ahmed, E. I., … El-Naggar, M. E. (2020). Curcumin nanoparticles have potential antioxidant effect and restore tetrahydrobiopterin levels in experimental diabetes. Biomedicine & Pharmacotherapy, 131, 110688.
10.1016/j.biopha.2020.110688
CAS PubMed Web of Science® Google Scholar
Adahoun, M. A. A., Al-Akhras, M.-A. H., Jaafar, M. S., & Bououdina, M. (2017). Enhanced anti-cancer and antimicrobial activities of curcumin nanoparticles. Artificial Cells, Nanomedicine, and Biotechnology, 45(1), 98–107.
10.3109/21691401.2015.1129628
CAS PubMed Web of Science® Google Scholar
Adusumilli, N. C., Mordorski, B., Nosanchuk, J., Friedman, J. M., & Friedman, A. J. (2021). Curcumin nanoparticles as a photoprotective adjuvant. Experimental Dermatology, 30, 705–709.
10.1111/exd.14282
CAS PubMed Web of Science® Google Scholar
Afshar, A., Aliaghaei, A., Nazarian, H., Abbaszadeh, H.-A., Naserzadeh, P., Fathabadi, F. F., … Norouzian, M. (2021). Curcumin-loaded Iron particle improvement of spermatogenesis in azoospermic mouse induced by long-term scrotal hyperthermia. Reproductive Sciences, 28(2), 371–380.
10.1007/s43032-020-00288-2
CAS PubMed Web of Science® Google Scholar
Agarwal, N. B., Jain, S., Nagpal, D., Agarwal, N. K., Mediratta, P. K., & Sharma, K. K. (2013). Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice. Fundamental & Clinical Pharmacology, 27(2), 169–172.
10.1111/j.1472-8206.2011.01002.x
CAS PubMed Web of Science® Google Scholar
Agarwal, Y., Rajinikanth, P., Ranjan, S., Tiwari, U., Balasubramnaiam, J., Pandey, P., … Deepak, P. (2021). Curcumin loaded polycaprolactone−/polyvinyl alcohol-silk fibroin based electrospun nanofibrous mat for rapid healing of diabetic wound: An in-vitro and in-vivo studies. International Journal of Biological Macromolecules, 176, 376–386.
10.1016/j.ijbiomac.2021.02.025
CAS PubMed Web of Science® Google Scholar
Agel, M. R., Baghdan, E., Pinnapireddy, S. R., Lehmann, J., Schäfer, J., & Bakowsky, U. (2019). Curcumin loaded nanoparticles as efficient photoactive formulations against gram-positive and gram-negative bacteria. Colloids and Surfaces B: Biointerfaces, 178, 460–468.
10.1016/j.colsurfb.2019.03.027
CAS PubMed Web of Science® Google Scholar
Agrahari, V., & Agrahari, V. (2018). Facilitating the translation of nanomedicines to a clinical product: Challenges and opportunities. Drug Discovery Today, 23(5), 974–991.
10.1016/j.drudis.2018.01.047
PubMed Web of Science® Google Scholar
Aguzzi, A., & O'connor, T. (2010). Protein aggregation diseases: Pathogenicity and therapeutic perspectives. Nature Reviews Drug Discovery, 9(3), 237–248.
10.1038/nrd3050
CAS PubMed Web of Science® Google Scholar
Ahmad, N., Ahmad, R., Ahmad, F. J., Ahmad, W., Alam, M. A., Amir, M., & Ali, A. (2020). Poloxamer-chitosan-based Naringenin nanoformulation used in brain targeting for the treatment of cerebral ischemia. Saudi Journal of Biological Sciences, 27(1), 500–517.
10.1016/j.sjbs.2019.11.008
CAS PubMed Web of Science® Google Scholar
Ahmad, N., Umar, S., Ashafaq, M., Akhtar, M., Iqbal, Z., Samim, M., & Ahmad, F. J. (2013). A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke. Protoplasma, 250(6), 1327–1338.
10.1007/s00709-013-0516-9
CAS PubMed Web of Science® Google Scholar
Ahmadi, M., Agah, E., Nafissi, S., Jaafari, M. R., Harirchian, M. H., Sarraf, P., … Aghamollaii, V. (2018). Safety and efficacy of nanocurcumin as add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: A pilot randomized clinical trial. Neurotherapeutics, 15(2), 430–438.
10.1007/s13311-018-0606-7
CAS PubMed Web of Science® Google Scholar
Ahn, J., Jeong, J., Lee, H., Sung, M.-J., Jung, C. H., Lee, H., … Ha, T. Y. (2017). Poly (lactic-co-glycolic acid) nanoparticles potentiate the protective effect of curcumin against bone loss in ovariectomized rats. Journal of Biomedical Nanotechnology, 13(6), 688–698.
10.1166/jbn.2017.2372
CAS Web of Science® Google Scholar
Ahsan, H., Ahad, A., Iqbal, J., & Siddiqui, W. A. (2014). Pharmacological potential of tocotrienols: A review. Nutrition & Metabolism, 11(1), 1–22.
10.1186/1743-7075-11-52
PubMed Web of Science® Google Scholar
Akhtar, F., Rizvi, M. M. A., & Kar, S. K. (2012). Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice. Biotechnology Advances, 30(1), 310–320.
10.1016/j.biotechadv.2011.05.009
CAS PubMed Web of Science® Google Scholar
Al Moubarak, A., El Joumaa, M., Slika, L., Patra, D., & Borjac, J. (2021). Curcumin-Polyallyhydrocarbon Nanocapsules potently suppress 1, 2-Dimethylhydrazine-induced colorectal Cancer in mice by inhibiting Wnt/β-catenin pathway. BioNanoScience, 11, 518–525.
10.1007/s12668-021-00842-5
Web of Science® Google Scholar
Alhusaini, A., Fadda, L., Hassan, I., Ali, H. M., Alsaadan, N., Aldowsari, N., … Alharbi, B. (2018). Liposomal curcumin attenuates the incidence of oxidative stress, inflammation, and DNA damage induced by copper sulfate in rat liver. Dose-Response, 16(3), 1559325818790869.
10.1177/1559325818790869
Web of Science® Google Scholar
Alihosseini, F., Azarmi, S., Ghaffari, S., Haghighat, S., & Sorkhabadi, S. M. R. (2016). Synergic antibacterial effect of curcumin with ampicillin; free drug solutions in comparison with SLN dispersions. Advanced Pharmaceutical Bulletin, 6(3), 461–465.
10.15171/apb.2016.060
CAS PubMed Web of Science® Google Scholar
Alippilakkotte, S., & Sreejith, L. (2018). Pectin mediated synthesis of curcumin loaded poly (lactic acid) nanocapsules for cancer treatment. Journal of Drug Delivery Science and Technology, 48, 66–74.
10.1016/j.jddst.2018.09.001
CAS Web of Science® Google Scholar
Alotaibi, B., Tousson, E., El-Masry, T. A., Altwaijry, N., & Saleh, A. (2021). Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice. Environmental Toxicology, 36(1), 105–113.
10.1002/tox.23016
CAS PubMed Web of Science® Google Scholar
Alqahtani, M. S., Alqahtani, A., Kazi, M., Ahmad, M. Z., Alahmari, A., Alsenaidy, M. A., & Syed, R. (2020). Wound-healing potential of curcumin loaded lignin nanoparticles. Journal of Drug Delivery Science and Technology, 60, 102020.
10.1016/j.jddst.2020.102020
CAS Web of Science® Google Scholar
Altunay, N., Elik, A., & Gürkan, R. (2020). Preparation and application of alcohol based deep eutectic solvents for extraction of curcumin in food samples prior to its spectrophotometric determination. Food Chemistry, 310, 125933.
10.1016/j.foodchem.2019.125933
CAS PubMed Web of Science® Google Scholar
Alyoussef, A., El-Gogary, R. I., Ahmed, R. F., Farid, O. A. A., Bakeer, R. M., & Nasr, M. (2021). The beneficial activity of curcumin and resveratrol loaded in nanoemulgel for healing of burn-induced wounds. Journal of Drug Delivery Science and Technology, 62, 102360.
10.1016/j.jddst.2021.102360
CAS Web of Science® Google Scholar
Amrouche, T., Noll, K. S., Wang, Y., Huang, Q., & Chikindas, M. L. (2010). Antibacterial activity of subtilosin alone and combined with curcumin, poly-lysine and zinc lactate against Listeria monocytogenes strains. Probiotics and Antimicrobial Proteins, 2(4), 250–257.
10.1007/s12602-010-9042-7
CAS PubMed Web of Science® Google Scholar
Andrabi, S. M., Majumder, S., Gupta, K. C., & Kumar, A. (2020). Dextran based amphiphilic nano-hybrid hydrogel system incorporated with curcumin and cerium oxide nanoparticles for wound healing. Colloids and Surfaces B: Biointerfaces, 195, 111263.
10.1016/j.colsurfb.2020.111263
CAS PubMed Web of Science® Google Scholar
Andrew, R., & Izzo, A. A. (2017). Principles of pharmacological research of nutraceuticals. Hoboken, NJ: Wiley Online Library.
10.1111/bph.13779
Google Scholar
Antony, B., Merina, B., Iyer, V., Judy, N., Lennertz, K., & Joyal, S. (2008). A pilot cross-over study to evaluate human oral bioavailability of BCM-95® CG (Biocurcumax™), a novel bioenhanced preparation of curcumin. Indian Journal of Pharmaceutical Sciences, 70(4), 445–449.
10.4103/0250-474X.44591
CAS PubMed Web of Science® Google Scholar
Araiza-Calahorra, A., Akhtar, M., & Sarkar, A. (2018). Recent advances in emulsion-based delivery approaches for curcumin: From encapsulation to bioaccessibility. Trends in Food Science & Technology, 71, 155–169.
10.1016/j.tifs.2017.11.009
CAS Web of Science® Google Scholar
Arora, R., Kuhad, A., Kaur, I., & Chopra, K. (2015). Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in rats. European Journal of Pain, 19(7), 940–952.
10.1002/ejp.620
CAS PubMed Web of Science® Google Scholar
Arya, G., Das, M., & Sahoo, S. K. (2018). Evaluation of curcumin loaded chitosan/PEG blended PLGA nanoparticles for effective treatment of pancreatic cancer. Biomedicine & Pharmacotherapy, 102, 555–566.
10.1016/j.biopha.2018.03.101
CAS PubMed Web of Science® Google Scholar
Asher, G. N., Xie, Y., Moaddel, R., Sanghvi, M., Dossou, K. S., Kashuba, A. D., … Hawke, R. L. (2017). Randomized pharmacokinetic crossover study comparing 2 curcumin preparations in plasma and rectal tissue of healthy human volunteers. The Journal of Clinical Pharmacology, 57(2), 185–193.
10.1002/jcph.806
CAS PubMed Web of Science® Google Scholar
Ashkbar, A., Rezaei, F., Attari, F., & Ashkevarian, S. (2020). Treatment of breast cancer in vivo by dual photodynamic and photothermal approaches with the aid of curcumin photosensitizer and magnetic nanoparticles. Scientific Reports, 10(1), 1–12.
10.1038/s41598-020-78241-1
PubMed Web of Science® Google Scholar
Azandeh, S. S., Abbaspour, M., Khodadadi, A., Khorsandi, L., Orazizadeh, M., & Heidari-Moghadam, A. (2017). Anticancer activity of curcumin-loaded PLGA nanoparticles on PC3 prostate cancer cells. Iranian Journal of Pharmaceutical Research, 16(3), 868–879.
CAS PubMed Web of Science® Google Scholar
Bagheri, M., Fens, M. H., Kleijn, T. G., Capomaccio, R. B., Mehn, D., Krawczyk, P. M., … van Kronenburg, N. C. (2021). In vitro and in vivo studies on HPMA-based polymeric micelles loaded with Curcumin. Molecular Pharmaceutics, 18, 1247–1263.
10.1021/acs.molpharmaceut.0c01114
CAS PubMed Web of Science® Google Scholar
Ban, C., Jo, M., Park, Y. H., Kim, J. H., Han, J. Y., Lee, K. W., … Choi, Y. J. (2020). Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles. Food Chemistry, 302, 125328.
10.1016/j.foodchem.2019.125328
CAS PubMed Web of Science® Google Scholar
Bapat, P., Ghadi, R., Chaudhari, D., Katiyar, S. S., & Jain, S. (2019). Tocophersolan stabilized lipid nanocapsules with high drug loading to improve the permeability and oral bioavailability of curcumin. International Journal of Pharmaceutics, 560, 219–227.
10.1016/j.ijpharm.2019.02.013
CAS PubMed Web of Science® Google Scholar
Barbara, R., Belletti, D., Pederzoli, F., Masoni, M., Keller, J., Ballestrazzi, A., … Grabrucker, A. M. (2017). Novel Curcumin loaded nanoparticles engineered for blood-brain barrier crossing and able to disrupt Abeta aggregates. International Journal of Pharmaceutics, 526(1–2), 413–424.
10.1016/j.ijpharm.2017.05.015
CAS PubMed Web of Science® Google Scholar
Basit, H. M., Mohd Amin, M. C. I., Ng, S.-F., Katas, H., Shah, S. U., & Khan, N. R. (2020). Formulation and evaluation of microwave-modified chitosan-Curcumin nanoparticles—A promising Nanomaterials platform for skin tissue regeneration applications following burn wounds. Polymers, 12(11), 2608.
10.3390/polym12112608
CAS PubMed Web of Science® Google Scholar
Basniwal, R. K., Buttar, H. S., Jain, V., & Jain, N. (2011). Curcumin nanoparticles: Preparation, characterization, and antimicrobial study. Journal of Agricultural and Food Chemistry, 59(5), 2056–2061.
10.1021/jf104402t
CAS PubMed Web of Science® Google Scholar
Beloqui, A., Memvanga, P. B., Coco, R., Reimondez-Troitino, S., Alhouayek, M., Muccioli, G. G., … Préat, V. (2016). A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease. Colloids and Surfaces B: Biointerfaces, 143, 327–335.
10.1016/j.colsurfb.2016.03.038
CAS PubMed Web of Science® Google Scholar
Berner, M. D., Sura, M. E., Alves, B. N., & Hunter, K. W., Jr. (2005). IFN-γ primes macrophages for enhanced TNF-α expression in response to stimulatory and non-stimulatory amounts of microparticulate β-glucan. Immunology Letters, 98(1), 115–122.
10.1016/j.imlet.2004.10.020
CAS PubMed Web of Science® Google Scholar
Bhuiyan, F. R., Howlader, S., Raihan, T., & Hasan, M. (2020). Plants metabolites: Possibility of natural therapeutics against the COVID-19 pandemic. Frontiers in Medicine, 7, 444.
10.3389/fmed.2020.00444
PubMed Web of Science® Google Scholar
Bhutta, Z. A., Ashar, A., Mahfooz, A., Khan, J. A., Saleem, M. I., Rashid, A., … Shoaib, M. (2021). Enhanced wound healing activity of nano ZnO and nano Curcuma longa in third-degree burn. Applied Nanoscience, 11, 1267–1278.
10.1007/s13204-020-01661-y
CAS Web of Science® Google Scholar
Boarescu, P.-M., Chirilă, I., Bulboacă, A. E., Bocșan, I. C., Pop, R. M., Gheban, D., & Bolboacă, S. D. (2019). Effects of curcumin nanoparticles in isoproterenol-induced myocardial infarction. Oxidative Medicine and Cellular Longevity, 2019, 1–13.
10.1155/2019/7847142
Web of Science® Google Scholar
Bocate, K. P., Reis, G. F., de Souza, P. C., Junior, A. G. O., Durán, N., Nakazato, G., … Panagio, L. A. (2019). Antifungal activity of silver nanoparticles and simvastatin against toxigenic species of Aspergillus. International Journal of Food Microbiology, 291, 79–86.
10.1016/j.ijfoodmicro.2018.11.012
CAS PubMed Web of Science® Google Scholar
Bollimpelli, V. S., Kumar, P., Kumari, S., & Kondapi, A. K. (2016). Neuroprotective effect of curcumin-loaded lactoferrin nano particles against rotenone induced neurotoxicity. Neurochemistry International, 95, 37–45.
10.1016/j.neuint.2016.01.006
CAS PubMed Web of Science® Google Scholar
Bonfim, C. M. d., Monteleoni, L. F., Calmon, M. d. F., Cândido, N. M., Provazzi, P. J. S., Lino, V. d. S., … Quintana, S. M. (2020). Antiviral activity of curcumin-nanoemulsion associated with photodynamic therapy in vulvar cell lines transducing different variants of HPV-16. Artificial Cells, Nanomedicine, and Biotechnology, 48(1), 515–524.
10.1080/21691401.2020.1725023
PubMed Web of Science® Google Scholar
Brasch, J., Beck-Jendroschek, V., Walther, G., & Rubbel, D. (2020). Clinical isolates of Trichophyton rubrum are completely inhibited by photochemical treatment with a γ-cyclodextrin formulation of curcuminoids. Mycoses, 63(4), 369–375.
10.1111/myc.13051
CAS PubMed Web of Science® Google Scholar
Briot, K., Geusens, P., Bultink, I. E., Lems, W., & Roux, C. (2017). Inflammatory diseases and bone fragility. Osteoporosis International, 28(12), 3301–3314.
10.1007/s00198-017-4189-7
CAS PubMed Web of Science® Google Scholar
Briskey, D., Sax, A., Mallard, A., & Rao, A. (2019). Increased bioavailability of curcumin using a novel dispersion technology system (LipiSperse®). European Journal of Nutrition, 58(5), 2087–2097.
10.1007/s00394-018-1766-2
CAS PubMed Web of Science® Google Scholar
Brownlee, W. J., Hardy, T. A., Fazekas, F., & Miller, D. H. (2017). Diagnosis of multiple sclerosis: Progress and challenges. The Lancet, 389(10076), 1336–1346.
10.1016/S0140-6736(16)30959-X
PubMed Web of Science® Google Scholar
Bugli, F., Cacaci, M., Palmieri, V., Di Santo, R., Torelli, R., Ciasca, G., … Sanguinetti, M. (2018). Curcumin-loaded graphene oxide flakes as an effective antibacterial system against methicillin-resistant Staphylococcus aureus. Interface Focus, 8(3), 20170059.
10.1098/rsfs.2017.0059
CAS PubMed Web of Science® Google Scholar
Bulboacă, A. E., Bolboacă, S. D., Bulboacă, A. C., Porfire, A. S., Tefas, L. R., Suciu, Ş. M., … Stănescu, I. C. (2019). Liposomal curcumin enhances the effect of naproxen in a rat model of migraine. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 25, 5087–5097.
10.12659/MSM.915607
CAS PubMed Web of Science® Google Scholar
Bulboacă, A. E., Bolboacă, S. D., Stănescu, I. C., Sfrângeu, C. A., Porfire, A., Tefas, L., & Bulboacă, A. C. (2018). The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats. International Journal of Nanomedicine, 13, 3093–3103.
10.2147/IJN.S162087
CAS PubMed Web of Science® Google Scholar
Busari, Z. A., Dauda, K. A., Morenikeji, O. A., Afolayan, F., Oyeyemi, O. T., Meena, J., … Panda, A. K. (2017). Antiplasmodial activity and toxicological assessment of curcumin PLGA-encapsulated nanoparticles. Frontiers in Pharmacology, 8, 622.
10.3389/fphar.2017.00622
PubMed Web of Science® Google Scholar
Chaniyilparampu, R. N., Nair, A. K., Parthasarathy, K., Gokaraju, G. R., Gokaraju, R. R., Bhuphatiraju, K., … Somashekara, N. (2014). Curcuminoids and its metabolites for the application in allergic ocular/nasal conditions. Google Patents.
Google Scholar
Chaubey, P., Mishra, B., Mudavath, S. L., Patel, R. R., Chaurasia, S., Sundar, S., … Monteiro, M. (2018). Mannose-conjugated curcumin-chitosan nanoparticles: Efficacy and toxicity assessments against Leishmania donovani. International Journal of Biological Macromolecules, 111, 109–120.
10.1016/j.ijbiomac.2017.12.143
CAS PubMed Web of Science® Google Scholar
Chauhan, S., Jaggi, M., & Yallapu, M. M. (2017). Magnetic nanoparticle formulations, methods for making such formulations, and methods for their use. Google Patents.
Google Scholar
Chegeni, M., Rozbahani, Z. S., Ghasemian, M., & Mehri, M. (2020). Synthesis and application of the calcium alginate/SWCNT-Gl as a bio-nanocomposite for the curcumin delivery. International Journal of Biological Macromolecules, 156, 504–513.
10.1016/j.ijbiomac.2020.04.068
CAS PubMed Web of Science® Google Scholar
Chen, P., Zhang, H., Cheng, S., Zhai, G., & Shen, C. (2016). Development of curcumin loaded nanostructured lipid carrier based thermosensitive in situ gel for dermal delivery. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 506, 356–362.
10.1016/j.colsurfa.2016.06.054
CAS Web of Science® Google Scholar
Chen, X.-P., Li, Y., Zhang, Y., & Li, G.-W. (2019). Formulation, characterization and evaluation of Curcumin-loaded PLGA-TPGS nanoparticles for liver Cancer treatment. Drug Design, Development and Therapy, 13, 3569–3578.
10.2147/DDDT.S211748
CAS PubMed Web of Science® Google Scholar
Chen, Y., Lu, Y., Lee, R. J., & Xiang, G. (2020). Nano encapsulated curcumin: And its potential for biomedical applications. International Journal of Nanomedicine, 15, 3099–3120.
10.2147/IJN.S210320
CAS PubMed Web of Science® Google Scholar
Cheng, C.-S., Liu, T.-P., Chien, F.-C., Mou, C.-Y., Wu, S.-H., & Chen, Y.-P. (2019). Codelivery of plasmid and curcumin with mesoporous silica nanoparticles for promoting neurite outgrowth. ACS Applied Materials & Interfaces, 11(17), 15322–15331.
10.1021/acsami.9b02797
CAS PubMed Web of Science® Google Scholar
Cheng, Y.-H., Ko, Y.-C., Chang, Y.-F., Huang, S.-H., & Liu, C. J.-L. (2019). Thermosensitive chitosan-gelatin-based hydrogel containing curcumin-loaded nanoparticles and latanoprost as a dual-drug delivery system for glaucoma treatment. Experimental Eye Research, 179, 179–187.
10.1016/j.exer.2018.11.017
CAS PubMed Web of Science® Google Scholar
Chiaoprakobkij, N., Suwanmajo, T., Sanchavanakit, N., & Phisalaphong, M. (2020). Curcumin-loaded bacterial cellulose/alginate/gelatin as a multifunctional biopolymer composite film. Molecules, 25(17), 3800.
10.3390/molecules25173800
CAS PubMed Web of Science® Google Scholar
Chibhabha, F., Yang, Y., Ying, K., Jia, F., Zhang, Q., Ullah, S., … Li, F. (2020). Non-invasive optical imaging of retinal Aβ plaques using curcumin loaded polymeric micelles in APP swe/PS1 ΔE9 transgenic mice for the diagnosis of Alzheimer's disease. Journal of Materials Chemistry B, 8(33), 7438–7452.
10.1039/D0TB01101K
PubMed Web of Science® Google Scholar
Ciofu, O., Rojo-Molinero, E., Macià, M. D., & Oliver, A. (2017). Antibiotic treatment of biofilm infections. APMIS, 125(4), 304–319.
10.1111/apm.12673
PubMed Web of Science® Google Scholar
Clinton, A., & Carter, T. (2015). Chronic wound biofilms: Pathogenesis and potential therapies. Laboratory Medicine, 46(4), 277–284.
10.1309/LMBNSWKUI4JPN7SO
PubMed Web of Science® Google Scholar
Cui, Y., Zhang, M., Zeng, F., Jin, H., Xu, Q., & Huang, Y. (2016). Dual-targeting magnetic PLGA nanoparticles for codelivery of paclitaxel and curcumin for brain tumor therapy. ACS Applied Materials & Interfaces, 8(47), 32159–32169.
10.1021/acsami.6b10175
CAS PubMed Web of Science® Google Scholar
Cuomo, J., Appendino, G., Dern, A. S., Schneider, E., McKinnon, T. P., Brown, M. J., … Dixon, B. M. (2011). Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. Journal of Natural Products, 74(4), 664–669.
10.1021/np1007262
CAS PubMed Web of Science® Google Scholar
da Silva, A. C., de Freitas Santos, P. D., do Prado Silva, J. T., Leimann, F. V., Bracht, L., & Gonçalves, O. H. (2018). Impact of curcumin nanoformulation on its antimicrobial activity. Trends in Food Science & Technology, 72, 74–82.
10.1016/j.tifs.2017.12.004
Web of Science® Google Scholar
Dang, L. H., Nguyen, T. H., Tran, H. L. B., Doan, V. N., & Tran, N. Q. (2018). Injectable nanocurcumin-formulated chitosan-g-pluronic hydrogel exhibiting a great potential for burn treatment. Journal of Healthcare Engineering, 2018, 14. https://doi.org/10.1155/2018/5754890.
10.1155/2018/5754890
Web of Science® Google Scholar
Date, A. A., Joshi, M. D., & Patravale, V. B. (2007). Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles. Advanced Drug Delivery Reviews, 59(6), 505–521.
10.1016/j.addr.2007.04.009
CAS PubMed Web of Science® Google Scholar
Davis, B. M., Pahlitzsch, M., Guo, L., Balendra, S., Shah, P., Ravindran, N., … Hamze, H. (2018). Topical curcumin nanocarriers are neuroprotective in eye disease. Scientific Reports, 8(1), 1–13.
10.1038/s41598-018-29393-8
PubMed Web of Science® Google Scholar
de Carvalho, F. B., de Gomes, M. G., Savall, A. S. P., Fidelis, E. M., Pinton, S., Ribeiro, A. C. F., … Haas, S. E. (2021). Evaluation of curcumin-loaded polymeric nanocapsules with different coatings in chick embryo model: Influence on angiogenesis, teratogenesis and oxidative stress. Pharmacological Reports, 73, 563–573.
10.1007/s43440-021-00218-2
PubMed Web of Science® Google Scholar
Del Prado-Audelo, M., Magaña, J., Mejía-Contreras, B., Borbolla-Jiménez, F., Giraldo-Gomez, D., Piña-Barba, M., … Leyva-Gómez, G. (2019). In vitro cell uptake evaluation of curcumin-loaded PCL/F68 nanoparticles for potential application in neuronal diseases. Journal of Drug Delivery Science and Technology, 52, 905–914.
10.1016/j.jddst.2019.05.042
CAS Web of Science® Google Scholar
Delavarian, Z., Pakfetrat, A., Ghazi, A., Jaafari, M. R., Homaei Shandiz, F., Dalirsani, Z., … Rahimi, H. R. (2019). Oral administration of nanomicelle curcumin in the prevention of radiotherapy-induced mucositis in head and neck cancers. Special Care in Dentistry, 39(2), 166–172.
10.1111/scd.12358
PubMed Web of Science® Google Scholar
Derjaguin, B., & Landau, L. (1993). Theory of the stability of strongly charged lyophobic sols and of the adhesion of strongly charged particles in solutions of electrolytes. Progress in Surface Science, 43(1–4), 30–59.
10.1016/0079-6816(93)90013-L
Web of Science® Google Scholar
Dhavamani, S., & Lokesh, B. (2019). Co-delivery of curcumin and fish oil in phospholipid nanoemulsions attenuates motor impairments and neuro-inflammation in MPTP induced Parkinson's disease rat model. The FASEB Journal, 33(S1), lb59-lb59.
10.1096/fasebj.2019.33.1_supplement.lb59
Google Scholar
Dhivya, R., Ranjani, J., Bowen, P. K., Rajendhran, J., Mayandi, J., & Annaraj, J. (2017). Biocompatible curcumin loaded PMMA-PEG/ZnO nanocomposite induce apoptosis and cytotoxicity in human gastric cancer cells. Materials Science and Engineering: C, 80, 59–68.
10.1016/j.msec.2017.05.128
CAS PubMed Web of Science® Google Scholar
Dhivya, R., Ranjani, J., Rajendhran, J., Mayandi, J., & Annaraj, J. (2018). Enhancing the anti-gastric cancer activity of curcumin with biocompatible and pH sensitive PMMA-AA/ZnO nanoparticles. Materials Science and Engineering: C, 82, 182–189.
10.1016/j.msec.2017.08.058
CAS PubMed Web of Science® Google Scholar
Dhule, S. S., Penfornis, P., Frazier, T., Walker, R., Feldman, J., Tan, G., … Pochampally, R. (2012). Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma. Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 440–451.
10.1016/j.nano.2011.07.011
CAS PubMed Web of Science® Google Scholar
Di Martino, R. M. C., Luppi, B., Bisi, A., Gobbi, S., Rampa, A., Abruzzo, A., & Belluti, F. (2017). Recent progress on curcumin-based therapeutics: A patent review (2012-2016). Part I: Curcumin. Expert Opinion on Therapeutic Patents, 27(5), 579–590.
10.1080/13543776.2017.1276566
CAS PubMed Web of Science® Google Scholar
Di Meo, F., Filosa, S., Madonna, M., Giello, G., Di Pardo, A., Maglione, V., … Crispi, S. (2019). Curcumin C3 complex®/Bioperine® has antineoplastic activity in mesothelioma: An in vitro and in vivo analysis. Journal of Experimental & Clinical Cancer Research, 38(1), 1–11.
10.1186/s13046-019-1368-8
CAS PubMed Web of Science® Google Scholar
Dilnessa, T., & Zeleke, H. (2017). Cell culture, cytopathic effect and immunofluorescence diagnosis of viral infection. Journal of Microbiology and Modern Techniques, 2, 102–110.
Google Scholar
Djalali, M., Abdolahi, M., Hosseini, R., Miraghajani, M., Mohammadi, H., & Djalali, M. (2020). The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial. Complementary Therapies in Clinical Practice, 41, 101256.
10.1016/j.ctcp.2020.101256
PubMed Web of Science® Google Scholar
Djalali, M., Djalali, M., Abdolahi, M., Mohammadi, H., Heidari, H., Hosseini, S., & Sadeghizadeh, M. (2020). The effect of Nano-Curcumin supplementation on Pentraxin 3 gene expression and serum level in migraine patients. Reports of Biochemistry & Molecular Biology, 9(1), 1–7.
10.29252/rbmb.9.1.1
CAS PubMed Web of Science® Google Scholar
Djiokeng Paka, G., Doggui, S., Zaghmi, A., Safar, R., Dao, L., Reisch, A., … Ramassamy, C. (2016). Neuronal uptake and neuroprotective properties of curcumin-loaded nanoparticles on SK-N-SH cell line: Role of poly (lactide-co-glycolide) polymeric matrix composition. Molecular Pharmaceutics, 13(2), 391–403.
10.1021/acs.molpharmaceut.5b00611
CAS PubMed Web of Science® Google Scholar
Dolatabadi, S., Karimi, M., Nasirizadeh, S., Hatamipour, M., Golmohammadzadeh, S., & Jaafari, M. R. (2021). Preparation, characterization and in vivo pharmacokinetic evaluation of curcuminoids-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). Journal of Drug Delivery Science and Technology, 62, 102352.
10.1016/j.jddst.2021.102352
CAS Web of Science® Google Scholar
Dolati, S., Aghebati-Maleki, L., Ahmadi, M., Marofi, F., Babaloo, Z., Ayramloo, H., … Younesi, V. (2018). Nanocurcumin restores aberrant miRNA expression profile in multiple sclerosis, randomized, double-blind, placebo-controlled trial. Journal of Cellular Physiology, 233(7), 5222–5230.
10.1002/jcp.26301
CAS PubMed Web of Science® Google Scholar
Dolati, S., Ahmadi, M., Aghebti-Maleki, L., Nikmaram, A., Marofi, F., Rikhtegar, R., … Yousefi, M. (2018). Nanocurcumin is a potential novel therapy for multiple sclerosis by influencing inflammatory mediators. Pharmacological Reports, 70(6), 1158–1167.
10.1016/j.pharep.2018.05.008
CAS PubMed Web of Science® Google Scholar
Dolati, S., Ahmadi, M., Rikhtegar, R., Babaloo, Z., Ayromlou, H., Aghebati-Maleki, L., … Yousefi, M. (2018). Changes in Th17 cells function after nanocurcumin use to treat multiple sclerosis. International Immunopharmacology, 61, 74–81.
10.1016/j.intimp.2018.05.018
CAS PubMed Web of Science® Google Scholar
Dolati, S., Babaloo, Z., Ayromlou, H., Ahmadi, M., Rikhtegar, R., Rostamzadeh, D., … Younesi, V. (2019). Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis. Journal of Neuroimmunology, 327, 15–21.
10.1016/j.jneuroim.2019.01.007
CAS PubMed Web of Science® Google Scholar
Dong, J., Tao, L., Abourehab, M. A., & Hussain, Z. (2018). Design and development of novel hyaluronate-modified nanoparticles for combo-delivery of curcumin and alendronate: Fabrication, characterization, and cellular and molecular evidences of enhanced bone regeneration. International Journal of Biological Macromolecules, 116, 1268–1281.
10.1016/j.ijbiomac.2018.05.116
CAS PubMed Web of Science® Google Scholar
dos Santos, R. B., Nakama, K. A., Pacheco, C. O., de Gomes, M. G., de Souza, J. F., de Souza Pinto, A. C., … Fajardo, A. R. (2020). Curcumin-loaded nanocapsules: Influence of surface characteristics on technological parameters and potential antimalarial activity. Materials Science and Engineering: C, 118, 111356.
10.1016/j.msec.2020.111356
PubMed Web of Science® Google Scholar
Doyle, K. P., Simon, R. P., & Stenzel-Poore, M. P. (2008). Mechanisms of ischemic brain damage. Neuropharmacology, 55(3), 310–318.
10.1016/j.neuropharm.2008.01.005
CAS PubMed Web of Science® Google Scholar
Draganski, A., Tar, M. T., Villegas, G., Friedman, J. M., & Davies, K. P. (2018). Topically applied curcumin-loaded nanoparticles treat erectile dysfunction in a rat model of type-2 diabetes. The Journal of Sexual Medicine, 15(5), 645–653.
10.1016/j.jsxm.2018.03.009
PubMed Web of Science® Google Scholar
Edvinsson, L., Villalón, C. M., & MaassenVanDenBrink, A. (2012). Basic mechanisms of migraine and its acute treatment. Pharmacology & Therapeutics, 136(3), 319–333.
10.1016/j.pharmthera.2012.08.011
CAS PubMed Web of Science® Google Scholar
Eftekhari, A., Alipour, M., Chodari, L., Maleki Dizaj, S., Ardalan, M. R., Samiei, M., … Khalilov, R. (2021). A comprehensive review of detection methods for SARS-CoV-2. Microorganisms, 9(2), 232.
10.3390/microorganisms9020232
CAS PubMed Web of Science® Google Scholar
El-Halim, S. M. A., Mamdouh, M. A., El-Haddad, A. E., & Soliman, S. M. (2020). Fabrication of anti-HSV-1 Curcumin stabilized nanostructured Proniosomal gel: Molecular docking studies on thymidine kinase proteins. Scientia Pharmaceutica, 88(1), 9.
10.3390/scipharm88010009
CAS Web of Science® Google Scholar
El-Shafey, A. A., Hegab, M. H., Seliem, M. M., Barakat, A. M., Mostafa, N. E., Abdel-Maksoud, H. A., & Abdelhameed, R. M. (2020). Curcumin@ metal organic frameworks nano-composite for treatment of chronic toxoplasmosis. Journal of Materials Science: Materials in Medicine, 31(11), 1–13.
10.1007/s10856-020-06429-y
Web of Science® Google Scholar
Ensign, L., Cone, R., & Hanes, J. (2017). Nanoparticle formulations with enhanced mucosal penetration. Google Patents.
Google Scholar
Fahimirad, S., Abtahi, H., Satei, P., Ghaznavi-Rad, E., Moslehi, M., & Ganji, A. (2021). Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles. Carbohydrate Polymers, 259, 117640.
10.1016/j.carbpol.2021.117640
CAS PubMed Web of Science® Google Scholar
Fan, S., Zheng, Y., Liu, X., Fang, W., Chen, X., Liao, W., … Ma, Q. (2018). Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease. Drug Delivery, 25(1), 1091–1102.
10.1080/10717544.2018.1461955
CAS PubMed Web of Science® Google Scholar
Fan, Z., Li, J., Liu, J., Jiao, H., & Liu, B. (2018). Anti-inflammation and joint lubrication dual effects of a novel hyaluronic acid/curcumin nanomicelle improve the efficacy of rheumatoid arthritis therapy. ACS Applied Materials & Interfaces, 10(28), 23595–23604.
10.1021/acsami.8b06236
CAS PubMed Web of Science® Google Scholar
Farjadian, F., Ghasemi, A., Gohari, O., Roointan, A., Karimi, M., & Hamblin, M. R. (2019). Nanopharmaceuticals and nanomedicines currently on the market: Challenges and opportunities. Nanomedicine, 14(1), 93–126.
10.2217/nnm-2018-0120
CAS PubMed Web of Science® Google Scholar
Fornaguera, C., & García-Celma, M. J. (2017). Personalized nanomedicine: A revolution at the nanoscale. Journal of Personalized Medicine, 7(4), 12.
10.3390/jpm7040012
PubMed Web of Science® Google Scholar
Ganesan, P., Kim, B., Ramalingam, P., Karthivashan, G., Revuri, V., Park, S., … Choi, D.-K. (2019). Antineuroinflammatory activities and neurotoxicological assessment of curcumin loaded solid lipid nanoparticles on LPS-stimulated BV-2 microglia cell models. Molecules, 24(6), 1170.
10.3390/molecules24061170
PubMed Web of Science® Google Scholar
Ganguly, R., Kumar, S., Kunwar, A., Nath, S., Sarma, H., Tripathi, A., … Melo, J. (2020). Structural and therapeutic properties of curcumin solubilized pluronic F127 micellar solutions and hydrogels. Journal of Molecular Liquids, 314, 113591.
10.1016/j.molliq.2020.113591
CAS Web of Science® Google Scholar
Ganguly, R., Kunwar, A., Dutta, B., Kumar, S., Barick, K., Ballal, A., … Hassan, P. (2017). Heat-induced solubilization of curcumin in kinetically stable pluronic P123 micelles and vesicles: An exploit of slow dynamics of the micellar restructuring processes in the aqueous pluronic system. Colloids and Surfaces B: Biointerfaces, 152, 176–182.
10.1016/j.colsurfb.2017.01.023
CAS PubMed Web of Science® Google Scholar
Gao, C., Wang, Y., Sun, J., Han, Y., Gong, W., Li, Y., … Li, Z. (2020). Neuronal mitochondria-targeted delivery of curcumin by biomimetic engineered nanosystems in Alzheimer's disease mice. Acta Biomaterialia, 108, 285–299.
10.1016/j.actbio.2020.03.029
CAS PubMed Web of Science® Google Scholar
Gao, Q., Wang, Z., Liu, Z., Li, X., Zhang, Y., Zhang, Z., & Cen, S. (2014). A cell-based high-throughput approach to identify inhibitors of influenza a virus. Acta Pharmaceutica Sinica B, 4(4), 301–306.
10.1016/j.apsb.2014.06.005
PubMed Web of Science® Google Scholar
Gaware, S. A., Rokade, K. A., & Kale, S. (2019). Silica-chitosan nanocomposite mediated pH-sensitive drug delivery. Journal of Drug Delivery Science and Technology, 49, 345–351.
10.1016/j.jddst.2018.11.022
CAS Web of Science® Google Scholar
Gawde, K. A., Sau, S., Tatiparti, K., Kashaw, S. K., Mehrmohammadi, M., Azmi, A. S., & Iyer, A. K. (2018). Paclitaxel and di-fluorinated curcumin loaded in albumin nanoparticles for targeted synergistic combination therapy of ovarian and cervical cancers. Colloids and Surfaces B: Biointerfaces, 167, 8–19.
10.1016/j.colsurfb.2018.03.046
CAS PubMed Web of Science® Google Scholar
Gelderblom, H. R. (1996). Structure and classification of viruses Medical Microbiology ( 4th ed.). Galveston: University of Texas Medical Branch.
Google Scholar
Geng, Y., Dalhaimer, P., Cai, S., Tsai, R., Tewari, M., Minko, T., & Discher, D. E. (2007). Shape effects of filaments versus spherical particles in flow and drug delivery. Nature Nanotechnology, 2(4), 249–255.
10.1038/nnano.2007.70
CAS PubMed Web of Science® Google Scholar
Gera, M., Sharma, N., Ghosh, M., Huynh, D. L., Lee, S. J., Min, T., … Jeong, D. K. (2017). Nanoformulations of curcumin: An emerging paradigm for improved remedial application. Oncotarget, 8(39), 66680–66698.
10.18632/oncotarget.19164
PubMed Google Scholar
Ghaee, A., Bagheri-Khoulenjani, S., Afshar, H. A., & Bogheiri, H. (2019). Biomimetic nanocomposite scaffolds based on surface modified PCL-nanofibers containing curcumin embedded in chitosan/gelatin for skin regeneration. Composites Part B: Engineering, 177, 107339.
10.1016/j.compositesb.2019.107339
CAS Web of Science® Google Scholar
Ghaffari, S., Alihosseini, F., Sorkhabadi, S. M. R., Bidgoli, S. A., Mousavi, S. E., Haghighat, S., … Kianvash, N. (2018). Nanotechnology in wound healing; semisolid dosage forms containing curcumin-ampicillin solid lipid nanoparticles, in-vitro, ex-vivo and in-vivo characteristics. Advanced Pharmaceutical Bulletin, 8(3), 395–400.
10.15171/apb.2018.046
CAS PubMed Web of Science® Google Scholar
Ghosh, A., Banerjee, T., Bhandary, S., & Surolia, A. (2014). Formulation of nanotized curcumin and demonstration of its antimalarial efficacy. International Journal of Nanomedicine, 9, 5373.
10.2147/IJN.S62756
PubMed Web of Science® Google Scholar
Giacomeli, R., Izoton, J. C., Dos Santos, R. B., Boeira, S. P., Jesse, C. R., & Haas, S. E. (2019). Neuroprotective effects of curcumin lipid-core nanocapsules in a model Alzheimer's disease induced by β-amyloid 1-42 peptide in aged female mice. Brain Research, 1721, 146325.
10.1016/j.brainres.2019.146325
CAS PubMed Web of Science® Google Scholar
Gil, A. (2002). Polyunsaturated fatty acids and inflammatory diseases. Biomedicine & Pharmacotherapy, 56(8), 388–396.
10.1016/S0753-3322(02)00256-1
CAS PubMed Web of Science® Google Scholar
Gómez-Estaca, J., Balaguer, M., López-Carballo, G., Gavara, R., & Hernández-Muñoz, P. (2017). Improving antioxidant and antimicrobial properties of curcumin by means of encapsulation in gelatin through electrohydrodynamic atomization. Food Hydrocolloids, 70, 313–320.
10.1016/j.foodhyd.2017.04.019
CAS Web of Science® Google Scholar
Gompelman, M., van Asten, S. A., & Peters, E. J. (2016). Update on the role of infection and biofilms in wound healing: Pathophysiology and treatment. Plastic and Reconstructive Surgery, 138(3S), 61S–70S.
10.1097/PRS.0000000000002679
CAS PubMed Web of Science® Google Scholar
Gopal, J., Muthu, M., & Chun, S.-C. (2016). Water soluble nanocurcumin extracted from turmeric challenging the microflora from human oral cavity. Food Chemistry, 211, 903–909.
10.1016/j.foodchem.2016.05.140
CAS PubMed Web of Science® Google Scholar
Gopi, S., Jacob, J., Varma, K., Jude, S., Amalraj, A., Arundhathy, C., … Kunnumakkara, A. B. (2017). Comparative oral absorption of curcumin in a natural turmeric matrix with two other curcumin formulations: An open-label parallel-arm study. Phytotherapy Research, 31(12), 1883–1891.
10.1002/ptr.5931
CAS PubMed Web of Science® Google Scholar
Gopinath, D., Ahmed, M. R., Gomathi, K., Chitra, K., Sehgal, P., & Jayakumar, R. (2004). Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials, 25(10), 1911–1917.
10.1016/S0142-9612(03)00625-2
CAS PubMed Web of Science® Google Scholar
Gorji, A., Straub, H., & Speckmann, E.-J. (2005). Epilepsy surgery: Perioperative investigations of intractable epilepsy. Anatomy and Embryology, 210(5–6), 525–537.
10.1007/s00429-005-0043-3
CAS PubMed Google Scholar
Gota, V. S., Maru, G. B., Soni, T. G., Gandhi, T. R., Kochar, N., & Agarwal, M. G. (2010). Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. Journal of Agricultural and Food Chemistry, 58(4), 2095–2099.
10.1021/jf9024807
CAS PubMed Web of Science® Google Scholar
Gratton, S. E., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008). The effect of particle design on cellular internalization pathways. Proceedings of the National Academy of Sciences, 105(33), 11613–11618.
10.1073/pnas.0801763105
CAS PubMed Web of Science® Google Scholar
Guo, R., Lan, Y., Xue, W., Cheng, B., Zhang, Y., Wang, C., & Ramakrishna, S. (2017). Collagen-cellulose nanocrystal scaffolds containing curcumin-loaded microspheres on infected full-thickness burns repair. Journal of Tissue Engineering and Regenerative Medicine, 11(12), 3544–3555.
10.1002/term.2272
CAS PubMed Web of Science® Google Scholar
Gupta, T., Singh, J., Kaur, S., Sandhu, S., Singh, G., & Kaur, I. P. (2020). Enhancing bioavailability and stability of Curcumin using solid lipid nanoparticles (CLEN): A covenant for its effectiveness. Frontiers in Bioengineering and Biotechnology, 8, 879.
10.3389/fbioe.2020.00879
PubMed Web of Science® Google Scholar
Gutiérrez-Gutiérrez, F., Sánchez-Jiménez, C., Rangel-Castañeda, I. A., Carbajal-Arízaga, G. G., Macías-Lamas, A. M., Castillo-Romero, A., & Parra-Saavedra, K. J. (2020). Encapsulation of curcumin into layered double hydroxides improve their anticancer and antiparasitic activity. Journal of Pharmacy and Pharmacology, 72(7), 897–908.
10.1111/jphp.13266
CAS PubMed Web of Science® Google Scholar
Hadjikhani, N., Albrecht, D. S., Mainero, C., Ichijo, E., Ward, N., Granziera, C., … Price, J. (2020). Extra-axial inflammatory signal in parameninges in migraine with visual aura. Annals of Neurology, 87(6), 939–949.
10.1002/ana.25731
PubMed Web of Science® Google Scholar
Hajivalili, M., Pourgholi, F., Samadi Kafil, H., Jadidi-Niaragh, F., & Yousefi, M. (2016). Mesenchymal stem cells in the treatment of amyotrophic lateral sclerosis. Current Stem Cell Research & Therapy, 11(1), 41–50.
10.2174/1574888X10666150902095031
CAS PubMed Web of Science® Google Scholar
Hamam, F., & Nasr, A. (2020). Curcumin-loaded mesoporous silica particles as wound-healing agent: An in vivo study. Saudi Journal of Medicine & Medical Sciences, 8(1), 17–24.
10.4103/sjmms.sjmms_2_19
PubMed Web of Science® Google Scholar
Hashemian, M., Anissian, D., Ghasemi-Kasman, M., Akbari, A., Khalili-Fomeshi, M., Ghasemi, S., … Ebrahimpour, A. (2017). Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 79, 462–471.
10.1016/j.pnpbp.2017.07.025
CAS PubMed Web of Science® Google Scholar
Hatamie, S., Nouri, M., Karandikar, S., Kulkarni, A., Dhole, S., Phase, D., & Kale, S. (2012). Complexes of cobalt nanoparticles and polyfunctional curcumin as antimicrobial agents. Materials Science and Engineering: C, 32(2), 92–97.
10.1016/j.msec.2011.10.002
CAS Web of Science® Google Scholar
He, X.-L., Yang, L., Wang, Z.-J., Huang, R.-Q., Zhu, R.-R., & Cheng, L.-M. (2021). Solid lipid nanoparticles loading with curcumin and dexanabinol to treat major depressive disorder. Neural Regeneration Research, 16(3), 537–542.
10.4103/1673-5374.293155
CAS PubMed Web of Science® Google Scholar
He, X., Zhu, Y., Wang, M., Jing, G., Zhu, R., & Wang, S. (2016). Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression. International Journal of Nanomedicine, 11, 4975–4990.
10.2147/IJN.S109088
CAS PubMed Web of Science® Google Scholar
Henchcliffe, C., & Beal, M. F. (2008). Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nature Clinical Practice Neurology, 4(11), 600–609.
10.1038/ncpneuro0924
CAS PubMed Google Scholar
Hoda, M., Hemaiswarya, S., & Doble, M. (2019). Role of phenolic phytochemicals in diabetes management: Phenolic Phytochemicals and Diabetes. Singapore: Springer Nature Singapore Pte Ltd.
10.1007/978-981-13-8997-9
Google Scholar
Howard, C. R., & Fletcher, N. F. (2012). Emerging virus diseases: Can we ever expect the unexpected? Emerging Microbes & Infections, 1(1), 1–9.
10.1038/emi.2012.47
Web of Science® Google Scholar
Hua, S., De Matos, M. B., Metselaar, J. M., & Storm, G. (2018). Current trends and challenges in the clinical translation of nanoparticulate nanomedicines: Pathways for translational development and commercialization. Frontiers in Pharmacology, 9, 790.
10.3389/fphar.2018.00790
PubMed Web of Science® Google Scholar
Huang, C.-C., Lin, C.-J., Chen, S.-Y., Chang, L., & Lin, H.-J. (2020). Curcumin carbon quantum dots and use thereof. Google Patents.
Google Scholar
Huang, R., Zhu, Y., Lin, L., Song, S., Cheng, L., & Zhu, R. (2020). Solid lipid nanoparticles enhanced the Neuroprotective role of Curcumin against epilepsy through activation of Bcl-2 family and P38 MAPK pathways. ACS Chemical Neuroscience, 11(13), 1985–1995.
10.1021/acschemneuro.0c00242
CAS PubMed Web of Science® Google Scholar
Huo, X., Zhang, Y., Jin, X., Li, Y., & Zhang, L. (2019). A novel synthesis of selenium nanoparticles encapsulated PLGA nanospheres with curcumin molecules for the inhibition of amyloid β aggregation in Alzheimer's disease. Journal of Photochemistry and Photobiology B: Biology, 190, 98–102.
10.1016/j.jphotobiol.2018.11.008
CAS PubMed Web of Science® Google Scholar
Ibrahim, S., Tagami, T., Kishi, T., & Ozeki, T. (2018). Curcumin marinosomes as promising nano-drug delivery system for lung cancer. International Journal of Pharmaceutics, 540(1–2), 40–49.
10.1016/j.ijpharm.2018.01.051
CAS PubMed Web of Science® Google Scholar
Imani, A., Maleki, N., Bohlouli, S., Kouhsoltani, M., Sharifi, S., & Maleki Dizaj, S. (2021). Molecular mechanisms of anticancer effect of rutin. Phytotherapy Research, 35(5), 2500–2513.
10.1002/ptr.6977
CAS PubMed Web of Science® Google Scholar
Ipar, V. S., Dsouza, A., & Devarajan, P. V. (2019). Enhancing curcumin oral bioavailability through nanoformulations. European Journal of Drug Metabolism and Pharmacokinetics, 44(4), 459–480.
10.1007/s13318-019-00545-z
CAS PubMed Web of Science® Google Scholar
Islam, S. U., Ahmed, M. B., Ul-Islam, M., Shehzad, A., & Lee, Y. S. (2019). Switching from conventional to Nano-natural phytochemicals to prevent and treat cancers: Special emphasis on resveratrol. Current Pharmaceutical Design, 25(34), 3620–3632.
10.2174/1381612825666191009161018
CAS PubMed Web of Science® Google Scholar
Izzo, A. A., Hoon-Kim, S., Radhakrishnan, R., & Williamson, E. M. (2016). A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies. Phytotherapy Research, 30(5), 691–700.
10.1002/ptr.5591
PubMed Web of Science® Google Scholar
Izzo, A. A., Teixeira, M., Alexander, S. P., Cirino, G., Docherty, J. R., George, C. H., … Panattieri, R. A. (2020). A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research. British Journal of Pharmacology, 177, 2169–2178.
10.1111/bph.15054
CAS PubMed Web of Science® Google Scholar
Jäger, R., Lowery, R. P., Calvanese, A. V., Joy, J. M., Purpura, M., & Wilson, J. M. (2014). Comparative absorption of curcumin formulations. Nutrition Journal, 13(1), 1–8.
10.1186/1475-2891-13-11
PubMed Web of Science® Google Scholar
Jain, A., Doppalapudi, S., Domb, A. J., & Khan, W. (2016). Tacrolimus and curcumin co-loaded liposphere gel: Synergistic combination towards management of psoriasis. Journal of Controlled Release, 243, 132–145.
10.1016/j.jconrel.2016.10.004
CAS PubMed Web of Science® Google Scholar
Javadi, M., Khadem Haghighian, H., Goodarzy, S., Abbasi, M., & Nassiri-Asl, M. (2019). Effect of curcumin nanomicelle on the clinical symptoms of patients with rheumatoid arthritis: A randomized, double-blind, controlled trial. International Journal of Rheumatic Diseases, 22(10), 1857–1862.
10.1111/1756-185X.13688
CAS PubMed Web of Science® Google Scholar
Jelcic, I., Al Nimer, F., Wang, J., Lentsch, V., Planas, R., Jelcic, I., … Frauenknecht, K. (2018). Memory B cells activate brain-homing, autoreactive CD4+ T cells in multiple sclerosis. Cell, 175(1), 85–100.e123.
10.1016/j.cell.2018.08.011
CAS PubMed Web of Science® Google Scholar
Jermy, B. R., & Ravinayagam, V. (2020). Curcumin-based magnetic nanostructured system for dual response of imaging and therapeutics. Google Patents.
Google Scholar
Jia, T., Rao, J., Zou, L., Zhao, S., Yi, Z., Wu, B., … Zhang, C. (2018). Nanoparticle-encapsulated curcumin inhibits diabetic neuropathic pain involving the P2Y12 receptor in the dorsal root ganglia. Frontiers in Neuroscience, 11, 755.
10.3389/fnins.2017.00755
PubMed Web of Science® Google Scholar
Jiang, T., Liao, W., & Charcosset, C. (2020). Recent advances in encapsulation of curcumin in nanoemulsions: A review of encapsulation technologies, bioaccessibility and applications. Food Research International, 132, 109035.
10.1016/j.foodres.2020.109035
CAS PubMed Web of Science® Google Scholar
Jose, A., Labala, S., Ninave, K. M., Gade, S. K., & Venuganti, V. V. K. (2018). Effective skin cancer treatment by topical co-delivery of curcumin and STAT3 siRNA using cationic liposomes. AAPS PharmSciTech, 19(1), 166–175.
10.1208/s12249-017-0833-y
CAS PubMed Web of Science® Google Scholar
Jose, A., Labala, S., & Venuganti, V. V. K. (2017). Co-delivery of curcumin and STAT3 siRNA using deformable cationic liposomes to treat skin cancer. Journal of Drug Targeting, 25(4), 330–341.
10.1080/1061186X.2016.1258567
CAS PubMed Web of Science® Google Scholar
Jourghanian, P., Ghaffari, S., Ardjmand, M., Haghighat, S., & Mohammadnejad, M. (2016). Sustained release curcumin loaded solid lipid nanoparticles. Advanced Pharmaceutical Bulletin, 6(1), 17–21.
10.15171/apb.2016.04
CAS PubMed Web of Science® Google Scholar
Kakkar, V., Muppu, S. K., Chopra, K., & Kaur, I. P. (2013). Curcumin loaded solid lipid nanoparticles: An efficient formulation approach for cerebral ischemic reperfusion injury in rats. European Journal of Pharmaceutics and Biopharmaceutics, 85(3), 339–345.
10.1016/j.ejpb.2013.02.005
CAS PubMed Web of Science® Google Scholar
Kalirajan, C., & Palanisamy, T. (2019). A ZnO–curcumin nanocomposite embedded hybrid collagen scaffold for effective scarless skin regeneration in acute burn injury. Journal of Materials Chemistry B, 7(38), 5873–5886.
10.1039/C9TB01097A
CAS PubMed Web of Science® Google Scholar
Kamar, S. S., Abdel-Kader, D. H., & Rashed, L. A. (2019). Beneficial effect of Curcumin nanoparticles-hydrogel on excisional skin wound healing in type-I diabetic rat: Histological and immunohistochemical studies. Annals of Anatomy-Anatomischer Anzeiger, 222, 94–102.
10.1016/j.aanat.2018.11.005
PubMed Web of Science® Google Scholar
Kamel, N. A., Soliman, A. A., Rozik, N. N., & Abd-Elmessieh, S. L. (2018). Biophysical investigation of curcumin based nanocomposite for wound dressing application. Journal of Applied Pharmaceutical Science, 8(05), 35–44.
CAS Google Scholar
Kanai, M., Imaizumi, A., Otsuka, Y., Sasaki, H., Hashiguchi, M., Tsujiko, K., … Chiba, T. (2012). Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemotherapy and Pharmacology, 69(1), 65–70.
10.1007/s00280-011-1673-1
CAS PubMed Web of Science® Google Scholar
Kanai, M., Otsuka, Y., Otsuka, K., Sato, M., Nishimura, T., Mori, Y., … Matsumoto, S. (2013). A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients. Cancer Chemotherapy and Pharmacology, 71(6), 1521–1530.
10.1007/s00280-013-2151-8
CAS PubMed Web of Science® Google Scholar
Kang, C., Jung, E., Hyeon, H., Seon, S., & Lee, D. (2020). Acid-activatable polymeric curcumin nanoparticles as therapeutic agents for osteoarthritis. Nanomedicine: Nanotechnology, Biology and Medicine, 23, 102104.
10.1016/j.nano.2019.102104
CAS PubMed Web of Science® Google Scholar
Kang, J.-Y., Kim, H., Mun, D., Yun, N., & Joung, B. (2021). Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction. Journal of Controlled Release, 331, 62–73.
10.1016/j.jconrel.2021.01.018
CAS PubMed Web of Science® Google Scholar
Karavasili, C., Andreadis, D. A., Katsamenis, O. L., Panteris, E., Anastasiadou, P., Kakazanis, Z., … Vizirianakis, I. S. (2019). Synergistic antitumor potency of a self-assembling peptide hydrogel for the local co-delivery of doxorubicin and curcumin in the treatment of head and neck cancer. Molecular Pharmaceutics, 16(6), 2326–2341.
10.1021/acs.molpharmaceut.8b01221
CAS PubMed Web of Science® Google Scholar
Karimi, A., Mahmoodpoor, A., Kooshki, F., Niazkar, H. R., Shoorei, H., & Tarighat-Esfanjani, A. (2020). Effects of nanocurcumin on inflammatory factors and clinical outcomes in critically ill patients with sepsis: A pilot randomized clinical trial. European Journal of Integrative Medicine, 36, 101122.
10.1016/j.eujim.2020.101122
Web of Science® Google Scholar
Karimi, M., Gheybi, F., Zamani, P., Mashreghi, M., Golmohammadzadeh, S., Darban, S. A., … Jaafari, M. R. (2020). Preparation and characterization of stable nanoliposomal formulations of Curcumin with high loading efficacy: In vitro and in vivo anti-tumor study. International Journal of Pharmaceutics, 580, 119211.
10.1016/j.ijpharm.2020.119211
CAS PubMed Web of Science® Google Scholar
Karthikeyan, A., Senthil, N., & Min, T. (2020). Nanocurcumin: A promising candidate for therapeutic applications. Frontiers in Pharmacology, 11, 437.
10.3389/fphar.2020.00487
PubMed Web of Science® Google Scholar
Kashyap, D., Tuli, H. S., Yerer, M. B., Sharma, A., Sak, K., Srivastava, S., … Bishayee, A. (2019). Natural product-based nanoformulations for cancer therapy: Opportunities and challenges. Paper presented at the Seminars in cancer biology.
Google Scholar
Kaur, I. P., Kakkar, V., Deol, P. K., Yadav, M., Singh, M., & Sharma, I. (2014). Issues and concerns in nanotech product development and its commercialization. Journal of Controlled Release, 193, 51–62.
10.1016/j.jconrel.2014.06.005
CAS PubMed Web of Science® Google Scholar
Kaur, S., Modi, N. H., Panda, D., & Roy, N. (2010). Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ–a structural insight to unveil antibacterial activity of curcumin. European Journal of Medicinal Chemistry, 45(9), 4209–4214.
10.1016/j.ejmech.2010.06.015
CAS PubMed Web of Science® Google Scholar
Khadijeh, K. (2020). Preparation and characterization of solid lipid nanoparticles and nanostructured lipid carriers for transdermal delivery of kojic acid. Mazandaran University of Medical Sciences.
Google Scholar
Khadrawy, Y. A., Hosny, E. N., El-Gizawy, M. M., Sawie, H. G., & Ezz, H. S. A. (2021). The effect of Curcumin nanoparticles on Cisplatin-induced Cardiotoxicity in male Wistar albino rats. Cardiovascular Toxicology, 21(6), 433–443.
10.1007/s12012-021-09636-3
CAS PubMed Web of Science® Google Scholar
Khatua, A., Prasad, A., Priyadarshini, E., Virmani, I., Ghosh, L., Paul, B., … Saravanan, M. (2020). CTAB-PLGA Curcumin nanoparticles: Preparation, biophysical characterization and their enhanced antifungal activity against Phytopathogenic fungus Pythium ultimum. ChemistrySelect, 5(34), 10574–10580.
10.1002/slct.202002158
CAS Web of Science® Google Scholar
Kheiripour, N., Plarak, A., Heshmati, A., Asl, S. S., Mehri, F., Ebadollahi-Natanzi, A., … Hosseini, A. (2021). Evaluation of the hepatoprotective effects of curcumin and nanocurcumin against paraquat-induced liver injury in rats: Modulation of oxidative stress and Nrf2 pathway. Journal of Biochemical and Molecular Toxicology, 35, e22739.
10.1002/jbt.22739
CAS PubMed Web of Science® Google Scholar
Khezri, K., Saeedi, M., & Dizaj, S. M. (2018). Application of nanoparticles in percutaneous delivery of active ingredients in cosmetic preparations. Biomedicine & Pharmacotherapy, 106, 1499–1505.
10.1016/j.biopha.2018.07.084
CAS PubMed Web of Science® Google Scholar
Khezri, K., Saeedi, M., Morteza-Semnani, K., Akbari, J., & Hedayatizadeh-Omran, A. (2021). A promising and effective platform for delivering hydrophilic depigmenting agents in the treatment of cutaneous hyperpigmentation: Kojic acid nanostructured lipid carrier. Artificial Cells, Nanomedicine, and Biotechnology, 49(1), 38–47.
10.1080/21691401.2020.1865993
CAS PubMed Web of Science® Google Scholar
Khezri, K., Saeedi, M., Morteza-Semnani, K., Akbari, J., & Rostamkalaei, S. S. (2020). An emerging technology in lipid research for targeting hydrophilic drugs to the skin in the treatment of hyperpigmentation disorders: Kojic acid-solid lipid nanoparticles. Artificial Cells, Nanomedicine, and Biotechnology, 48(1), 841–853.
10.1080/21691401.2020.1770271
CAS PubMed Web of Science® Google Scholar
Kianvash, N., Bahador, A., Pourhajibagher, M., Ghafari, H., Nikoui, V., Rezayat, S. M., … Partoazar, A. (2017). Evaluation of propylene glycol nanoliposomes containing curcumin on burn wound model in rat: Biocompatibility, wound healing, and anti-bacterial effects. Drug Delivery and Translational Research, 7(5), 654–663.
10.1007/s13346-017-0405-4
CAS PubMed Web of Science® Google Scholar
Kim, D.-W., Choi, C.-H., Park, J. P., & Lee, S.-J. (2020). Nanospheres loaded with curcumin improve the bioactivity of umbilical cord BLOOD-mesenchymal stem cells via c-Src activation during the skin wound healing process. Cell, 9(6), 1467.
10.3390/cells9061467
CAS PubMed Web of Science® Google Scholar
Kimura, K., Hohjoh, H., Fukuoka, M., Sato, W., Oki, S., Tomi, C., … Yamamura, T. (2018). Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis. Nature Communications, 9(1), 1–14.
10.1038/s41467-017-02406-2
PubMed Web of Science® Google Scholar
Kitture, R., Ghosh, S., More, P. A., Gaware, S., Datar, S., Chopade, B. A., & Kale, S. (2015). Curcumin-loaded, self-assembled aloevera template for superior antioxidant activity and trans-membrane drug release. Journal of Nanoscience and Nanotechnology, 15(6), 4039–4045.
10.1166/jnn.2015.10322
CAS PubMed Web of Science® Google Scholar
Klickovic, U., Doberer, D., Gouya, G., Aschauer, S., Weisshaar, S., Storka, A., … Wolzt, M. (2014). Human pharmacokinetics of high dose oral curcumin and its effect on heme oxygenase-1 expression in healthy male subjects. BioMed Research International, 2014, 458592.
10.1155/2014/458592
PubMed Web of Science® Google Scholar
Koehler, J., Brandl, F. P., & Goepferich, A. M. (2018). Hydrogel wound dressings for bioactive treatment of acute and chronic wounds. European Polymer Journal, 100, 1–11.
10.1016/j.eurpolymj.2017.12.046
CAS Web of Science® Google Scholar
Kole, S., Gotmare, V., & Athawale, R. (2019). Novel approach for development of eco-friendly antimicrobial textile material for health care application. The Journal of the Textile Institute, 110(2), 254–266.
10.1080/00405000.2018.1477319
CAS Web of Science® Google Scholar
Kovacs, G. G. (2014). Current concepts of neurodegenerative diseases. European Medical Journal Neurology, 1, 78–86.
Google Scholar
Kovacs, G. G. (2016). Molecular pathological classification of neurodegenerative diseases: Turning towards precision medicine. International Journal of Molecular Sciences, 17(2), 189.
10.3390/ijms17020189
PubMed Web of Science® Google Scholar
Kovacs, G. G. (2018). Concepts and classification of neurodegenerative diseases. In Handbook of clinical neurology (Vol. 145, pp. 301–307). Amsterdam, Netherlands: Elsevier.
Google Scholar
Krausz, A. E., Adler, B. L., Cabral, V., Navati, M., Doerner, J., Charafeddine, R. A., … Clendaniel, A. (2015). Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine: Nanotechnology, Biology and Medicine, 11(1), 195–206.
10.1016/j.nano.2014.09.004
CAS PubMed Web of Science® Google Scholar
Krishnakumar, I., Ravi, A., Kumar, D., Kuttan, R., & Maliakel, B. (2012). An enhanced bioavailable formulation of curcumin using fenugreek-derived soluble dietary fibre. Journal of Functional Foods, 4(1), 348–357.
10.1016/j.jff.2012.01.004
Web of Science® Google Scholar
Krishnan, L. K., & Pillai, L. S. (2018). Fibrin wafer/disc as a biological carrier for sustained delivery of curcumin. Google Patents.
Google Scholar
Kumar, A., Mohapatra, S. S., & Cameron, D. F. (2015). Nanoparticle targeted drug delivery to the lungs using extra-testicular sertoli cells. Google Patents.
Google Scholar
Kumar, A., Sirohi, V. K., Anum, F., Singh, P. K., Gupta, K., Gupta, D., … Chourasia, M. K. (2017). Enhanced apoptosis, survivin down-regulation and assisted immunochemotherapy by curcumin loaded amphiphilic mixed micelles for subjugating endometrial cancer. Nanomedicine: Nanotechnology, Biology and Medicine, 13(6), 1953–1963.
10.1016/j.nano.2017.04.014
CAS PubMed Web of Science® Google Scholar
Kumar, D., Jacob, D., Subash, P., Maliakkal, A., Johannah, N., Kuttan, R., … Krishnakumar, I. (2016). Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study. Journal of Functional Foods, 22, 578–587.
10.1016/j.jff.2016.01.039
CAS Web of Science® Google Scholar
Kundu, P., Das, M., Tripathy, K., & Sahoo, S. K. (2016). Delivery of dual drug loaded lipid based nanoparticles across the blood–brain barrier impart enhanced neuroprotection in a rotenone induced mouse model of Parkinson's disease. ACS Chemical Neuroscience, 7(12), 1658–1670.
10.1021/acschemneuro.6b00207
CAS PubMed Web of Science® Google Scholar
Kuo, Y.-C., Wang, L.-J., & Rajesh, R. (2019). Targeting human brain cancer stem cells by curcumin-loaded nanoparticles grafted with anti-aldehyde dehydrogenase and sialic acid: Colocalization of ALDH and CD44. Materials Science and Engineering: C, 102, 362–372.
10.1016/j.msec.2019.04.065
CAS PubMed Web of Science® Google Scholar
Kurzrock, R., Li, L., Mehta, K., & Aggarwal, B. B. (2019). Liposomal Curcumin for treatment of Cancer. Google Patents.
Google Scholar
Lai, K.-C., Chueh, F.-S., Hsiao, Y.-T., Cheng, Z.-Y., Lien, J.-C., Liu, K.-C., … Chung, J.-G. (2019). Gefitinib and curcumin-loaded nanoparticles enhance cell apoptosis in human oral cancer SAS cells in vitro and inhibit SAS cell xenografted tumor in vivo. Toxicology and Applied Pharmacology, 382, 114734.
10.1016/j.taap.2019.114734
CAS PubMed Web of Science® Google Scholar
Lazar, A. N., Mourtas, S., Youssef, I., Parizot, C., Dauphin, A., Delatour, B., … Duyckaerts, C. (2013). Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease. Nanomedicine: Nanotechnology, Biology and Medicine, 9(5), 712–721.
10.1016/j.nano.2012.11.004
CAS PubMed Web of Science® Google Scholar
Lee, H.-J., Jeong, M., Na, Y.-G., Kim, S.-J., Lee, H.-K., & Cho, C.-W. (2020). An EGF-and Curcumin-co-encapsulated nanostructured lipid carrier accelerates chronic-wound healing in diabetic rats. Molecules, 25(20), 4610.
10.3390/molecules25204610
CAS PubMed Web of Science® Google Scholar
Lee, W.-H., Loo, C.-Y., Young, P. M., Traini, D., Mason, R. S., & Rohanizadeh, R. (2014). Recent advances in curcumin nanoformulation for cancer therapy. Expert Opinion on Drug Delivery, 11(8), 1183–1201.
10.1517/17425247.2014.916686
CAS PubMed Web of Science® Google Scholar
Leuci, R., Brunetti, L., Poliseno, V., Laghezza, A., Loiodice, F., Tortorella, P., & Piemontese, L. (2021). Natural compounds for the prevention and treatment of cardiovascular and neurodegenerative diseases. Food, 10(1), 29.
10.3390/foods10010029
CAS Web of Science® Google Scholar
Li, C., & Schluesener, H. (2017). Health-promoting effects of the citrus flavanone hesperidin. Critical Reviews in Food Science and Nutrition, 57(3), 613–631.
10.1080/10408398.2014.906382
CAS PubMed Web of Science® Google Scholar
Li, D., Nie, W., Chen, L., Miao, Y., Zhang, X., Chen, F., … He, C. (2017). Fabrication of curcumin-loaded mesoporous silica incorporated polyvinyl pyrrolidone nanofibers for rapid hemostasis and antibacterial treatment. RSC Advances, 7(13), 7973–7982.
10.1039/C6RA27319J
CAS Web of Science® Google Scholar
Li, H., Yan, L., Tang, E. K., Zhang, Z., Chen, W., Liu, G., & Mo, J. (2019). Synthesis of TPGS/curcumin nanoparticles by thin-film hydration and evaluation of their anti-colon cancer efficacy in vitro and in vivo. Frontiers in Pharmacology, 10, 769.
10.3389/fphar.2019.00769
CAS PubMed Web of Science® Google Scholar
Li, Y., Zhang, Q., Qi, D., Zhang, L., Yi, L., Li, Q., & Zhang, Z. (2016). Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-кB. The Journal of Headache and Pain, 17(1), 49.
10.1186/s10194-016-0631-z
PubMed Web of Science® Google Scholar
Li, Z., Shi, M., Li, N., & Xu, R. (2020). Application of functional biocompatible Nanomaterials to improve Curcumin bioavailability. Frontiers in Chemistry, 8, 929.
10.3389/fchem.2020.589957
Web of Science® Google Scholar
Liang, J., Dong, X., Yang, A., Zhu, D., Kong, D., & Lv, F. (2019). A dual fluorescent reverse targeting drug delivery system based on curcumin-loaded ovalbumin nanoparticles for allergy treatment. Nanomedicine: Nanotechnology, Biology and Medicine, 16, 56–68.
10.1016/j.nano.2018.11.010
CAS PubMed Web of Science® Google Scholar
Lin, C. J., Chang, L., Chu, H. W., Lin, H. J., Chang, P. C., Wang, R. Y., … Huang, C. C. (2019). High amplification of the antiviral activity of curcumin through transformation into carbon quantum dots. Small, 15(41), 1902641.
10.1002/smll.201902641
CAS PubMed Web of Science® Google Scholar
Liu, C., Yu, F., Niu, X., Wang, X., Li, G., & Li, X. (2020). Co-loading of Levodopa and curcumin using brain-targeted protocells as a drug delivery system for improving the efficacy of Parkinson's disease.
Google Scholar
Liu, J., Chen, Z., Wang, J., Li, R., Li, T., Chang, M., … Wang, Y. (2018). Encapsulation of curcumin nanoparticles with MMP9-responsive and thermos-sensitive hydrogel improves diabetic wound healing. ACS Applied Materials & Interfaces, 10(19), 16315–16326.
10.1021/acsami.8b03868
CAS PubMed Web of Science® Google Scholar
Liu, X.-F., Hao, J.-L., Xie, T., Mukhtar, N. J., Zhang, W., Malik, T. H., … Zhou, D.-D. (2017). Curcumin, a potential therapeutic candidate for anterior segment eye diseases: A review. Frontiers in Pharmacology, 8, 66.
10.3389/fphar.2017.00066
PubMed Web of Science® Google Scholar
Lo, T.-H., Wu, Z.-Y., Chen, S.-Y., Meng, F.-Y., Chou, P.-T., Wang, C.-M., & Lin, H.-M. (2021). Curcumin-loaded mesoporous silica nanoparticles with dual-imaging and temperature control inhibits the infection of Zika virus. Microporous and Mesoporous Materials, 314, 110886.
10.1016/j.micromeso.2021.110886
CAS Web of Science® Google Scholar
Loo, C.-Y., Rohanizadeh, R., Young, P. M., Traini, D., Cavaliere, R., Whitchurch, C. B., & Lee, W.-H. (2016). Combination of silver nanoparticles and curcumin nanoparticles for enhanced anti-biofilm activities. Journal of Agricultural and Food Chemistry, 64(12), 2513–2522.
10.1021/acs.jafc.5b04559
CAS PubMed Web of Science® Google Scholar
Lopresti, A. L., Smith, S. J., Rea, A., & Michel, S. (2021). Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: A randomised, double-blind, placebo-controlled study. BMC Complementary Medicine and Therapies, 21(1), 1–17.
10.1186/s12906-021-03220-6
PubMed Web of Science® Google Scholar
Lou, J., Hu, W., Tian, R., Zhang, H., Jia, Y., Zhang, J., & Zhang, L. (2014). Optimization and evaluation of a thermoresponsive ophthalmic in situ gel containing curcumin-loaded albumin nanoparticles. International Journal of Nanomedicine, 9, 2517.
PubMed Web of Science® Google Scholar
Loutfy, S. A., Elberry, M. H., Farroh, K. Y., Mohamed, H. T., Mohamed, A. A., Mohamed, E. B., … Mousa, S. A. (2020). Antiviral activity of chitosan nanoparticles encapsulating Curcumin against hepatitis C virus genotype 4a in human Hepatoma cell lines. International Journal of Nanomedicine, 15, 2699–2715.
10.2147/IJN.S241702
CAS PubMed Web of Science® Google Scholar
Lu, L., Qi, S., Chen, Y., Luo, H., Huang, S., Yu, X., … Zhang, Z. (2020). Targeted immunomodulation of inflammatory monocytes across the blood-brain barrier by curcumin-loaded nanoparticles delays the progression of experimental autoimmune encephalomyelitis. Biomaterials, 245, 119987.
10.1016/j.biomaterials.2020.119987
CAS PubMed Web of Science® Google Scholar
Yallapu, M. M., Jaggi, M., & Chauhan, S. C. (2013). Curcumin nanomedicine: A road to cancer therapeutics. Current Pharmaceutical Design, 19(11), 1994–2010.
CAS PubMed Web of Science® Google Scholar
Ma, Z., Wang, N., He, H., & Tang, X. (2019). Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application. Journal of Controlled Release, 316, 359–380.
10.1016/j.jconrel.2019.10.053
CAS PubMed Web of Science® Google Scholar
Madan, S., Nehate, C., Barman, T. K., Rathore, A. S., & Koul, V. (2019). Design, preparation, and evaluation of liposomal gel formulations for treatment of acne: In vitro and in vivo studies. Drug Development and Industrial Pharmacy, 45(3), 395–404.
10.1080/03639045.2018.1546310
CAS PubMed Web of Science® Google Scholar
Maddahi, A. (2012). MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia. Lund, Sweden: Lund University.
Google Scholar
Madhavi, D., & Kagan, D. (2014). Bioavailability of a sustained release formulation of curcumin. Integrative Medicine: A Clinician's Journal, 13(3), 24.
Google Scholar
Maghbooli, M., Safarnejad, B., Mostafavi, H., Mazloomzadeh, S., & Ghoreishi, A. (2019). Effect of Nanomicelle Curcumin on quality of life and sleep in patients with Parkinson's disease: A double-blind, randomized, and placebo-controlled trial. International Clinical Neuroscience Journal, 6(4), 140–145.
10.15171/icnj.2019.26
Google Scholar
Maheshwari, M. (2010). Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model. Journal of Functional Foods, 2(1), 60–65.
10.1016/j.jff.2010.01.004
Web of Science® Google Scholar
Maiti, P., Paladugu, L., & Dunbar, G. L. (2018). Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer's disease. BMC Neuroscience, 19(1), 1–18.
10.1186/s12868-018-0406-3
PubMed Web of Science® Google Scholar
Malathi, S., Pavithra, P., Sridevi, S., & Verma, R. S. (2020). Fabrication of nanopatterned PLGA films of curcumin and TPGS for skin cancer. International Journal of Pharmaceutics, 578, 119100.
10.1016/j.ijpharm.2020.119100
CAS PubMed Web of Science® Google Scholar
Manca, M. L., Castangia, I., Zaru, M., Nácher, A., Valenti, D., Fernàndez-Busquets, X., … Manconi, M. (2015). Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring. Biomaterials, 71, 100–109.
10.1016/j.biomaterials.2015.08.034
CAS PubMed Web of Science® Google Scholar
Mansoor, S. R., Hashemian, M., Khalili-Fomeshi, M., Ashrafpour, M., Moghadamnia, A. A., & Ghasemi-Kasman, M. (2018). Upregulation of klotho and erythropoietin contributes to the neuroprotection induced by curcumin-loaded nanoparticles in experimental model of chronic epilepsy. Brain Research Bulletin, 142, 281–288.
10.1016/j.brainresbull.2018.08.010
CAS PubMed Web of Science® Google Scholar
Mao, K.-L., Fan, Z.-L., Yuan, J.-D., Chen, P.-P., Yang, J.-J., Xu, J., … Shen, B.-X. (2017). Skin-penetrating polymeric nanoparticles incorporated in silk fibroin hydrogel for topical delivery of curcumin to improve its therapeutic effect on psoriasis mouse model. Colloids and Surfaces B: Biointerfaces, 160, 704–714.
10.1016/j.colsurfb.2017.10.029
CAS PubMed Web of Science® Google Scholar
Mardani, R., Hamblin, M. R., Taghizadeh, M., Banafshe, H. R., Nejati, M., Mokhtari, M., … Jaafari, M. R. (2020). Nanomicellar-curcumin exerts its therapeutic effects via affecting angiogenesis, apoptosis, and T cells in a mouse model of melanoma lung metastasis. Pathology-Research and Practice, 216(9), 153082.
10.1016/j.prp.2020.153082
CAS PubMed Web of Science® Google Scholar
Marković, Z. M., Kepić, D. P., Matijašević, D., Pavlović, V. B., Jovanović, S. P., Stanković, N., … Bajuk-Bogdanović, D. V. (2017). Ambient light induced antibacterial action of curcumin/graphene nanomesh hybrids. RSC Advances, 7(57), 36081–36092.
10.1039/C7RA05027E
CAS Web of Science® Google Scholar
Marques, M., Cordeiro, M., Marinho, M., Vian, C., Vaz, G., Alves, B., … Horn, A. (2020). Curcumin-loaded nanoemulsion improves haemorrhagic stroke recovery in wistar rats. Brain Research, 1746, 147007.
10.1016/j.brainres.2020.147007
CAS PubMed Web of Science® Google Scholar
Mathew, A., Fukuda, T., Nagaoka, Y., Hasumura, T., Morimoto, H., Yoshida, Y., … Kumar, D. S. (2012). Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS One, 7(3), e32616.
10.1371/journal.pone.0032616
CAS PubMed Web of Science® Google Scholar
Mathew, D., & Hsu, W.-L. (2018). Antiviral potential of curcumin. Journal of Functional Foods, 40, 692–699.
10.1016/j.jff.2017.12.017
CAS Web of Science® Google Scholar
Mellitus, D. (2005). Diagnosis and classification of diabetes mellitus. Diabetes Care, 28(S37), S5–S10.
Google Scholar
Memvanga, P. B., Coco, R., & Préat, V. (2013). An oral malaria therapy: Curcumin-loaded lipid-based drug delivery systems combined with β-arteether. Journal of Controlled Release, 172(3), 904–913.
10.1016/j.jconrel.2013.09.001
CAS PubMed Web of Science® Google Scholar
Meng, F., Asghar, S., Gao, S., Su, Z., Song, J., Huo, M., … Xiao, Y. (2015). A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease. Colloids and Surfaces B: Biointerfaces, 134, 88–97.
10.1016/j.colsurfb.2015.06.025
CAS PubMed Web of Science® Google Scholar
Meng, N., Gong, Y., Zhang, J., Mu, X., Song, Z., Feng, R., & Zhang, H. (2019). A novel curcumin-loaded nanoparticle restricts atherosclerosis development and promotes plaques stability in apolipoprotein E deficient mice. Journal of Biomaterials Applications, 33(7), 946–954.
10.1177/0885328218815328
CAS PubMed Web of Science® Google Scholar
Mirzahosseinipour, M., Khorsandi, K., Hosseinzadeh, R., Ghazaeian, M., & Shahidi, F. K. (2020). Antimicrobial photodynamic and wound healing activity of curcumin encapsulated in silica nanoparticles. Photodiagnosis and Photodynamic Therapy, 29, 101639.
10.1016/j.pdpdt.2019.101639
CAS PubMed Web of Science® Google Scholar
Mishra, S., & Palanivelu, K. (2008). The effect of curcumin (turmeric) on Alzheimer's disease: An overview. Annals of Indian Academy of Neurology, 11(1), 13–19.
10.4103/0972-2327.40220
PubMed Web of Science® Google Scholar
Mithu, V. S., Sarkar, B., Bhowmik, D., Das, A. K., Chandrakesan, M., Maiti, S., & Madhu, P. K. (2014). Curcumin alters the salt bridge-containing turn region in amyloid β (1–42) aggregates. Journal of Biological Chemistry, 289(16), 11122–11131.
10.1074/jbc.M113.519447
CAS PubMed Web of Science® Google Scholar
Mohammed, H. S., Hosny, E. N., Khadrawy, Y. A., Magdy, M., Attia, Y. S., Sayed, O. A., & AbdElaal, M. (2020). Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1866(5), 165665.
10.1016/j.bbadis.2020.165665
CAS PubMed Web of Science® Google Scholar
Mohanty, C., & Pradhan, J. (2020). A human epidermal growth factor-curcumin bandage bioconjugate loaded with mesenchymal stem cell for in vivo diabetic wound healing. Materials Science and Engineering: C, 111, 110751.
10.1016/j.msec.2020.110751
CAS PubMed Web of Science® Google Scholar
Mohanty, C., & Sahoo, S. K. (2017). Curcumin and its topical formulations for wound healing applications. Drug Discovery Today, 22(10), 1582–1592.
10.1016/j.drudis.2017.07.001
CAS PubMed Web of Science® Google Scholar
Mokbel, K. E.-D. M., Baiuomy, I. R., Sabry, A. E.-H. A., Mohammed, M. M., & El-Dardiry, M. A. (2020). In vivo assessment of the antischistosomal activity of curcumin loaded nanoparticles versus praziquantel in the treatment of Schistosoma mansoni. Scientific Reports, 10(1), 1–9.
10.1038/s41598-020-72901-y
PubMed Web of Science® Google Scholar
Morimoto, T., Sunagawa, Y., Katanasaka, Y., Hirano, S., Namiki, M., Watanabe, Y., … Yamauchi, M. (2013). Drinkable preparation of Theracurmin exhibits high absorption efficiency—A single-dose, double-blind, 4-way crossover study. Biological and Pharmaceutical Bulletin, 36(11), 1708–1714.
10.1248/bpb.b13-00150
CAS PubMed Web of Science® Google Scholar
Morton, L. M., & Phillips, T. J. (2016). Wound healing and treating wounds: Differential diagnosis and evaluation of chronic wounds. Journal of the American Academy of Dermatology, 74(4), 589–605.
10.1016/j.jaad.2015.08.068
PubMed Web of Science® Google Scholar
Moss, D. M., Curley, P., Kinvig, H., Hoskins, C., & Owen, A. (2018). The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery. Expert Review of Gastroenterology & Hepatology, 12(3), 223–236.
10.1080/17474124.2018.1399794
CAS PubMed Web of Science® Google Scholar
Motavaf, M., Sadeghizadeh, M., Babashah, S., Zare, L., & Javan, M. (2020). Dendrosomal nanocurcumin promotes remyelination through induction of oligodendrogenesis in experimental demyelination animal model. Journal of Tissue Engineering and Regenerative Medicine, 14, 1449–1464.
10.1002/term.3110
CAS PubMed Web of Science® Google Scholar
Muankaew, C., & Loftsson, T. (2018). Cyclodextrin-based formulations: A non-invasive platform for targeted drug delivery. Basic & Clinical Pharmacology & Toxicology, 122(1), 46–55.
10.1111/bcpt.12917
CAS PubMed Web of Science® Google Scholar
Mulik, R. S., Mönkkönen, J., Juvonen, R. O., Mahadik, K. R., & Paradkar, A. R. (2010). ApoE3 mediated poly (butyl) cyanoacrylate nanoparticles containing curcumin: Study of enhanced activity of curcumin against beta amyloid induced cytotoxicity using in vitro cell culture model. Molecular Pharmaceutics, 7(3), 815–825.
10.1021/mp900306x
CAS PubMed Web of Science® Google Scholar
Mursaleen, L., Somavarapu, S., & Zariwala, M. G. (2020). Deferoxamine and curcumin loaded nanocarriers protect against rotenone-induced neurotoxicity. Journal of Parkinson's Disease, 10(1), 99–111.
10.3233/JPD-191754
CAS PubMed Web of Science® Google Scholar
Murthy, K. C., Monika, P., Jayaprakasha, G., & Patil, B. S. (2018). Nanoencapsulation: An advanced nanotechnological approach to enhance the biological efficacy of curcumin. In Advances in plant Phenolics: From chemistry to human health (pp. 383–405). Washington, DC: ACS Publications.
10.1021/bk-2018-1286.ch021
Google Scholar
Nabila, N., Suada, N. K., Denis, D., Yohan, B., Adi, A. C., Veterini, A. S., … Rachmawati, H. (2020). Antiviral action of curcumin encapsulated in nanoemulsion against four serotypes of dengue virus. Pharmaceutical Nanotechnology, 8(1), 54–62.
10.2174/2211738507666191210163408
CAS PubMed Google Scholar
Naksuriya, O., Okonogi, S., Schiffelers, R. M., & Hennink, W. E. (2014). Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. Biomaterials, 35(10), 3365–3383.
10.1016/j.biomaterials.2013.12.090
CAS PubMed Web of Science® Google Scholar
Nazari-Vanani, R., Moezi, L., & Heli, H. (2017). In vivo evaluation of a self-nanoemulsifying drug delivery system for curcumin. Biomedicine & Pharmacotherapy, 88, 715–720.
10.1016/j.biopha.2017.01.102
CAS PubMed Web of Science® Google Scholar
Negahdari, R., Bohlouli, S., Sharifi, S., Maleki Dizaj, S., Rahbar Saadat, Y., Khezri, K., … Raeesi, S. (2021). Therapeutic benefits of rutin and its nanoformulations. Phytotherapy Research, 35(4), – 1719–1738.
10.1002/ptr.6904
CAS PubMed Web of Science® Google Scholar
Ng, Z. Y., Wong, J.-Y., Panneerselvam, J., Madheswaran, T., Kumar, P., Pillay, V., … Wark, P. (2018). Assessing the potential of liposomes loaded with curcumin as a therapeutic intervention in asthma. Colloids and Surfaces B: Biointerfaces, 172, 51–59.
10.1016/j.colsurfb.2018.08.027
CAS PubMed Web of Science® Google Scholar
Niemirowicz, K., Durnaś, B., Piktel, E., & Bucki, R. (2017). Development of antifungal therapies using nanomaterials. Nanomedicine, 12(15), 1891–1905.
10.2217/nnm-2017-0052
CAS PubMed Web of Science® Google Scholar
Niranjan, R. (2014). The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: Focus on astrocytes. Molecular Neurobiology, 49(1), 28–38.
10.1007/s12035-013-8483-x
CAS PubMed Web of Science® Google Scholar
No, D. S., Algburi, A., Huynh, P., Moret, A., Ringard, M., Comito, N., … Chikindas, M. L. (2017). Antimicrobial efficacy of curcumin nanoparticles against Listeria monocytogenes is mediated by surface charge. Journal of Food Safety, 37(4), e12353.
10.1111/jfs.12353
Web of Science® Google Scholar
Öien, R., & Ragnarson Tennvall, G. (2006). Accurate diagnosis and effective treatment of leg ulcers reduce prevalence, care time and costs. Journal of Wound Care, 15(6), 259–262.
10.12968/jowc.2006.15.6.26922
CAS PubMed Google Scholar
Omar, A., Wright, J. B., Schultz, G., Burrell, R., & Nadworny, P. (2017). Microbial biofilms and chronic wounds. Microorganisms, 5(1), 9.
10.3390/microorganisms5010009
PubMed Web of Science® Google Scholar
Oyeyemi, O., Morenkeji, O., Afolayan, F., Dauda, K., Busari, Z., Meena, J., & Panda, A. (2018). Curcumin-artesunate based polymeric nanoparticle; antiplasmodial and toxicological evaluation in murine model. Frontiers in Pharmacology, 9, 562.
10.3389/fphar.2018.00562
PubMed Web of Science® Google Scholar
Pacho, M. N., Pugni, E. N., Díaz Sierra, J. B., Morell, M. L., Sepúlveda, C. S., Damonte, E. B., … D'Accorso, N. B. (2021). Antiviral activity against Zika virus of a new formulation of curcumin in poly lactic-co-glycolic acid nanoparticles. Journal of Pharmacy and Pharmacology, 73, 357–365.
10.1093/jpp/rgaa045
PubMed Web of Science® Google Scholar
Palmieri, V., Bugli, F., Cacaci, M., Perini, G., Maio, F. D., Delogu, G., … Spirito, M. D. (2018). Graphene oxide coatings prevent Candida albicans biofilm formation with a controlled release of curcumin-loaded nanocomposites. Nanomedicine, 13(22), 2867–2879.
10.2217/nnm-2018-0183
CAS PubMed Web of Science® Google Scholar
Parohan, M., Sarraf, P., Javanbakht, M. H., Foroushani, A. R., Ranji-Burachaloo, S., & Djalali, M. (2021). The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Nutritional Neuroscience, 24(4), 317–326.
10.1080/1028415X.2019.1627770
CAS PubMed Web of Science® Google Scholar
Pascual, J. (2015). CGRP antibodies: The holy grail for migraine prevention? The Lancet. Neurology, 14(11), 1066–1067.
PubMed Web of Science® Google Scholar
Pasquel, F. J., Lansang, M. C., Dhatariya, K., & Umpierrez, G. E. (2021). Management of diabetes and hyperglycaemia in the hospital. The Lancet Diabetes & Endocrinology, 9, 174–188.
10.1016/S2213-8587(20)30381-8
CAS PubMed Web of Science® Google Scholar
Patel, S. S., Acharya, A., Ray, R., Agrawal, R., Raghuwanshi, R., & Jain, P. (2020). Cellular and molecular mechanisms of curcumin in prevention and treatment of disease. Critical Reviews in Food Science and Nutrition, 60(6), 887–939.
10.1080/10408398.2018.1552244
CAS PubMed Web of Science® Google Scholar
Patil, S., Choudhary, B., Rathore, A., Roy, K., & Mahadik, K. (2015). Enhanced oral bioavailability and anticancer activity of novel curcumin loaded mixed micelles in human lung cancer cells. Phytomedicine, 22(12), 1103–1111.
10.1016/j.phymed.2015.08.006
CAS PubMed Web of Science® Google Scholar
Pattayil, A. J., & Jayaprabha, K. N. (2016). Curcumin coated magnetite nanoparticles for biomedical applications. Google Patents.
Google Scholar
Pattayil, A. J., & Jayaprabha, K. N. (2017). Curcumin coated magnetite nanoparticles for biomedical applications. Google Patents.
Google Scholar
Paul, S., Mohanram, K., & Kannan, I. (2018). Antifungal activity of curcumin-silver nanoparticles against fluconazole-resistant clinical isolates of Candida species. Ayu, 39(3), 182–186.
10.4103/ayu.AYU_24_18
PubMed Google Scholar
Perera, W., Dissanayake, R. K., Ranatunga, U., Hettiarachchi, N., Perera, K., Unagolla, J. M., … Pahalagedara, L. (2020). Curcumin loaded zinc oxide nanoparticles for activity-enhanced antibacterial and anticancer applications. RSC Advances, 10(51), 30785–30795.
10.1039/D0RA05755J
CAS PubMed Web of Science® Google Scholar
Pescosolido, N., Giannotti, R., Plateroti, A. M., Pascarella, A., & Nebbioso, M. (2014). Curcumin: Therapeutical potential in ophthalmology. Planta Medica, 80(04), 249–254.
CAS PubMed Web of Science® Google Scholar
Petry, K. G., Boiziau, C., Dousset, V., & Brochet, B. (2007). Magnetic resonance imaging of human brain macrophage infiltration. Neurotherapeutics, 4(3), 434–442.
10.1016/j.nurt.2007.05.005
CAS PubMed Web of Science® Google Scholar
Pham-Huy, L. A., He, H., & Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. International Journal of Biomedical Science, 4(2), 89–96.
10.59566/IJBS.2008.4089
CAS PubMed Google Scholar
Pichler, M., & Hocker, S. (2017). Management of status epilepticus. In Handbook of clinical neurology (Vol. 140, pp. 131–151). Amsterdam, Netherlands: Elsevier.
Google Scholar
Pieretti, S., Ranjan, A. P., Di Giannuario, A., Mukerjee, A., Marzoli, F., Di Giovannandrea, R., & Vishwanatha, J. K. (2017). Curcumin-loaded poly (d, l-lactide-co-glycolide) nanovesicles induce antinociceptive effects and reduce pronociceptive cytokine and BDNF release in spinal cord after acute administration in mice. Colloids and Surfaces B: Biointerfaces, 158, 379–386.
10.1016/j.colsurfb.2017.07.027
CAS PubMed Web of Science® Google Scholar
Pontes-Quero, G. M., Benito-Garzón, L., Cano, J. P., Aguilar, M. R., & Vázquez-Lasa, B. (2021). Amphiphilic polymeric nanoparticles encapsulating curcumin: Antioxidant, anti-inflammatory and biocompatibility studies. Materials Science and Engineering: C, 121, 111793.
10.1016/j.msec.2020.111793
CAS PubMed Web of Science® Google Scholar
Pote, A. K., Pande, V. V., Patel, V. P., Giri, M. A., Bhalke, R. D., & Pund, A. U. (2021). Design & Development of Curcumin loaded zinc oxide nanoparticles decorated Mesoporous silica liquid stitches: A proof of concept in animals. Materials Technology, 1–14.
Web of Science® Google Scholar
Prado-Audelo, D., María, L., Caballero-Florán, I. H., Meza-Toledo, J. A., Mendoza-Muñoz, N., González-Torres, M., … Leyva-Gómez, G. (2019). Formulations of curcumin nanoparticles for brain diseases. Biomolecules, 9(2), 56.
10.3390/biom9020056
PubMed Web of Science® Google Scholar
Prasanna, A., Niranjan, R., Kaushik, M., Devasena, T., Kumar, J., Chelliah, R., … Swaminathan, S. (2018). Metal oxide curcumin incorporated polymer patches for wound healing. Applied Surface Science, 449, 603–609.
10.1016/j.apsusc.2018.01.143
Web of Science® Google Scholar
Preis, E., Baghdan, E., Agel, M. R., Anders, T., Pourasghar, M., Schneider, M., & Bakowsky, U. (2019). Spray dried curcumin loaded nanoparticles for antimicrobial photodynamic therapy. European Journal of Pharmaceutics and Biopharmaceutics, 142, 531–539.
10.1016/j.ejpb.2019.07.023
CAS PubMed Web of Science® Google Scholar
Priya, P., Raj, R. M., Vasanthakumar, V., & Raj, V. (2020). Curcumin-loaded layer-by-layer folic acid and casein coated carboxymethyl cellulose/casein nanogels for treatment of skin cancer. Arabian Journal of Chemistry, 13(1), 694–708.
10.1016/j.arabjc.2017.07.010
CAS Web of Science® Google Scholar
Purpura, M., Lowery, R. P., Wilson, J. M., Mannan, H., Münch, G., & Razmovski-Naumovski, V. (2018). Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects. European Journal of Nutrition, 57(3), 929–938.
10.1007/s00394-016-1376-9
CAS PubMed Web of Science® Google Scholar
Rafiee, Z., Nejatian, M., Daeihamed, M., & Jafari, S. M. (2019). Application of curcumin-loaded nanocarriers for food, drug and cosmetic purposes. Trends in Food Science & Technology, 88, 445–458.
10.1016/j.tifs.2019.04.017
CAS Web of Science® Google Scholar
Rai, M., Ingle, A. P., Pandit, R., Paralikar, P., Anasane, N., & Santos, C. A. D. (2020). Curcumin and curcumin-loaded nanoparticles: Antipathogenic and antiparasitic activities. Expert Review of Anti-Infective Therapy, 18(4), 367–379.
10.1080/14787210.2020.1730815
CAS PubMed Web of Science® Google Scholar
Rai, M., Yadav, A., Ingle, A. P., Reshetilov, A., Blanco-Prieto, M. J., & Feitosa, C. M. (2019). Neurodegenerative diseases: The real problem and Nanobiotechnological solutions. In Nanobiotechnology in neurodegenerative diseases (pp. 1–17). Berlin, Germany: Springer.
10.1007/978-3-030-30930-5_1
Google Scholar
Rakotoarisoa, M., Angelov, B., Garamus, V. M., & Angelova, A. (2019). Curcumin-and fish oil-loaded spongosome and cubosome nanoparticles with neuroprotective potential against H2O2-induced oxidative stress in differentiated human SH-SY5Y cells. ACS Omega, 4(2), 3061–3073.
10.1021/acsomega.8b03101
CAS Web of Science® Google Scholar
Ranjbar-Mohammadi, M., Rabbani, S., Bahrami, S. H., Joghataei, M., & Moayer, F. (2016). Antibacterial performance and in vivo diabetic wound healing of curcumin loaded gum tragacanth/poly (ε-caprolactone) electrospun nanofibers. Materials Science and Engineering: C, 69, 1183–1191.
10.1016/j.msec.2016.08.032
PubMed Web of Science® Google Scholar
Rapalli, V. K., Kaul, V., Waghule, T., Gorantla, S., Sharma, S., Roy, A., … Singhvi, G. (2020). Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: Optimization, scale-up, in-vitro characterization and assessment of ex-vivo skin deposition. European Journal of Pharmaceutical Sciences, 152, 105438.
10.1016/j.ejps.2020.105438
CAS PubMed Web of Science® Google Scholar
Ray, A., Rana, S., Banerjee, D., Mitra, A., Datta, R., Naskar, S., & Sarkar, S. (2016). Improved bioavailability of targeted curcumin delivery efficiently regressed cardiac hypertrophy by modulating apoptotic load within cardiac microenvironment. Toxicology and Applied Pharmacology, 290, 54–65.
10.1016/j.taap.2015.11.011
CAS PubMed Web of Science® Google Scholar
Raza, S. S., Khan, M. M., Ahmad, A., Ashafaq, M., Khuwaja, G., Tabassum, R., … Islam, F. (2011). Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke. Brain Research, 1420, 93–105.
10.1016/j.brainres.2011.08.047
CAS PubMed Web of Science® Google Scholar
Reshmi, C., Suja, P., Manaf, O., Sanu, P., & Sujith, A. (2018). Nanochitosan enriched poly ε-caprolactone electrospun wound dressing membranes: A fine tuning of physicochemical properties, hemocompatibility and curcumin release profile. International Journal of Biological Macromolecules, 108, 1261–1272.
10.1016/j.ijbiomac.2017.11.035
PubMed Web of Science® Google Scholar
Rivera, S. J. G., Orellana, P. P. C., García, V. D., Arenas, P. A. L., Andrea, A. M., Campos, L. L., … Palma, A. I. V. (2018). Curcumin-loaded nanoemulsions, method of manufacture, and method of preventive treatment using the same. Google Patents.
Google Scholar
Rodero, C. F., Fioramonti Calixto, G. M., Cristina dos Santos, K., Sato, M. R., Aparecido dos Santos Ramos, M., Miró, M. S., … Sotomayor, C. E. (2018). Curcumin-loaded liquid crystalline systems for controlled drug release and improved treatment of vulvovaginal candidiasis. Molecular Pharmaceutics, 15(10), 4491–4504.
10.1021/acs.molpharmaceut.8b00507
CAS PubMed Web of Science® Google Scholar
Saber-Moghaddam, N., Salari, S., Hejazi, S., Amini, M., Taherzadeh, Z., Eslami, S., … Elyasi, S. (2021). Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label nonrandomized clinical trial. Phytotherapy Research, 35(5), 2616–2623.
10.1002/ptr.7004
CAS PubMed Web of Science® Google Scholar
Sadegh Malvajerd, S., Azadi, A., Izadi, Z., Kurd, M., Dara, T., Dibaei, M., … Hamidi, M. (2018). Brain delivery of curcumin using solid lipid nanoparticles and nanostructured lipid carriers: Preparation, optimization, and pharmacokinetic evaluation. ACS Chemical Neuroscience, 10(1), 728–739.
10.1021/acschemneuro.8b00510
PubMed Web of Science® Google Scholar
Sadegh Malvajerd, S., Izadi, Z., Azadi, A., Kurd, M., Derakhshankhah, H., Sharifzadeh, M., … Hamidi, M. (2019). Neuroprotective potential of curcumin-loaded nanostructured lipid carrier in an animal model of Alzheimer's disease: Behavioral and biochemical evidence. Journal of Alzheimer's Disease, 69(3), 671–686.
10.3233/JAD-190083
CAS PubMed Web of Science® Google Scholar
Saeedi, M., Eslamifar, M., & Khezri, K. (2019). Kojic acid applications in cosmetic and pharmaceutical preparations. Biomedicine & Pharmacotherapy, 110, 582–593.
10.1016/j.biopha.2018.12.006
CAS PubMed Web of Science® Google Scholar
Saeedi, M., Eslamifar, M., Khezri, K., & Dizaj, S. M. (2019). Applications of nanotechnology in drug delivery to the central nervous system. Biomedicine & Pharmacotherapy, 111, 666–675.
10.1016/j.biopha.2018.12.133
CAS PubMed Web of Science® Google Scholar
Saeedi, M., Khezri, K., & Mohammadamini, H. (2021). A comprehensive review of the therapeutic potential of α-arbutin. Phytotherapy Research.
10.1002/ptr.7076
PubMed Web of Science® Google Scholar
Sagitha, P., Reshmi, C., Sundaran, S. P., Binoy, A., Mishra, N., & Sujith, A. (2019). In-vitro evaluation on drug release kinetics and antibacterial activity of dextran modified polyurethane fibrous membrane. International Journal of Biological Macromolecules, 126, 717–730.
10.1016/j.ijbiomac.2018.12.155
CAS PubMed Web of Science® Google Scholar
Sai, N., Dong, X., Huang, P., You, L., Yang, C., Liu, Y., … Du, Y. (2020). A novel gel-forming solution based on PEG-DSPE/Solutol HS 15 mixed micelles and gellan gum for ophthalmic delivery of curcumin. Molecules, 25(1), 81.
10.3390/molecules25010081
CAS Web of Science® Google Scholar
Salehi, B., Prado-Audelo, D., María, L., Cortés, H., Leyva-Gómez, G., Stojanović-Radić, Z., … Martins, N. (2020). Therapeutic applications of curcumin nanomedicine formulations in cardiovascular diseases. Journal of Clinical Medicine, 9(3), 746.
10.3390/jcm9030746
CAS PubMed Web of Science® Google Scholar
Salehi, B., Stojanović-Radić, Z., Matejić, J., Sharifi-Rad, M., Kumar, N. V. A., Martins, N., & Sharifi-Rad, J. (2019). The therapeutic potential of curcumin: A review of clinical trials. European Journal of Medicinal Chemistry, 163, 527–545.
10.1016/j.ejmech.2018.12.016
CAS PubMed Web of Science® Google Scholar
Salmazi, R., Calixto, G., Bernegossi, J., dos Santos Ramos, M. A., Bauab, T. M., & Chorilli, M. (2015). A curcumin-loaded liquid crystal precursor mucoadhesive system for the treatment of vaginal candidiasis. International Journal of Nanomedicine, 10, 4815.
CAS PubMed Web of Science® Google Scholar
Samrot, A. V., Burman, U., Philip, S. A., Shobana, N., & Chandrasekaran, K. (2018). Synthesis of curcumin loaded polymeric nanoparticles from crab shell derived chitosan for drug delivery. Informatics in Medicine Unlocked, 10, 159–182.
10.1016/j.imu.2017.12.010
Google Scholar
Sandhir, R., Yadav, A., Mehrotra, A., Sunkaria, A., Singh, A., & Sharma, S. (2014). Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of Huntington's disease. Neuromolecular Medicine, 16(1), 106–118.
10.1007/s12017-013-8261-y
CAS PubMed Web of Science® Google Scholar
Sandhiutami, N. M. D., Arozal, W., Louisa, M., Rahmat, D., & Wuyung, P. E. (2021). Curcumin nanoparticle enhances the anticancer effect of Cisplatin by inhibiting PI3K/AKT and JAK/STAT3 pathway in rat ovarian carcinoma induced by DMBA. Frontiers in Pharmacology, 11, 2199.
10.3389/fphar.2020.603235
Web of Science® Google Scholar
Santos, A. C., Pereira, I., Pereira-Silva, M., Ferreira, L., Caldas, M., Collado-González, M., … Veiga, F. (2019). Nanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivity. Colloids and Surfaces B: Biointerfaces, 180, 127–140.
10.1016/j.colsurfb.2019.04.030
CAS PubMed Web of Science® Google Scholar
Sarika, P., & Nirmala, R. J. (2016). Curcumin loaded gum arabic aldehyde-gelatin nanogels for breast cancer therapy. Materials Science and Engineering: C, 65, 331–337.
10.1016/j.msec.2016.04.044
CAS PubMed Web of Science® Google Scholar
Sarkar, N., & Bose, S. (2019). Liposome-encapsulated curcumin-loaded 3D printed scaffold for bone tissue engineering. ACS Applied Materials & Interfaces, 11(19), 17184–17192.
10.1021/acsami.9b01218
CAS PubMed Web of Science® Google Scholar
Sasaki, H., Sunagawa, Y., Takahashi, K., Imaizumi, A., Fukuda, H., Hashimoto, T., … Fujita, M. (2011). Innovative preparation of curcumin for improved oral bioavailability. Biological and Pharmaceutical Bulletin, 34(5), 660–665.
10.1248/bpb.34.660
CAS PubMed Web of Science® Google Scholar
Schiborr, C., Kocher, A., Behnam, D., Jandasek, J., Toelstede, S., & Frank, J. (2014). The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Molecular Nutrition & Food Research, 58(3), 516–527.
10.1002/mnfr.201300724
CAS PubMed Web of Science® Google Scholar
Schobert, R., & Biersack, B. (2019). Chemical and biological aspects of garcinol and isogarcinol: Recent developments. Chemistry & Biodiversity, 16(9), e1900366.
10.1002/cbdv.201900366
PubMed Web of Science® Google Scholar
Sebastiammal, S., Fathima, A. S. L., Devanesan, S., AlSalhi, M. S., Henry, J., Govindarajan, M., & Vaseeharan, B. (2020). Curcumin-encased hydroxyapatite nanoparticles as novel biomaterials for antimicrobial, antioxidant and anticancer applications: A perspective of nano-based drug delivery. Journal of Drug Delivery Science and Technology, 57, 101752.
10.1016/j.jddst.2020.101752
CAS Web of Science® Google Scholar
Sengupta, S. (2014). Clinical translational challenges in nanomedicine. MRS Bulletin, 39(3), 259–264.
10.1557/mrs.2014.29
Web of Science® Google Scholar
Setthacheewakul, S., Mahattanadul, S., Phadoongsombut, N., Pichayakorn, W., & Wiwattanapatapee, R. (2010). Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats. European Journal of Pharmaceutics and Biopharmaceutics, 76(3), 475–485.
10.1016/j.ejpb.2010.07.011
CAS PubMed Web of Science® Google Scholar
Shailendiran, D., Pawar, N., Chanchal, A., Pandey, R., Bohidar, H., & Verma, A. (2011). Characterization and antimicrobial activity of nanocurcumin and curcumin. Paper presented at the 2011 International Conference on Nanoscience, Technology and Societal Implications.
Google Scholar
Shamsi-Goushki, A., Mortazavi, Z., Mirshekar, M. A., Mohammadi, M., Moradi-Kor, N., Jafari-Maskouni, S., & Shahraki, M. (2020). Comparative effects of Curcumin versus Nano-Curcumin on insulin resistance, serum levels of Apelin and lipid profile in type 2 diabetic rats. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, 2337–2346.
10.2147/DMSO.S247351
CAS PubMed Web of Science® Google Scholar
Shanmugam, M. K., Warrier, S., Kumar, A. P., Sethi, G., & Arfuso, F. (2017). Potential role of natural compounds as anti-Angiogenic agents in Cancer. Current Vascular Pharmacology, 15(6), 503–519.
10.2174/1570161115666170713094319
CAS PubMed Web of Science® Google Scholar
Shanmugarajan, D., Prabitha, P., Kumar, B. P., & Suresh, B. (2020). Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: Computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets. RSC Advances, 10(52), 31385–31399.
10.1039/D0RA03167D
PubMed Web of Science® Google Scholar
Sharifi, S., Fathi, N., Memar, M. Y., Hosseiniyan Khatibi, S. M., Khalilov, R., Negahdari, R., … Maleki Dizaj, S. (2020). Anti-microbial activity of curcumin nanoformulations: New trends and future perspectives. Phytotherapy Research, 34, 1926–1946.
10.1002/ptr.6658
CAS PubMed Web of Science® Google Scholar
Sharifian, P., Yaslianifard, S., Fallah, P., Aynesazi, S., Bakhtiyari, M., & Mohammadzadeh, M. (2020). Investigating the effect of nano-curcumin on the expression of biofilm regulatory genes of Pseudomonas aeruginosa. Infection and Drug Resistance, 13, 2477–2484.
10.2147/IDR.S263387
CAS PubMed Web of Science® Google Scholar
Sharma, R. K., Cwiklinski, K., Aalinkeel, R., Reynolds, J. L., Sykes, D. E., Quaye, E., … Schwartz, S. A. (2017). Immunomodulatory activities of curcumin-stabilized silver nanoparticles: Efficacy as an antiretroviral therapeutic. Immunological Investigations, 46(8), 833–846.
10.1080/08820139.2017.1371908
CAS PubMed Web of Science® Google Scholar
Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64, 353–356.
10.1055/s-2006-957450
CAS PubMed Web of Science® Google Scholar
Shome, S., Talukdar, A. D., Choudhury, M. D., Bhattacharya, M. K., & Upadhyaya, H. (2016). Curcumin as potential therapeutic natural product: A nanobiotechnological perspective. Journal of Pharmacy and Pharmacology, 68(12), 1481–1500.
10.1111/jphp.12611
CAS PubMed Web of Science® Google Scholar
Shrotriya, S., Ranpise, N., Satpute, P., & Vidhate, B. (2018). Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis. Artificial Cells, Nanomedicine, and Biotechnology, 46(7), 1471–1482.
10.1080/21691401.2017.1373659
CAS PubMed Web of Science® Google Scholar
Siddique, Y. H., Khan, W., Singh, B. R., & Naqvi, A. H. (2013). Synthesis of alginate-curcumin nanocomposite and its protective role in transgenic Drosophila model of Parkinson's disease. International Scholarly Research Notices, 2013, 794582.
10.1155/2013/794582
Google Scholar
Singh, A. K., Prakash, P., Singh, R., Nandy, N., Firdaus, Z., Bansal, M., … Mishra, B. (2017). Curcumin quantum dots mediated degradation of bacterial biofilms. Frontiers in Microbiology, 8, 1517.
10.3389/fmicb.2017.01517
PubMed Web of Science® Google Scholar
Singh, Y. P., Girisa, S., Banik, K., Ghosh, S., Swathi, P., Deka, M., … Fan, L. (2019). Potential application of zerumbone in the prevention and therapy of chronic human diseases. Journal of Functional Foods, 53, 248–258.
10.1016/j.jff.2018.12.020
CAS Web of Science® Google Scholar
Sookhaklari, R., Geramizadeh, B., Abkar, M., & Moosavi, M. (2019). The neuroprotective effect of BSA-based nanocurcumin against 6-OHDA-induced cell death in SH-SY5Y cells. Avicenna Journal of Phytomedicine, 9(2), 92–100.
CAS PubMed Web of Science® Google Scholar
Soumya, K., Snigdha, S., Sugathan, S., Mathew, J., & Radhakrishnan, E. (2017). Zinc oxide–curcumin nanocomposite loaded collagen membrane as an effective material against methicillin-resistant coagulase-negative staphylococci. 3 Biotech, 7(4), 238.
10.1007/s13205-017-0861-z
CAS PubMed Google Scholar
Souza, J. M. T., de Araujo, A. R., de Carvalho, A. M. A., Amorim, A. D. G. N., Daboit, T. C., de Almeida, J. R. D. S., … Eaton, P. (2020). Sustainably produced cashew gum-capped zinc oxide nanoparticles show antifungal activity against Candida parapsilosis. Journal of Cleaner Production, 247, 119085.
10.1016/j.jclepro.2019.119085
CAS Web of Science® Google Scholar
Sprenger, T., Viana, M., & Tassorelli, C. (2018). Current prophylactic medications for migraine and their potential mechanisms of action. Neurotherapeutics, 15(2), 313–323.
10.1007/s13311-018-0621-8
CAS PubMed Web of Science® Google Scholar
Stohs, S. J., Chen, O., Ray, S. D., Ji, J., Bucci, L. R., & Preuss, H. G. (2020). Highly bioavailable forms of curcumin and promising avenues for curcumin-based research and application: A review. Molecules, 25(6), 1397.
10.3390/molecules25061397
CAS PubMed Web of Science® Google Scholar
Stohs, S. J., Ji, J., Bucci, L. R., & Preuss, H. G. (2018). A comparative pharmacokinetic assessment of a novel highly bioavailable curcumin formulation with 95% curcumin: A randomized, double-blind, crossover study. Journal of the American College of Nutrition, 37(1), 51–59.
10.1080/07315724.2017.1358118
CAS PubMed Web of Science® Google Scholar
Su, H., Han, L., & Huang, X. (2018). Potential targets for the development of new antifungal drugs. The Journal of Antibiotics, 71(12), 978–991.
10.1038/s41429-018-0100-9
CAS PubMed Web of Science® Google Scholar
Subtaweesin, C., Woraharn, W., Taokaew, S., Chiaoprakobkij, N., Sereemaspun, A., & Phisalaphong, M. (2018). Characteristics of curcumin-loaded bacterial cellulose films and anticancer properties against malignant melanoma skin cancer cells. Applied Sciences, 8(7), 1188.
10.3390/app8071188
Google Scholar
Sudirman, S., Lai, C.-S., Yan, Y.-L., Yeh, H.-I., & Kong, Z.-L. (2019). Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model. Scientific Reports, 9(1), 1–11.
10.1038/s41598-019-51821-6
CAS PubMed Web of Science® Google Scholar
Sufi, S. A., Hoda, M., Pajaniradje, S., Mukherjee, V., Coumar, S. M., & Rajagopalan, R. (2020). Enhanced drug retention, sustained release, and anti-cancer potential of curcumin and indole-curcumin analog-loaded polysorbate 80-stabilizied PLGA nanoparticles in colon cancer cell line SW480. International Journal of Pharmaceutics, 588, 119738.
10.1016/j.ijpharm.2020.119738
CAS PubMed Web of Science® Google Scholar
Sunagawa, Y., Hirano, S., Katanasaka, Y., Miyazaki, Y., Funamoto, M., Okamura, N., … Yokoji, T. (2015). Colloidal submicron-particle Curcumin exhibits high absorption efficiency—A double-blind, 3-way crossover study—. Journal of Nutritional Science and Vitaminology, 61(1), 37–44.
10.3177/jnsv.61.37
CAS PubMed Web of Science® Google Scholar
Suwannateep, N., Wanichwecharungruang, S., Haag, S., Devahastin, S., Groth, N., Fluhr, J., … Meinke, M. (2012). Encapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation. European Journal of Pharmaceutics and Biopharmaceutics, 82(3), 485–490.
10.1016/j.ejpb.2012.08.010
CAS PubMed Web of Science® Google Scholar
Szunerits, S., Melinte, S., Barras, A., Pagneux, Q., Voronova, A., Abderrahmani, A., & Boukherroub, R. (2021). The impact of chemical engineering and technological advances on managing diabetes: Present and future concepts. Chemical Society Reviews, 50, 2102–2146.
10.1039/C9CS00886A
CAS PubMed Web of Science® Google Scholar
Takeda, S., Hirayama, A., Urata, S., Mano, N., Fukagawa, K., Imamura, M., … Nomiyama, M. (2011). Cannabidiol-2′, 6′-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro. Biological and Pharmaceutical Bulletin, 34(8), 1252–1256.
10.1248/bpb.34.1252
CAS PubMed Web of Science® Google Scholar
Talebi, M., Talebi, M., Farkhondeh, T., & Samarghandian, S. (2021). Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway. Phytotherapy Research, 35(4), 1739–1753.
10.1002/ptr.6905
CAS PubMed Web of Science® Google Scholar
Tavakol, S., Zare, S., Hoveizi, E., Tavakol, B., & Rezayat, S. M. (2019). The impact of the particle size of curcumin nanocarriers and the ethanol on beta_1-integrin overexpression in fibroblasts: A regenerative pharmaceutical approach in skin repair and anti-aging formulations. DARU Journal of Pharmaceutical Sciences, 27(1), 159–168.
10.1007/s40199-019-00258-3
CAS PubMed Web of Science® Google Scholar
Tavano, L., Muzzalupo, R., Picci, N., & de Cindio, B. (2014). Co-encapsulation of lipophilic antioxidants into niosomal carriers: Percutaneous permeation studies for cosmeceutical applications. Colloids and Surfaces B: Biointerfaces, 114, 144–149.
10.1016/j.colsurfb.2013.09.055
CAS PubMed Web of Science® Google Scholar
Teng, F., Deng, P., Song, Z., Zhou, F., & Feng, R. (2017). Enhanced effect in combination of curcumin-and ketoconazole-loaded methoxy poly (ethylene glycol)-poly (ε-caprolactone) micelles. Biomedicine & Pharmacotherapy, 88, 43–51.
10.1016/j.biopha.2017.01.033
CAS PubMed Web of Science® Google Scholar
Teow, S.-Y., Liew, K., Ali, S. A., Khoo, A. S.-B., & Peh, S.-C. (2016). Antibacterial action of curcumin against Staphylococcus aureus: A brief review. Journal of Tropical Medicine, 2016, 1–10.
10.1155/2016/2853045
Web of Science® Google Scholar
Thomsen, G. M., Gowing, G., Svendsen, S., & Svendsen, C. N. (2014). The past, present and future of stem cell clinical trials for ALS. Experimental Neurology, 262, 127–137.
10.1016/j.expneurol.2014.02.021
CAS PubMed Web of Science® Google Scholar
Tong, W. Y., Bin Abdullah, A. Y. K., Binti Rozman, N. A. S., Bin Wahid, M. I. A., Hossain, M. S., Ring, L. C., … Tan, W.-N. (2018). Antimicrobial wound dressing film utilizing cellulose nanocrystal as drug delivery system for curcumin. Cellulose, 25(1), 631–638.
10.1007/s10570-017-1562-9
CAS Web of Science® Google Scholar
Trigo Gutierrez, J. K., Zanatta, G. C., Ortega, A. L. M., Balastegui, M. I. C., Sanita, P. V., Pavarina, A. C., … Mima, E. G. D. O. (2017). Encapsulation of curcumin in polymeric nanoparticles for antimicrobial photodynamic therapy. PLoS One, 12(11), e0187418.
10.1371/journal.pone.0187418
PubMed Web of Science® Google Scholar
Tripathi, P. K., Gupta, S., Rai, S., Shrivatava, A., Tripathi, S., Singh, S., … Kesharwani, P. (2020). Curcumin loaded poly (amidoamine) dendrimer-plamitic acid core-shell nanoparticles as anti-stress therapeutics. Drug Development and Industrial Pharmacy, 46(3), 412–426.
10.1080/03639045.2020.1724132
CAS PubMed Web of Science® Google Scholar
Tripodo, G., Chlapanidas, T., Perteghella, S., Vigani, B., Mandracchia, D., Trapani, A., … Gaetani, P. (2015). Mesenchymal stromal cells loading curcumin-INVITE-micelles: A drug delivery system for neurodegenerative diseases. Colloids and Surfaces B: Biointerfaces, 125, 300–308.
10.1016/j.colsurfb.2014.11.034
CAS PubMed Web of Science® Google Scholar
Tu, K. N., Lie, J. D., Wan, C. K. V., Cameron, M., Austel, A. G., Nguyen, J. K., … Hyun, D. (2018). Osteoporosis: A review of treatment options. Pharmacy and Therapeutics, 43(2), 92–104.
Google Scholar
Tysnes, O.-B., & Storstein, A. (2017). Epidemiology of Parkinson's disease. Journal of Neural Transmission, 124(8), 901–905.
10.1007/s00702-017-1686-y
PubMed Web of Science® Google Scholar
Udompornmongkol, P., & Chiang, B.-H. (2015). Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications. Journal of Biomaterials Applications, 30(5), 537–546.
10.1177/0885328215594479
CAS PubMed Web of Science® Google Scholar
Vafadar_afshar, G., Khadem-Ansari, M.-H., Makhdomii, K., & Rasooli, J. (2020). The effects of Nano-curcumin supplementation on serum level of hs-CRP, adhesion molecules, and lipid profiles in hemodialysis patients, a randomized controlled clinical trial. Iranian Journal of Kidney Diseases, 14(1), 52–61.
PubMed Web of Science® Google Scholar
Vareed, S. K., Kakarala, M., Ruffin, M. T., Crowell, J. A., Normolle, D. P., Djuric, Z., & Brenner, D. E. (2008). Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiology and Prevention Biomarkers, 17(6), 1411–1417.
10.1158/1055-9965.EPI-07-2693
CAS PubMed Web of Science® Google Scholar
Velier, M., Magalon, J., Daumas, A., Cassar, M., Francois, P., Ghazouane, A., … Bernot, D. (2018). Production of platelet-rich plasma gel from elderly patients under antithrombotic drugs: Perspectives in chronic wounds care. Platelets, 29(5), 496–503.
10.1080/09537104.2017.1336212
CAS PubMed Web of Science® Google Scholar
Venkatasubbu, G. D., & Anusuya, T. (2017). Investigation on Curcumin nanocomposite for wound dressing. International Journal of Biological Macromolecules, 98, 366–378.
10.1016/j.ijbiomac.2017.02.002
CAS PubMed Web of Science® Google Scholar
Vitali, D., Bagri, P., Wessels, J. M., Arora, M., Ganugula, R., Parikh, A., … Kumar, M. (2020). Curcumin can decrease tissue inflammation and the severity of HSV-2 infection in the female reproductive mucosa. International Journal of Molecular Sciences, 21(1), 337.
10.3390/ijms21010337
CAS PubMed Web of Science® Google Scholar
Wang, W., Chen, T., Xu, H., Ren, B., Cheng, X., Qi, R., … Chen, S. (2018). Curcumin-loaded solid lipid nanoparticles enhanced anticancer efficiency in breast cancer. Molecules, 23(7), 1578.
10.3390/molecules23071578
PubMed Web of Science® Google Scholar
Wanker, E. E. (2000). Protein aggregation and pathogenesis of Huntingtons disease: Mechanisms and correlations. Biological Chemistry, 381(9–10), 937–942.
10.1515/BC.2000.114
CAS PubMed Web of Science® Google Scholar
Wick, P., Manser, P., Limbach, L. K., Dettlaff-Weglikowska, U., Krumeich, F., Roth, S., … Bruinink, A. (2007). The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicology Letters, 168(2), 121–131.
10.1016/j.toxlet.2006.08.019
CAS PubMed Web of Science® Google Scholar
Xu, L., Zhang, H., & Wu, Y. (2014). Dendrimer advances for the central nervous system delivery of therapeutics. ACS Chemical Neuroscience, 5(1), 2–13.
10.1021/cn400182z
CAS PubMed Web of Science® Google Scholar
Xue, B., Zhang, Y., Xu, M., Wang, C., Huang, J., Zhang, H., … Li, X. (2019). Curcumin-silk fibroin nanoparticles for enhanced anti-Candida albicans activity in vitro and in vivo. Journal of Biomedical Nanotechnology, 15(4), 769–778.
10.1166/jbn.2019.2722
CAS PubMed Web of Science® Google Scholar
Yallapu, M. M., Ebeling, M. C., Chauhan, N., Jaggi, M., & Chauhan, S. C. (2011). Interaction of curcumin nanoformulations with human plasma proteins and erythrocytes. International Journal of Nanomedicine, 6, 2779.
CAS PubMed Web of Science® Google Scholar
Yallapu, M. M., Gupta, B. K., Jaggi, M., & Chauhan, S. C. (2010). Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. Journal of Colloid and Interface Science, 351(1), 19–29.
10.1016/j.jcis.2010.05.022
CAS PubMed Web of Science® Google Scholar
Yallapu, M. M., Khan, S., Maher, D. M., Ebeling, M. C., Sundram, V., Chauhan, N., … Zafar, N. (2014). Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer. Biomaterials, 35(30), 8635–8648.
10.1016/j.biomaterials.2014.06.040
CAS PubMed Web of Science® Google Scholar
Yan, J., & Greer, J. M. (2008). NF-κB, a potential therapeutic target for the treatment of multiple sclerosis. CNS & Neurological Disorders-Drug Targets, 7(6), 536–557.
10.2174/187152708787122941
CAS PubMed Web of Science® Google Scholar
Yan, M. H., Wang, X., & Zhu, X. (2013). Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radical Biology and Medicine, 62, 90–101.
10.1016/j.freeradbiomed.2012.11.014
CAS PubMed Web of Science® Google Scholar
Yang, R., Zheng, Y., Wang, Q., & Zhao, L. (2018). Curcumin-loaded chitosan–bovine serum albumin nanoparticles potentially enhanced Aβ 42 phagocytosis and modulated macrophage polarization in Alzheimer's disease. Nanoscale Research Letters, 13(1), 330.
10.1186/s11671-018-2759-z
PubMed Web of Science® Google Scholar
Yang, S.-T., Wang, X., Jia, G., Gu, Y., Wang, T., Nie, H., … Liu, Y. (2008). Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. Toxicology Letters, 181(3), 182–189.
10.1016/j.toxlet.2008.07.020
CAS PubMed Web of Science® Google Scholar
Yang, X. X., Li, C. M., Li, Y. F., Wang, J., & Huang, C. Z. (2017). Synergistic antiviral effect of curcumin functionalized graphene oxide against respiratory syncytial virus infection. Nanoscale, 9(41), 16086–16092.
10.1039/C7NR06520E
CAS PubMed Web of Science® Google Scholar
Yavarpour-Bali, H., Ghasemi-Kasman, M., & Pirzadeh, M. (2019). Curcumin-loaded nanoparticles: A novel therapeutic strategy in treatment of central nervous system disorders. International Journal of Nanomedicine, 14, 4449–4460.
10.2147/IJN.S208332
CAS PubMed Web of Science® Google Scholar
Zahiri, M., Khanmohammadi, M., Goodarzi, A., Ababzadeh, S., Farahani, M. S., Mohandesnezhad, S., … Ai, J. (2020). Encapsulation of curcumin loaded chitosan nanoparticle within poly (ε-caprolactone) and gelatin fiber mat for wound healing and layered dermal reconstitution. International Journal of Biological Macromolecules, 153, 1241–1250.
10.1016/j.ijbiomac.2019.10.255
CAS PubMed Web of Science® Google Scholar
Zambrano, L. M., Brandao, D. A., Rocha, F. R., Marsiglio, R. P., Longo, I. B., Primo, F. L., … Junior, C. R. (2018). Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease. Scientific Reports, 8(1), 1–11.
10.1038/s41598-018-24866-2
PubMed Web of Science® Google Scholar
Zhang, L., Yang, S., Wong, L. R., Xie, H., & Ho, P. C.-L. (2020). In vitro and in vivo comparison of Curcumin-encapsulated chitosan-coated poly (lactic-co-glycolic acid) nanoparticles and Curcumin/Hydroxypropyl-β-Cyclodextrin inclusion complexes administered Intranasally as therapeutic strategies for Alzheimer's disease. Molecular Pharmaceutics, 17(11), 4256–4269.
10.1021/acs.molpharmaceut.0c00675
CAS PubMed Web of Science® Google Scholar
Zhang, L., Zhang, Y., Du, Y., Wang, J., & Chi, L. (2020). Development of curcumin-loaded silk fibroin nanoparticles as drug delivery vehicle for the treatment of ischemic stroke for patients in nursing care in hospitals. Journal of Drug Delivery Science and Technology, 55, 101360.
10.1016/j.jddst.2019.101360
CAS Web of Science® Google Scholar
Zhang, N., Yan, F., Liang, X., Wu, M., Shen, Y., Chen, M., … Tang, C. (2018). Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy. Theranostics, 8(8), 2264–2277.
10.7150/thno.23734
CAS PubMed Web of Science® Google Scholar
Zhang, X., Li, X., Hua, H., Wang, A., Liu, W., Li, Y., … Sun, K. (2017). Cyclic hexapeptide-conjugated nanoparticles enhance curcumin delivery to glioma tumor cells and tissue. International Journal of Nanomedicine, 12, 5717–5732.
10.2147/IJN.S138501
CAS PubMed Web of Science® Google Scholar
Zhang, Z., Han, S., Liu, P., Yang, X., Han, J., Wang, A., & Zhang, J. (2020). Healing effects of Curcumin nanoparticles in deep tissue injury mouse model. Current Drug Delivery, 18.
10.2174/1567201818666201214125237
Google Scholar
Zheng, J., Cheng, J., Zheng, S., Feng, Q., & Xiao, X. (2018). Curcumin, a polyphenolic curcuminoid with its protective effects and molecular mechanisms in diabetes and diabetic cardiomyopathy. Frontiers in Pharmacology, 9, 472.
10.3389/fphar.2018.00472
PubMed Web of Science® Google Scholar

Citing Literature

Volume35, Issue10

October 2021

Pages 5527-5563

This article also appears in:

Phytocompounds and COVID-19: two years of knowledge

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Abstract

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Abstract

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Related

Information