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Research Article
Open Access

oa

Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer

Dexter Kai Hao Thng, Lissa Hooi, Clarissa Chin Min Toh, Jhin Jieh Lim, Deepa Rajagopalan, Imran Qamar Charles Syariff, Zher Min Tan, Masturah Bte Mohd Abdul Rashid, Lei Zhou, Alfred Wei Chieh Kow, Glenn Kunnath Bonney, Brian Kim Poh Goh, Juinn Huar Kam, Sudhakar Jha, Yock Young Dan, Pierce Kah Hoe Chow, Tan Boon Toh, Edward Kai-Hua Chow,

Molecular Oncology Volume 17, Issue 11
First published: 10 March 2023

Abstract
RESEARCH ARTICLE
Open Access

oa

Splice-switch oligonucleotide-based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC-driven hepatocellular carcinoma

Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce Kah-Hoe Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee, Edward Kai-Hua Chow,

Bioengineering & Translational Medicine Volume 8, Issue 1
First published: 03 September 2022

Abstract
RESEARCH ARTICLE
Open Access

oa

Clinical Service Incorporating Mobile Technology on Weight Loss in Patients With Metabolic Dysfunction–Associated Steatotic Liver Disease: A Translation From Research Trial

Siew Min Ang, Su Lin Lim, Yock Young Dan, Yiong Huak Chan, Qai Ven Yap, Juliana Chen,

Endocrinology, Diabetes & Metabolism Volume 7, Issue 3
First published: 29 April 2024

Abstract
Liver Biology/Pathobiology
Free Access

free

Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice ^†

Narci C. Teoh, Yock Young Dan, Karen Swisshelm, Stacey Lehman, Jocelyn H. Wright, Jamil Haque, Yansong Gu, Nelson Fausto,

Hepatology Volume 47, Issue 6
First published: 07 January 2008

Abstract
REVIEW

no

Placebo effect on progression and regression in NASH: Evidence from a meta-analysis

Cheng Han Ng, Jieling Xiao, Wen Hui Lim, Yip Han Chin, Jie Ning Yong, Darren Jun Hao Tan, Phoebe Tay, Nicholas Syn, Roger Foo, Mark Chan, Nicholas Chew, Eunice XX Tan, Daniel Q. Huang, Yock Young Dan, Nobuharu Tamaki, Mohammad Shadab Siddiqui, Arun J. Sanyal, Rohit Loomba, Mazen Noureddin, Mark D. Muthiah,

Hepatology Volume 75, Issue 6
First published: 06 January 2022

Abstract
ORIGINAL ARTICLE
Open Access

oa

Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in HCC

Sheena Suthen, Chun Jye Lim, Phuong H. D. Nguyen, Charles-Antoine Dutertre, Hannah L. H. Lai, Martin Wasser, Camillus Chua, Tony K. H. Lim, Wei Qiang Leow, Tracy Jiezhen Loh, Wei Keat Wan, Yin Huei Pang, Gwyneth Soon, Peng Chung Cheow, Juinn Huar Kam, Shridhar Iyer, Alfred Kow, Wai Leong Tam, Timothy W. H. Shuen, Han Chong Toh, Yock Young Dan, Glenn K. Bonney, Chung Yip Chan, Alexander Chung, Brian K. P. Goh, Weiwei Zhai, Florent Ginhoux, Pierce K. H. Chow, Salvatore Albani, Valerie Chew,

Hepatology Volume 76, Issue 5
First published: 20 February 2022

Abstract
ORIGINAL ARTICLE

no

Global burden of liver cancer in males and females: Changing etiological basis and the growing contribution of NASH

Darren Jun Hao Tan, Veronica Wendy Setiawan, Cheng Han Ng, Wen Hui Lim, Mark D. Muthiah, Eunice X. Tan, Yock Young Dan, Lewis R. Roberts, Rohit Loomba, Daniel Q. Huang,

Hepatology Early View
First published: 29 August 2022

Abstract
Original Article
Open Access

oa

Targeted Inhibition of Purine Metabolism Is Effective in Suppressing Hepatocellular Carcinoma Progression

Yong Chun Chong, Tan Boon Toh, Zhiling Chan, Quy Xiao Xuan Lin, Dexter Kai Hao Thng, Lissa Hooi, Zhaobing Ding, Timothy Shuen, Han Chong Toh, Yock Young Dan, Glenn Kunnath Bonney, Lei Zhou, Pierce Chow, Yulan Wang, Touati Benoukraf, Edward Kai-Hua Chow, Weiping Han,

Hepatology Communications Volume 4, Issue 9
First published: 27 July 2020

Abstract
Original Article
Open Access

oa

ALT Levels for Asians With Metabolic Diseases: A Meta-analysis of 86 Studies With Individual Patient Data Validation

Daniel Q. Huang, Yee Hui Yeo, Eunice Tan, Hirokazu Takahashi, Satoshi Yasuda, Junji Saruwatari, Kenichi Tanaka, Kentaro Oniki, Leslie Y. Kam, Mark D. Muthiah, Hideyuki Hyogo, Masafumi Ono, Scott D. Barnett, Jie Li, Biyao Zou, James Fung, Teng-Yu Lee, Vincent Wai-Sun Wong, Man-Fung Yuen, Yock Young Dan, Seng Gee Lim, Ramsey Cheung, Hidenori Toyoda, Yuichiro Eguchi, Mindie H. Nguyen,

Hepatology Communications Volume 4, Issue 11
First published: 09 September 2020

Abstract
Original Article
Open Access

oa

Effects of Cirrhosis and Diagnosis Scenario in Metabolic-Associated Fatty Liver Disease-Related Hepatocellular Carcinoma

Vincent L. Chen, Ming-Lun Yeh, Ju Dong Yang, Jennifer Leong, Daniel Q. Huang, Hidenori Toyoda, Yao-Li Chen, Jennifer Guy, Mayumi Maeda, Pei-Chien Tsai, Chung-Feng Huang, Satoshi Yasuda, An K. Le, Hansen Dang, Nasra H. Giama, Hamdi A. Ali, Ning Zhang, Xiaozhong Wang, Dae Won Jun, Cheng-Hao Tseng, Yao-Chun Hsu, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Qiang Zhu, Yock Young Dan, Myron Schwartz, Lewis R. Roberts, Ming-Lung Yu, Mindie H. Nguyen,

Hepatology Communications Volume 5, Issue 1
First published: 24 September 2020

Abstract
EDITORIAL
Open Access

oa

What's in a disease like non-alcoholic fatty liver disease—East versus West?

Yock Young Dan,

JGH Open Volume 6, Issue 8
First published: 02 August 2022
Research Article
Full Access

full

Do different lamivudine-resistant hepatitis B genotypes carry the same risk of entecavir resistance?^†

Guan Huei Lee, Myat Oo Aung, Yock Young Dan, Yin Mei Lee, Belinda Mak, How Cheng Low, Kieron Lim, Maung Aye Thwin, Poh Seng Tan, Seng Gee Lim,

Journal of Medical Virology Volume 85, Issue 1
First published: 28 September 2012

Abstract
Original Articles
Free Access

free

Prophylactic strategies for hepatitis B patients undergoing liver transplant: A cost-effectiveness analysis

Yock Young Dan, Chun Tao Wai, Khay Guan Yeoh, Seng Gee Lim,

Liver Transplantation Volume 12, Issue 5
First published: 20 April 2006

Abstract
Original Article

no

A Diagnostic Test Meta-Analysis Evaluating Imaging-Based and Blood Biomarker–Based Assessment Tools for Fibrosis After Liver Transplantation

Cheng Han Ng, Darren Jun Hao Tan, Xiong Chang Lim, Jie Ning Yong, Nicholas Syn, Gwyneth Shook Ting Soon, Daniel Q. Huang, Jieling Xiao, Grace En Hui Lim, Wen Hui Lim, Eunice Xiang Xuan Tan, Yock Young Dan, Mazen Noureddin, Mohammad Shadab Siddiqui, Mark D. Muthiah,

Liver Transplantation Volume 28, Issue 4
First published: 29 October 2021

Abstract
ORIGINAL REPORT

no

Comparison of laboratory threshold criteria in drug-induced liver injury detection algorithms for use in pharmacovigilance

Eng Hooi Tan, Zheng Jye Ling, Pei San Ang, Cynthia Sung, Yock Young Dan, Bee Choo Tai,

Pharmacoepidemiology and Drug Safety Volume 29, Issue 11
First published: 26 August 2020

Abstract
Tissue-Specific Stem Cells
Free Access

free

Long-Term Fate of Human Fetal Liver Progenitor Cells Transplanted in Injured Mouse Livers

Antony Irudayaswamy, Mark Muthiah, Lei Zhou, Hau Hung, Nur Halisah Bte Jumat, Jamil Haque, Narcissus Teoh, Geoffrey Farrell, Kimberly J. Riehle, Jaymie Siqi Lin, Lin Lin Su, Jerry Ky Chan, Mahesh Choolani, Peng Cheang Wong, Aileen Wee, Seng Gee Lim, Jean Campbell, Nelson Fausto, Yock Young Dan,

STEM CELLS Volume 36, Issue 1
First published: 28 September 2017

Abstract
RESEARCH ARTICLE

no

Enhanced hepatic differentiation of human amniotic epithelial cells on polyethylene glycol-linked multiwalled carbon nanotube-coated hydrogels

Chunyan Zhao, Jamie Siqi Lin, Mahesh Choolani, Yock Young Dan, Giorgia Pastorin, Han Kiat Ho,

Journal of Tissue Engineering and Regenerative Medicine Volume 12, Issue 7
First published: 26 April 2018

Abstract
SYSTEMATIC REVIEW WITH META-ANALYSIS

no

Systematic review with meta-analysis: extrahepatic manifestations in chronic hepatitis C virus-infected patients in East Asia

Zobair M. Younossi, Linda Henry, Janus P. Ong, Atsushi Tanaka, Yuichiro Eguchi, Masashi Mizokami, Young-Suk Lim, Yock Young Dan, Ming-Lung Yu, Maria Stepanova,

Alimentary Pharmacology & Therapeutics Volume 49, Issue 6
First published: 13 February 2019

Abstract
ORIGINAL ARTICLE

no

Comparative biomarkers for HBsAg loss with antiviral therapy shows dominant influence of quantitative HBsAg (qHBsAg)

Seng Gee Lim, Wah Wah Phyo, Joanna Zhi Jie Ling, Gavin Cloherty, Emily K. Butler, Mary C. Kuhns, Anne L. McNamara, Vera Holzmayer, Jeffrey Gersch, Wei Lyn Yang, Jing Hieng Ngu, Jason Chang, Jessica Tan, Taufique Ahmed, Yock Young Dan, Yin Mei Lee, Guan Huei Lee, Poh Seng Tan, Daniel Q. Huang, Htet Toe Wai Khine, Chris Lee, Amy Tay, Edwin Chan,

Alimentary Pharmacology & Therapeutics Volume 53, Issue 1
First published: 07 November 2020

Abstract
RESEARCH ARTICLE
Full Access

full

Neutrophils differentially attenuate immune response to Aspergillus infection through complement receptor 3 and induction of myeloperoxidase

Jessamine G. Goh, Sharada Ravikumar, Mar Soe Win, Qiong Cao, Ai Ling Tan, Joan H. J. Lim, Winnie Leong, Raoul Herbrecht, Peter F. Troke, Bart Jan Kullberg, Mihai G. Netea, Wee Joo Chng, Yock Young Dan, Louis Y. A. Chai,

Cellular Microbiology ,
First published: 31 October 2017

Abstract

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oa Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer

oa Splice-switch oligonucleotide-based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC-driven hepatocellular carcinoma

oa Clinical Service Incorporating Mobile Technology on Weight Loss in Patients With Metabolic Dysfunction–Associated Steatotic Liver Disease: A Translation From Research Trial

free Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice†

no Placebo effect on progression and regression in NASH: Evidence from a meta-analysis

oa Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in HCC

no Global burden of liver cancer in males and females: Changing etiological basis and the growing contribution of NASH

oa Targeted Inhibition of Purine Metabolism Is Effective in Suppressing Hepatocellular Carcinoma Progression

oa ALT Levels for Asians With Metabolic Diseases: A Meta-analysis of 86 Studies With Individual Patient Data Validation

oa Effects of Cirrhosis and Diagnosis Scenario in Metabolic-Associated Fatty Liver Disease-Related Hepatocellular Carcinoma

oa What's in a disease like non-alcoholic fatty liver disease—East versus West?

full Do different lamivudine-resistant hepatitis B genotypes carry the same risk of entecavir resistance?†

free Prophylactic strategies for hepatitis B patients undergoing liver transplant: A cost-effectiveness analysis

no A Diagnostic Test Meta-Analysis Evaluating Imaging-Based and Blood Biomarker–Based Assessment Tools for Fibrosis After Liver Transplantation

no Comparison of laboratory threshold criteria in drug-induced liver injury detection algorithms for use in pharmacovigilance

free Long-Term Fate of Human Fetal Liver Progenitor Cells Transplanted in Injured Mouse Livers

no Enhanced hepatic differentiation of human amniotic epithelial cells on polyethylene glycol-linked multiwalled carbon nanotube-coated hydrogels

no Systematic review with meta-analysis: extrahepatic manifestations in chronic hepatitis C virus-infected patients in East Asia

no Comparative biomarkers for HBsAg loss with antiviral therapy shows dominant influence of quantitative HBsAg (qHBsAg)

full Neutrophils differentially attenuate immune response to Aspergillus infection through complement receptor 3 and induction of myeloperoxidase

oa

Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer

oa

Splice-switch oligonucleotide-based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC-driven hepatocellular carcinoma

oa

Clinical Service Incorporating Mobile Technology on Weight Loss in Patients With Metabolic Dysfunction–Associated Steatotic Liver Disease: A Translation From Research Trial

free

Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice ^†

no

Placebo effect on progression and regression in NASH: Evidence from a meta-analysis

oa

Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in HCC

no

Global burden of liver cancer in males and females: Changing etiological basis and the growing contribution of NASH

oa

Targeted Inhibition of Purine Metabolism Is Effective in Suppressing Hepatocellular Carcinoma Progression

oa

ALT Levels for Asians With Metabolic Diseases: A Meta-analysis of 86 Studies With Individual Patient Data Validation

oa

Effects of Cirrhosis and Diagnosis Scenario in Metabolic-Associated Fatty Liver Disease-Related Hepatocellular Carcinoma

oa

What's in a disease like non-alcoholic fatty liver disease—East versus West?

full

Do different lamivudine-resistant hepatitis B genotypes carry the same risk of entecavir resistance?^†

free

Prophylactic strategies for hepatitis B patients undergoing liver transplant: A cost-effectiveness analysis

no

A Diagnostic Test Meta-Analysis Evaluating Imaging-Based and Blood Biomarker–Based Assessment Tools for Fibrosis After Liver Transplantation

no

Comparison of laboratory threshold criteria in drug-induced liver injury detection algorithms for use in pharmacovigilance

free

Long-Term Fate of Human Fetal Liver Progenitor Cells Transplanted in Injured Mouse Livers

no

Enhanced hepatic differentiation of human amniotic epithelial cells on polyethylene glycol-linked multiwalled carbon nanotube-coated hydrogels

no

Systematic review with meta-analysis: extrahepatic manifestations in chronic hepatitis C virus-infected patients in East Asia

no

Comparative biomarkers for HBsAg loss with antiviral therapy shows dominant influence of quantitative HBsAg (qHBsAg)

full

Neutrophils differentially attenuate immune response to Aspergillus infection through complement receptor 3 and induction of myeloperoxidase