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Issue Information

  • First Published: 15 October 2020

EXPERT PERSPECTIVE
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Expert perspective: Highlights on myeloma cell therapy from the American Society of Hematology Annual Meeting 2019

  • First Published: 26 May 2020
Expert perspective: Highlights on myeloma cell therapy from the American Society of Hematology Annual Meeting 2019

One possible mechanism of relapsed disease is the downregulation of surface B-cell maturation antigen (BCMA) by gamma secretase. The gamma secretase inhibitor (JSMD194) can increase surface BCMA expression and decrease soluble BCMA.