• Issue

    Annals of Clinical and Translational Neurology: Volume 12, Issue 4

    671-883
    April 2025
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Issue Information

Open Access

Issue Information

  • Pages: 671-673
  • First Published: 29 April 2025

Review

Open Access

Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy

Julie Choi,  Zitian Tang,  Wendy Dong,  Jenna Ulibarri,  Elvisa Mehinovic,  Simone Thomas,  Ahmet Höke,  Sheng Chih Jin, 
  • Pages: 674-685
  • First Published: 24 March 2025

Research Article

Open Access

An MRI assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis

Ermelinda De Meo,  Ferran Prados Carrasco,  J. William L. Brown,  Alasdair J. Coles,  Nick G. Cunniffe,  Amy E. Jolly,  Baris Kanber,  Rebecca Samson,  Frederik Barkhof,  Declan Chard, 
  • Pages: 686-700
  • First Published: 27 January 2025
An MRI assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis

By applying the tensor model, we analysed lesion orientation and the directionality of lesion expansion/contraction in multiple sclerosis. Each lesion is summarized as an ellipsoid, and the tensor model is applied to calculate lesion anisotropy. From the top to the bottom white matter atlas, surface-in gradient segmentation and venous atlas used in the present study are represented together with examples of lesions aligned with each orientation assessed.

Open Access

Epigenome-wide association study, meta-analysis, and multiscore profiling of whole blood in Parkinson's disease

Ingeborg Haugesag Lie,  Manuela M. X. Tan,  Maren Stolp Andersen,  Mathias Toft,  Lasse Pihlstrøm, 
  • Pages: 701-713
  • First Published: 05 February 2025
Open Access

ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression

Eleanor V. Thomas,  Changee Han,  Woo Jae Kim,  Seneshaw Asress,  Yingjie Li,  Jennifer A. Taylor,  Marla Gearing,  Christina N. Fournier,  Zachary T. McEachin,  Nicholas T. Seyfried,  Jonathan D. Glass, 
  • Pages: 714-723
  • First Published: 06 February 2025
Open Access

Cerebral autoregulation in patients with acute lacunar infarction: a reliable predictor of outcome

Xiang-Kun Si,  Song Xue,  Xin Zhou,  Ya-Nan Guo,  Wen-Yu Du,  Yang Qu,  Xin Sun,  Zhen-Ni Guo, 
  • Pages: 724-736
  • First Published: 11 February 2025
Open Access

Skin calcium deposits in primary familial brain calcification: A novel potential biomarker

Aron Emmi,  Giulia Bonato,  Aleksandar Tushevski,  Cinzia Bertolin,  Francesco Cavallieri,  Andrea Porzionato,  Angelo Antonini,  Leonardo Salviati,  Miryam Carecchio, 
  • Pages: 737-745
  • First Published: 11 February 2025
Open Access

Liraglutide for idiopathic intracranial hypertension: a real-world propensity score-matched study

Ahmed Y. Azzam,  Muhammed Amir Essibayi,  Dhrumil Vaishnav,  Mohammed A. Azab,  Mahmoud M. Morsy,  Osman Elamin,  Adam Elswedy,  Oday Atallah,  Hana J. Abukhadijah,  Adam A. Dmytriw,  Amanda Baker,  Deepak Khatri,  Neil Haranhalli,  David J. Altschul, 
  • Pages: 746-755
  • First Published: 13 February 2025
Open Access

Twelve-month change in quantitative MRI calf muscle fat fraction in CMT1A predicts clinical change over 4 years

Matthew R. B. Evans,  Hamza A. Salhab,  Christopher D. J. Sinclair,  Sachit Shah,  Michael G. Hanna,  Tarek A. Yousry,  John S. Thornton,  Jasper M. Morrow,  Mary M. Reilly, 
  • Pages: 756-767
  • First Published: 17 February 2025
Open Access

Amygdala Neurodegeneration: A Key Driver of Visual Dysfunction in Parkinson's Disease

Asier Erramuzpe,  Ane Murueta-Goyena,  Antonio Jimenez-Marin,  Marian Acera,  Sara Teijeira-Portas,  Rocío Del Pino,  Tamara Fernández-Valle,  Ibai Diez,  Unai Sainz-Lugarezaresti,  Naroa Ibarretxe-Bilbao,  Unai Ayala,  Maitane Barrenechea,  Alberto Cabrera-Zubizarreta,  Jesús Cortés,  Juan Carlos Gómez-Esteban,  Iñigo Gabilondo, 
  • Pages: 768-779
  • First Published: 17 February 2025
Open Access

Associations of Cerebrospinal Fluid Orexin-A, Alzheimer Disease Biomarkers, and Cognitive Performance

Ruijin Lu,  Krish Shah,  Cristina D. Toedebusch,  Ashley Hess,  Rachel Richardson,  Emmanuel Mignot,  Suzanne E. Schindler,  Tammie L. S. Benzinger,  Shaney Flores,  Jason Hassenstab,  Chengjie Xiong,  John C. Morris,  David M. Holtzman,  Brendan P. Lucey, 
  • Pages: 780-791
  • First Published: 17 February 2025
Open Access

Clinical impact and safety of brain biopsy in unexplained central nervous system disorders: a real-world cohort study

Robin W. van Steenhoven,  Saan Salih,  Juna M. de Vries,  Ide Smets,  Rob M. Verdijk,  Mayke Gardeniers,  Jeroen Kerstens,  Juliette Brenner,  Yvette S. Crijnen,  Marjolein Geurts,  Jacoline E. C. Bromberg,  Corine H. GeurtsvanKessel,  Peter A. E. Sillevis Smitt,  Rutger K. Balvers,  Maarten J. Titulaer, 
  • Pages: 792-804
  • First Published: 21 February 2025
Open Access

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Jonathan D. Santoro,  Neetha Paul Eduthan,  Mellad M. Khoshnood,  Saba Jafarpour,  Natalie K. Boyd,  Benjamin N. Vogel,  Lina Nguyen,  Lilia Kazerooni,  Eleanor Britton,  Hannah R. Lyford,  Matthew D. Galbraith,  Angela L. Rachubinski,  Joaquin M. Espinosa, 
  • Pages: 805-820
  • First Published: 25 February 2025
Open Access

Capturing what matters: Patient-reported LGI1-ANTibody encephalitis outcome RatiNg scale (LANTERN)

Mark J Kelly,  Barbara Wagner,  Bryan Ceronie,  Christine Strippel,  Ann Yee Lin,  Adam Handel,  John Soltys,  Sophie Binks,  Philip A Powell,  Sarosh R Irani, 
  • Pages: 821-831
  • First Published: 25 February 2025
Open Access

Targeted Long-Read Sequencing as a Single Assay Improves the Diagnosis of Spastic-Ataxia Disorders

Laura Ivete Rudaks,  Igor Stevanovski,  Dennis Yeow,  Andre L. M. Reis,  Sanjog R. Chintalaphani,  Pak Leng Cheong,  Hasindu Gamaarachchi,  Lisa Worgan,  Kate Ahmad,  Michael Hayes,  Andrew Hannaford,  Samuel Kim,  Victor S. C. Fung,  Gabor M. Halmagyi,  Andrew Martin,  David Manser,  Michel Tchan,  Karl Ng,  Marina L. Kennerson,  Ira W. Deveson,  Kishore Raj Kumar, 
  • Pages: 832-841
  • First Published: 25 February 2025
Open Access

Longitudinal Trajectories of Digital Cognitive Biomarkers for Multiple Sclerosis

Yi Chao Foong,  Daniel Merlo,  Melissa Gresle,  Chao Zhu,  Katherine Buzzard,  Jeannette Lechner-Scott,  Michael Barnett,  Chenyu Wang,  Bruce V. Taylor,  Tomas Kalincik,  Trevor Kilpatrick,  David Darby,  Pamela Dobay,  Johan van Beek,  Robert Hyde,  Steve Simpson-Yap,  Helmut Butzkueven,  Anneke van der Walt, 
  • Pages: 842-850
  • First Published: 25 February 2025

Brief Communication

Open Access

Heterozygous variants in AP4S1 are not associated with a neurological phenotype

Vicente Quiroz,  Umar Zubair,  Luca Schierbaum,  Amy Tam,  Nicole Battaglia,  Joshua Rong,  Habibah A. P. Agianda,  Julian E. Alecu,  Kathryn Yang,  Darius Ebrahimi-Fakhari, 
  • Pages: 851-854
  • First Published: 27 January 2025
Open Access

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity

Yahel Segal,  Georgios Mangioris,  Vanda Lennon,  Binxia Yang,  Divyanshu Dubey,  Eoin P. Flanagan,  Andrew McKeon,  John R. Mills,  Michel Toledano,  Ivana Vodopivec,  Sean J. Pittock,  Anastasia Zekeridou, 
  • Pages: 855-860
  • First Published: 27 January 2025
Open Access

Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD

Young Nam Kwon,  Nanthaya Tisavipat,  Yong Guo,  Stephanie B. Syc-Mazurek,  Ji Yeon Han,  Jun-Soon Kim,  Kyomin Choi,  Seong-il Oh,  Seok-Jin Choi,  Eunhee Sohn,  Jeeyoung Oh,  Seung Woo Kim,  Ha Young Shin,  Byung Chan Lim,  Byoung Joon Kim,  Kyung Seok Park,  Jung-Joon Sung,  Se Hoon Kim,  Sung-Hye Park,  Anastasia Zekeridou,  Claudia F. Lucchinetti,  Sean J. Pittock,  John J. Chen,  Eoin P. Flanagan,  Sung-Min Kim, 
  • Pages: 861-870
  • First Published: 11 February 2025
Open Access

Combined Systemic Immunotherapy and Intrathecal Dexamethasone in Febrile Infection Related Epilepsy Syndrome

Kristen S. Fisher,  Alexander Ankar,  Jon Cokley,  Eyal Muscal,  James J. Riviello,  Yi-Chen Lai, 
  • Pages: 871-875
  • First Published: 11 February 2025
Open Access

High-Throughput Immunoassays for Cavin-4 IgG: A Diagnostic Tool for Immune-Mediated Rippling Muscle Disease

Reghann G. LaFrance-Corey,  Haidara Kherbek,  Nimalan Harinesan,  Margherita Milone,  Naveen K. Paramasivan,  Pallab Sarker,  Andrew M. Knight,  Carley Karsten,  Surendra Dasari,  Teerin Liewluck,  William J. Litchy,  Sean J. Pittock,  John R. Mills,  Divyanshu Dubey, 
  • Pages: 876-880
  • First Published: 17 February 2025

interACTN Case

Open Access

Case of a 96-year-old woman with tilt of the subjective vertical axis

Markus A. Hobert,  Patrik Theodor Nerdal,  Klaus Jahn,  Johannes Hensler,  Walter Maetzler, 
  • Pages: 881-883
  • First Published: 11 February 2025