• Issue

    Pulmonary Circulation: Volume 11, Issue 4

    1-6
    October‐December 2021
Previous Issue|Next Issue
Export Citation(s)Download PDF(s)

Case Report

Open Access

BMPR2 mutations and response to inhaled or parenteral prostanoids: a case series

Laura Scelsi,  Alessandra Greco,  Mauro Acquaro,  Carla Olivieri,  Matteo Sobrero,  Annalisa Turco,  Donata Cappelletti,  Luigi Oltrona Visconti,  Stefano Ghio, 
  • Pages: 1-5
  • First Published: 01 December 2021

Original Research Articles

Open Access

Ubiquitin-specific protease 7 mediates platelet-derived growth factor-induced pulmonary arterial smooth muscle cells proliferation

Yanting Zhu,  Qianqian Zhang,  Xin Yan,  Lu Liu,  Cui Zhai,  Qingting Wang,  Limin Chai,  Manxiang Li, 
  • Pages: 1-9
  • First Published: 01 September 2021
Open Access

Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization

Mingmei Xiong,  Pritesh P. Jain,  Jiyuan Chen,  Aleksandra Babicheva,  Tengteng Zhao,  Mona Alotaibi,  Nick H. Kim,  Ning Lai,  Amin Izadi,  Marisela Rodriguez,  Jifeng Li,  Angela Balistrieri,  Francesca Balistrieri,  Sophia Parmisano,  Xin Sun,  Daniela Valdez-Jasso,  John Y-J. Shyy,  Patricia A. Thistlethwaite,  Jian Wang,  Ayako Makino,  Jason X.-J. Yuan, 
  • Pages: 1-17
  • First Published: 01 September 2021
Open Access

“It is the fear of exercise that stops me” – attitudes and dimensions influencing physical activity in pulmonary hypertension patients

Ciara McCormack,  Sarah Cullivan,  Brona Kehoe,  Noel McCaffrey,  Sean Gaine,  Brian McCullagh,  Niall M. Moyna,  Sarah J. Hardcastle, 
  • Pages: 1-9
  • First Published: 01 November 2021

Review Article

Open Access

Serious illness conversations in pulmonary hypertension

Reem Ismail,  Sara Hegab,  Bryan Kelly,  Domingo J. Franco-Palacios,  Gillian Grafton,  Zachary R. Smith,  Rana L.A. Awdish, 
  • Pages: 1-6
  • First Published: 01 October 2021

Original Research Articles

Open Access

Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb

Mohamed Ahmed,  Nahla Zaghloul,  Prisca Zimmerman,  Nancy G. Casanova,  Xiaoguang Sun,  Jin H. Song,  Vivian Reyes Hernon,  Saad Sammani,  Franz Rischard,  Olga Rafikova,  Ruslan Rafikov,  Ayako Makino,  Carrie L. Kempf,  Sara M. Camp,  Jian Wang,  Ankit A. Desai,  Yves Lussier,  Jason X.-J. Yuan,  Joe G.N. Garcia, 
  • Pages: 1-14
  • First Published: 01 November 2021
Open Access

Reasons for refusing parenteral therapy: a qualitative study of patients with pulmonary arterial hypertension

Kellie Morland,  Amresh Raina,  Abigail Nails,  Peter Classi,  Martine Etschmaier,  Robert P. Frantz, 
  • Pages: 1-7
  • First Published: 01 September 2021
Open Access

Impact of pulmonary hypertension in patients with acute exacerbation of chronic obstructive pulmonary disease and its effect on healthcare utilization

Rezwan F. Munshi MD,  James R. Pellegrini Jr MD,  Pranavi Patel MD,  Maxim Kashin MD,  James Kang MD,  Robert Sexton MD,  Jose R. Russe MD,  Amgad N. Makaryus MD,  Palakkumar Patel MD,  Samarthkumar Thakkar MD,  Brandon Pelletier MD,  Tinu Abraham MD,  Muhammad Tiwana MD,  Fatima Anjum MD, 
  • Pages: 1-6
  • First Published: 01 September 2021
Open Access

PeakPETCO2 combined with FEV1/FVC predicts vasodilator-responsive patients with idiopathic pulmonary arterial hypertension

Ci-Jun Luo,  Hong-Ling Qiu,  Chang-Wei Wu,  Jing He,  Ping Yuan,  Qin-Hua Zhao,  Rong Jiang,  Wen-Hui Wu,  Su-Gang Gong,  Jian Guo,  Rui Zhang,  Jin-Ming Liu,  Lan Wang, 
  • Pages: 1-8
  • First Published: 01 December 2021
Open Access

Positioning imatinib for pulmonary arterial hypertension: A phase I/II design comprising dose finding and single-arm efficacy

Martin R. Wilkins,  Mikel A. Mckie,  Martin Law,  Andreas A. Roussakis,  Lars Harbaum,  Colin Church,  J Gerry Coghlan,  Robin Condliffe,  Luke S Howard,  David G Kiely,  Jim Lordan,  Alexander Rothman,  Jay Suntharalingam,  Mark Toshner,  Stephen J Wort,  Sofía S. Villar, 
  • Pages: 1-12
  • First Published: 01 October 2021

Review Article

Open Access

Liver abnormalities in pulmonary arterial hypertension

Nils P. Nickel,  Gian M. Galura,  Marc J. Zuckerman,  M. Nawar Hakim,  Haider Alkhateeb,  Debabrata Mukherjee,  Eric D. Austin,  Gustavo A. Heresi, 
  • Pages: 1-12
  • First Published: 01 October 2021

Original Research Articles

Open Access

Health-related quality of life and hospitalizations in chronic thromboembolic pulmonary hypertension versus idiopathic pulmonary arterial hypertension: an analysis from the Pulmonary Hypertension Association Registry (PHAR)

Jasleen Minhas,  Sai Prasanna Narasimmal,  Todd M. Bull,  Teresa De Marco,  John Wesley McConnell,  Matthew R. Lammi,  Thenappan Thenappan,  Jeremy P. Feldman,  Jeffrey S. Sager,  David B. Badesch,  John J. Ryan,  Daniel C. Grinnan,  Dianne Zwicke,  Evelyn M. Horn,  Jean M. Elwing,  John E. Moss,  Michael Eggert,  Oksana A. Shlobin,  Robert P. Frantz,  Sonja D. Bartolome,  Stephen C. Mathai,  Sula Mazimba,  Steven C. Pugliese,  Nadine Al-Naamani,  PHAR investigators , 
  • Pages: 1-11
  • First Published: 01 October 2021

Research Letter

Open Access

Bisoprolol and/or hyperoxic breathing do not reduce hyperventilation in pulmonary arterial hypertension patients

Eva L. Peters,  Jasmijn S.J.A van Campen,  Herman Groepenhoff,  Frances S. de Man,  Anton Vonk Noordegraaf,  Harm J. Bogaard, 
  • Pages: 1-4
  • First Published: 01 December 2021

Original Research Articles

Open Access

Global trends in chronic thromboembolic pulmonary hypertension clinical trials and dissemination of results

Micheal C. McInnis,  Clement T. Chow,  Alexandre Boutet,  Sebastian Mafeld,  John Granton,  Karen McRae,  Laura Donahoe,  Marc de Perrot, 
  • Pages: 1-8
  • First Published: 01 November 2021
Open Access

Metabolic endophenotype associated with right ventricular glucose uptake in pulmonary hypertension

Samar Farha,  Suzy Comhair,  Yuan Hou,  Margaret M. Park,  Jacqueline Sharp,  Laura Peterson,  Belinda Willard,  Renliang Zhang,  Frank P. DiFilippo,  Donald Neumann,  W.H. Wilson Tang,  Feixiong Cheng,  Serpil Erzurum, 
  • Pages: 1-12
  • First Published: 01 November 2021
Open Access

A computational model of contributors to pulmonary hypertensive disease: impacts of whole lung and focal disease distributions

Behdad Shaarbaf Ebrahimi,  Merryn H. Tawhai,  Haribalan Kumar,  Kelly S. Burrowes,  Eric A. Hoffman,  Margaret L. Wilsher,  David Milne,  Alys R. Clark, 
  • Pages: 1-15
  • First Published: 01 November 2021
Open Access

Vascular remodeling of the small pulmonary arteries and measures of vascular pruning on computed tomography

Andrew J. Synn,  Constance De Margerie-Mellon,  Sun Young Jeong,  Farbod N. Rahaghi,  Iny Jhun,  George R. Washko,  Raúl San José Estépar,  Alexander A. Bankier,  Murray A. Mittleman,  Paul A. VanderLaan,  Mary B. Rice, 
  • Pages: 1-9
  • First Published: 01 November 2021

Letter to the Editor

Open Access

Sugen, hypoxia and the lung circulation

Norbert F. Voelkel,  Harm J. Bogaard, 
  • Pages: 1-3
  • First Published: 01 October 2021

Case Report

Open Access

Carfilzomib-associated pulmonary arterial hypertension in multiple myeloma

Jenny Z. Yang,  Taylor Buckstaff,  Anna Narezkina,  Timothy M. Fernandes, 
  • Pages: 1-3
  • First Published: 01 September 2021

Original Research Articles

Open Access

Plasma ADAMTS13 and von Willebrand factor in diagnosis and prediction of prognosis in pulmonary arterial hypertension

Abdulla Ahmed,  Salaheldin Ahmed,  Göran Rådegran, 
  • Pages: 1-15
  • First Published: 01 September 2021
Open Access

PKR deficiency alleviates pulmonary hypertension via inducing inflammasome adaptor ASC inactivation

Yapei Li,  Ying Li,  Lijun Li,  Minghui Yin,  Jiangang Wang,  Xiaohui Li, 
  • Pages: 1-13
  • First Published: 01 September 2021

Conference Abstract

Open Access

2021 Annual World Congress of the Pulmonary Vascular Research Institute Webinar Series

  • Pages: 1-24
  • First Published: 01 October 2021

Original Research Articles

Open Access

Dyspnea after pulmonary embolism: a nation-wide population-based case–control study

Lars T. Nilsson,  Therese Andersson,  Flemming Larsen,  Irene M. Lang,  Per Liv,  Stefan Söderberg, 
  • Pages: 1-9
  • First Published: 01 September 2021

Case Report

Open Access

Transition from parenteral prostacyclins to selexipag: safety and feasibility in selected patients

Nael Aldweib,  Nathan J. Verlinden,  Hayah Kassis-George,  Amresh Raina, 
  • Pages: 1-5
  • First Published: 01 October 2021

Original Research Articles

Open Access

Right ventricular function as assessed by cardiac magnetic resonance imaging-derived strain parameters compared to high-fidelity micromanometer catheter measurements

Takahiro Sato,  Bharath Ambale-Venkatesh,  Stefan L. Zimmerman,  Ryan J. Tedford,  Steven Hsu,  Ela Chamera,  Tomoki Fujii,  Christopher J. Mullin,  Valentina Mercurio,  Rubina Khair,  Celia P. Corona-Villalobos,  Catherine E. Simpson,  Rachel L. Damico,  Todd M. Kolb,  Stephen C. Mathai,  Joao A.C. Lima,  David A. Kass,  Ichizo Tsujino,  Paul M. Hassoun, 
  • Pages: 1-10
  • First Published: 01 September 2021
Open Access

Acetazolamide prevents hypoxia-induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle

Larissa A. Shimoda,  Karthik Suresh,  Clark Undem,  Haiyang Jiang,  Xin Yun,  J.T. Sylvester,  Erik R. Swenson, 
  • Pages: 1-12
  • First Published: 01 October 2021
Open Access

Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia

Vijaya Karoor,  Delaney Swindle,  David I Pak,  Julie Harral,  Derek Strassheim,  Mehdi A Fini,  Edward Dempsey,  Kurt R Stenmark,  Kathryn Hassell,  Rachelle Nuss,  Paul W. Buehler,  David C. Irwin, 
  • Pages: 1-11
  • First Published: 01 November 2021

Open Access

Sex and survival following pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a Scandinavian observational cohort study

Janica Kallonen,  Kasper Korsholm,  Fredrik Bredin,  Matthias Corbascio,  Mads Jønsson Andersen,  Lars Bo Ilkjær,  Søren Mellemkjær,  Ulrik Sartipy, 
  • Pages: 1-9
  • First Published: 01 October 2021
Open Access

Serum cartilage oligomeric matrix protein is decreased in patients with pulmonary hypertension: a potential protective factor

Dan-dan Chen,  Wei-ping Hu,  Liang Xie,  Gui-ling Xiang,  Qin-han Wu,  Jie-ming Qu,  Shan-qun Li,  Li-hua Guan,  Dong Liu, 
  • Pages: 1-6
  • First Published: 01 September 2021

Research Letter

Open Access

Systemic arterial properties in pulmonary hypertension

Randi Goodman,  Julio A. Chirinos,  Bonnie Ky,  Jeremy A. Mazurek,  Kerri Akaya Smith,  Harold I. Palevsky,  Jason S. Fritz,  Steven C. Pugliese,  Steven M. Kawut,  Nadine Al-Naamani, 
  • Pages: 1-3
  • First Published: 01 October 2021

Original Research Articles

Open Access

Murine models of sickle cell disease and beta-thalassemia demonstrate pulmonary hypertension with distinctive features

Paul W. Buehler,  Delaney Swindle,  David I. Pak,  Mehdi A. Fini,  Kathryn Hassell,  Rachelle Nuss,  Rebecca B. Wilkerson,  Angelo D’Alessandro,  David C. Irwin, 
  • Pages: 1-12
  • First Published: 01 November 2021

Corrigendum

Open Access

Corrigendum for Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia

  • Page: 1
  • First Published: 01 October 2021

Original Research Articles

Open Access

Pulmonary hypertension associated with busulfan

Jean Hagenburg,  Laurent Savale,  Benoit Lechartier,  Maria-Rosa Ghigna,  Marie-Camille Chaumais,  Xavier Jaïs,  Olivier Sitbon,  Marc Humbert,  David Montani, 
  • Pages: 1-12
  • First Published: 01 September 2021
Open Access

Cardiac biomarkers as indicators of right ventricular dysfunction and recovery in chronic thromboembolic pulmonary hypertension patients after balloon pulmonary angioplasty therapy – a cardiac magnetic resonance imaging cohort study

Steffen D. Kriechbaum,  Julia M. Vietheer,  Christoph B. Wiedenroth,  Felix Rudolph,  Marta Barde,  Jan-Sebastian Wolter,  Moritz Haas,  Ulrich Fischer-Rasokat,  Maren Weferling,  Andreas Rolf,  Christian W. Hamm,  Eckhard Mayer,  Stefan Guth,  Till Keller,  Fritz C. Roller,  Christoph Liebetrau, 
  • Pages: 1-10
  • First Published: 01 December 2021
Open Access

Vasodilator therapy for pulmonary hypertension in children: a national study of patient characteristics and current treatment strategies

Ida Jeremiasen,  Estelle Naumburg,  Christian Westöö,  Constance G. Weismann,  Karin Tran-Lundmark, 
  • Pages: 1-8
  • First Published: 01 December 2021

Letter to the Editor

Open Access

Book review on hypoxic respiratory failure in the newborn – from origins to clinical management

Kurt Stenmark, 
  • Pages: 1-2
  • First Published: 01 October 2021

Original Research Articles

Open Access

Increased serum PCSK9 in patients with idiopathic pulmonary arterial hypertension: insights from inflammatory cytokines

Dong-Xiang Zhong,  Yuan Zhang,  Qi Jin,  Xiao-Chun Zhang,  Feng Zhang,  Dan-Dan Chen,  Li-Hua Guan,  Da-Xin Zhou,  Jun-Bo Ge, 
  • Pages: 1-9
  • First Published: 01 October 2021
Open Access

Survival and drug persistence in patients receiving inhaled treprostinil at doses greater than 54 µg (nine breaths) four times daily

Shelley Shapiro,  Stacy Mandras,  Ricardo Restrepo-Jaramillo,  Eric Shen,  Meredith Broderick,  Youlan Rao,  Dasom Lee,  Andrew C. Nelsen, 
  • Pages: 1-7
  • First Published: 01 October 2021
Open Access

Effect of dose, dosing intervals, and hypoxic stress on the reversal of pulmonary hypertension by mesenchymal stem cell extracellular vesicles

James R Klinger,  Mandy Pereira,  Michael Del Tatto,  Mark S Dooner,  Sicheng Wen,  Peter J Quesenberry,  Olin D Liang, 
  • Pages: 1-11
  • First Published: 01 October 2021

Case Report

Open Access

Pulmonary arterial hypertension in pediatric patients undergoing high-dose carboplatin/thiotepa and stem cell transplant

Gretchen Hackett,  Farrah Munir,  Teresa Shapiro,  Robert Greiner,  Daniel J. McKeone,  Vincent P.R. Aluquin, 
  • Pages: 1-3
  • First Published: 01 October 2021

Original Research Articles

Open Access

The association of six-minute walk work and other clinical measures to cardiopulmonary exercise test parameters in pulmonary vascular disease

Lucy C. Robertson,  Katrina E. Oates,  Andrew J. Fletcher,  Karl P. Sylvester, 
  • Pages: 1-12
  • First Published: 01 December 2021
Open Access

Clinical characteristics and prognosis analysis of idiopathic and hereditary pulmonary hypertension patients with ACVRL1 gene mutations

Xinyu Zhang,  Chen Zhang,  Qiangqiang Li,  Chunmei Piao,  Hongsheng Zhang,  Hong Gu, 
  • Pages: 1-8
  • First Published: 01 October 2021
Open Access

Effect of spironolactone use in pulmonary arterial hypertension – analysis from pivotal trial databases

Zeenat Safdar,  Eunah Cho, 
  • Pages: 1-11
  • First Published: 01 November 2021
Open Access

TORREY, a Phase 2 study to evaluate the efficacy and safety of inhaled seralutinib for the treatment of pulmonary arterial hypertension

Robert P. Frantz,  Raymond L. Benza,  Richard N. Channick,  Kelly Chin,  Luke S. Howard,  Vallerie V. McLaughlin,  Olivier Sitbon,  Roham T. Zamanian,  Anna R. Hemnes,  Matt Cravets,  Jean-Marie Bruey,  Robert Roscigno,  David Mottola,  Erin Elman,  Lawrence S. Zisman,  Hossein-Ardeschir Ghofrani, 
  • Pages: 1-7
  • First Published: 01 November 2021
Open Access

EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability

Joseph B. Mascarenhas,  Amir A. Gaber,  Tania M. Larrinaga,  Rachel Mayfield,  Stefanie Novak,  Sara M. Camp,  Carol Gregorio,  Jeffrey R. Jacobson,  Anne E. Cress,  Steven M. Dudek,  Joe G.N. Garcia, 
  • Pages: 1-10
  • First Published: 01 October 2021
Open Access

Characteristics of chronic thromboembolic pulmonary hypertension in Ireland

Sarah Cullivan,  Ciara McCormack,  Marissa O’Callaghan,  Barry Kevane,  Fionnuala NiAinle,  Brian McCullagh,  Sean P. Gaine, 
  • Pages: 1-6
  • First Published: 01 October 2021