CSN6 was overexpressed in human PTCs, and loss of CSN6 attenuated tumor proliferation and migration. In PTC patients, the level of CSN6 was significantly (inversely) correlated with tumor size, the presence of multifocal lesions, and TNM stage.

In this work, we evaluated the frequency of Th17 cells in peripheral blood samples obtained from cervical squamous cell carcinoma patients, CIN1 patients, CIN2 patients, CIN3 patients, high-risk HPV-infected women with normal cervical cytology, and healthy controls,as well as the levels of IL-17 in peripheral blood samples and in supernatant of cervical tissue homogenate. So we had come to the conclusion that Th17 cells and IL-17 may play a role of immune enhancement in the infection of high-risk HPV, which contribute to the disease progression of its associated cervical lesions.

Long-term analysis of 865 patients with newly diagnosed multiple myeloma treated with first-line autologous stem cell transplantation reveals sustained response after transplantation as a major prognostic factor for survival. Administration of maintenance therapy independently improves outcome, supporting the hypothesis that interventions to prolong responses achieved may be essential to reach long-term survival.

Since Imatinib is usually administered for a prolonged period, rational management of its side effects is of great importance. Few studies have been conducted to investigate the association between plasma concentration and side effects. In this study, Imatinib-induced myelosuppression was found to be correlated significantly with Imatinib concentration, and the estimated exposure threshold for myelosuppression was 1451.6 ng/mL with ROCAUC (95% CI) of 0.693 (0.597–0.789).

The currents study indicates that the diameters of maximum cancer lesions in patients with prostate volume ≥ 50 mL were significantly smaller than those in patients with prostate volume <50 mL. Loss of diagnostic accuracy of markers in patients with prostate volume ≥ 50mL indicates a decrease in serum levels of PSA produced by prostate cancer, which suggests growth inhibition of the cancer.

We used a novel method to identify a prognostic signature in gastric cancer, which removed the batch effects. The signature also showed a better predictive accuracy than other prognostic signatures.

The efficacy and safety of carbon ion radiotherapy with concurrent chemotherapy was evaluated in patients with locally advanced uterine cervical adenocarcinoma. This strategy was well tolerated in the majority of patients.

Preoperative anemia, even mild anemia, is a useful predictor of outcomes in tumor–nodes–metastasis stage III gastric cancer.

This is the first European study to investigate the impact of spatial barriers upon appropriate radiotherapy (RT) in breast cancer patients. In Umbria, central Italy, journey times >40 min significantly decreased the probability of receiving RT and were consequently associated with poor outcome. New RT centers provided more patients with appropriate treatment, raising the issue of a “hub and spoke” approach. Spatial barriers to RT in Europe deserve investigation.

Our research reported an artemisinin derivative, SM1044, induces autophagy-dependent apoptosis which is triggered by an increased acetylation of Survivin, a modification which induces its interaction with LC3-II and its degradation. We also unraveled that the activation of CaMKK2–AMPK–ULK1 axis was molecular basis of SM1044-dependent stimulation of autophagy. These investigations not only point to SM1044 as a promising molecule in fighting diffuse large B-cell lymphoma (DLBCL), but also unravel important information of the molecular pathways involved in the oncogenesis of DLBCL.

Suppressing effect of Tanshinone IIA (TAN) on the survival of oral squamous cell carcinoma (OSCC), which was dependent on the Beclin-1-induced autophagic process.

We established vinorelbine-resistant lung cancer cells and examined its transcriptional changes, protein expressions, and activations. On the basis of these results, we focused on the focal adhesion (FA) pathway and tested the effects of gene silencing and inhibitors. In conclusion, FA pathway, particularly integrin and SFK, are promising targets for vinorelbine-resistant lung cancer.

In summary, our results indicate that high NDC80 expression is correlated with advanced tumor stage and unfavorable prognosis in CRC patients. In addition, we also find NDC80 drives malignant progression of CRC cells partly by inactivating DUSP5 and FOXO1. Taken together, these evidences suggest NDC80 is not only a promising clinical biomarker for patient management, but also a potential therapeutical target for CRC diagnosis and treatment.

This work aimed to investigate the prevalence of MLH1 constitutional methylation in colorectal cancer patients with abnormal expression of the MLH1 protein in their tumors and without germline mutations. We provide evidence that MLH1 constitutional hypermethylation is the molecular mechanism behind about 3% of Lynch syndrome families, most likely in patients with early onset or multiple primary tumors without significant family history.

AKT3 expression is associated with bad prognosis in head and neck cancer. Taking advantage of a novel mouse model, we report that conditional Akt3 overexpression triggers adenoid cystic carcinomas in the salivary glands of mice with 100% penetrance. We further show that these adenoid cystic carcinomas are completely dependent on expression of the oncogene.

This study revealed that the SALL4 - KHDRBS3 network augments stemness through modulation of CD44 splicing in basal-like breast cancer. This network enhances anoikis resistance for stemness. This study may contribute to the establishment of therapies targeting cancer stemness.

This study found a novel function of 5-chloro-2,4-dihydroxypyridine (CDHP), a component of the anti-cancer drug S-1, on cancer metastasis. CDHP-treated cells reduces cell migration and lung metastasis. Our findings may contribute to the development of metastasis prevention therapies.

Autophagy: Novel applications of nonsteroidal anti-inflammatory drugs for primary cancer.

Dialysis patients had a higher risk of some cancer while comparing to nonuremia group. But there is no significant different cancer risk between two dialysis groups if comparing these two groups directly.

SEER analysis reveals a significant increase in incidence of second primary acute lymphoblastic leukemia (ALL) in adults, an underrecognized entity. Associated with a significantly worse 5-year survival with different demographic characteristics compared to de novo primary ALL.

The aim of this study was to detect prognostic factors for febrile neutropenia (FN) in patients with testicular germ cell tumors. We identified (1) higher age, (2) poor performance status, (3) poor IGCCCG risk classification, and (4) prior radiotherapy in the seminoma subpopulation as risk factors for FN in patients with testicular cancer.

Type A personality traits (i.e., sense of time urgency, high job involvement, competitiveness) independently predicted mammography use among 2691 postmenopausal women of the GAZEL Cohort Study (adjusted Odds Ratio [95% confidence interval]: 1.46: [1.13–1.90], P < 0.01). While paying more attention to the adherence of women with low levels of these traits, clinicians may help those with higher levels to better consider the risks of false positives and overdiagnosis.

Disparities in pancreatic cancer outcomes exists, but are not fully understood. Our research uses SEER–Medicare data to determine which factors contribute to the differences in treatment receipt and survival outcomes among age, sex, and racial/ethnic subgroups. Our conclusion that disparities continue to persist after adjusting for various covariates highlights the need for additional research in this area.