Highlights

• During the past 30 years, globally, the disease burden of stroke burden has decreased substantially; however, the disease burden of stroke attributable to high fasting plasma glucose (HFPG) failed to achieve a significant decline. The population-attributable fraction of HFPG for stroke burden has been increasing across different regions regardless of the sociodemographic index (SDI) of each region.
• The age-standardized rate of disability-adjusted life years (DALYs) of HFPG-attributable stroke burden shifted from higher SDI regions to lower SDI regions.
• Older adults and males were the key populations concerning the control of HFPG-attributable stroke in all SDI regions and all stroke subtypes.
• The increase of HFPG-attributable stroke burden in females in low SDI regions and the slower decrease of DALYs of HFPG-attributable stroke rates among 25–69 years old adults in high SDI regions compared with high-middle SDI regions are worth attention as well.

Highlights

• Glomerular cell cross talk is essential for maintaining the glomerular filtration barrier.
• In-depth exploration of intraglomerular signaling pathway changes during diabetic kidney disease may help discover new therapeutic targets.

Highlights

• In this ESCAPE-extension study, cilostazol treatment reduced the incidence of adverse cardiovascular events in patients with type 2 diabetes when compared with aspirin for a 5.2-year median follow-up.
• During the follow-up period, no adverse events were noted in the cilostazol group that exceeded those in the aspirin group.
• Cilostazol may be an effective antiplatelet therapy to lower cardiovascular risk in patients with type 2 diabetes who have well-controlled low-density lipoprotein-cholesterol levels with statin treatment. A longer-term study with a larger sample size is required to confirm this premise.

Highlights

• There has been an increase in new cases of youth onset type 2 diabetes during the pandemic.
• Non-Hispanic Black youth have been most affected the increase in youth onset type 2 diabetes during the pandemic.
• No significant correlation was identified with clinical or biochemical COVID-19 infection in those tested.

Highlights

This is the first multicenter, large-sampled cross-sectional study of the association between different metabolic phenotypes and urinary albumin-creatinine ratio (UACR) in Chinese community adults. Our study may be helpful for people with increased albuminuria. We recommend that they have their UACR checked regularly and maintain a healthy lifestyle to reduce their risk of chronic kidney disease.

Highlights

• This is the first randomized, single-blind, double-dummy, parallel controlled clinical trial collecting data on the efficacy and safety of Chinese herbal medicines compared to that of pregabalin in patients with painful diabetic neuropathy.
• The Xiaoketongbi Formula is an effective treatment that can relieve pain symptoms, improve quality of life, and potentially improve nerve conduction velocity in patients suffering from painful diabetic neuropathy.