• Issue

    Journal of Diabetes: Volume 14, Issue 12

    787-850
    December 2022
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ISSUE INFORMATION

Open Access

Issue Information

  • Pages: 787-789
  • First Published: 24 December 2022

EDITORIAL

Open Access

Diabetes epidemiology: Analysis of trends over time

Zachary T. Bloomgarden, 
  • Pages: 790-791
  • First Published: 09 December 2022

EDITOR'S RECOMMENDATION

Open Access

A novel index, Chinese visceral adiposity index is closely associated with urinary albumin-creatinine ratio in Chinese community adults, especially in hypertensive or hyperglycemic population: Results from the REACTION study
一个新的指标, 中国人内脏脂肪指数与中国社区成年人(特别是高血压或高血糖人群)尿白蛋白-肌酐比值密切相关:来自REACTION研究的结果

Binqi Li,  Weiqing Wang,  Zhengnan Gao,  Xulei Tang,  Li Yan,  Qin Wan,  Zuojie Luo,  Guijun Qin,  Lulu Chen,  Guang Ning,  Yiming Mu, 
  • Pages: 792-805
  • First Published: 29 November 2022
A novel index, Chinese visceral adiposity index is closely associated with urinary albumin-creatinine ratio in Chinese community adults, especially in hypertensive or hyperglycemic population: Results from the REACTION study 一个新的指标, 中国人内脏脂肪指数与中国社区成年人(特别是高血压或高血糖人群)尿白蛋白-肌酐比值密切相关:来自REACTION研究的结果

Highlights

  • This is the first large-sample, multicenter study of the relationship between Chinese Visceral Adiposity Index (CVAI) and urinary albumin to creatinine ratio (UACR) in Chinese community adults.
  • CVAI and UACR were significantly associated in both genders.
  • At higher CVAI levels, the population with prediabetes, diabetes, and hypertension has a more significant correlation between CVAI and UACR.

REVIEW ARTICLE

Open Access

Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure
二甲双胍和生长分化因子15 (GDF15)在2型糖尿病中的作用:一个隐藏的宝藏

Hayder M. Al-kuraishy,  Ali I. Al-Gareeb,  Athanasios Alexiou,  Marios Papadakis,  Eman Hassan Nadwa,  Sarah M. Albogami,  Mohammed Alorabi,  Hebatallah M. Saad,  Gaber El-Saber Batiha, 
  • Pages: 806-814
  • First Published: 28 November 2022
Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure 二甲双胍和生长分化因子15 (GDF15)在2型糖尿病中的作用:一个隐藏的宝藏

Highlights

  • Metformin activates GDF15 expression, which reduces appetite with induction of weight loss in both diabetic and non-diabetic patients.
  • GDF15 level is linked and correlated with the progression of diabetic complications including thrombosis, diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy.

ORIGINAL ARTICLES

Open Access

Are U-shaped relationships between risk factors and outcomes artifactual?
风险因素与结果之间的U或J型关系以及分布偏倚的作用

Reema Shah,  Lehana Thabane,  Hertzel C. Gerstein, 
  • Pages: 815-821
  • First Published: 08 December 2022
Are U-shaped relationships between risk factors and outcomes artifactual? 风险因素与结果之间的U或J型关系以及分布偏倚的作用

Highlights

  • U-shaped relationships between three common cardiovascular risk factors (weight, systolic blood pressure, and insulin) and hazards of composite cardiovascular outcomes were analyzed in three study samples: entire sample, “high” subgroup, and “low” subgroup.
  • Nadir values for all three risk factors were shifted left in the low-subgroup population and shifted right in the high-subgroup population when compared to the nadir value in the original population.
  • Recommendations that risk factor levels below or above some specific nadir should not be therapeutically targeted in the underlying population based on U- or J- shape relationships observed in epidemiologic studies should be supported by randomized controlled trials.

Open Access

Yogliptin monotherapy in type 2 diabetes: A 12-week randomized, double-blind, placebo-controlled phase II study
优格列汀单药治疗2型糖尿病:一项12周随机、双盲、安慰剂对照的II期研究

Xin Wang,  Ying Wang,  Xiaolan Yong,  Bojun Wu,  Zilin Sun,  Ning Lou,  Qing Wen,  Yufang Zhang,  Shiyun Li,  Jiarui Li,  Yan He,  Jinluo Cheng,  Xiangdong Zhong,  Jing Shen,  Wenying Yang, 
  • Pages: 822-830
  • First Published: 14 December 2022
Yogliptin monotherapy in type 2 diabetes: A 12-week randomized, double-blind, placebo-controlled phase II study 优格列汀单药治疗2型糖尿病:一项12周随机、双盲、安慰剂对照的II期研究

Highlights

  • Yogliptin at 200, 300, and 400 mg significantly improves glycemic control in diabetics with suboptimal control.
  • Yogliptin at all doses was safe in type 2 diabetic patients.

Open Access

Serum sodium level is inversely associated with new-onset diabetes in hypertensive patients
血清钠水平与高血压患者新发糖尿病呈负相关

Qi Cheng,  Xiaocong Liu,  Anping Cai,  Dan Zhou,  Yuqing Huang,  Yingqing Feng, 
  • Pages: 831-839
  • First Published: 05 December 2022
Serum sodium level is inversely associated with new-onset diabetes in hypertensive patients 血清钠水平与高血压患者新发糖尿病呈负相关

Highlights

  • There is an inverse association between serum sodium and new-onset diabetes in a Chinese community-based hypertensive population.
  • Sodium control may need to be further refined to provide comprehensive cardiovascular and diabetes risk management for hypertensive patients.

Open Access

Prevalence of type 1 and type 2 diabetes in children and adolescents in Germany from 2002 to 2020: A study based on electronic health record data from the DPV registry
2002~2020年德国儿童和青少年1型和2型糖尿病的患病率:一项基于来自DPV登记系统的电子健康记录数据的研究

Anna Stahl-Pehe,  Clemens Kamrath,  Nicole Prinz,  Thomas Kapellen,  Ulrike Menzel,  Olga Kordonouri,  K. Otfried Schwab,  Susanne Bechtold-Dalla Pozza,  Joachim Rosenbauer,  Reinhard W. Holl, 
  • Pages: 840-850
  • First Published: 14 December 2022
Prevalence of type 1 and type 2 diabetes in children and adolescents in Germany from 2002 to 2020: A study based on electronic health record data from the DPV registry 2002~2020年德国儿童和青少年1型和2型糖尿病的患病率:一项基于来自DPV登记系统的电子健康记录数据的研究

Highlights

  • The prevalence rates of type 1 diabetes and type 2 diabetes in Germany are higher than estimated by the International Diabetes Federation (IDF).
  • Since 2014, prevalence rates have increased only in 15–19-year-olds.