• Ethanol precipitation concentration impact the prebiotic activity.
• CPS70, CPS75, and CPS80 exhibited strong nondigestibility.
• CPS75 showed the strongest proliferative effect and stimulated the most SCFAs output.

In this study, we evaluated the protective capacity of chlorogenic acid (CGA) against NaNO₂ induced damage to rat erythrocytes. We infer that the reaction of CGA and NaNO₂ may suppress the cytotoxicity of nitrite on erythrocytes and avoid the generation of oxidative stress induced by NaNO₂. Our results suggest a novel diet strategy for preventing the adverse effects of nitrite in those people with exposure to nitrite.

• Production of a thermostable pullulanase by DO-stat fed-batch fermentation of recombinant Escherichia coli BL 21 was investigated in a 5 L fermentor.
• The effect of three oxygen control strategies, glucose feedback, shifting fermentor pressure and adding oxygen-enriched air, on cell growth and pullulanase expression were examined.
• Adding oxygen-enriched air strategy was suggested as an effective approach to enhance both cell growth and pullulanase production.

Hongjv peel (HP), a spice rich in polyphenols, is generally dried for its preservation. Multivariate analysis showed the effects of hot air drying at 50°C, 60°C, 70°C and 80°C on the polyphenol profile of HP.

Bioactive peptides are of utmost importance for new drug discovery while marine organisms, particularly fish, represent a great reservoir for novel biomolecules identification. The current work was able to describe 2 multifunctional bioactive peptides from Trachinus Draco (Greeter weveer) myofibrillar proteins after sequential hydrolysis and HPLC fractionation. The de novo sequenced peptides showed ACE inhibitory, DPP4 inhibitory, antioxidant, and metal chelation activities that have a great potential for aging-related pathologies such as diabetes and hypertension.

Dietary spermine supplementation and its extended duration may improve digestion by increasing the levels of digestive enzymes and their gene expression levels; spermine intake can result in the high expression of amino acid transporters in the jejuna of piglets; and spermine supplementation can modulate lipid and amino acid metabolisms in the jejuna of piglets.

1. HFD increases the body weight, biochemical factors, serum adipokine and inflammatory levels in Wistar rats.
2. FA mix promotes cell growth, proliferation, migration and invasion in the SKOV3 ovarian cancer cell line.
3. FA mix enhances the expression of inflammatory factors in SKOV3 ovarian cancer cell line.

The aim of the current study was to assess the antioxidant and renoprotective effects of Stachys pilifera Benth (S.P.B) hydroalcoholic extract on nephrotoxicity induced with cisplatin (CP). The results showed that S.P.B hydroalcoholic extract improved the biochemical parameters and kidney function as well as restored antioxidant activity in CP-induced nephrotoxicity.

Two main fractions named SPSS1 and SPSS2 were obtained and analyzed from apostichopus japonicuss permary. In addition to the high content of lactose in both kinds of polysaccharides, the highest content of monosaccharide in SPSS1 was galactose, while in SPSS2 it was fucose. Further, the antitumor study of SPSS1 was carried, and the results showed SPSS1 treatment inhibited the proliferation of HepG2 cells.

• Agaricus blazei Murrill extracts showed antioxidant activity.
• Agaricus blazei Murrill extracts showed the protective effect on the recovery of the impaired pancreatic tissue.
• Agaricus blazei Murril extracts demonstrated potential anti-diabetic activity.

Punica granatum L. (pomegranate) fruit peel acetone extract demonstrated potent radical scavenging activity, inhibitory effects against glycation and α-amylase activity, modulatory effect on hepatocyte glucose uptake, as well as protective capacity against oxidative-stress induced hepatocyte cell injury, which may be influenced by its rich polyphenol and flavonoid content and the presence of some bioactive phenolic acid.

Deep frying degrades cooking oil and generates harmful products. The reused palm oils from frying pork or potato induced mRNA profiles of CYPs and SLCO1B1 while the new oil up-regulated CYP2E1, CYP3A4, and CYP4A11. Both of the reused oils induced PPAR-α but suppressed SREBP-1a and SREBP-1c mRNA. The induction of CYPs, PPAR-α, and SLCO1B1 might contribute to an increased risk of fatty acid accumulation. Hence, consumption of palm oil or reused cooking oil should be of concern.

• Polyphenols can increase total antioxidant capacity
• Weight loss by diet or exercise increase the activity of enzymatic antioxidants
• Consumption of vegetable protein or fiber reduce oxidative stress

Morinda morindoides extracts could be new sources of bioactive agents.

• Odorants in 23 YE samples were identified and quantitatively analyzed.
• Of them, yeasty off-odor compounds were screened out by aroma model.
• Differences in strains and processing of YE may be the possible causes of yeasty note.

The cholesterol-lowering activity of the leaves, pulp and seeds of Synsepalum dulcificum was screened using a hamster model. The ethanolic extract of the seeds showed the best activity and triterpenoid (lupeol acetate and β-amyrin acetate) was one of cholesterol-lowering components in the seeds.

Alcalase hydrolysates presented higher (DH) and (TCA-NSI). Peptides fraction <3 kDa exhibited better free radicals scavenging activity. Seventeen novel potential antioxidant peptides were identified and discussed.

Degradation of Enteromorpha prolifera polysaccharides were achieved by using pectinase. The obtained polysaccharides were found to possess superior antioxidant and immunomodulatory activities to those of unhydrolysed polysaccharides in RAW264.7 cell models.

• Antioxidant and anti-inflammatory effects of Lilium lancifolium bulbs extract
• Wan-Sup Sim, Sun-Il Choi, Tae-Dong Jung, Bong-Yeon Cho, Seung-Hyun Choi, Sung-Min Park, Ok-Hwan Lee
• p-Coumaric acid and ferulic acid contents of Korean L. lancifolium extract were higher than Japanese extract. Korean L. lancifolium bulbs extract exhibited significant antioxidant effects, compared to Japanese extract. Korean L. lancifolium bulbs extract significantly inhibited pro-inflammatory protein expressions through MyD88 dependent pathway, compared to Japanese extract.

According to the results, the produced CABE-NE drug delivery system could be considered as a promising alternative to prevent lung cancer progression and it provides a new way to enhance the therapeutic value of the plant phytochemicals.

In this paper, results showed that oligopeptides with different N-terminal amino acids had a wide range of permeability values and could be divided into three levels with different correlations to log D and MW. It was found for the first time that the transport permeabilities of oligopeptides across Caco-2 cell monolayers might be closely related to log D and MW. In addition, the transcellular and paracellular pathways may be coexisted for the transport of oligopeptides.

We prepared palatinose–sucrose (PS) mixtures (namely, 30% PS mixture and 50% PS mixture) from sucrose by enzymatic bioconversion to improve low sweetness and low solubility of palatinose and to develop a sugar substitute that can lower blood sugar levels. The results of animal experiments indicated that PS mixtures could prevent metabolic syndrome resulting from excessive sugar levels by regulating hepatic lipogenesis and cholesterol homeostasis. Thus, PS mixtures could be a good alternative to sucrose as a healthy sweetener.

Rubusoside (Rbs) effectively attenuated ovalbumin (OVA)-induced inflammatory reactions in a mouse model of asthma. The 300 mg/kg dose of Rbs decreased the OVA-induced total-IgE and anti-IgG1 generation, and regulated the balance between Th2 and Th1 cytokines in mice with asthma. The anti-inflammatory activity of Rbs was associated with modulating activation of the NF-κB pathway and regulating the Th1 and Th2 cytokine imbalance.

• Cranberry juice fractions and cell wall constituents extracted from probiotic biomass were more effective in inhibiting the growth of HT-29 as compared to the cranberry fractions tested alone, indicating a possible synergy effect between these biofunctional compounds.
• Cranberry juice fraction composes of phenolic acids inhibited the growth of the HT-29 cells' line.
• Cranberry juice fraction containing flavonols had potency as QR inducer.