The cover image is based on the article An overview of S100 proteins and their functions in skin homeostasis, interface dermatitis conditions and other skin pathologies by Jillian Richmond et al., https://doi.org/10.1111/exd.15158.

This groundbreaking study highlights the potential for skin irritation and oxidative stress induced by chronic exposure to sulfuric acid (SA) in Swiss albino mice. In addition, it elucidates the ability of SA to promote neoplastic proliferation characterized by significant expressions of Ki-67 and p53 markers.

One hundred eighty polymorphisms were analysed in 90 patients with plaque psoriasis treated with tildrakizumab in routine clinical practice. The combination of four polymorphisms in TNFAIP3, ATG5 PDE4D and IL17RC genes, along with weight (>76 kg) and disease duration (>27 years), showed a sensitivity of 88.5% and specificity of 83.3% to discriminate responders (PASI ≤1) and non-responders (PASI >1) at 12 months.

Combining antiplatelet therapy with up-dosing antihistamines significantly improves symptoms and reduces platelet activation in chronic spontaneous urticaria patients with elevated D-dimer levels.