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    Annals of Neurology: Volume 93, Issue 3

    C1, i-vi, 427-639
    March 2023
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Free Access

Annals of Neurology: Volume 93, Number 3, March 2023

  • Page: C1
  • First Published: 24 February 2023

Issue Information

Free Access

Issue Information

  • Pages: i-vi
  • First Published: 24 February 2023

Neuro Genesis

Experimental Neurotherapeutics: Surfing the Tidal Wave of New Opportunities

Lauren B. Reoma MD,  Ania Busza MD, PhD,  M. Maral Mouradian MD,  Petra Kaufmann MD,  Erika F. Augustine MD, MS,  Samuel Frank MD,  Thomas P. Sutula MD, PhD,  Andrew J. Cole MD,  Heather D. Fitter MD,  William Meurer MD, MS,  Avindra Nath MD,  Robert C. Griggs MD, 
  • Pages: 427-430
  • First Published: 22 December 2022

Research Articles

Cell-Specific Dysregulation of Iron and Oxygen Homeostasis as a Novel Pathophysiology in PSP

Seojin Lee BMSc,  Ivan Martinez-Valbuena PhD,  Carlos E. de Andrea MD, PhD,  Maria Villalba-Esparza PhD,  Suganthini Ilaalagan BEng/Bsc,  Blas Couto MD,  Naomi P. Visanji PhD,  Anthony E. Lang MD, FRCPC,  Gabor G. Kovacs MD, PhD, FRCPC, 
  • Pages: 431-445
  • First Published: 30 October 2022

A Combined Panel of Salivary Biomarkers in de novo Parkinson's Disease

Maria Ilenia De Bartolo MD,  Giorgio Vivacqua MD, PhD,  Daniele Belvisi MD, PhD,  Romina Mancinelli PhD,  Andrea Fabbrini MD,  Nicoletta Manzo MD, PhD,  Matteo Costanzo MD,  Giorgio Leodori MD, PhD,  Antonella Conte MD, PhD,  Giovanni Fabbrini MD,  Sergio Morini MD,  Alfredo Berardelli MD, 
  • Pages: 446-459
  • First Published: 16 November 2022
Open Access

DystoniaBoTXNet: Novel Neural Network Biomarker of Botulinum Toxin Efficacy in Isolated Dystonia

Dongren Yao PhD,  Lena C. O'Flynn BA,  Kristina Simonyan MD, PhD, DrMed, 
  • Pages: 460-471
  • First Published: 28 November 2022

Brief Communication

Open Access

Extra Movements in Healthy People: Challenging the Definition and Diagnostic Practice of Tic Disorders

Stefanie Bartha BSc,  Annet Bluschke PhD,  Tina Rawish MSc,  Kim E. R. Naumann,  Paul Wendiggensen MSc,  Tobias Bäumer MD,  Veit Roessner MD,  Alexander Münchau MD,  Christian Beste PhD, 
  • Pages: 472-478
  • First Published: 24 December 2022

Research Articles

Open Access

Atrial Fibrillation Risk Assessment after Embolic Stroke of Undetermined Source

Aenne S. von Falkenhausen MD,  Katharina Feil MD,  Moritz F. Sinner MD, MPH,  Sonja Schönecker MD,  Johanna Müller MD,  Johannes Wischmann MD,  Elodie Eiffener MSc,  Sebastian Clauss MD,  Sven Poli MD,  Khouloud Poli MD,  Christine S. Zuern MD,  Ulf Ziemann MD,  Jörg Berrouschot MD,  Alkisti Kitsiou,  Wolf-Rüdiger Schäbitz MD,  Marianne Dieterich MD,  Steffen Massberg MD,  Stefan Kääb MD, PhD,  Lars Kellert MD, 
  • Pages: 479-488
  • First Published: 13 November 2022
Open Access

Tenecteplase Improves Reperfusion across Time in Large Vessel Stroke

Vignan Yogendrakumar MD,  James Beharry MBChB,  Leonid Churilov PhD,  Khairunnisa Alidin CNC,  Melissa Ugalde CNC,  Lauren Pesavento CNC,  Louise Weir NP,  Peter J. Mitchell MMed,  Timothy J. Kleinig PhD,  Nawaf Yassi PhD,  Vincent Thijs PhD,  Teddy Y. Wu PhD,  Darshan G. Shah MBBS,  Helen M. Dewey PhD,  Tissa Wijeratne PhD,  Bernard Yan DMedSc,  Patricia M. Desmond MD,  Gagan Sharma MCA,  Mark W. Parsons PhD,  Geoffrey A. Donnan MD,  Stephen M. Davis MD,  Bruce C. V. Campbell PhD,  for the Royal Melbourne Stroke Registry and EXTEND-IA TNK Collaborators , 
  • Pages: 489-499
  • First Published: 16 November 2022

Plasma Metabolites Link Dietary Patterns to Stroke Risk

Varun M. Bhave BA,  Zsuzsanna Ament PhD,  Amit Patki MS,  Yan Gao MPH,  Naruchorn Kijpaisalratana MD, PhD,  Boyi Guo MS,  Ninad S. Chaudhary PhD,  Ana-Lucia Garcia Guarniz MD,  Robert Gerszten MD,  Adolfo Correa MD, PhD,  Mary Cushman MD, MS,  Suzanne Judd PhD,  M. Ryan Irvin PhD,  W. Taylor Kimberly MD, PhD, 
  • Pages: 500-510
  • First Published: 14 November 2022
Open Access

A Managed Care System with Telemedicine Support for Neurological Emergencies

Hebun Erdur MD,  Joachim E. Weber MD,  Anselm Angermaier MD,  Stephan Kinze MD,  Ali Sotoodeh MD,  Claudia Gorski Dipl FH,  Kerstin Bollweg PhD,  Stefanie Ernst MSc,  Farid I. Kandil PhD,  Janina Behrens MD,  Ramanan Ganeshan MD,  Anne Keysers MD,  Malgorzata Kotlarz-Böttcher MD,  Daniel Peters MD,  Ludwig Schlemm MD,  Kirsten Stangenberg-Gliss Dipl FH,  Carl Witt MD,  Beata Hennig Dipl FH,  Katrin C. Reber PhD,  Udo Schneider PhD,  Christiana Franke MD,  Ingo Schmehl MD,  Hans-Beatus Straub MD,  Agnes Flöel MD,  Sarah Theen MSc,  Matthias Endres MD,  Tobias Kurth MD,  Heinrich J. Audebert MD, 
  • Pages: 511-521
  • First Published: 18 November 2022

A Subpopulation of Spikes Predicts Successful Epilepsy Surgery Outcome

John Thomas PhD,  Philippe Kahane MD, PhD,  Chifaou Abdallah MD,  Tamir Avigdor MSc,  Willemiek J. E. M. Zweiphenning MD,  Stephan Chabardes MD, PhD,  Kassem Jaber B. Eng.,  Véronique Latreille PhD,  Lorella Minotti MD,  Jeff Hall MD,  François Dubeau MD,  Jean Gotman PhD,  Birgit Frauscher MD, PD, 
  • Pages: 522-535
  • First Published: 13 November 2022
Open Access

Neuropathological Insights into Unexpected Cognitive Decline in Epilepsy

Annika Reimers MS,  Christoph Helmstaedter PhD,  Christian E. Elger MD,  Julika Pitsch PhD,  Motaz Hamed MD,  Albert J. Becker MD,  Juri-Alexander Witt PhD, 
  • Pages: 536-550
  • First Published: 21 November 2022
Open Access

Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations

Jacqueline M. Cohen PhD,  Silje Alvestad MD, PhD,  Carolyn E. Cesta PhD,  Marte-Helene Bjørk MD, PhD,  Maarit K. Leinonen MD, PhD,  Mette Nørgaard MD, PhD,  Kristjana Einarsdóttir PhD,  Anders Engeland PhD,  Mika Gissler PhD,  Øystein Karlstad PhD,  Kari Klungsøyr MD, PhD,  Ingvild Odsbu PhD,  Johan Reutfors MD, PhD,  Randi M. Selmer PhD,  Torbjörn Tomson MD, PhD,  Sinna Pilgaard Ulrichsen MSc,  Helga Zoega PhD,  Kari Furu PhD, 
  • Pages: 551-562
  • First Published: 26 November 2022

Disease Progression in Charcot–Marie–Tooth Disease Related to MPZ Mutations: A Longitudinal Study

Vera Fridman MD,  Stefan Sillau PhD,  Jacob Bockhorst BA,  Kaitlin Smith MS, CGC,  Isabella Moroni MD,  Emanuela Pagliano MD,  Chiara Pisciotta MD, PhD,  Guiseppe Piscosquito MD,  Matilde Laurá MD, PhD,  Francesco Muntoni MD, FRCPCH,  Chelsea Bacon BS,  Shawna Feely MS, CGC,  Tiffany Grider MS, CGC,  Laurie Gutmann MD,  Rosemary Shy MD,  Janel Wilcox MS, CGC,  David N. Herrmann MD,  Jun Li MD, PhD,  Sindhu Ramchandren MD, MS,  Charlotte J. Sumner MD,  Thomas E. Lloyd MD, PhD,  John Day MD, PhD,  Carly E. Siskind MS, CGC,  Sabrina W. Yum MD,  Reza Sadjadi MD,  Richard S. Finkel MD,  Steven S. Scherer MD, PhD,  Davide Pareyson MD,  Mary M. Reilly MD, FCRP,  Michael E. Shy MD,  the Inherited Neuropathies Consortium–Rare Diseases Clinical Research Network , 
  • Pages: 563-576
  • First Published: 06 October 2022
Open Access

Tubers Affecting the Fusiform Face Area Are Associated with Autism Diagnosis

Alexander L. Cohen MD, PhD,  Mallory R. Kroeck MA,  Juliana Wall BA,  Peter McManus BA,  Arina Ovchinnikova BS,  Mustafa Sahin MD, PhD,  Darcy A. Krueger MD, PhD,  E. Martina Bebin MD, MPA,  Hope Northrup MD,  Joyce Y. Wu MD,  Simon K. Warfield PhD,  Jurriaan M. Peters MD, PhD,  Michael D. Fox MD, PhD, on behalf of the Tuberous Sclerosis Complex Autism Center of Excellence Network Study Group , 
  • Pages: 577-590
  • First Published: 16 November 2022
Open Access

Breast Milk Exposure is Associated With Cortical Maturation in Preterm Infants

Gemma Sullivan MRCPCH, PhD,  Kadi Vaher BA, MRes,  Manuel Blesa PhD,  Paola Galdi PhD,  David Q. Stoye MRCPCH, PhD,  Alan J. Quigley MBChB, FRCR,  Michael J. Thrippleton PhD,  John Norrie MSc,  Mark E. Bastin DPhil,  James P. Boardman FRCPCH, PhD, 
  • Pages: 591-603
  • First Published: 22 November 2022

Dimethyl Fumarate Delays Multiple Sclerosis in Radiologically Isolated Syndrome

Darin T. Okuda MD,  Orhun Kantarci MD,  Christine Lebrun-Frénay MD, PhD,  Maria Pia Sormani PhD,  Christina J. Azevedo MD, MPH,  Francesca Bovis PhD,  Le H. Hua MD,  Lilyana Amezcua MD, MS,  Ellen M. Mowry MD, MCR,  Christophe Hotermans MD, PhD,  Jason Mendoza PhD,  John S. Walsh MD,  Christian von Hehn MD, PhD,  Wendy S. Vargas MD,  Stacy Donlon MD,  Robert T. Naismith MD,  Annette Okai MD,  Gabriel Pardo MD,  Pavle Repovic MD, PhD,  Olaf Stüve MD, PhD,  Aksel Siva MD,  Daniel Pelletier MD, 
  • Pages: 604-614
  • First Published: 18 November 2022
Dimethyl Fumarate Delays Multiple Sclerosis in Radiologically Isolated Syndrome

This multi-center, randomized, double-blinded trial by Okuda, et al. assessed the impact of dimethyl fumarate (DMF) in the time to onset of first clinical symptoms attributable to a central nervous system (CNS) demyelinating event within a follow-up period of 96 weeks. Treatment with DMF resulted in over 80% risk reduction relative to placebo in the prevention of a first acute clinical event related to multiple sclerosis. A significant reduction in new and/or newly-enlarging T2-weighted hyperintense lesions was also observed.

Pathogen and Antibody Identification in Children with Encephalitis in Myanmar

Maria M. Galardi MD,  Gavin M. Sowa MD, MS,  Cameron D. Crockett MD,  Robert Rudock MD,  Alyssa E. Smith MD,  Ei E. Shwe MBBS,  Thidar San MBBS,  Kyaw Linn MBBS,  Aye Mya M. Aye MBBS,  Prashanth S. Ramachandran MBBS,  Maham Zia BA,  Anne E. Wapniarski BA,  Isobel A. Hawes BA,  Chaw S. Hlaing MBBS,  Ei H. Kyu MBBS,  Cho Thair MBBS,  Yi Y. Mar MBBS,  Nway Nway MBBS,  Gregory A. Storch MD,  Kristine M. Wylie PhD,  Todd N. Wylie BS,  Josep Dalmau MD PhD,  Michael R. Wilson MD, MAS,  Soe S. Mar MD, 
  • Pages: 615-628
  • First Published: 28 November 2022

Brief Communication

Alzheimer's Disease Genetic Risk, Cognition, and Brain Aging in Midlife

Willa D. Brenowitz PhD, MPH,  Myriam Fornage PhD,  Lenore J. Launer PhD,  Mohamad Habes PhD,  Christos Davatzikos PhD,  Kristine Yaffe MD, 
  • Pages: 629-634
  • First Published: 13 December 2022

Neuro-Images

Free Access

Increased Cerebellum 18F-DPA-714 Uptake in Anti-Glutamate Kainate Receptor Subunit 2 Autoimmune Encephalitis

Yizongheng Zhang BM,  Qinming Zhou MD, PhD,  Lisheng Peng PhD,  Sheng Chen MD, PhD, 
  • Pages: 635-636
  • First Published: 08 December 2022
Free Access

Intracranial Aneurysmosis with Multilobular Aneurysms and Brain Microaneurysms

Andrew Jin MD,  Crystal Fong MD,  Jian-Qiang Lu MD, PhD, 
  • Pages: 637-639
  • First Published: 13 December 2022