• Issue

    Hepatology: Volume 72, Issue 3

    791-1161
    September 2020
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Cover Image

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Cover Image

  • First Published: 28 September 2020

Issue Information

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Masthead

  • First Published: 28 September 2020
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Table of contents

  • First Published: 28 September 2020

Hepatology Highlights

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Hepatology Highlights

Alyson Kaplan,  Russell Rosenblatt,  Adam Buckholz,  Sonal Kumar,  Gopanandan Parthasarathy,  Robert E. Schwartz,  Petra Hirsova,  Robert E. Schwartz,  Joseph F. Pisa,  Robert S. Brown Jr.,  Nidhi Jalan-Sakrikar,  Robert E. Schwartz,  Arun B. Jesudian,  Nicholas W. Russo,  Chaitanya Allamneni,  Ravi S. Vora,  Enis Kostallari,  Robert E. Schwartz, 
  • Pages: 791-793
  • First Published: 28 September 2020

Editorials

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Genetic Determinants of Cirrhosis and Hepatocellular Carcinoma Due to Fatty Liver Disease: What’s the Score?

Ruth M. Pfeiffer Ph.D.,  Yaron Rotman M.D.,  Thomas R. O’Brien M.D., 
  • Pages: 794-796
  • First Published: 07 June 2020
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Acyl Coenzyme A Thioesterase 9: A Novel Target for Nonalcoholic Fatty Liver Disease by Shuttling Mitochondrial Short-Chain Fatty Acids?

Xiaoxiao Jiang Ph.D. ,  Wen-Xing Ding Ph.D., 
  • Pages: 797-800
  • First Published: 02 July 2020

Introduction to the AASLD President

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Introducing Jorge A. Bezerra, M.D., Our 2020 AASLD President

William F. Balistreri, 
  • Pages: 801-806
  • First Published: 11 July 2020

Rapid Communication

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Acute Liver Injury in COVID-19: Prevalence and Association with Clinical Outcomes in a Large U.S. Cohort

Meaghan M. Phipps,  Luis H. Barraza,  Elijah D. LaSota,  Magdalena E. Sobieszczyk,  Marcus R. Pereira,  Elizabeth X. Zheng,  Alyson N. Fox,  Jason Zucker,  Elizabeth C. Verna, 
  • Pages: 807-817
  • First Published: 30 May 2020

Original Articles

Viral Hepatitis

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Model for End-Stage Liver Disease With Additional Criteria to Predict Short-Term Mortality in Severe Flares of Chronic Hepatitis B

James Fung,  Lung-Yi Mak,  Albert Chi-Yan Chan,  Kenneth Siu-Ho Chok,  Tiffany Cho-Lam Wong,  Tan-To Cheung,  Wing-Chiu Dai,  Sui-Ling Sin,  Wong-Hoi She,  Ka-Wing Ma,  Wai-Kay Seto,  Ching-Lung Lai,  Chung-Mau Lo,  Man-Fung Yuen, 
  • Pages: 818-828
  • First Published: 23 December 2019
Open Access

Hepatitis B Virus Particles Activate Toll-Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes

Zhenhua Zhang,  Martin Trippler,  Catherine I. Real,  Melanie Werner,  Xufeng Luo,  Stefan Schefczyk,  Thekla Kemper,  Olympia E. Anastasiou,  Yvonne Ladiges,  Juergen Treckmann,  Andreas Paul,  Hideo A. Baba,  Lena Allweiss,  Maura Dandri,  Guido Gerken,  Heiner Wedemeyer,  Joerg F. Schlaak,  Mengji Lu,  Ruth Broering, 
  • Pages: 829-844
  • First Published: 11 January 2020

Steatohepatitis/Metabolic Liver Disease

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Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population

Helene Gellert-Kristensen,  Tom G. Richardson,  George Davey Smith,  Børge G. Nordestgaard,  Anne Tybjærg-Hansen,  Stefan Stender, 
  • Pages: 845-856
  • First Published: 19 March 2020
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Acyl-Coenzyme A Thioesterase 9 Traffics Mitochondrial Short-Chain Fatty Acids Toward De Novo Lipogenesis and Glucose Production in the Liver

Sandra Steensels,  Jixuan Qiao,  Yanzhen Zhang,  Kristal M. Maner-Smith,  Nourhan Kika,  Corey D. Holman,  Kathleen E. Corey,  W. Clay Bracken,  Eric A. Ortlund,  Baran A. Ersoy, 
  • Pages: 857-872
  • First Published: 04 June 2020
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Protective and Detrimental Roles of p38α Mitogen-Activated Protein Kinase in Different Stages of Nonalcoholic Fatty Liver Disease

Seonghwan Hwang,  Xiaolin Wang,  Robim M. Rodrigues,  Jing Ma,  Yong He,  Wonhyo Seo,  Seol Hee Park,  Seung-Jin Kim,  Dechun Feng,  Bin Gao, 
  • Pages: 873-891
  • First Published: 28 May 2020
Open Access

Cenicriviroc Treatment for Adults With Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study

Vlad Ratziu,  Arun Sanyal,  Stephen A. Harrison,  Vincent Wai-Sun Wong,  Sven Francque,  Zachary Goodman,  Guruprasad P. Aithal,  Kris V. Kowdley,  Star Seyedkazemi,  Laurent Fischer,  Rohit Loomba,  Manal F. Abdelmalek,  Frank Tacke, 
  • Pages: 892-905
  • First Published: 13 January 2020

Hepatobiliary Malignancies

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Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis

Zhi-Qiang Hu,  Shao-Lai Zhou,  Jia Li,  Zheng-Jun Zhou,  Peng-Cheng Wang,  Hao-Yang Xin,  Li Mao,  Chu-Bin Luo,  Song-Yang Yu,  Xiao-Wu Huang,  Ya Cao,  Jia Fan,  Jian Zhou, 
  • Pages: 906-922
  • First Published: 15 December 2019
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TMPRSS4 Drives Angiogenesis in Hepatocellular Carcinoma by Promoting HB-EGF Expression and Proteolytic Cleavage

Zhao-Ru Dong,  Dong Sun,  Ya-Fei Yang,  Wei Zhou,  Rui Wu,  Xiao-Wei Wang,  Kai Shi,  Yu-Chuan Yan,  Lun-Jie Yan,  Cheng-Yu Yao,  Zhi-Qiang Chen,  Xu-Ting Zhi,  Tao Li, 
  • Pages: 923-939
  • First Published: 22 December 2019
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Endoscopic Ultrasound/Fine Needle Aspiration Is Effective for Lymph Node Staging in Patients With Cholangiocarcinoma

Thomas Malikowski,  Michael J. Levy,  Ferga C. Gleeson,  Andrew C. Storm,  Eric J. Vargas,  Mark D. Topazian,  Barham K. Abu Dayyeh,  Prasad G. Iyer,  Elizabeth Rajan,  Gregory J. Gores,  Lewis R. Roberts,  Vinay Chandrasekhara, 
  • Pages: 940-948
  • First Published: 20 December 2019
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MRP3-Mediated Chemoresistance in Cholangiocarcinoma: Target for Chemosensitization Through Restoring SOX17 Expression

Elisa Lozano,  Maitane Asensio,  Laura Perez-Silva,  Jesus M. Banales,  Oscar Briz,  Jose J.G. Marin, 
  • Pages: 949-964
  • First Published: 20 December 2019
Open Access

Identification of Four Immune Subtypes Characterized by Distinct Composition and Functions of Tumor Microenvironment in Intrahepatic Cholangiocarcinoma

Sylvie Job,  Delphine Rapoud,  Alexandre Dos Santos,  Patrick Gonzalez,  Christophe Desterke,  Gérard Pascal,  Nabila Elarouci,  Mira Ayadi,  René Adam,  Daniel Azoulay,  Denis Castaing,  Eric Vibert,  Daniel Cherqui,  Didier Samuel,  Antonio Sa Cuhna,  Agnès Marchio,  Pascal Pineau,  Catherine Guettier,  Aurélien de Reyniès,  Jamila Faivre, 
  • Pages: 965-981
  • First Published: 25 December 2019
Open Access

Modulation of Biliary Cancer Chemo-Resistance Through MicroRNA-Mediated Rewiring of the Expansion of CD133+ Cells

Pietro Carotenuto,  Somaieh Hedayat,  Matteo Fassan,  Vincenzo Cardinale,  Andrea Lampis,  Vincenza Guzzardo,  Caterina Vicentini,  Aldo Scarpa,  Luciano Cascione,  Daniele Costantini,  Guido Carpino,  Domenico Alvaro,  Michele Ghidini,  Francesco Trevisani,  Robert Te Poele,  Massimiliano Salati,  Sofia Ventura,  Georgios Vlachogiannis,  Jens C. Hahne,  Luke Boulter,  Stuart J. Forbes,  Rachel V. Guest,  Umberto Cillo,  Ian Said-Huntingford,  Ruwaida Begum,  Elizabeth Smyth,  Vasiliki Michalarea,  David Cunningham,  Lorenza Rimassa,  Armando Santoro,  Massimo Roncalli,  Vladimir Kirkin,  Paul Clarke,  Paul Workman,  Nicola Valeri,  Chiara Braconi, 
  • Pages: 982-996
  • First Published: 26 December 2019
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PTPRε Acts as a Metastatic Promoter in Hepatocellular Carcinoma by Facilitating Recruitment of SMAD3 to TGF-β Receptor 1

Zhibin Liao,  Lin Chen,  Xuewu Zhang,  Hongwei Zhang,  Xiaolong Tan,  Keshuai Dong,  Xun Lu,  He Zhu,  Qiumeng Liu,  Zhanguo Zhang,  Zeyang Ding,  Wei Dong,  Peng Zhu,  Liang Chu,  Huifang Liang,  Pran K. Datta,  Bixiang Zhang,  Xiaoping Chen, 
  • Pages: 997-1012
  • First Published: 06 January 2020

Autoimmune, Cholestatic and Biliary Disease

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Targeted Apoptosis of Ductular Reactive Cells Reduces Hepatic Fibrosis in a Mouse Model of Cholestasis

Adiba I. Azad,  Anuradha Krishnan,  Leia Troop,  Ying Li,  Tomohiro Katsumi,  Kevin Pavelko,  Enis Kostallari,  Maria Eugenia Guicciardi,  Gregory J. Gores, 
  • Pages: 1013-1028
  • First Published: 03 March 2020

Liver Failure/Cirrhosis/Portal Hypertension

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Ordinal Outcomes Are Superior to Binary Outcomes for Designing and Evaluating Clinical Trials in Compensated Cirrhosis

Gennaro D’Amico,  Juan G. Abraldes,  Paola Rebora,  Maria Grazia Valsecchi,  Guadalupe Garcia-Tsao, 
  • Pages: 1029-1042
  • First Published: 14 December 2019
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Paracentesis-Induced Circulatory Dysfunction With Modest-Volume Paracentesis Is Partly Ameliorated by Albumin Infusion in Acute-on-Chronic Liver Failure

Vinod Arora,  Rajan Vijayaraghavan,  Rakhi Maiwall,  Amrish Sahney,  Sherin Sarah Thomas,  Rehmat Ali,  Priyanka Jain,  Guresh Kumar,  Shiv Kumar Sarin, 
  • Pages: 1043-1055
  • First Published: 17 December 2019

Liver Injury/Regeneration

Open Access

Human Antigen R (HuR): A Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplant Injury

Kenneth J. Dery,  Kojiro Nakamura,  Kentaro Kadono,  Hirofumi Hirao,  Shoichi Kageyama,  Takahiro Ito,  Hidenobu Kojima,  Fady M. Kaldas,  Ronald W. Busuttil,  Jerzy W. Kupiec-Weglinski, 
  • Pages: 1056-1072
  • First Published: 27 December 2019

Liver Biology/Pathobiology

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Moesin, an Ezrin/Radixin/Moesin Family Member, Regulates Hepatic Fibrosis

Serhan Karvar,  Ephraim A. Ansa-Addo,  Jo Suda,  Shweta Singh,  Lixin Zhu,  Zihai Li,  Don C. Rockey, 
  • Pages: 1073-1084
  • First Published: 20 December 2019
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Uncovering Biological Factors That Regulate Hepatocellular Carcinoma Growth Using Patient-Derived Xenograft Assays

Min Zhu,  Lin Li,  Tianshi Lu,  Hyesun Yoo,  Ji Zhu,  Purva Gopal,  Sam C. Wang,  Matthew R. Porembka,  Nicole E. Rich,  Sofia Kagan,  Mobolaji Odewole,  Veronica Renteria,  Akbar K. Waljee,  Tao Wang,  Amit G. Singal,  Adam C. Yopp,  Hao Zhu, 
  • Pages: 1085-1101
  • First Published: 03 January 2020

Special Article

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Coronavirus Disease 2019 Hangover: A Rising Tide of Alcohol Use Disorder and Alcohol-Associated Liver Disease

Ben L. Da,  Gene Y. Im,  Thomas D. Schiano, 
  • Pages: 1102-1108
  • First Published: 05 May 2020

Concise Review

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Considerations for Prognosis, Goals of Care, and Specialty Palliative Care for Hospitalized Patients With Acute-on-Chronic Liver Failure

Ruben Hernaez,  Arpan Patel,  Leanne K. Jackson,  Ursula K. Braun,  Anne M. Walling,  Hugo R. Rosen, 
  • Pages: 1109-1116
  • First Published: 16 May 2020

Reviews

Open Access

The Role of Metabolic Lipases in the Pathogenesis and Management of Liver Disease

Matteo Tardelli,  Francesca Virginia Bruschi,  Michael Trauner, 
  • Pages: 1117-1126
  • First Published: 01 April 2020
Free Access

The Role of the Intestine in the Pathogenesis of Primary Sclerosing Cholangitis: Evidence and Therapeutic Implications

Gregory Dean,  Stephen Hanauer,  Josh Levitsky, 
  • Pages: 1127-1138
  • First Published: 11 May 2020

Hepatology Elsewhere

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The Metabolic Sensor Adenosine Monophosphate–Activated Protein Kinase Regulates Apoptosis in Nonalcoholic Steatohepatitis

Maria Eugenia Guicciardi Ph.D., Yasuhiko Nakao M.D., Gregory J. Gores M.D., 
  • Pages: 1139-1141
  • First Published: 27 April 2020
Free Access

Have the Starting Lineup of Five for Hepatitis B Virus Covalently Closed Circular DNA Synthesis Been Identified?

Qiong Zhao Ph.D.,  Ju-Tao Guo M.D., 
  • Pages: 1142-1144
  • First Published: 05 June 2020

Clinical Observations In Hepatology

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Recurrent Isolated Hyperbilirubinemia From Drug-Induced Impaired Hepatic Bilirubin Uptake

Alick Feng,  Maen Masadeh,  Arvind R. Murali, 
  • Pages: 1145-1147
  • First Published: 31 January 2020
Open Access

Living Donor Liver Transplantation From Hepatitis C–Infected Donor to Hepatitis C–Infected Recipient

Henrik Junger,  Birgit Knoppke,  Kilian Weigand,  Katja Evert,  Frank W. Brennfleck,  Michael Melter,  Hans J. Schlitt,  Stefan M. Brunner, 
  • Pages: 1148-1151
  • First Published: 17 February 2020
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Could Autoimmune Disease Contribute to the Abscopal Effect in Metastatic Hepatocellular Carcinoma?

Carolien Beyls,  Karin Haustermans,  Christophe M. Deroose,  Steven Pans,  Dirk Vanbeckevoort,  Chris Verslype,  Jeroen Dekervel, 
  • Pages: 1152-1154
  • First Published: 29 April 2020

Correspondence

Open Access

Letter to the Editor: Emergence of Zoonotic Rat Hepatitis E Virus Infection

Cornelia Adlhoch Ph.D.,  Sally A. Baylis Ph.D., 
  • Page: 1155
  • First Published: 19 March 2020
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Reply

Siddharth Sridhar FRCPath,  Kwok-Yung Yuen M.D., 
  • Pages: 1155-1156
  • First Published: 19 March 2020
Open Access

Letter to the Editor: Does Augmenter of Liver Regeneration Deficiency Pave the Way for Nonalcoholic Steatohepatitis Progression?

Thomas S. Weiss Ph.D.,  Michael Melter M.D.,  Rania Dayoub Ph.D., 
  • Pages: 1156-1157
  • First Published: 29 March 2020
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Reply

Alok K. Verma Ph.D.,  Chandrashekhar R. Gandhi M.Sc., Ph.D., 
  • Pages: 1157-1158
  • First Published: 27 March 2020
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Letter to the Editor: Thromboelastography-Guided Blood Product Transfusion in Cirrhosis With Coagulopathy: Real Saving or Just Less Waste?

Massimo Primignani M.D.,  Giulia Tosetti M.D.,  Armando Tripodi Ph.D., 
  • Pages: 1158-1159
  • First Published: 08 April 2020
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Reply

Manoj Kumar M.B.B.S., M.D., D.M., 
  • Page: 1160
  • First Published: 08 April 2020

Correction

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Correction

  • Page: 1161
  • First Published: 25 August 2020

Issue Information

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Instructions to Authors

  • First Published: 28 September 2020