• Issue

    Hepatology: Volume 63, Issue 6

    1749-2068
    June 2016
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Issue Information

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Masthead

  • First Published: 20 May 2016
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Table of contents

  • First Published: 20 May 2016

Hepatology Highlights

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Hepatology highlights

Jean-François Dufour, 
  • Pages: 1749-1751
  • First Published: 20 May 2016

Comments from the Editors

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Not all mice are the same: Standardization of animal research data presentation

M. Bishr Omary,  David E. Cohen,  Emad M. El-Omar,  Rajiv Jalan,  Malcolm J. Low,  Michael H. Nathanson,  Richard M. Peek Jr.,  Jerrold R. Turner, 
  • Pages: 1752-1754
  • First Published: 20 May 2016

Editorials

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Quality of care metrics in chronic hepatitis B

Jessica Mellinger M.D., M.Sc.,  Robert J. Fontana M.D., 
  • Pages: 1755-1758
  • First Published: 18 February 2016
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Retinoids: The Link Between Alcohol and Interferon?

Steven A. Weinman M.D., Ph.D.,  Irina Tikhanovich Ph.D., 
  • Pages: 1759-1761
  • First Published: 07 March 2016
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Nonalcoholic fatty liver disease and elastography: Incremental advances but work still to be done

William N. Hannah Jr. M.D.,  Stephen A. Harrison M.D., 
  • Pages: 1762-1764
  • First Published: 18 February 2016
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Broadening the implications of gene discovery

Eve A. Roberts M.D., Ph.D., FRCPC, FAASLD, 
  • Pages: 1765-1767
  • First Published: 28 January 2016
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Deflating balloon tamponade: Should we expand the use of stents for severe refractory esophageal variceal bleeding?

Loren Laine M.D., 
  • Pages: 1768-1770
  • First Published: 11 January 2016
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Beta-blockers in 2016: Still the safest and most useful drugs for portal hypertension?

Gennaro D'Amico MD,  Giuseppe Malizia MD,  Jaime Bosch MD, 
  • Pages: 1771-1773
  • First Published: 18 February 2016

Viral Hepatitis

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Care delivery and outcomes among US veterans with hepatitis B: A national cohort study

Marina Serper,  Gina Choi,  Kimberly A. Forde,  David E. Kaplan, 
  • Pages: 1774-1782
  • First Published: 11 November 2015
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Retinoid regulation of antiviral innate immunity in hepatocytes

Noell E. Cho,  Bo-Ram Bang,  Purnima Gurung,  Meng Li,  Dahn L. Clemens,  T. Michael Underhill,  Laura P. James,  Jenifer R. Chase,  Takeshi Saito, 
  • Pages: 1783-1795
  • First Published: 05 December 2015
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Is increased hepatitis C virus case-finding combined with current or 8-week to 12-week direct-acting antiviral therapy cost-effective in UK prisons? A prevention benefit analysis

Natasha K. Martin,  Peter Vickerman,  Iain F. Brew,  Joan Williamson,  Alec Miners,  William L. Irving,  Sushma Saksena,  Sharon J. Hutchinson,  Sema Mandal,  Eamonn O'Moore,  Matthew Hickman, 
  • Pages: 1796-1808
  • First Published: 10 February 2016
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Retreatment with sofosbuvir and simeprevir of patients with hepatitis C virus genotype 1 or 4 who previously failed a daclatasvir-containing regimen

Christophe Hézode,  Stéphane Chevaliez,  Giovanna Scoazec,  Alexandre Soulier,  Anne Varaut,  Magali Bouvier-Alias,  Isaac Ruiz,  Françoise Roudot-Thoraval,  Ariane Mallat,  Cyrille Féray,  Jean-Michel Pawlotsky, 
  • Pages: 1809-1816
  • First Published: 08 February 2016

Steatohepatitis/Metabolic Liver Disease

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Liver stiffness in nonalcoholic fatty liver disease: A comparison of supersonic shear imaging, FibroScan, and ARFI with liver biopsy

Christophe Cassinotto,  Jérome Boursier,  Victor de Lédinghen,  Jérome Lebigot,  Bruno Lapuyade,  Paul Cales,  Jean-Baptiste Hiriart,  Sophie Michalak,  Brigitte Le Bail,  Victoire Cartier,  Amaury Mouries,  Frédéric Oberti,  Isabelle Fouchard-Hubert,  Julien Vergniol,  Christophe Aubé, 
  • Pages: 1817-1827
  • First Published: 13 December 2015
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Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B−/− (Wilson disease) mice

James P. Hamilton,  Lahari Koganti,  Abigael Muchenditsi,  Venkata S. Pendyala,  David Huso,  Joseph Hankin,  Robert C. Murphy,  Dominik Huster,  Uta Merle,  Christopher Mangels,  Nan Yang,  James J. Potter,  Esteban Mezey,  Svetlana Lutsenko, 
  • Pages: 1828-1841
  • First Published: 17 December 2015
Open Access

Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants

Giancarlo Chesi,  Ramanath N. Hegde,  Simona Iacobacci,  Mafalda Concilli,  Seetharaman Parashuraman,  Beatrice Paola Festa,  Elena V. Polishchuk,  Giuseppe Di Tullio,  Annamaria Carissimo,  Sandro Montefusco,  Diana Canetti,  Maria Monti,  Angela Amoresano,  Piero Pucci,  Bart van de Sluis,  Svetlana Lutsenko,  Alberto Luini,  Roman S. Polishchuk, 
  • Pages: 1842-1859
  • First Published: 13 December 2015
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Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice

Yuanyuan Li,  Munaf Zalzala,  Kavita Jadhav,  Yang Xu,  Takhar Kasumov,  Liya Yin,  Yanqiao Zhang, 
  • Pages: 1860-1874
  • First Published: 25 January 2016
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Development and validation of a noninvasive prediction model for nonalcoholic steatohepatitis resolution after lifestyle intervention

Eduardo Vilar-Gomez,  Ali Yasells-Garcia,  Yadina Martinez-Perez,  Luis Calzadilla-Bertot,  Ana Torres-Gonzalez,  Bienvenido Gra-Oramas,  Licet Gonzalez-Fabian,  Oscar Villa-Jimenez,  Scott L. Friedman,  Moises Diago,  Manuel Romero-Gomez, 
  • Pages: 1875-1887
  • First Published: 05 February 2016

Hepatobiliary Malignancies

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Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype

Matthias S. Matter,  Jens U. Marquardt,  Jesper B. Andersen,  Cristina Quintavalle,  Nikolay Korokhov,  Jim K. Stauffer,  Kosuke Kaji,  Thomas Decaens,  Luca Quagliata,  Fathi Elloumi,  Tanya Hoang,  Alfredo Molinolo,  Elizabeth A. Conner,  Achim Weber,  Mathias Heikenwalder,  Valentina M. Factor,  Snorri S. Thorgeirsson, 
  • Pages: 1888-1899
  • First Published: 04 February 2016
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Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans

Lei Li,  Li Che,  Kevin M. Tharp,  Hyo-Min Park,  Maria G. Pilo,  Dan Cao,  Antonio Cigliano,  Gavinella Latte,  Zhong Xu,  Silvia Ribback,  Frank Dombrowski,  Matthias Evert,  Gregory J. Gores,  Andreas Stahl,  Diego F. Calvisi,  Xin Chen, 
  • Pages: 1900-1913
  • First Published: 22 February 2016
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FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance through Keap1-Nrf2 signaling

Li Guan,  Lei Zhang,  Zhicheng Gong,  Xiaonan Hou,  Yuxiu Xu,  Xinhua Feng,  Hongyang Wang,  Han You, 
  • Pages: 1914-1927
  • First Published: 09 February 2016
Open Access

MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription

Yue Li,  Chi Kwan Tsang,  Suihai Wang,  Xiao-Xing Li,  Yang Yang,  Liwu Fu,  Wenlin Huang,  Ming Li,  Hui-Yun Wang,  X.F. Steven Zheng, 
  • Pages: 1928-1942
  • First Published: 22 February 2016

Autoimmune, Cholestatic and Biliary Disease

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Genome-wide association study in mice identifies loci affecting liver-related phenotypes including Sel1l influencing serum bile acids

Wei Wu,  Ami Patel,  Kaisa Kyöstilä,  Hannes Lohi,  Nikol Mladkova,  Krzysztof Kiryluk,  Xiaoyun Sun,  Jay H. Lefkowitch,  Howard J. Worman,  Ali G. Gharavi, 
  • Pages: 1943-1956
  • First Published: 09 February 2016

Liver Failure/Cirrhosis/Portal Hypertension

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Esophageal balloon tamponade versus esophageal stent in controlling acute refractory variceal bleeding: A multicenter randomized, controlled trial

Àngels Escorsell,  Oana Pavel,  Andrés Cárdenas,  Rosa Morillas,  Elba Llop,  Càndid Villanueva,  Juan C. Garcia-Pagán,  Jaime Bosch, ; for the Variceal Bleeding Study Group , 
  • Pages: 1957-1967
  • First Published: 24 November 2015
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Nonselective β-blockers do not affect mortality in cirrhosis patients with ascites: Post Hoc analysis of three randomized controlled trials with 1198 patients

Lars Bossen,  Aleksander Krag,  Hendrik Vilstrup,  Hugh Watson,  Peter Jepsen, 
  • Pages: 1968-1976
  • First Published: 24 November 2015
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Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension

Sílvia Vilarinho,  Sinan Sari,  Güldal Yilmaz,  Amy L. Stiegler,  Titus J. Boggon,  Dhanpat Jain,  Gulen Akyol,  Buket Dalgic,  Murat Günel,  Richard P. Lifton, 
  • Pages: 1977-1986
  • First Published: 13 February 2016

Liver Injury/Regeneration

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c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

Sanda Win,  Tin Aung Than,  Robert Win Maw Min,  Mariam Aghajan,  Neil Kaplowitz, 
  • Pages: 1987-2003
  • First Published: 04 February 2016
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P2X1-regulated IL-22 secretion by innate lymphoid cells is required for efficient liver regeneration

Ramesh Kudira,  Thomas Malinka,  Andreas Kohler,  Michel Dosch,  Mercedes Gomez de Agüero,  Nicolas Melin,  Stefanie Haegele,  Patrick Starlinger,  Niran Maharjan,  Smita Saxena,  Adrian Keogh,  Deborah Stroka,  Daniel Candinas,  Guido Beldi, 
  • Pages: 2004-2017
  • First Published: 08 February 2016

Liver Capsule

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Liver capsule: Molecular-based signatures in hepatocellular carcinoma

Amanda J. Craig,  Augusto Villanueva, 
  • Page: 2018
  • First Published: 09 February 2016

Reviews

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Antibiotic prophylaxis in cirrhosis: Good and bad

Javier Fernández,  Puneeta Tandon,  Jose Mensa,  Guadalupe Garcia-Tsao, 
  • Pages: 2019-2031
  • First Published: 03 November 2015
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Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice

Giulio Marchesini,  Salvatore Petta,  Riccardo Dalle Grave, 
  • Pages: 2032-2043
  • First Published: 11 December 2015

Hepatology Elsewhere

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Statins and portal hypertension: A tale of two models

Juan P. Arab M.D.,  Vijay H. Shah M.D., 
  • Pages: 2044-2047
  • First Published: 25 March 2016
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Statins in Cirrhosis: The Magic Pill?

Giuseppe Malizia M.D.,  Gennaro D'Amico M.D., 
  • Pages: 2047-2049
  • First Published: 26 April 2016

Clinical Observations in Hepatology

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A Case of Sphenoid Sinus Metastasis in Hepatocellular Carcinoma

Tae Hoon Lee,  Vikram Rangan,  Hicham Khallafi, 
  • Pages: 2050-2053
  • First Published: 29 February 2016

Correspondence

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Further support for the association of GNPAT variant rs11558492 with severe iron overload in hemochromatosis

Céline Besson-Fournier M.Sc.,  Maria Martinez Ph.D.,  Jean-Pierre Vinel M.D.,  Patricia Aguilar-Martinez M.D., Ph.D.,  Hélène Coppin Ph.D.,  Marie-Paule Roth M.D., 
  • Pages: 2054-2055
  • First Published: 29 September 2015
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GNPAT variant is not associated with severe iron overload in Irish C282Y homozygotes

Eleanor Ryan Ph.D.,  Jennifer Russell Ph.D.,  John D Ryan MB.BCh., M.R.C.P.I., Ph.D.,  John Crowe Ph.D., F.R.C.P.I., F.R.C.P.E., F.A.C.P., A.G.A.F.,  Stephen Stewart MB.BCh., Ph.D., F.R.C.P.I., 
  • Pages: 2055-2056
  • First Published: 29 September 2015
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Reply

Christine E. McLaren Ph.D.,  James C. Barton M.D.,  Pradyumna D. Phatak M.D.,  Mary J. Emond Ph.D.,  V. Nathan Subramaniam Ph.D.,  Lyle C. Gurrin Ph.D.,  Paul C. Adams M.D.,  Lawrie W. Powell M.D., Ph.D.,  Grant A. Ramm Ph.D.,  Gregory J. Anderson Ph.D.,  Gordon D. McLaren M.D., 
  • Pages: 2056-2057
  • First Published: 29 September 2015
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GNPAT variant is associated with iron phenotype in healthy Taiwanese women: A population without the HFE C282Y mutation

Shu-Chen Hsiao M.Sc.,  Chien-Te Lee M.D., Ph.D.,  Sung-Nan Pei M.D., 
  • Pages: 2057-2058
  • First Published: 04 February 2016
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Reply

Christine E. McLaren Ph.D.,  James C. Barton M.D.,  V. Nathan Subramaniam Ph.D.,  Grant A. Ramm Ph.D.,  Pradyumna D. Phatak M.D.,  Mary J. Emond Ph.D.,  Lyle C. Gurrin Ph.D.,  Paul C. Adams M.D.,  Lawrie W. Powell M.D., Ph.D.,  Gregory J. Anderson Ph.D.,  Gordon D. McLaren M.D., 
  • Pages: 2058-2060
  • First Published: 04 February 2016
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A morphodynamic evaluation of the portal and hepatic venous system in cirrhosis can predict a progression of portal hypertension

Antonio Manenti M.D.,  Erica Pavesi M.D.,  Alberto Farinetti M.D.,  Dario Colasanto M.D., 
  • Pages: 2060-2061
  • First Published: 30 June 2015
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Is cryoablation really more effective than radiofrequency ablation in hepatocellular carcinoma?

Gin-Ho Lo M.D., 
  • Page: 2061
  • First Published: 23 July 2015
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Reply

Chunping Wang M.Phil.,  Ke-Qin Hu M.D.,  Yongping Yang M.D., Ph.D., 
  • Pages: 2061-2062
  • First Published: 23 July 2015
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Bridging basic science and liver disease: Symposium

Irwin Rosenberg M.D.,  Elihu Schimmel M.D., 
  • Pages: 2062-2063
  • First Published: 14 July 2015

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Severe hepatotoxicity associated with asunaprevir and daclatasvir in chronic hepatitis C

Soichiro Shibata MD,  Takeji Umemura MD, PhD,  Michiharu Komatsu MD, PhD,  Eiji Tanaka MD, PhD, 
  • Pages: 2063-2064
  • First Published: 06 August 2015
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Reply

Yohei Fujii M.D.,  Yoshihito Uchida M.D., Ph.D.,  Satoshi Mochida M.D., Ph.D., 
  • Pages: 2064-2065
  • First Published: 06 August 2015
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Hypoglycemia in a diabetic patient during hepatitis C therapy

Vicente Soriano M.D., Ph.D.,  Pablo Barreiro M.D., Ph.D.,  Carmen de Mendoza Ph.D., 
  • Pages: 2065-2066
  • First Published: 27 August 2015
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Reply

Tracey G. Simon M.D.,  Raymond T. Chung M.D., 
  • Pages: 2066-2067
  • First Published: 27 August 2015
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Research is needed on the difficult-to-cure population of hepatitis C virus patients with disability

Viktor Chirikov,  Fadia Shaya,  C. Daniel Mullins,  Susan dosReis,  Eberechukwu Onukwugha,  Charles Howell, 
  • Pages: 2067-2068
  • First Published: 11 August 2015

Issue Information

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Notices

  • First Published: 20 May 2016
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Instructions for authors

  • First Published: 20 May 2016
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Information for readers

  • First Published: 20 May 2016