• Issue

    Hepatology: Volume 59, Issue 4

    1217-1656
    April 2014
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Hepatology Highlights

Free Access

Hepatology highlights

Jean-François Dufour, 
  • Pages: 1217-1219
  • First Published: 24 March 2014

Editorials

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Serum bile acids in intrahepatic cholestasis of pregnancy: Not just a diagnostic test

Laura N. Bull,  Juan Vargas, 
  • Pages: 1220-1222
  • First Published: 09 October 2013
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New highlights for relaxin

Klaas Poelstra, 
  • Pages: 1223-1224
  • First Published: 28 August 2013
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Type I and type III interferon-induced immune response: It's a matter of kinetics and magnitude

David Olagnier Ph.D.,  John Hiscott Ph.D., 
  • Pages: 1225-1228
  • First Published: 04 December 2013
Free Access

PKCs: Pernicious kinase culprits in acetaminophen pathogenesis

Cynthia Ju,  Robert A. Roth, 
  • Pages: 1229-1231
  • First Published: 08 November 2013
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Antitumor CD8+T cells in hepatocellular carcinoma: Present but exhausted

Ka-Kit Li,  David H. Adams, 
  • Pages: 1232-1234
  • First Published: 09 October 2013
Free Access

Drinking coffee burns hepatic fat by inducing lipophagy coupled with mitochondrial β-oxidation

Wen-Xing Ding Ph.D., 
  • Pages: 1235-1238
  • First Published: 01 October 2013
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Hepatorenal syndrome type 1 and bacterial infection: A catastrophic association in patients with cirrhosis

Francesco Salerno,  Valentina Monti, 
  • Pages: 1239-1241
  • First Published: 15 January 2014
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Reconsidering a “chopped liver”: The need for improving glomular filtration rate estimation for hepatic transplantation

Chirag R. Parikh M.D., Ph.D,  Justin M. Belcher M.D., 
  • Pages: 1242-1245
  • First Published: 27 January 2014
Free Access

Sticker shock and the price of new therapies for hepatitis C: Is it worth it?

Nancy S. Reau,  Donald M. Jensen, 
  • Pages: 1246-1249
  • First Published: 03 February 2014

Viral Hepatitis

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Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus

Nikolaus Jilg,  Wenyu Lin,  Jian Hong,  Esperance A. Schaefer,  David Wolski,  James Meixong,  Kaku Goto,  Cynthia Brisac,  Pattranuch Chusri,  Dahlene N. Fusco,  Stephane Chevaliez,  Jay Luther,  Kattareeya Kumthip,  Thomas J. Urban,  Lee F. Peng,  Georg M. Lauer,  Raymond T. Chung, 
  • Pages: 1250-1261
  • First Published: 01 August 2013
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Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression

Christopher R. Bolen,  Siyuan Ding,  Michael D. Robek,  Steven H. Kleinstein, 
  • Pages: 1262-1272
  • First Published: 08 August 2013
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The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis

Darragh Duffy,  Rasha Mamdouh,  Melissa Laird,  Charlotte Soneson,  Lenaig Le Fouler,  Maï El-Daly,  Armanda Casrouge,  Jérémie Decalf,  Amal Abbas,  Noha Sharaf Eldin,  Magnus Fontes,  Mohamed Abdel-Hamid,  Mostafa K. Mohamed,  Mona Rafik,  Arnaud Fontanet,  Matthew L. Albert, 
  • Pages: 1273-1282
  • First Published: 21 October 2013
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The 104-week efficacy and safety of telbivudine-based optimization strategy in chronic hepatitis B patients: A randomized, controlled study

Jian Sun,  Qing Xie,  Deming Tan,  Qin Ning,  Junqi Niu,  Xuefan Bai,  Rong Fan,  Shijun Chen,  Jun Cheng,  Yanyan Yu,  Hao Wang,  Min Xu,  Guangfeng Shi,  Mobin Wan,  Xinyue Chen,  Hong Tang,  Jifang Sheng,  Xiaoguang Dou,  Junping Shi,  Hong Ren,  Maorong Wang,  Hongfei Zhang,  Zhiliang Gao,  Chengwei Chen,  Hong Ma,  Jidong Jia,  Jinlin Hou, 
  • Pages: 1283-1292
  • First Published: 14 November 2013
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Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients

Yao-Chun Hsu,  Jaw-Town Lin,  Hsiu J. Ho,  Yu-Hsi Kao,  Yen-Tsung Huang,  Nai-Wan Hsiao,  Ming-Shiang Wu,  Yi-Ya Liu,  Chun-Ying Wu, 
  • Pages: 1293-1302
  • First Published: 12 October 2013
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Assessment of current criteria for primary nonresponse in chronic hepatitis B patients receiving entecavir therapy

Young-Joo Yang,  Ju Hyun Shim,  Kang Mo Kim,  Young-Suk Lim,  Han Chu Lee, 
  • Pages: 1303-1310
  • First Published: 29 October 2013
Free Access

Hepatitis C disease severity in living versus deceased donor liver transplant recipients: An extended observation study

Norah A. Terrault,  R. Todd Stravitz,  Anna S.F. Lok,  Greg T. Everson,  Robert S. Brown Jr.,  Laura M. Kulik,  Kim M. Olthoff,  Sammy Saab,  Ovedele Adeyi,  Curtis K. Argo,  Jay E. Everhart,  Del R. Rodrigo,  the A2ALL Study Group , 
  • Pages: 1311-1319
  • First Published: 31 October 2013
Open Access

Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner

Nicola F. Fletcher,  Rupesh Sutaria,  Juandy Jo,  Amy Barnes,  Miroslava Blahova,  Luke W. Meredith,  Francois-Loic Cosset,  Stuart M. Curbishley,  David H. Adams,  Antonio Bertoletti,  Jane A. McKeating, 
  • Pages: 1320-1330
  • First Published: 29 October 2013
Free Access

Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment

Juanjuan Zhao,  Zheng Zhang,  Yan Luan,  Zhengsheng Zou,  Yanling Sun,  Yonggang Li,  Lei Jin,  Chunbao Zhou,  Junliang Fu,  Bin Gao,  Yangxin Fu,  Fu-Sheng Wang, 
  • Pages: 1331-1342
  • First Published: 29 October 2013
Open Access

Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection

Sam Lattimore,  Will Irving,  Sarah Collins,  Celia Penman,  Mary Ramsay,  on Behalf of the Collaboration for the Sentinel Surveillance of Blood-Borne Virus Testing , 
  • Pages: 1343-1350
  • First Published: 09 November 2013
Open Access

Liver-primed CD8+ T cells suppress antiviral adaptive immunity through galectin-9-independent T-Cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice

Joseph S. Dolina,  Thomas J. Braciale,  Young S. Hahn, 
  • Pages: 1351-1365
  • First Published: 20 November 2013

Steatohepatitis/Metabolic Liver Disease

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Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

Rohit A. Sinha,  Benjamin L. Farah,  Brijesh K. Singh,  Monowarul M. Siddique,  Ying Li,  Yajun Wu,  Olga R. Ilkayeva,  Jessica Gooding,  Jianhong Ching,  Jin Zhou,  Laura Martinez,  Sherwin Xie,  Boon-Huat Bay,  Scott A. Summers,  Christopher B. Newgard,  Paul M. Yen, 
  • Pages: 1366-1380
  • First Published: 08 August 2013
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Nuclear factor (erythroid-derived 2)-like 2 activation-induced hepatic very-low-density lipoprotein receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice

Zhigang Wang,  Xiaobing Dou,  Songtao Li,  Ximei Zhang,  Xinguo Sun,  Zhanxiang Zhou,  Zhenyuan Song, 
  • Pages: 1381-1392
  • First Published: 29 October 2013
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The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease

Victoria L. Gadd,  Richard Skoien,  Elizabeth E. Powell,  Kevin J. Fagan,  Clay Winterford,  Leigh Horsfall,  Katharine Irvine,  Andrew D. Clouston, 
  • Pages: 1393-1405
  • First Published: 20 November 2013
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Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis

Ju Dong Yang,  Manal F. Abdelmalek,  Herbert Pang,  Cynthia D. Guy,  Alastair D. Smith,  Anna Mae Diehl,  Ayako Suzuki, 
  • Pages: 1406-1414
  • First Published: 01 October 2013

Hepatobiliary Malignancies

Open Access

Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma

Tobias Flecken,  Nathalie Schmidt,  Sandra Hild,  Emma Gostick,  Oliver Drognitz,  Robert Zeiser,  Peter Schemmer,  Helge Bruns,  Thomas Eiermann,  David A. Price,  Hubert E. Blum,  Christoph Neumann-Haefelin,  Robert Thimme, 
  • Pages: 1415-1426
  • First Published: 03 September 2013
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Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

Yasuhito Arai,  Yasushi Totoki,  Fumie Hosoda,  Tomoki Shirota,  Natsuko Hama,  Hiromi Nakamura,  Hidenori Ojima,  Koh Furuta,  Kazuaki Shimada,  Takuji Okusaka,  Tomoo Kosuge,  Tatsuhiro Shibata, 
  • Pages: 1427-1434
  • First Published: 09 October 2013
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Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen–positive myeloid cell infiltration in mice

Yunching Chen,  Yuhui Huang,  Thomas Reiberger,  Annique M. Duyverman,  Peigen Huang,  Rekha Samuel,  Lotte Hiddingh,  Sylvie Roberge,  Christina Koppel,  Gregory Y. Lauwers,  Andrew X. Zhu,  Rakesh K. Jain,  Dan G. Duda, 
  • Pages: 1435-1447
  • First Published: 14 November 2013
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Epitope-optimized alpha-fetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma

Yuan Hong,  Yibing Peng,  Z. Sheng Guo,  Jose Guevara-Patino,  Junfeng Pang,  Lisa H. Butterfield,  Nahid F. Mivechi,  David H. Munn,  David L. Bartlett,  Yukai He, 
  • Pages: 1448-1458
  • First Published: 12 October 2013
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Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma

Hua Tian,  Chao Ge,  Hong Li,  Fangyu Zhao,  Helei Hou,  Taoyang Chen,  Guoping Jiang,  Haiyang Xie,  Ying Cui,  Ming Yao,  Jinjun Li, 
  • Pages: 1459-1470
  • First Published: 09 November 2013
Free Access

Hepatocellular carcinoma screening in patients with compensated hepatitis C virus (HCV)-related cirrhosis aware of their HCV status improves survival: A modeling approach

Abbas Mourad,  Sylvie Deuffic-Burban,  Nathalie Ganne-Carrié,  Thibaud Renaut-Vantroys,  Isabelle Rosa,  Anne-Marie Bouvier,  Guy Launoy,  Stephane Cattan,  Alexandre Louvet,  Sébastien Dharancy,  Jean-Claude Trinchet,  Yazdan Yazdanpanah,  Philippe Mathurin, 
  • Pages: 1471-1481
  • First Published: 21 November 2013

Autoimmune, Cholestatic and Biliary Disease

Open Access

Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: A prospective population-based case-control study

Victoria Geenes,  Lucy C. Chappell,  Paul T. Seed,  Philip J. Steer,  Marian Knight,  Catherine Williamson, 
  • Pages: 1482-1491
  • First Published: 15 July 2013

Liver Failure/Cirrhosis/Portal Hypertension

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Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo

Jonathan A. Fallowfield,  Annette L. Hayden,  Victoria K. Snowdon,  Rebecca L. Aucott,  Ben M. Stutchfield,  Damian J. Mole,  Antonella Pellicoro,  Timothy T. Gordon-Walker,  Alexander Henke,  Joerg Schrader,  Palak J. Trivedi,  Marc Princivalle,  Stuart J. Forbes,  Jane E. Collins,  John P. Iredale, 
  • Pages: 1492-1504
  • First Published: 19 July 2013
Free Access

Type-1 hepatorenal syndrome associated with infections in cirrhosis: Natural history, outcome of kidney function, and survival

Rogelio Barreto,  Claudia Fagundes,  Mónica Guevara,  Elsa Solà,  Gustavo Pereira,  Ezequiel Rodríguez,  Isabel Graupera,  Marta Martín-Llahí,  Xavier Ariza,  Andrés Cárdenas,  Javier Fernández,  Juan Rodés,  Vicente Arroyo,  Pere Ginès, 
  • Pages: 1505-1513
  • First Published: 19 August 2013
Free Access

Glomerular filtration rate equations for liver-kidney transplantation in patients with cirrhosis: Validation of current recommendations

Claire Francoz,  Mitra K. Nadim,  Aurore Baron,  Dominique Prié,  Corinne Antoine,  Jacques Belghiti,  Dominique Valla,  Richard Moreau,  François Durand, 
  • Pages: 1514-1521
  • First Published: 26 August 2013
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Creatinine- versus cystatine C-based equations in assessing the renal function of candidates for liver transplantation with cirrhosis

Vandréa De Souza,  Aoumeur Hadj-Aissa,  Olga Dolomanova,  Muriel Rabilloud,  Nicolas Rognant,  Sandrine Lemoine,  Sylvie Radenne,  Jérôme Dumortier,  Colette Chapuis-Cellier,  Françoise Beyerle,  Chantal Bon,  Jean Iwaz,  Luciano Selistre,  Laurence Dubourg, 
  • Pages: 1522-1531
  • First Published: 09 October 2013
Free Access

Performance of chronic kidney disease epidemiology collaboration creatinine-cystatin C equation for estimating kidney function in cirrhosis

Ayse L. Mindikoglu,  Thomas C. Dowling,  Matthew R. Weir,  Stephen L. Seliger,  Robert H. Christenson,  Laurence S. Magder, 
  • Pages: 1532-1542
  • First Published: 06 June 2013

Liver Injury/Regeneration

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Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways

Behnam Saberi,  Maria D. Ybanez,  Heather S. Johnson,  William A. Gaarde,  Derick Han,  Neil Kaplowitz, 
  • Pages: 1543-1554
  • First Published: 19 July 2013
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Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice

Elea Conrad,  Theresa K. Resch,  Patricia Gogesch,  Ulrich Kalinke,  Ingo Bechmann,  Christian Bogdan,  Zoe Waibler, 
  • Pages: 1555-1563
  • First Published: 29 October 2013
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Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure

Charalambos Gustav Antoniades,  Wafa Khamri,  Robin D. Abeles,  Leonie S. Taams,  Evangelos Triantafyllou,  Lucia A. Possamai,  Christine Bernsmeier,  Ragai R. Mitry,  Alistair O'Brien,  Derek Gilroy,  Robert Goldin,  Michael Heneghan,  Nigel Heaton,  Wayel Jassem,  William Bernal,  Diego Vergani,  Yun Ma,  Alberto Quaglia,  Julia Wendon,  Mark Thursz, 
  • Pages: 1564-1576
  • First Published: 27 November 2013

Liver Biology/Pathobiology

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Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma

Bryan C. Fuchs,  Yujin Hoshida,  Tsutomu Fujii,  Lan Wei,  Suguru Yamada,  Gregory Y. Lauwers,  Christopher M. McGinn,  Danielle K. DePeralta,  Xintong Chen,  Toshihiko Kuroda,  Michael Lanuti,  Anthony D. Schmitt,  Supriya Gupta,  Andrew Crenshaw,  Robert Onofrio,  Bradley Taylor,  Wendy Winckler,  Nabeel Bardeesy,  Peter Caravan,  Todd R. Golub,  Kenneth K. Tanabe, 
  • Pages: 1577-1590
  • First Published: 21 October 2013
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Inhibition of Niemann-Pick-type C1-like1 by ezetimibe activates autophagy in human hepatocytes and reduces mutant α1-antitrypsin Z deposition

Takeshi Yamamura,  Yuki Ohsaki,  Michitaka Suzuki,  Yuki Shinohara,  Tsuyako Tatematsu,  Jinglei Cheng,  Masato Okada,  Naoki Ohmiya,  Yoshiki Hirooka,  Hidemi Goto,  Toyoshi Fujimoto, 
  • Pages: 1591-1599
  • First Published: 09 November 2013
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Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice

Xiaodong Ge,  Tung-Ming Leung,  Elena Arriazu,  Yongke Lu,  Raquel Urtasun,  Brian Christensen,  Maria Isabel Fiel,  Satoshi Mochida,  Esben S. Sørensen,  Natalia Nieto, 
  • Pages: 1600-1616
  • First Published: 09 November 2013

New Horizons

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Liver regeneration by stem/progenitor cells

Tohru Itoh,  Atsushi Miyajima, 
  • Pages: 1617-1626
  • First Published: 01 October 2013

Review

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Pulmonary complications in chronic liver disease

Victor I. Machicao,  Maya Balakrishnan,  Michael B. Fallon, 
  • Pages: 1627-1637
  • First Published: 02 October 2013

Hepatology Elsewhere

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Bile acids reach out to the spinal cord: New insights to the pathogenesis of itch and analgesia in cholestatic liver disease

Paul A. Dawson Ph.D.,  Saul J. Karpen M.D., Ph.D., 
  • Pages: 1638-1641
  • First Published: 08 October 2013
Free Access

Advances in interferon-free hepatitis C therapy: 2014 and beyond

Souvik Sarkar M.D.,  Joseph K. Lim M.D., 
  • Pages: 1641-1644
  • First Published: 07 February 2014

Clinical Observations in Hepatology

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Never forget aceruloplasminemia in case of highly suggestive Wilson's disease score

Marjon Kerkhof,  Pieter Honkoop, 
  • Pages: 1645-1647
  • First Published: 03 September 2013

Correspondence

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Hepcidin as a predictor of treatment response in chronic hepatitis C infection

Pavel Strnad M.D.,  Renwar Nuraldeen M.D.,  Janett Fischer Ph.D.,  Thomas Berg M.D.,  Christian Trautwein M.D., 
  • Page: 1648
  • First Published: 01 August 2013
Free Access

Reply

John Denis Ryan M.B., B.Ch.,  Sandro Altamura Ph.D.,  Martina Muckenthaler Ph.D.,  John Crowe Ph.D., PRCPI, 
  • Pages: 1648-1649
  • First Published: 01 October 2013
Free Access

Platelet count and survival of patients with compensated cirrhosis and small hepatocellular carcinoma treated with surgery

Edoardo G. Giannini M.D., Ph.D., FACG,  Vincenzo Savarino M.D., 
  • Page: 1649
  • First Published: 15 July 2013
Free Access

Sublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma

Jiwen Cheng Ph.D.,  MuXing Li M.D.,  Yi Lv M.D., Ph.D., 
  • Page: 1650
  • First Published: 31 July 2013
Free Access

Disease progression during advanced fibrosis: IL28B genotype or HCV RNA levels?

Jason Grebely Ph.D.,  Bart Grady M.D.,  Behzad Hajarizadeh M.D.,  Kimberly Page Ph.D.,  Gregory J. Dore B.Sc., MBBS, MPH, Ph.D.,  On Behalf of the INC Study Group , 
  • Pages: 1650-1651
  • First Published: 08 August 2013
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Reply

Mazen Noureddin M.D.,  Elizabeth C. Wright M.D.,  Marc G. Ghany M.D., 
  • Page: 1651
  • First Published: 19 August 2013
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Did postoperative peg-interferon plus ribavirin really reduce recurrence of hepatitis C virus–related hepatocellular carcinoma?

Gin-Ho Lo M.D., 
  • Page: 1652
  • First Published: 19 August 2013
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Reply

Yao-Chun Hsu M.D,  Chun-Ying Wu M.D., MPH., Ph.D, 
  • Pages: 1652-1653
  • First Published: 19 August 2013
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A comparison of surgical resection and radiofrequency ablation for the treatment of single small hepatocellular carcinoma ≤2 cm

Yun Ku Cho M.D., 
  • Page: 1653
  • First Published: 19 August 2013
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Reply

Sasan Roayaie M.D., 
  • Pages: 1653-1654
  • First Published: 19 August 2013

Obituary

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In memoriam: Burton Combes, M.D.

Steven Schenker, 
  • Pages: 1655-1656
  • First Published: 05 February 2014