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    Liver International: Volume 45, Issue 7

    July 2025
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FEATURED COVER

Free Access

Featured Cover

Yazhou Chen,  Benjamin P. M. Laevens,  Teresa Lemainque,  Gustav Anton Müller-Franzes,  Tobias Seibel,  Carola Dlugosch,  Jan Clusmann,  Paul-Henry Koop,  Rongpeng Gong,  Yuanyuan Liu,  Niharika Jakhar,  Feng Cao,  Simon Schophaus,  Thriveni Basavanapura Raju,  Anastasia Artemis Raptis,  Felix van Haag,  Joel Joy,  Rohit Loomba,  Luca Valenti,  Jakob Nikolas Kather,  Titus J. Brinker,  Moritz Herzog,  Ivan G. Costa,  Diego Hernando,  Kai Markus Schneider,  Daniel Truhn,  Carolin V. Schneider, 
  • First Published: 25 July 2025
Featured Cover Volume 45 Issue 7, 2025

The cover image is based on the article Deep Learning Reveals Liver MRI Features Associated With PNPLA3 I148M in Steatotic Liver Disease by Carolin Victoria Schneider et al., https://doi.org/10.1111/liv.70164.

ISSUE INFORMATION

Free Access

Issue Information

  • First Published: 28 May 2025

ORIGINAL ARTICLE

Rationalising Hepatocellular Carcinoma Screening in Chronic Hepatitis B: Evaluation of Predictive Scores in an Australian Cohort

Thisuri Jayawardena,  Zein Salim,  Luis Calzadilla Bertot,  Joanne Bunney,  Nicolas Demasi,  Joanne Vallve,  Leon Adams,  Gary Jeffrey,  David Speers,  Gerry MacQuillan,  Tim Mitchell, 
  • First Published: 29 May 2025

CLINICAL IMAGE

The Shunting Puzzle: Congenital Portosystemic Shunts With Multisystem Manifestations

Maofeng Gong,  Jianping Gu, 
  • First Published: 03 June 2025

LETTER TO THE EDITOR

Pregnancy, Thyroid Function and Inflammation Mediation: Critical Gaps in Studying MASLD's Impact on Accelerated Brain Ageing

Yi Ding, 
  • First Published: 04 June 2025

REVIEW

Open Access

Clinical Utility of Non-Invasive Tests for Liver Fibrosis in People Living With Alpha-1 Antitrypsin Deficiency

Joost Boeckmans,  Jörn M. Schattenberg,  Malin Fromme,  Pavel Strnad,  Hannes Hagström, 
  • First Published: 06 June 2025

RESEARCH LETTER

End-Stage Liver Disease Mortality Among Asian American Subgroups in the United States: A Disaggregated Analysis From 2021 to 2023

Muhammad Ali Tariq,  Minhail Khalid Malik,  Aeman Asrar,  Zoha Khalid, 
  • First Published: 05 June 2025

LETTER TO THE EDITOR

Methodological Considerations and Future Directions in Cardiac Geometry Assessment for Cirrhotic Cardiomyopathy

Chun-Yan Li,  Yuan Xin Lee,  Jing Jiang,  Wen-Jing Zhang, 
  • First Published: 05 June 2025

ORIGINAL ARTICLE

Open Access

HFD Exacerbates Hepatic Lipid Metabolism Disorders After Cholecystectomy by Regulating the Bile Acid and Neutrophil Recruitment

Yanting Xu,  Feng Zhang,  Ziliang Ke,  Yiken Lin,  Yang Zhang,  Yun Liu,  Yifan Zhang,  Jun Xu,  Yulan Liu, 
  • First Published: 27 June 2025

Open Access

Deep Learning Reveals Liver MRI Features Associated With PNPLA3 I148M in Steatotic Liver Disease

Yazhou Chen,  Benjamin P. M. Laevens,  Teresa Lemainque,  Gustav Anton Müller-Franzes,  Tobias Seibel,  Carola Dlugosch,  Jan Clusmann,  Paul-Henry Koop,  Rongpeng Gong,  Yuanyuan Liu,  Niharika Jakhar,  Feng Cao,  Simon Schophaus,  Thriveni Basavanapura Raju,  Anastasia Artemis Raptis,  Felix van Haag,  Joel Joy,  Rohit Loomba,  Luca Valenti,  Jakob Nikolas Kather,  Titus J. Brinker,  Moritz Herzog,  Ivan G. Costa,  Diego Hernando,  Kai Markus Schneider,  Daniel Truhn,  Carolin V. Schneider, 
  • First Published: 06 June 2025

Open Access

A Prospective, Blinded Study of Symptom Prevalence and Specificity of Porphyrin Precursors in Carriers of Acute Hepatic Porphyria

Mohsen Merati,  Nanditha Jayakumar,  Yuvraaj Kapoor,  Hetanshi Naik,  Manisha Balwani,  Karl E. Anderson,  Herbert L. Bonkovsky,  Robert J. Desnick,  Brendan McGuire,  John Phillips,  D. Montgomery Bissell,  Bruce Wang, 
  • First Published: 09 June 2025

Myeloid Glutamine Synthetase Protects Against Acute Liver Injury in Mice Independent of Its Enzyme Activity

Jianghong Yu,  Menglin Shi,  Yumeng Guo,  Kaiyi Fu,  Jun Zhang,  Hao Ding,  Mengxiao Ge,  Shuangyi Sun,  Huilu Zhang,  Jie Liu, 
  • First Published: 09 June 2025

LETTER TO THE EDITOR

Strengthening the Assessment of Antifibrotic Therapy in Compensated Cirrhosis

Sheng Li,  Xiao Wu, 
  • First Published: 10 June 2025

ORIGINAL ARTICLE

Open Access

Mortality and Cancer in Offspring of Mothers With Biopsy-Proven MASLD During Pregnancy: A Nationwide Cohort Study

Carole A. Marxer,  Fahim Ebrahimi,  David Bergman,  Jiangwei Sun,  Hannes Hagström,  Marcus Thuresson,  Olof Stephansson,  Jonas F. Ludvigsson, 
  • First Published: 11 June 2025

LETTER TO THE EDITOR

MASLD-Brain Aging Study Biases: Distribution Shift and Self-Cancellation

Shiqin Chen,  Hui Li,  Qingfeng Wang, 
  • First Published: 11 June 2025

Unravelling the Complex Role of Glycine-Conjugated Bile Acids and Gut-Liver Axis in Progressive Alcohol-Related Liver Disease

Yunyi Yang,  Yanming He,  Hongjie Yang, 
  • First Published: 11 June 2025

ORIGINAL ARTICLE

Open Access

Targeting the Liver Serine Protease TMPRSS6 Ameliorates Steatosis and Attenuates Fibrosis in Experimental MASLD

Mariateresa Pettinato,  Valeria Furiosi,  Rossana Carleo,  Letizia Bavuso Volpe,  Shuling Guo,  Valeria Mannella,  Giovanna Musco,  Enrica Gilberti,  Giuseppe De Palma,  Giorgia Federico,  Francesca Carlomagno,  Alessandro Cherubini,  Serena Pelusi,  Anxhela Dano,  Antonella Nai,  Luca Valenti,  Sandro Altamura,  Alessia Pagani,  Laura Silvestri, 
  • First Published: 11 June 2025

LETTER TO THE EDITOR

Reply to Reader—Pregnancy, Thyroid Disease Did Not Alter MASLD-Brain Aging Associations and Mediation of Inflammation

Jiao Wang,  Rongrong Yang,  Weili Xu, 
  • First Published: 11 June 2025

RESEARCH LETTER

Open Access

Histopathological Changes as a Predictor of Fatal Outcome in Patients With Drug-Induced Liver Injury

Sabine Weber,  Franziska Erhardt,  Jens Neumann,  Julian Allgeier,  Didem Saka,  Nirali Donga,  Izabel Mircheva,  Rochell Balakumar,  Christian M. Lange,  Alexander L. Gerbes, 
  • First Published: 13 June 2025

ORIGINAL ARTICLE

A Deep Learning Model Based on High-Frequency Ultrasound Images for Classification of Different Stages of Liver Fibrosis

Linlin Zhang,  Zhengbo Tan,  Chunlei Li,  Lichao Mou,  Yi Lei Shi,  Xiao Xiang Zhu,  Yan Luo, 
  • First Published: 13 June 2025

LETTER TO THE EDITOR

Response to Letter to the Editor: ‘Insights Into Comparison of Bacterial Infections in Patients With Cirrhosis Between Hospitals With and Without Liver Transplant’

Clàudia Torras,  Oriol Gasch,  José Ferrusquía-Acosta,  Cristina Solé, 
  • First Published: 13 June 2025

Insights Into Comparison of Bacterial Infections in Patients With Cirrhosis Between Hospitals With and Without Liver Transplant

Lei Pu,  Huan Luo, 
  • First Published: 16 June 2025

ORIGINAL ARTICLE

Open Access

Digital Pathology Quantification of the Continuum of Cirrhosis Severity in Human Liver Biopsies

Louis Petitjean,  Li Chen,  Xiaofei Zhang,  Thomas Schiano,  Mathieu Petitjean,  Arun J. Sanyal,  MariaIsabel Fiel, 
  • First Published: 16 June 2025

BRIEF REPORT

Open Access

Analysis of Hyperexpanded T Cell Clones in SARS-CoV-2 Vaccine-Associated Liver Injury by Spatial Proteomics and Transcriptomics

Sarp Uzun,  Asmita Pant,  Ewelina Bartoszek,  Paul Gueguen,  Stefan Frei,  Hélène Heusler,  Ilaria Arborelli,  Carl Philipp Zinner,  Neşe Karadağ Soylu,  Benedetta Terziroli Beretta-Piccoli,  Cumali Efe,  Matthias S. Matter, 
  • First Published: 16 June 2025

ORIGINAL ARTICLE

Open Access

HERACLIS_BLV_D: Increasing Response Rates During 2-Year Bulevirtide Real-Life Therapy in Chronic Hepatitis D

Margarita Papatheodoridi,  Vasilios Sevastianos,  Kalliopi Zachou,  Dimitrios Christodoulou,  John Koskinas,  Melanie Deutsch,  Alexandra Alexopoulou,  Ioannis Elefsiniotis,  Christos Triantos,  Elena Gigi,  Theodoros Androutsakos,  Dimitrios Karagiannakis,  Iliana Mani,  Dimitrios Dimitroulopoulos,  Maria Mela,  Emmanouil Sinakos,  Spyros Michopoulos,  Konstantinos Mimidis,  Nikolaos Papadopoulos,  Athanasios Kontos,  Christos Veretanos,  Dimitrios Lymperopoulos,  George Giannoulis,  Vasilios Papadimitropoulos,  Evdoxia Avramopoulou,  Alkistis Papatheodoridi,  Spyridon Pantzios,  Larisa Vasilieva,  Hariklia Kranidioti,  Emmanouil Koullias,  Nikolaos Psychos,  Paraskevi Fytili,  John Vlachogiannakos,  Evangelos Cholongitas,  Spilios Manolakopoulos,  Ioannis Goulis,  George Dalekos,  George Papatheodoridis, 
  • First Published: 16 June 2025

A Prognostic Index for Advanced Biliary Tract Cancer Treated With Cisplatin, Gemcitabine and Durvalumab: The MAGIC-D Index

Mara Persano,  Margherita Rimini,  Francesca Salani,  Federica Lo Prinzi,  Federico Nichetti,  Anna Saborowski,  Lorenzo Antonuzzo,  Laura Passeri,  Tomoyuki Satake,  Frederik Peeters,  Caterina Vivaldi,  Tiziana Pressiani,  Jessica Lucchetti,  Jin Won Kim,  Oluseyi Abidoye,  Salvatore Corallo,  Ilario Giovanni Rapposelli,  Stefano Tamberi,  Fabian Finkelmeier,  Guido Giordano,  Chiara Pircher,  Hong Jae Chon,  Chiara Braconi,  Aitzaz Qaisar,  Chiara Pirrone,  Florian Castet,  Emiliano Tamburini,  Changhoon Yoo,  Alessandro Parisi,  Anna Diana,  Mario Scartozzi,  Gerald W. Prager,  Antonio Avallone,  Marta Schirripa,  Il Hwan Kim,  Lukas Perkhofer,  Ester Oneda,  Monica Verrico,  Nuno Couto,  Jorge Adeva,  Stephen L. Chan,  Gian Paolo Spinelli,  Nicola Personeni,  Ingrid Garajova,  Maria Grazia Rodriquenz,  Silvana Leo,  Cecilia Melo Alvim,  Ricardo Roque,  Giovanni Farinea,  Lorenzo Fornaro,  Antonio De Rosa,  Irene Lanzetta,  Rita Balsano,  Daniele Lavacchi,  Silvia Camera,  Masafumi Ikeda,  Jeroen Dekervel,  Monica Niger,  Giulia Tesini,  Giuseppe Tonini,  Minsu Kang,  Tanios Bekaii-Saab,  Luca Esposito,  Alessandra Boccaccino,  Michele Ferrara,  Vera Himmelsbach,  Matteo Landriscina,  Selma Ahcene Djaballah,  Gianluca Masi,  Arndt Vogel,  Sara Lonardi,  Lorenza Rimassa,  Andrea Casadei-Gardini, 
  • First Published: 17 June 2025

LETTER TO THE EDITOR

Alcohol Cessation as a Multidisciplinary Imperative in Liver Cancer Survivorship: Clinical and Psychosocial Considerations

Yuning Wang,  Jiatong Ding,  Shuhang Wang,  Ning Li, 
  • First Published: 17 June 2025

Prevalence Trends of Hepatitis B and D in the United States From 1999 to 2020

Sisi Yang,  Qiaofeng Ye,  Zhenxuan Ma, 
  • First Published: 18 June 2025

ORIGINAL ARTICLE

Open Access

Amelioration of Liver Fibrosis via In Situ Hepatic Stellate Cell Conversion Through Co-Inhibition of TGF-β and GSK-3 Signalling

Xiang-Jie Zhu,  Zhi Zhong,  Jiang-Chuan Du,  Jiu-Yu Zhang,  Xu Zhang,  Xiu-Liang Cui,  Ling-Ting Guan,  Yan-Yu Hu,  Can Chen,  Han Wang,  Xiang-Yu Wu,  Wei-Jia Zhang,  Pei-Lin Zhang,  Hong-Yang Wang, 
  • First Published: 27 June 2025

LETTER TO THE EDITOR

Response Letter to: Expanding Perspectives on FIB-4 as a Predictor of Hepatic and Extrahepatic Malignancy Risk

Shira Zelber-Sagi,  Yochai Schonmann,  Galit Weinstein,  Hanny Yeshua, 
  • First Published: 20 June 2025

REVIEW

Free Access

Hepatitis D Virus Infection: Pathophysiology, Epidemiology and Treatment. Report From the Third Delta Cure Meeting 2024

Elisabetta Degasperi, Lisa Sandmann, Heiner Wedemeyer, Pietro Lampertico,  on behalf of the Delta Cure 2024 Working Group , 
  • First Published: 20 June 2025

LETTER TO THE EDITOR

Refining HCC Risk Stratification in CHB: Evaluating Predictive Model Applicability in Diverse Populations

Sihui Zhang,  Yunyao Ye,  Shanxun Yu, 
  • First Published: 21 June 2025

ORIGINAL ARTICLE

Open Access

Hepatitis B Virus Variants and Cytokine Patterns in Acute Liver Failure and Transplant-Free Survival

Nishi H. Patel,  Annie Y. Chen,  Carla Osiowy,  Valerie Durkalski Mauldin,  William M. Lee,  Carla S. Coffin,  Constantine J. Karvellas,  the US Acute Liver Failure Study Group , 
  • First Published: 20 June 2025

LETTER TO THE EDITOR

From Image to Insight: Is MRI-Based Genotyping Ready for the Clinic?

Zhihao Lei, 
  • First Published: 23 June 2025

Reply to: ‘MASLD-Brain Aging Study Biases: Distribution Shift and Self-Cancellation’

Jiao Wang,  Huijie Huang,  Rongrong Yang,  Weili Xu, 
  • First Published: 23 June 2025

Letter to the Editor: Advancing TMPRSS6-Targeted Therapy for MASLD: Mechanistic and Translational Perspectives

Zongyu Yang,  Songjie Liao, 
  • First Published: 24 June 2025

EDITORIAL

Free Access

Digital Histopathology and AI: A New Era of Liver Fibrosis Quantification

Luigi M. Terracciano,  Luca Di Tommaso, 
  • First Published: 24 June 2025

ORIGINAL ARTICLE

Open Access

Prognostic Value of the TLM3 Biomarker Panel for Early Fibrosis Development in MASLD Within the General Population

Koen C. van Son,  Jelle C. B. C. de Jong,  Serdar Özsezen,  Martien P. M. Caspers,  Quinten J. J. Augustijn,  Jessica Snabel,  Henrike Galenkamp,  Henrike M. Hamer,  Anne-Marieke van Dijk,  Arianne van Koppen,  Anne Linde Mak,  Bert-Jan van den Born,  Max Nieuwdorp,  Joost P. H. Drenth,  Lise Lotte Gluud,  Maarten E. Tushuizen,  Roeland Hanemaaijer,  Lars Verschuren,  Adriaan G. Holleboom, 
  • First Published: 24 June 2025

LETTER TO THE EDITOR

Expanding Perspectives on FIB-4 as a Predictor of Hepatic and Extrahepatic Malignancy Risk

Yuning Wang,  Yufei Huang,  Shuhang Wang,  Ning Li, 
  • First Published: 17 June 2025

ORIGINAL ARTICLE

Acquisition Process and Clinical Relevance of dMMR-Associated Mutational Signatures in Hepatocellular Carcinoma

Masayuki Ueno,  Haruhiko Takeda,  Atsushi Takai,  Shigeharu Nakano,  Yosuke Fujii,  Masako Mishima,  Eriko Iguchi,  Tadashi Inuzuka,  Takahiro Shimizu,  Keita Jinnouchi,  Hironori Haga,  Etsuro Hatano,  Hiroshi Seno, 
  • First Published: 25 June 2025

LETTER TO THE EDITOR

Hepatitis Delta Virus Prevalence in the U.S. Is Lower Than Previous Estimates

Robert J. Wong, 
  • First Published: 25 June 2025

ORIGINAL ARTICLE

Clinical Impact of Serum CRP Levels on Advanced HCC Treated With Durvalumab and Tremelimumab: A Multicentre Study

Takeshi Hatanaka, Yutaka Yata, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Satoru Kakizaki, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hidenori Toyoda, Yuichi Koshiyama, Chikara Ogawa, Hiroki Nishikawa, Takashi Nishimura, Kazuhito Kawata, Hisashi Kosaka, Kosuke Matsui, Atsushi Naganuma, Hironori Tanaka, Hideko Ohama, Hidekatsu Kuroda, Tomomitsu Matono, Tomoko Aoki, Hironori Ochi, Michitaka Imai, Shinichiro Nakamura, Yuki Kanayama, Kazunari Tanaka, Fujimasa Tada, Osamu Yoshida, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Hirayuki Enomoto, Masaki Kaibori, Yoichi Hiasa, Masatoshi Kudo, Takashi Kumada,  on behalf of the Real-life Practice Experts for HCC (RELPEC) Study Group, HCC 48 Group (hepatocellular carcinoma experts from 48 clinics in Japan) , 
  • First Published: 25 June 2025

Open Access

Hospitalisations With Cryoglobulin-Related Diseases in Spain Over 25 Years

Mario Martín-Portugués,  Jorge Esteban-Sampedro,  Carmen de Mendoza,  Guillermo Ruiz-Irastorza,  Ana Royuela,  Alfonso Ortega-de la Puente,  Marina de la Cruz-Echeandía,  Xiomara Patricia Blanco-Valencia,  Vicente Soriano,  Víctor Moreno-Torres, 
  • First Published: 27 June 2025
Open Access

Impact of Socio-Economic, Behavioural and Clinical Factors on Liver Disease Progression in Individuals With HIV and Hepatitis B

Clémence Ramier,  Anders Boyd,  Colette Smit,  Rosan van Zoest,  Mark A. A. Claassen,  Katalin Pogány,  Dirk Posthouwer,  Theodora E. M. S. de Vries-Sluijs,  Patrizia Carrieri,  Marc Van der Valk, 
  • First Published: 27 June 2025

Open Access

Extrahepatic Replication and Genomic Signatures of the Hepatitis E Virus in the Kidney

Avista Wahid,  Nele Meyer,  Christine Wundes,  Lucas Hüffner,  Saskia Janshoff,  Nicola Frericks,  Martina Friesland,  Katja Dinkelborg,  Elmira Aliabadi,  Fenja Laue,  Markus Cornberg,  Benjamin Maasoumy,  Birgit Bremer,  Sven Pischke,  Tobias Müller,  Julian Zur Schulze Wiesch,  Julia Benckert,  Rainer G. Ulrich,  Svenja Hardtke,  Petra Dörge,  Florian Vondran,  Ansgar Lohse,  Michael Peter Manns,  Daniel Todt,  Heiner Wedemeyer,  Thomas Pietschmann,  Eike Steinmann,  André Gömer,  Patrick Behrendt, 
  • First Published: 27 June 2025
Open Access

Hepatic Phenotype in NBAS-Associated Disease: Clinical Course, Prognostic Factors and Outcome in 230 Patients

Bianca Peters,  Lea Dewi Schlieben,  Heiko Brennenstuhl,  Cigdem Arikan,  Sarah M. Bedoyan,  Fatma Derya Bulut,  Ellen Crushell,  Carlo Dionisi-Vici,  Ada Drab,  Alexander Fichtner,  Aixa Gonzalez Garcia,  Deanna Fry,  Sven F. Garbade,  Nicole Hammann,  Nedim Hadzic,  Robert Hegarty,  Marianne Hørby Jørgensen,  Martin Laaß,  Elke Lainka,  Lina Leghlam,  Eberhard Lurz,  Halise Neslihan Önenli Mungan,  Andrea Pietrobattista,  Begona Polo,  Piotr Socha,  James E. Squires,  Tian Sun,  Georg F. Vogel,  Holger Prokisch,  Stefan Kölker,  Georg F. Hoffmann,  Christian Staufner,  Dominic Lenz, 
  • First Published: 28 May 2025

A Multifaceted Approach Leads to Improved Linkage to HCV Therapy: A Multicenter Randomised Controlled Trial

Peng Xu,  Dandan Yang,  Yan Guo,  Jiejun Yu,  Wanyue Zhang,  Xiaobin Zhang,  Chuanwu Sun,  Xingyun Chen,  Peidong Zhang,  Zhongfu Liu,  Jian Li, 
  • First Published: 27 June 2025

LETTER TO THE EDITOR

A Commentary on ‘Safety, Pharmacokinetics and Antiviral Efficacy of Capsid Assembly Modulator Freethiadine in Healthy Volunteers and Chronic Hepatitis B Patients’

Shuo Zhou,  Chujun Luo,  Liangliang Chen, 
  • First Published: 29 May 2025

MASLD and MASH Risk: Does Losing Obesity Reverse the Metabolic Footprint

Laurens A. van Kleef,  Jesse Pustjens,  Willem Pieter Brouwer, 
  • First Published: 29 May 2025