• Issue

    Aging Cell: Volume 11, Issue 3

    371-557
    June 2012
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Reviews

The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases

Peter W. Stacpoole, 
  • Pages: 371-377
  • First Published: 09 February 2012

Is cellular senescence an example of antagonistic pleiotropy?

Stefano Giaimo,  Fabrizio d’Adda di Fagagna, 
  • Pages: 378-383
  • First Published: 14 February 2012

Original Articles

Wild-type amyloid beta 1-40 peptide induces vascular smooth muscle cell death independently from matrix metalloprotease activity

Régis Blaise,  Véronique Mateo,  Clotilde Rouxel,  François Zaccarini,  Martine Glorian,  Gilbert Béréziat,  Vladislav S. Golubkov,  Isabelle Limon, 
  • Pages: 384-393
  • First Published: 19 January 2012

Activity of mannose-binding lectin in centenarians

Rossella Tomaiuolo,  Anna Ruocco,  Chiara Salapete,  Ciriaco Carru,  Giovannella Baggio,  Claudio Franceschi,  Angelo Zinellu,  James Vaupel,  Chiara Bellia,  Bruna Lo Sasso,  Marcello Ciaccio,  Giuseppe Castaldo,  Luca Deiana, 
  • Pages: 394-400
  • First Published: 12 January 2012

Comparative and meta-analytic insights into life extension via dietary restriction

Shinichi Nakagawa,  Malgorzata Lagisz,  Katie L. Hector,  Hamish G. Spencer, 
  • Pages: 401-409
  • First Published: 23 January 2012

Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway

Yuhong Wang,  Makoto Kuro-o,  Zhongjie Sun, 
  • Pages: 410-417
  • First Published: 19 January 2012

Effects of diet on synaptic vesicle release in dynactin complex mutants: a mechanism for improved vitality during motor disease

Joel M. Rawson,  Tabita Kreko,  Holly Davison,  Rebekah Mahoney,  Alex Bokov,  Leo Chang,  Jon Gelfond,  Greg T. Macleod,  Benjamin A. Eaton, 
  • Pages: 418-427
  • First Published: 23 January 2012
Open Access

Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations

Wenyu Luo,  Wen-Feng Chen,  Zhifeng Yue,  Dechun Chen,  Mallory Sowcik,  Amita Sehgal,  Xiangzhong Zheng, 
  • Pages: 428-438
  • First Published: 23 January 2012

O-GlcNAcase is essential for embryonic development and maintenance of genomic stability

Yong Ryoul Yang,  Minseok Song,  Ho Lee,  Yoon Jeon,  Eun-Jeong Choi,  Hyun-Jun Jang,  Hyo Youl Moon,  Ha-Young Byun,  Eung-Kyun Kim,  Dae Hyun Kim,  Mi Nam Lee,  Ara Koh,  Jaewang Ghim,  Jang Hyun Choi,  Whaseon Lee-Kwon,  Kyong Tai Kim,  Sung Ho Ryu,  Pann-Ghill Suh, 
  • Pages: 439-448
  • First Published: 07 February 2012

Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function

Zhangfa Song,  Junling Zhang,  Zhenyu Ju,  K. Lenhard Rudolph, 
  • Pages: 449-455
  • First Published: 28 January 2012

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

Deborah L. Croteau,  Marie L. Rossi,  Chandrika Canugovi,  Jane Tian,  Peter Sykora,  Mahesh Ramamoorthy,  ZhengMing Wang,  Dharmendra Kumar Singh,  Mansour Akbari,  Rajesh Kasiviswanathan,  William C. Copeland,  Vilhelm A. Bohr, 
  • Pages: 456-466
  • First Published: 01 February 2012

Strontium ranelate rebalances bone marrow adipogenesis and osteoblastogenesis in senescent osteopenic mice through NFATc/Maf and Wnt signaling

Zuzana Saidak,  Eric Haÿ,  Caroline Marty,  Alain Barbara,  Pierre J. Marie, 
  • Pages: 467-474
  • First Published: 09 February 2012

Human longevity and common variations in the LMNA gene: a meta-analysis

Karen N. Conneely,  Brian C. Capell,  Michael R. Erdos,  Paola Sebastiani,  Nadia Solovieff,  Amy J. Swift,  Clinton T. Baldwin,  Temuri Budagov,  Nir Barzilai,  Gil Atzmon,  Annibale A. Puca,  Thomas T. Perls,  Bard J. Geesaman,  Michael Boehnke,  Francis S. Collins, 
  • Pages: 475-481
  • First Published: 16 February 2012

hTERT mutations associated with idiopathic pulmonary fibrosis affect telomerase activity, telomere length, and cell growth by distinct mechanisms

Allison R. Tsang,  Haley D.M. Wyatt,  Nicholas S.Y. Ting,  Tara L. Beattie, 
  • Pages: 482-490
  • First Published: 24 February 2012
Free Access

Temporal requirements of heat shock factor-1 for longevity assurance

Yuli Volovik,  Moria Maman,  Tatyana Dubnikov,  Michal Bejerano-Sagie,  Derek Joyce,  Erik A Kapernick,  Ehud Cohen,  Andrew Dillin, 
  • Pages: 491-499
  • First Published: 23 February 2012

MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling

Mingyi Wang,  Zongming Fu,  James Wu,  Jing Zhang,  Liqun Jiang,  Benjamin Khazan,  Richard Telljohann,  Mingming Zhao,  Alexander W. Krug,  Maria Pikilidou,  Robert E. Monticone,  Robert Wersto,  Jennifer Van Eyk,  Edward G. Lakatta, 
  • Pages: 500-508
  • First Published: 03 March 2012

Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells

Lishi Sun,  Vincent J. Hurez,  Suzanne R. Thibodeaux,  Mark J. Kious,  Aijie Liu,  Peiyi Lin,  Kruthi Murthy,  Srilakshmi Pandeswara,  Tahiro Shin,  Tyler J. Curiel, 
  • Pages: 509-519
  • First Published: 28 February 2012

An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress

Barbara Pascucci,  Tiziana Lemma,  Egidio Iorio,  Sara Giovannini,  Bruno Vaz,  Ivano Iavarone,  Angelo Calcagnile,  Laura Narciso,  Paolo Degan,  Franca Podo,  Vera Roginskya,  Bratislav M. Janjic,  Bennett Van Houten,  Miria Stefanini,  Eugenia Dogliotti,  Mariarosaria D’Errico, 
  • Pages: 520-529
  • First Published: 08 March 2012

A synthetic amino acid substitution of Tyr10 in Aβ peptide sequence yields a dominant negative variant in amyloidogenesis

Honoree Mazargui,  Christian Lévêque,  Dirk Bartnik,  Jacques Fantini,  Tiphany Gouget,  Mariarosa A. B. Melone,  Susanne A. Funke,  Dieter Willbold,  Lorena Perrone, 
  • Pages: 530-541
  • First Published: 03 March 2012

Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling

Carlos J. Miranda,  Lyndsey Braun,  Yuying Jiang,  Mark E. Hester,  Ling Zhang,  Matthew Riolo,  Haijuan Wang,  Meghan Rao,  Rachel A. Altura,  Brian K. Kaspar, 
  • Pages: 542-552
  • First Published: 08 March 2012

Short Take

Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells

Akiyuki Hirosue,  Ko Ishihara,  Kazuaki Tokunaga,  Takehisa Watanabe,  Noriko Saitoh,  Masafumi Nakamoto,  Tamir Chandra,  Masashi Narita,  Masanori Shinohara,  Mitsuyoshi Nakao, 
  • Pages: 553-556
  • First Published: 16 February 2012

Announcement

The NIA Interventions Testing Program Announces the 2012 Solicitation of Proposals

  • Page: 557
  • First Published: 11 May 2012