• Issue

    Aging Cell: Volume 11, Issue 2

    181-369
    April 2012
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Hot Topics

Open Access

Hot topics in epigenetic mechanisms of aging: 2011

María Berdasco,  Manel Esteller, 
  • Pages: 181-186
  • First Published: 09 February 2012

Review

Pharmacological maintenance of protein homeostasis could postpone age-related disease

Silvestre Alavez,  Gordon J. Lithgow, 
  • Pages: 187-191
  • First Published: 07 January 2012

Original Articles

New genes that extend Caenorhabditis elegans’ lifespan in response to reproductive signals

Mark McCormick,  Kan Chen,  Priya Ramaswamy,  Cynthia Kenyon, 
  • Pages: 192-202
  • First Published: 15 November 2011

Myosin light chain 3f attenuates age-induced decline in contractile velocity in MHC type II single muscle fibers

Jong-Hee Kim,  Windy S. Torgerud,  Kelsey H. H. Mosser,  Hiroyuki Hirai,  Shuichi Watanabe,  Atsushi Asakura,  LaDora V. Thompson, 
  • Pages: 203-212
  • First Published: 21 November 2011

Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity

Yael H. Edrey,  Diana Casper,  Dorothee Huchon,  James Mele,  Jonathan A. Gelfond,  Deborah M. Kristan,  Eviatar Nevo,  Rochelle Buffenstein, 
  • Pages: 213-222
  • First Published: 21 November 2011

Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis

Mette Soerensen,  Mikael Thinggaard,  Marianne Nygaard,  Serena Dato,  Qihua Tan,  Jacob Hjelmborg,  Karen Andersen-Ranberg,  Tinna Stevnsner,  Vilhelm A. Bohr,  Masayuki Kimura,  Abraham Aviv,  Kaare Christensen,  Lene Christiansen, 
  • Pages: 223-227
  • First Published: 02 December 2011

The CETP I405V polymorphism is associated with an increased risk of Alzheimer’s disease

Lei Yu,  Joshua M. Shulman,  Lori Chibnik,  Sue Leurgans,  Julie A. Schneider,  Philip L. De Jager,  David A. Bennett, 
  • Pages: 228-233
  • First Published: 28 November 2011
Open Access

Characterization of cellular senescence mechanisms in human corneal endothelial cells

Angela N. Sheerin,  S. Kaye Smith,  Katrin Jennert-Burston,  Amy J. Brook,  Marcus C. Allen,  Badr Ibrahim,  Dawn Jones,  Corrin Wallis,  Katrin Engelmann,  William Rhys-Williams,  Richard G. A. Faragher,  David Kipling, 
  • Pages: 234-240
  • First Published: 29 November 2011
Open Access

Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging

Eva Terzibasi Tozzini,  Mario Baumgart,  Giorgia Battistoni,  Alessandro Cellerino, 
  • Pages: 241-251
  • First Published: 15 December 2011
Open Access

Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri– a new vertebrate model for age research

Jeanette Kirschner,  David Weber,  Christina Neuschl,  Andre Franke,  Marco Böttger,  Lea Zielke,  Eileen Powalsky,  Marco Groth,  Dmitry Shagin,  Andreas Petzold,  Nils Hartmann,  Christoph Englert,  Gudrun A. Brockmann,  Matthias Platzer,  Alessandro Cellerino,  Kathrin Reichwald, 
  • Pages: 252-261
  • First Published: 16 December 2011

CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength

Lorna W. Harries,  Luke C. Pilling,  L. Dena G. Hernandez,  Rachel Bradley-Smith,  William Henley,  Andrew B. Singleton,  Jack M. Guralnik,  Stefania Bandinelli,  Luigi Ferrucci,  David Melzer, 
  • Pages: 262-268
  • First Published: 08 December 2011

Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

Bradley S. Fleenor,  Douglas R. Seals,  Melanie L. Zigler,  Amy L. Sindler, 
  • Pages: 269-276
  • First Published: 13 December 2011

Age-dependent skewing of X chromosome inactivation appears delayed in centenarians’ offspring. Is there a role for allelic imbalance in Healthy Aging and Longevity?

Davide Gentilini,  Davide Castaldi,  Daniela Mari,  Daniela Monti,  Claudio Franceschi,  Anna Maria Di Blasio,  Giovanni Vitale, 
  • Pages: 277-283
  • First Published: 01 February 2012

Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging

Águeda González-Rodríguez,  Jose A. Más-Gutierrez,  Mercedes Mirasierra,  Antonio Fernandez-Pérez,  Yong J. Lee,  Hwi J. Ko,  Jason K. Kim,  Eduardo Romanos,  Jose M. Carrascosa,  Manuel Ros,  Mario Vallejo,  Cristina M. Rondinone,  Ángela M. Valverde, 
  • Pages: 284-296
  • First Published: 29 December 2011

Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver?

Swapna V. Shenvi,  Eric Smith,  Tory M. Hagen, 
  • Pages: 297-304
  • First Published: 28 December 2011

Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation

Hitoshi Takahashi,  Daiki Okamura,  Marlene E. Starr,  Hiroshi Saito,  B. Mark Evers, 
  • Pages: 305-314
  • First Published: 30 December 2011

Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans

Zhuoyu Ni,  Atsushi Ebata,  Elham Alipanahiramandi,  Siu Sylvia Lee, 
  • Pages: 315-325
  • First Published: 29 December 2011

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

Smita Majumder,  Antonella Caccamo,  David X. Medina,  Adriana D. Benavides,  Martin A. Javors,  Ellen Kraig,  Randy Strong,  Arlan Richardson,  Salvatore Oddo, 
  • Pages: 326-335
  • First Published: 31 December 2011

Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting d-serine-dependent NMDA receptor activation

Coline Haxaire,  Fabrice R Turpin,  Brigitte Potier,  Myriam Kervern,  Pierre-Marie Sinet,  Gérard Barbanel,  Jean-Pierre Mothet,  Patrick Dutar,  Jean-Marie Billard, 
  • Pages: 336-344
  • First Published: 09 January 2012
Open Access

A senescent cell bystander effect: senescence-induced senescence

Glyn Nelson,  James Wordsworth,  Chunfang Wang,  Diana Jurk,  Conor Lawless,  Carmen Martin-Ruiz,  Thomas von Zglinicki, 
  • Pages: 345-349
  • First Published: 09 February 2012

Linkage of cardiac gene expression profiles and ETS2 with lifespan variability in rats

Anna Sheydina,  Maria Volkova,  Liqun Jiang,  Ondrej Juhasz,  Jing Zhang,  Hyun-Jin Tae,  Maria G. Perino,  Mingyi Wang,  Yi Zhu,  Edward G. Lakatta,  Kenneth R. Boheler, 
  • Pages: 350-359
  • First Published: 17 January 2012

Short Takes

A neuroprotective role for the DNA damage checkpoint in tauopathy

Vikram Khurana,  Paola Merlo,  Brian DuBoff,  Tudor A. Fulga,  Katherine A. Sharp,  Shelagh D. Campbell,  Jürgen Götz,  Mel B. Feany, 
  • Pages: 360-362
  • First Published: 19 December 2011

Replication factor C1, the large subunit of replication factor C, is proteolytically truncated in Hutchinson–Gilford progeria syndrome

Hui Tang,  Benjamin Hilton,  Phillip R. Musich,  Ding Zhi Fang,  Yue Zou, 
  • Pages: 363-365
  • First Published: 13 December 2011

Monitoring of cellular senescence by DNA-methylation at specific CpG sites

Carmen M. Koch,  Sylvia Joussen,  Anne Schellenberg,  Qiong Lin,  Martin Zenke,  Wolfgang Wagner, 
  • Pages: 366-369
  • First Published: 16 December 2011