The CETP I405V polymorphism is associated with an increased risk of Alzheimer’s disease
Lei Yu
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorJoshua M. Shulman
Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Institute for the Neurosciences, Brigham and Women’s Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Search for more papers by this authorLori Chibnik
Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Institute for the Neurosciences, Brigham and Women’s Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Search for more papers by this authorSue Leurgans
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorJulie A. Schneider
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorPhilip L. De Jager
Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Institute for the Neurosciences, Brigham and Women’s Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Search for more papers by this authorDavid A. Bennett
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorLei Yu
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorJoshua M. Shulman
Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Institute for the Neurosciences, Brigham and Women’s Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Search for more papers by this authorLori Chibnik
Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Institute for the Neurosciences, Brigham and Women’s Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Search for more papers by this authorSue Leurgans
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorJulie A. Schneider
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorPhilip L. De Jager
Program in Translational NeuroPsychiatric Genomics, Departments of Neurology & Psychiatry, Institute for the Neurosciences, Brigham and Women’s Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Search for more papers by this authorDavid A. Bennett
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorSummary
The cholesteryl ester transfer protein (CETP) gene plays an essential role in regulating cholesterol homeostasis and is a candidate susceptibility gene for late-onset Alzheimer’s disease (AD). Recent finding suggests that the CETP I405V polymorphism (rs5882) is associated with a slower rate of memory decline and a lower risk of incident dementia. Using data from two ongoing epidemiologic clinical–pathologic cohort studies of aging and dementia in the United States, the Religious Order Study and the Memory and Aging Project, we evaluated the association of the CETP I405V polymorphism (rs5882) with cognitive decline and risk of incident AD in more than 1300 participants of European ancestry. Our results suggest that the CETP I405V polymorphism was associated with a faster rather than a slower rate of decline in cognition over time, and an increased risk of incident AD. This finding is consistent with data showing that the CETP I405V is associated with increased neuritic plaque density at autopsy.
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