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    Journal of Cellular Physiology: Volume 240, Issue 1

    January 2025
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ISSUE INFORMATION

Free Access

Issue Information

  • First Published: 29 December 2024

RESEARCH ARTICLE

Open Access

Feedback modulation of Orai1α and Orai1β protein content mediated by STIM proteins

Joel Nieto-Felipe,  Alvaro Macias-Díaz,  Vanesa Jimenez-Velarde,  Jose J. Lopez,  Gines M. Salido,  Tarik Smani,  Isaac Jardin,  Juan A. Rosado, 
  • First Published: 02 October 2024

REVIEW ARTICLE

Open Access

Signaling Regulation of FAM134-Dependent ER-Phagy in Cells

Alessandro Palma,  Alessio Reggio, 
  • First Published: 25 November 2024

SPECIAL ISSUE ARTICLE

Review Article

Metabolic Reprogramming in Cancer

Full Access

Mitochondrial metabolism: A moving target in hepatocellular carcinoma therapy

Monika Komza,  Jerry Edward Chipuk, 
  • First Published: 26 September 2024

RESEARCH ARTICLE

Open Access

Phenomics Demonstrates Cytokines Additive Induction of Epithelial to Mesenchymal Transition

Alphonse Boché,  Alexandra Landras,  Mathieu Morel,  Sabrina Kellouche,  Franck Carreiras,  Ambroise Lambert, 
  • First Published: 20 November 2024
Phenomics Demonstrates Cytokines Additive Induction of Epithelial to Mesenchymal Transition

An image based, low experimental cost single cell phenomics identifies epithelial to mesenchymal transition (EMT) states. Clustering discriminates 4 cell lines spanning across cancer EMT spectrum. A single normalised value of EMT induction is made, based on 50 single cell features. Cytokines combination in EMT induction is additive regardless of cancer cell line.

Open Access

Carboxyl Terminal Modulator Protein Induces Cell Senescence and Is Upregulated With Aging by Zic2 in Rats

Weiran Shan,  Jun Li,  Zachary Philpot,  Zhiyi Zuo, 
  • First Published: 30 January 2025
Open Access

Serinc5 Regulates Sequential Chondrocyte Differentiation by Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes

Kenji Hata,  Kanta Wakamori,  Akane Hirakawa-Yamamura,  Sachi Ichiyama-Kobayashi,  Masaya Yamaguchi,  Daisuke Okuzaki,  Yoshifumi Takahata,  Tomohiko Murakami,  Narikazu Uzawa,  Takashi Yamashiro,  Riko Nishimura, 
  • First Published: 20 November 2024

CORRECTION

Free Access

Corrigendum to “Defining Early Hematopoietic-Fated Primitive Streak Specification of Human Pluripotent Stem Cells by the Orchestrated Balance of Wnt, Activin, and BMP Signaling”

  • First Published: 26 January 2025

SPECIAL ISSUE ARTICLE

Review Article

Full Access

Cancer knocks you out by fasting: Cachexia as a consequence of metabolic alterations in cancer

Salvatore Cortellino,  Margherita D'Angelo,  Massimiliano Quintiliani,  Antonio Giordano, 
  • First Published: 08 September 2024

REVIEW ARTICLE

Full Access

Rho GTPase Signaling: A Molecular Switchboard for Regulating the Actin Cytoskeleton in Axon Guidance

Madhavi Gorla,  Digvijay Singh Guleria, 
  • First Published: 30 January 2025

RESEARCH ARTICLE

Full Access

CD44/Integrin β1 Association Drives Fast Motility on Hyaluronic Acid Substrates

Tanusri Roy,  Sarbajeet Dutta,  Swetlana Ghosh,  Lakshmi Kavitha Sthanam,  Shamik Sen, 
  • First Published: 21 January 2025
Open Access

CCL2-CCR2 Axis Inhibition in Osteosarcoma Cell Model: The Impact of Oxygen Level on Cell Phenotype

Agne Petrosiute,  Justina Musvicaitė,  Donatas Petroška,  Alvilė Ščerbavičienė,  Sascha Arnold,  Jurgita Matulienė,  Aurelija Žvirblienė,  Daumantas Matulis,  Asta Lučiūnaitė, 
  • First Published: 25 November 2024

CORRECTION

Free Access

Corrigendum to “Immortalized Hertwig's Epithelial Root Sheath Cell Line Works as a Model for Epithelial-Mesenchymal Interaction During Tooth Root Formation”

  • First Published: 26 January 2025

RESEARCH ARTICLE

Full Access

Single-Cell RNA-Seq and Histological Analysis Reveals Dynamic Lrig1 Expression During Salivary Gland Development

Shumin Liu,  Yuanyuan Li,  Delan Huang,  Ming Liu,  Xinye Zhang,  Hui Zhao,  Huan Liu,  Qiuhui Li,  Zhi Chen, 
  • First Published: 25 November 2024
Single-Cell RNA-Seq and Histological Analysis Reveals Dynamic Lrig1 Expression During Salivary Gland Development

Lrig1 was widely distributed in both mesenchyme and bud-derived epithelial branches throughout embryonic and neonatal stages, with an increase during developmental stages and a peak at PN5, followed by a moderate decline in adulthood and specific localization in the more mature epithelium.

SPECIAL ISSUE ARTICLE

Research Article

Full Access

Reprogramming of Fatty Acid Metabolism in Acute Leukemia

Judith Sokei,  Joice Kanefsky,  Stephen M. Sykes, 
  • First Published: 21 January 2025
Reprogramming of Fatty Acid Metabolism in Acute Leukemia

RESEARCH ARTICLE

Full Access

WHAMM Inhibits Type II Alveolar Epithelial Cell EMT by Mediating Autophagic Degradation of TGF-β1 in Bronchopulmonary Dysplasia

Shaodong Hua,  Jinghan Chi,  Ning Zhang,  Xiao Yang,  Pan Zhang,  Chenyang Jiang,  Yao Feng,  Xiaoyang Hong,  Zhichun Feng,  Yurou Yan, 
  • First Published: 20 November 2024

RETRACTION

Free Access

RETRACTION: Promotion of Cell Autophagy and Apoptosis in Cervical Cancer by Inhibition of Long Noncoding RNA LINC00511 via Transcription Factor RXRA-regulated PLD1

  • First Published: 30 January 2025

RETRACTION NOTICE

Free Access

RETRACTION: Long Noncoding RNA LEF1-AS1 Silencing Suppresses the Initiation and Development of Prostate Cancer by Acting as a Molecular Sponge of miR-330-5p via LEF1 Repression

  • First Published: 13 January 2025

REVIEW ARTICLE

Full Access

Osteoclast Secretes Stage-Specific Key Molecules for Modulating Osteoclast–Osteoblast Communication

Yi-fei Fu,  Shu-wen Shi,  Jun-jie Wu,  Zheng-dong Yuan,  Lei-sheng Wang,  Hao Nie,  Zheng-yu Zhang,  Xian Wu,  Yue-chun Chen,  Hui-bo Ti,  Ke-yue Zhang,  Dong Mao,  Jun-xing Ye,  Xia Li,  Feng-lai Yuan, 
  • First Published: 28 November 2024

RETRACTION

Free Access

RETRACTION: Long Noncoding RNA LINC00958 Regulates Cell Sensitivity to Radiotherapy Through RRM2 by Binding to microRNA-5095 in Cervical Cancer

  • First Published: 13 January 2025

RESEARCH ARTICLE

Full Access

High Glucose Inhibits O-GlcNAc Transferase Translocation in Early Osteoblast Differentiation by Altering Protein Phosphatase 2A Activity

Heriati Sitosari,  Yoko Fukuhara,  Yao Weng,  Yilin Zheng,  Yuhan He,  Xinyu Zheng,  Mika Ikegame,  Hirohiko Okamura, 
  • First Published: 12 January 2025
High Glucose Inhibits O-GlcNAc Transferase Translocation in Early Osteoblast Differentiation by Altering Protein Phosphatase 2A Activity

  • OGT translocation from the nucleus to the cytoplasm can be observed in early osteoblast differentiation.

  • High glucose condition disrupts OGT translocation in differentiating osteoblast, but this condition can be alleviated by PP2A inhibition.

  • Changes in OGT localization affect O-GlcNAcylation level of proteins in nucleus and cytoplasm.

  • Ser73 is identified as potential O-GlcNAc modification site in Osterix.

Full Access

Estrogen Regulates Mitochondrial Activity Through Inducing Brain-Derived Neurotrophic Factor Expression in Skeletal Muscle

Margaret Chui Ling Tse,  Brian Pak Shing Pang,  Xinyi Bi,  Teresa Xinci Ooi,  Wing Suen Chan,  Jiangwen Zhang,  Chi Bun Chan, 
  • First Published: 12 November 2024
Full Access

Glucose Transporter 1 Deficiency Impairs Glucose Metabolism and Barrier Induction in Human Induced Pluripotent Stem Cell-Derived Astrocytes

Iqra Pervaiz,  Yash Mehta,  Abraham Jacob Al-Ahmad, 
  • First Published: 14 January 2025
Glucose Transporter 1 Deficiency Impairs Glucose Metabolism and Barrier Induction in Human Induced Pluripotent Stem Cell-Derived Astrocytes
Graphical Abstract

Schematic representation of the major phenotype differences observed in GLUT1DS-iAstrocytes (iAstros) compared to their parental control clones. GLUT1DS-iAstros displayed reduced glucose uptake, reduced glycolysis and oxidative phosphorylation and reduced extracellular glutamate and lactate release.

Open Access

SMAD4 Regulates the Expression of LCK Affecting Chimeric Antigen Receptor-T Cells Proliferation Through PI3K/Akt Signaling Pathway

Rongxue Wan,  Bowen Fu,  Xiaokang Fu,  Zengping Liu,  Nafeisha Simayi,  Yongshui Fu,  Huaqin Liang,  Chengyao Li,  Wenhua Huang, 
  • First Published: 06 January 2025

SMAD4 Regulates the Expression of LCK Affecting Chimeric Antigen Receptor-T Cells Proliferation Through PI3K/Akt Signaling Pathway

SMAD4, essential for CAR-T cells proliferation, binds to LCK promoter regulating LCK expression involving in PI3K/Akt signaling pathway to affect CAR-T cells proliferation, apoptosis and cell cycle.

REVIEW ARTICLE

Full Access

Function and Regulation of Age-Associated B Cells in Diseases

Zi Geng,  Yejin Cao,  Longhao Zhao,  Likun Wang,  Yingjie Dong,  Yujing Bi,  Guangwei Liu, 
  • First Published: 03 January 2025

RESEARCH ARTICLE

Open Access

Spontaneously Immortalised Nonhuman Primate Müller Glia Cell Lines as Source to Explore Retinal Reprogramming Mechanisms for Cell Therapies

Ahmed Salman,  Arantxa Bolinches-Amorós,  Tina Storm,  Daniela Moralli,  Paulina Bryika,  Angela J. Russell,  Stephen G. Davies,  Alun R. Barnard,  Robert E. MacLaren, 
  • First Published: 28 November 2024
Open Access

Point of No Return—What Is the Threshold of Mitochondria With Permeability Transition in Cells to Trigger Cell Death

Kristina A. Kritskaya,  Olga A. Stelmashchuk,  Andrey Y. Abramov, 
  • First Published: 06 January 2025
Full Access

FMNL3 Promotes Migration and Invasion of Breast Cancer Cells via Inhibiting Rad23B-Induced Ubiquitination of Twist1

Binggong Zhao,  Dong-Man Ye,  Shujing Li,  Yong Zhang,  Yang Zheng,  Jie Kang,  Luhong Wang,  Nannan Zhao,  Bashir Ahmad,  Jing Sun,  Tao Yu,  Huijian Wu, 
  • First Published: 25 November 2024

RETRACTION

Free Access

RETRACTION: Role of Mirnas in Lung Cancer

  • First Published: 30 January 2025

RESEARCH ARTICLE

Full Access

Glucose Upregulates ChREBP via Phosphorylation of AKT and AMPK to Modulate MALT1 and WISP1 Expression

Syue-Ting Chen,  Kang-Shuo Chang,  Yu-Hsiang Lin,  Chen-Pang Hou,  Wei-Yin Lin,  Shu-Yuan Hsu,  Hsin-Ching Sung,  Tsui-Hsia Feng,  Ke-Hung Tsui,  Horng-Heng Juang, 
  • First Published: 12 November 2024
Glucose Upregulates ChREBP via Phosphorylation of AKT and AMPK to Modulate MALT1 and WISP1 Expression

The modulation of glucose on WISP1 and MALT1 expression via the upregulation of carbohydrate response element binding protein in the human prostate cells.

Open Access

Dynamic mRNA Stability Buffer Transcriptional Activation During Neuronal Differentiation and Is Regulated by SAMD4A

Yuan Zhou,  Sherif Rashad,  Daisuke Ando,  Yuki Kobayashi,  Teiji Tominaga,  Kuniyasu Niizuma, 
  • First Published: 08 November 2024
Open Access

Vacuolar H+-ATPase and Megalin-Mediated Prorenin Uptake: Focus on Elements Beyond the (Pro)Renin Receptor

Na Wang,  Xifeng Lu,  A. H. Jan Danser, 
  • First Published: 02 January 2025
Open Access

Muscle PGC-1α Overexpression Drives Metabolite Secretion Boosting Subcutaneous Adipocyte Browning

Caterina Miro,  Ciro Menale,  Lucia Acampora,  Annarita Nappi,  Serena Sagliocchi,  Federica Restolfer,  Sepehr Torabinejad,  Mariano Stornaiuolo,  Monica Dentice,  Annunziata Gaetana Cicatiello, 
  • First Published: 15 December 2024
Full Access

Primary Cilia Regulate the Homeostasis and Regeneration of the Stem Cell Niche in the Tooth

Xinming Zhang,  Yuxin Cao,  Mengge Wang,  Yujia Li,  Hanxiao Yin,  Hua Ni,  Song Yang,  Fan Yu,  Jia Yang,  Lisu Peng,  Meilin Hu,  Dengwen Li,  Dayong Liu, 
  • First Published: 29 December 2024
Full Access

Cholesterol Depletion Activate Hepatic Stellate Cells Mediated Through SREBP-2 Signaling

Nivya Vijayan,  Madan Kumar Perumal, 
  • First Published: 13 November 2024
Open Access

Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling

Sepideh Fakhari,  Gabriel Campolina-Silva,  Farnaz Asayesh,  Laura Girardet,  Marie-Pier Scott-Boyer,  Arnaud Droit,  Denis Soulet,  Jesse Greener,  Clémence Belleannée, 
  • First Published: 07 November 2024
Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling

Influence of shear stress on epididymis epithelial cells through primary cilia mechanosensory signaling. (a) Anatomical illustration of the male reproductive system highlighting the epididymis three main segments: caput, corpus, and cauda. (b) Luminal fluid flow-induced shear stress within the epididymal duct. (c) Cross-sectional diagram of the epididymal epithelium showing various cell types including undifferentiated cells, differentiated principal, and clear cells. Primary cilia elongate from the basal body of undifferentiated cells and principal cells. (d) Fluid shear stress-induced calcium signaling and gene expression in principal cells. Fluid flow induces Ca²⁺ influx through the primary cilium, activating the release of calcium from endoplasmic reticulium (ER) and leading to the modulation of over 100 genes, including flow-sensitive genes, cilia-dependent genes, and genes dependent on both flow and the presence of cilia.

Full Access

KIF18A Is a Novel Target of JNK1/c-Jun Signaling Pathway Involved in Cervical Tumorigenesis

Yajie Wang,  Bowen Zhou,  Xiaoying Lian,  Siqi Yu,  Baihai Huang,  Xinyue Wu,  Lianpu Wen,  Changjun Zhu, 
  • First Published: 03 January 2025

SPECIAL ISSUE ARTICLE

Review Article

Full Access

Advances in Aggrephagy: Mechanisms, Disease Implications, and Therapeutic Strategies

Haixia Zhuang,  Xinyu Ma, 
  • First Published: 03 January 2025
Advances in Aggrephagy: Mechanisms, Disease Implications, and Therapeutic Strategies

New insights into organellar structure and function.

RESEARCH ARTICLE

Full Access

miR-1224 Controls Mammal Cerebral Cortex Development by Targeting the 3’-UTR of the Dlx1 mRNA

Chenglong Liu,  Liyu Zhou,  Qingbai Liu,  Li Ni,  Jianping Yang, 
  • First Published: 02 January 2025
Full Access

NAT10 functions as a pivotal regulator in gastric cancer metastasis and tumor immunity

Yuqian Mo,  Enyu Huang,  Chao Deng,  Haofeng Huang,  Ying Zhu,  Xinlong Wei,  Jinlin Zhong,  Yuzhi Wang,  Zhigang Huang,  Jingjing Zhang, 
  • First Published: 28 October 2024

RETRACTION

Free Access

RETRACTION: MiR-145 Promotes MiR-133b Expression Through c-myc and DNMT3A-mediated Methylation in Ovarian Cancer Cells

  • First Published: 13 January 2025

RESEARCH ARTICLE

Full Access

Single-Cell Transcriptomic Analysis Reveals Biomechanical Loading-Induced Imbalance in Bone and Fat, Leading to Ossification in Lumbar Intervertebral Disc Nucleus Pulposus Degeneration

Ping Zhang,  Yuan Wang,  Jianqi Bai,  Jingru Zhang,  Shimin Zhang,  Xiaofei Guo,  Jiawen Zhan,  Liguo Zhu, 
  • First Published: 24 January 2025

Trial Registration: Clinical Registration number: ChiCTR2200064033 (Date: 2022-09-24, URL: https://www.chictr.org.cn/showproj.html?proj=180927).

REVIEW ARTICLE

Full Access

Novel Therapeutic Strategies Targeting Fibroblasts to Improve Heart Disease

Yujuan Li, 
  • First Published: 17 December 2024

RESEARCH ARTICLE

Full Access

CBFβ Regulates RUNX3 ADP-Ribosylation to Mediate Homologous Recombination Repair

William E. Samsa,  Zhen Zhang,  Zihua Gong, 
  • First Published: 18 December 2024

REVIEW ARTICLE

Open Access

Physiological Insights Into the Role of Pericytes in Spinal Cord Injury

Haiming Jin,  Jessica Rawlins,  Yiqi Chen,  Xiaohang Zheng,  Oscar Charlesworth,  Junchun Chen,  Gang Wang,  Huoling Luo,  Wenxiang Cheng,  Zhong Alan Li,  Sipin Zhu,  Jiake Xu, 
  • First Published: 06 January 2025

RESEARCH ARTICLE

Full Access

Pregnancy Entails a Metabolic Rewiring of Maternal Circulating Neutrophils

Guillermina Calo,  Fátima Merech,  Florencia Sabbione,  Vanesa Hauk,  Brenda Lara,  Luciana Doga,  Luciana D'eramo,  Aldo Squassi,  Rosanna Ramhorst,  Analía Trevani,  Daiana Vota,  Claudia Pérez Leirós, 
  • First Published: 16 December 2024
Full Access

RRM2 Is a Putative Biomarker and Promotes Bladder Cancer Progression via PI3K/AKT/mTOR Pathway

Linfa Guo,  Yiqiao Zhao,  Xiaojie Bai,  Xiaolong Wang,  Kuerban Tuoheti,  Yuanfei Cao,  Yingtong Zuo,  Xinhua Zhang,  Tongzu Liu, 
  • First Published: 16 December 2024
Full Access

Tissue Engineering 3D-Printed Scaffold Using Allograft/Alginate/Gelatin Hydrogels Coated With Platelet-Rich Fibrin or Adipose Stromal Vascular Fraction Induces Osteogenesis In Vitro

Sahar Baniameri,  Hossein Aminianfar,  Niusha Gharehdaghi,  Amir-Ali Yousefi-Koma,  Sadra Mohaghegh,  Hanieh Nokhbatolfoghahaei,  Arash Khojasteh, 
  • First Published: 19 December 2024

REVIEW ARTICLE

Full Access

Regulation of the Cilia as a Potential Treatment for Senescence and Tumors: A Review

Danping Zhu,  Yuqin Pan,  Yong Yang,  Shukui Wang, 
  • First Published: 11 December 2024

RESEARCH ARTICLE

Full Access

METTL3-Dependent YTHDF2 Mediates TSC1 Expression to Regulate Alveolar Epithelial Mesenchymal Transition and Promote Idiopathic Pulmonary Fibrosis

Min Liu,  Yingying Sheng,  Mengyu Li,  Tianyu Pan,  Wei Jiang,  Yafei Zhang,  Xin Pan,  Cheng Huang,  Jun Li,  Yuanyuan Wang, 
  • First Published: 28 November 2024
Full Access

Tumor-Derived GDF15 Induces Tumor Associated Fibroblast Transformation From BMSCs and Fibroblasts in Oral Squamous Cell Carcinoma

Jingjing Zhao,  Yahui Li,  Yingying Huang,  Peng Su,  Fujiao Nie,  Pishan Yang,  Chengzhe Yang, 
  • First Published: 05 December 2024
Tumor-Derived GDF15 Induces Tumor Associated Fibroblast Transformation From BMSCs and Fibroblasts in Oral Squamous Cell Carcinoma

We investigated the effect of OSCC cells derived GDF15 on CAF transformation from BMSCs and HGFs and underlying mechanisms. Our findings indicate that tumor cells derived GDF15 contributes to the progression of OSCC by promoting transformation of CAFs through the ERK1/2 pathway.

Full Access

Fish collagen sponge with human umbilical cord mesenchymal stem cells for diabetic wound repair in rats

Che Haijie,  Wang Lei,  Wang Kai,  Lin Guodong,  Liu Guolong,  Yang Zhongzhen,  Wang Junru,  Liu Ying,  Jiang Xiaorui, 
  • First Published: 21 October 2024
Fish collagen sponge with human umbilical cord mesenchymal stem cells for diabetic wound repair in rats

A study explored the effects of human umbilical cord mesenchymal stem cells loaded onto a fish collagen sponge for wound healing in diabetic rats. Results showed improved wound repair time, healing outcomes, and collagen deposition regulation compared to self-healing methods, suggesting promise for treating diabetes-induced wounds with this innovative approach.

REVIEW ARTICLE

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Maintenance of Cardiac Microenvironmental Homeostasis: A Joint Battle of Multiple Cells

Jiayu Yao,  Youtao Zhang,  Ziwen Wang,  Yuejun Chen,  Xingjuan Shi, 
  • First Published: 04 December 2024

RESEARCH ARTICLE

Full Access

Epigenetic regulation of myogenesis by vitamin C

Sachiko Yamashita Takeuchi,  Chirada Dusadeemeelap,  Tatsuo Kawamoto,  Takuma Matsubara,  Shoichiro Kokabu,  William N. Addison, 
  • First Published: 24 October 2024

REVIEW ARTICLE

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RHO subfamily of small GTPases in the development and function of hematopoietic cells

Stephany Suelen de Castro Sampaio,  Maria Carolina Clares Ramalho,  Caroline Santos de Souza,  Beatriz de Almeida Rodrigues,  Guilherme Ramos Sales de Mendonça,  Mariana Lazarini, 
  • First Published: 21 October 2024
RHO subfamily of small GTPases in the development and function of hematopoietic cells

RHO subfamily of small GTPases in hematopoietic cells. Critical roles of RHOA, RHOB and RHOC have been described in hematopoietic cells. (1) Proper functioning of the RHO pathway is necessary for the normal development and activity of blood cells, (2) whereas several RHO abnormalities are found in hematological malignancies.

RESEARCH ARTICLE

Open Access

Leukotriene B4 is elevated in diabetes and promotes ventricular arrhythmogenesis in guinea pig

Andrea Corbin,  Kelly A. Aromolaran,  Ademuyiwa S. Aromolaran, 
  • First Published: 14 October 2024
Open Access

N-terminomics profiling of naïve and inflamed murine colon reveals proteolytic signatures of legumain

Alexander R. Ziegler,  Bethany M. Anderson,  Rocco Latorre,  Rachel M. McQuade,  Antoine Dufour,  Brian L. Schmidt,  Nigel W. Bunnett,  Nichollas E. Scott,  Laura E. Edgington-Mitchell, 
  • First Published: 11 October 2024

SPECIAL ISSUE ARTICLE

Research Article

Full Access

Exploring Metabolic Approaches for Epithelial Ovarian Cancer Therapy

Sangeeta Kumari,  Shraddha Gupta,  Aisha Jamil,  Deyana Tabatabaei,  Sergey Karakashev, 
  • First Published: 15 December 2024

REVIEW ARTICLE

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HO-1: An emerging target in fibrosis

Chenxi Lu,  Yuan Liu,  Feifei Ren,  Haoran Zhang,  Yafang Hou,  Hong Zhang,  Zhiyong Chen,  Xia Du, 
  • First Published: 17 October 2024
HO-1: An emerging target in fibrosis

Overview of the molecular mechanism of heme oxygenase-1 in fibrosis development.

RESEARCH ARTICLE

Open Access

Investigation into the significant role of dermal-epidermal interactions in skin ageing utilising a bioengineered skin construct

Lydia Costello,  Kirsty Goncalves,  Paola De Los Santos Gomez,  Ben Hulette,  Teresa Dicolandrea,  Michael J. Flagler,  Robert Isfort,  John Oblong,  Charlie Bascom,  Stefan Przyborski, 
  • First Published: 08 October 2024
Investigation into the significant role of dermal-epidermal interactions in skin ageing utilising a bioengineered skin construct

An ageing dermis contributes to age-associated changes in epidermal morphology through a paracrine mechanism. Paracrine mediators that govern this response may be released as ageing fibroblasts exhibit a Pro-inflammatory secretome.

Full Access

Taurine reduces glycolysis of pig skeletal muscle by inhibiting HIF-1α signaling

Xiaoling Chen,  An Wenting,  Huang Zhiqing,  Gang Jia,  Hua Zhao, 
  • First Published: 07 October 2024

REVIEW ARTICLE

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Advances in the mechanisms of vascular calcification in chronic kidney disease

Ziyang Wang,  Zebin Gui,  Lirong Zhang,  Zhongqun Wang, 
  • First Published: 11 October 2024
Advances in the mechanisms of vascular calcification in chronic kidney disease

This article reviews how various factors, such as disturbances in calcium and phosphorus metabolism, imbalances in inhibitors of calcification, and accumulation of uremia toxins, promote vascular calcification (VC) in the chronic kidney disease state. Epigenetics provides new tools to study the mechanisms of VC and to discover excellent circulating markers.

RESEARCH ARTICLE

Open Access

A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts

Anastasia Thoma,  Razan Alomosh,  Holly L. Bond,  Tania Akter-Miah,  Nasser Al-Shanti,  Hans Degens,  Vanja Pekovic-Vaughan,  Adam P. Lightfoot, 
  • First Published: 09 October 2024

REVIEW ARTICLE

Open Access

Emerging understandings of the role of exosomes in atherosclerosis

Zena Wehbe,  Maya Wehbe,  Ali Al Khatib,  Ali H. Dakroub,  Gianfranco Pintus,  Firas Kobeissy,  Ali H. Eid, 
  • First Published: 06 October 2024
Full Access

Pharmacological activity, phytochemistry, and organ protection of lithospermic acid

Wenwen Yang,  Jiayan Li,  Jiayin Tian,  Xiaoyi Liu,  Wentao Xie,  Xue Wu,  Zhe Zhang,  Yuefei Song,  Shuya Wang,  Shiyan Zhao,  Zheng Wang,  Yang Yang,  Zhenxiao Jin, 
  • First Published: 14 October 2024

RESEARCH ARTICLE

Open Access

Compensatory reactions of B cells in response to chronic HIV-1 Tat exposure

Anna A. Valyaeva,  Maria A. Tikhomirova,  Junyi Feng,  Anastasia A. Zharikova,  Daria M. Potashnikova,  Yana R. Musinova,  Andrey A. Mironov,  Yegor S. Vassetzky,  Eugene V. Sheval, 
  • First Published: 07 October 2024
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Pressure loading regulates the stemness of liver cancer stem cells via YAP/BMF signaling axis

Di Ma,  Rui Liang,  Qing Luo,  Guanbin Song, 
  • First Published: 02 October 2024
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DMT1 Maintains Iron Homeostasis to Regulate Mitochondrial Function in Porcine Oocytes

Jin-Xin Zhang,  Meng-Fan Lan,  Jian-Zhou Shang,  Xin-Le Lai,  Li-Shu Li,  Tong-Tong Duan,  Ru-Hai Xu,  Kun-Lin Chen,  Xing Duan, 
  • First Published: 05 December 2024
DMT1 Maintains Iron Homeostasis to Regulate Mitochondrial Function in Porcine Oocytes

This study provided compelling evidence that DMT1 and iron homeostasis were crucial for maintaining the capacity of porcine oocyte maturation. Moreover, the results hinted at the potential of DMT1 as a novel therapeutic target for treating iron deficiency-related female reproductive disorders.

Full Access

Ethionine-induced S-adenosylmethionine deficiency suppressed H3K27me3 and cell differentiation during neural tube development in mice

Li Zhang,  Xiaona Zhang,  Yurong Liu,  Kaixin Wei,  Huijing Ma,  Li Xia,  Rui Cao,  Yuqing Sun,  Ronghua Zheng,  Xiuwei Wang,  Bingmei Chang, 
  • First Published: 06 October 2024