Natural Sciences is an interdisciplinary open access journal publishing top-tier research from biology, chemistry, physics and their interfaces, as well as seminal works from related fields such as engineering and biomedical research.

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RESEARCH ARTICLE
Open access

Biomechanical Analysis of Mongolian Bronze and Iron Age Four‐Legged Walking Petroglyphs

  •  23 June 2025

Graphical Abstract

Biomechanical Analysis of Mongolian Bronze and Iron Age Four-Legged Walking Petroglyphs Issue 3, 2025

Top: Photograph (by Krisztián Bécs) of an Iron Age Mongolian rock-goatpetroglyph. Bottom:

RESEARCH ARTICLE
Open access

Atomic Force Microscopy of Emulsions and Their Interfacial Nanoparticles

  •  18 June 2025

Graphical Abstract

Atomic Force Microscopy of Emulsions and Their Interfacial Nanoparticles Issue 3, 2025

Emulsion droplets and their interfacial nanoparticles were imaged under water by atomic force microscopy. Changes in the sample were triggered by increasing the applied mechanical force. Mechanical data was overlaid on the topography data for an improved understanding of the properties and behavior of the droplets and particles.

RESEARCH ARTICLE
Open access

Trikafta Rescues F508del‐CFTR by Tightening Specific Phosphorylation‐Dependent Interdomain Interactions

  •  26 May 2025

Graphical Abstract

Trikafta Rescues F508del-CFTR by Tightening Specific Phosphorylation-Dependent Interdomain Interactions Issue 3, 2025

The most common cystic fibrosis mutation, F508del, destabilizes the first of two nucleotide-binding domains (NBD1 and NBD2) and compromises Mg/ATP-dependent gating at the interface between two transmembrane domains (TMD1 and TMD2) in the human cystic fibrosis transmembrane conductance regulator (CFTR). However, Trikafta can correct thermal and gating defects by enhancing TMD1–TMD2 (blue) and NBD1–NBD2 (orange) interactions and regulating the thermoring structures (red) of NBD1 through the specific binding of the dynamic phosphorylated regulatory domain (purple) to the TMD1/TMD2/NBD1 interfaces (cyan).

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The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.

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Para‐ortho hydrogen conversion: Solving a 90‐year old mystery

  •  12 January 2021

Graphical Abstract

Para-ortho hydrogen conversion: Solving a 90-year old mystery Issue 1, 2021

First-principles quantum calculations finally explain how para-ortho hydrogen conversion is catalyzed by paramagnetic molecules.

Open access

Consecutively fused single‐, double‐, and triple‐expanded helicenes

  •  3 March 2022

Graphical Abstract

Consecutively fused single-, double-, and triple-expanded helicenes Issue 2, 2022

Defect-free single-, double-, and triple-expanded helicenes with C-, S-, and M-shaped fully conjugated helical ladder structures, respectively, are quantitatively and chemoselectively synthesized through acid-promoted intramolecular multistep cascade alkyne benzannulations of anthracene-based cyclization precursors composed of a large number of chiral (racemo) and achiral (meso) dynamic stereoisomers arising from axial chirality. The configurationally stable and optically pure triple-expanded helicene emits intense circularly polarized light with the highest circularly polarized luminescence brightness among all the reported CPL-active helicenes and helicenoids.

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