Pediatric Transplantation

This study examines the oral health of children who have undergone liver transplantation, highlighting dental development delays despite similar caries rates compared to their healthy peers. Findings emphasize the need for integrated dental-medical care, focusing on dental age assessment and early intervention to optimize oral health outcomes in this vulnerable population.

This is a retrospective study to investigate the incidence and clinical prognosis of acute kidney injury and different modes of recovery after pediatric liver transplantation.

Cidofovir (CDV) prophylaxis significantly reduces the incidence of BK virus-associated hemorrhagic cystitis in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation. Early BKV copy number reduction and lower graft-versus-host disease prevalence in the CDV group suggest its potential as an effective preventive treatment.

Machine learning identified key predictors of pediatric heart transplant waitlist mortality, including candidate-specific factors (e.g., diagnosis, ventilator use) and institutional practices (e.g., organ refusal rates). Centers with high refusal rates had worse outcomes, highlighting the need to standardize organ acceptance criteria and address modifiable risk factors to improve survival.

ARD is prevalent among ESKD children. Younger age, lower BMI Z-scores, HTN, and increased Ca × Ph are risk factors for ARD. ARD frequency decreases on ≥ 6-month follow-up of patients.

Young adults who initiate dialysis before 18 years old are disadvantaged by current OPTN waitlist and organ allocation policies for kidney transplantation. Compared to adolescents and other young adults, these patients spend the longest time on dialysis, have the highest incidence of waitlist removal without transplant, and have the worst graft survival after kidney transplantation.

Semilunar valves from the hearts of patients receiving a retransplant can be used for partial heart transplants.

Rapid weight gain (RWG) in the first year following kidney transplantation occurred frequently in the North American Pediatric Trials and Collaborative Studies cohort and was significantly associated with obesity but not hypertension up to 5 years post-transplant. RWG was lower in children who received steroid minimization protocols.

In a review of a national database spanning the past three decades, researchers investigated delayed graft function (DGF) in pediatric recipients of deceased donor kidney transplants. This study found that DGF was associated with reduced survival after cases and controls were matched across various donor, recipient, and transplant factors.

We investigated the factors associated with intraoperative hypothermia in 111 patients who underwent pediatric liver transplantation between 2019 and 2020 at a single tertiary pediatric center. The results of multivariate analysis indicated that only rejection was significantly associated with intraoperative hypothermia during pediatric liver transplantation.

Intestinal complications (IC) are significant adverse events following liver transplantation (LT), yet research on pediatric cohorts remains limited. This study aims to describe IC in children after LT and identify factors associated with their occurrence. Recognizing these factors may help medical teams diagnose IC earlier in pediatric LT patients, leading to improved outcomes.

Examining social determinants of health (SDOH) in pediatric liver transplant recipients, the study identifies childhood opportunity, but not race or insurance status, as a significant predictor of graft survival. Patient survival was not impacted by any SDOH indicators.

We retrospectively reviewed 1645 LTx of which 421 transplantations were performed in 405 pediatric recipients. This patient collective was further analyzed for various study endpoints such as pleural effusions, vascular complications, and biliary complications within the first 30 postoperative days or retransplantation and patient survival within the first year after transplantation.